Patents Assigned to System of Higher Education
  • Small molecules that specifically inhibit TNF-induced NF-KB inflammation pathway
    Patent number: 11858877
    Abstract: Provided herein are small molecules that specifically inhibit TNF-induced nuclear factor kB (NF-kB) inflammation pathway. Also provided are methods of screening compounds to identify molecules that specifically inhibit a TNF-induced NF-kB inflammation pathway, methods of inhibiting TNF-induced NF-kB inflammation pathway, and methods of preventing formation of mature TNFR1 complex.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: January 2, 2024
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Carlos Jaime Camacho, Robin E. C. Lee
  • Protection and delivery of multiple therapeutic proteins
    Patent number: 11857631
    Abstract: Compositions are provided herein comprising a coacervate of a polycationic polymer, a polyanionic polymer, and platelet-rich plasma and/or serum, or a fraction or concentrate thereof. The composition is useful in wound healing. Compositions also are provided that comprise a hydrogel comprising TIMP-3; and a complex of a polycationic polymer, a polyanionic polymer, FGF-2 and SDF-1? embedded in the hydrogel, which is useful in treating a myocardial infarction.
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: January 2, 2024
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Eric M. Jeffries, Yadong Wang, Daniel Long, Noah R. Johnson
  • Time window-based platform for the rapid stratification of blunt trauma patients into distinct outcome cohorts
    Patent number: 11854701
    Abstract: Provided herein are methods for segregating trauma, e.g., blunt trauma, patients into different cohorts based on risk of multiple organ dysfunction syndrome using patient data obtained within a short time window following injury. The methods are useful in providing treatment to trauma patients, and for separating trauma patients into cohorts.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: December 26, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Gregory M. Constantine, Timothy Billiar, Qi Mi, Rami Namas, Lukas Schimunek, Yoram Vodovotz
  • Bioerodible wraps and uses therefor
    Patent number: 11850141
    Abstract: A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: December 26, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Mohammed S. El-Kurdi, William R. Wagner, David A. Vorp, John J. Stankus, Lorenzo Soletti, Jonathan McGrath, Yi Hong, J Christopher Flaherty
  • Acidic dystroglycan oligosaccharide compound and method for making same
    Patent number: 11851455
    Abstract: A synthetic dystroglycan oligosaccharide comprising: wherein a repeating disaccharide motif consists of Glucuronic Acid (ClcA) and Xylose (Xyl) having a defined glycosyl connection GlcA-?-(1?3)-Xyl-?-(1?3)-GlcA; wherein either end of the synthetic dystroglycan oligosaccharide is conjugatable with chemical or biological vehicle or support; wherein the non-reducing terminal is conjugatable win any oligosaccharides or groups that can modify a hydroxyl functionality; and wherein the reducing terminal is conjugatable with any tags, oligosaccharides or anything that can modify a hydroxyl functionality.
    Type: Grant
    Filed: January 7, 2019
    Date of Patent: December 26, 2023
    Assignee: University of Pittsburgh Of The Commonwealth System of Higher Education
    Inventors: Xinyu Liu, Aniruddha Sasmal
  • Modular, microfluidic, mechanically active bioreactor for 3D, multi-tissue, tissue culture
    Patent number: 11845961
    Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.
    Type: Grant
    Filed: January 19, 2021
    Date of Patent: December 19, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Rocky S. Tuan, Hang Lin, Thomas P. Lozito, Peter Alexander, Douglas Allen Nelson, Jr., Riccardo Gottardi
  • Treatment of ocular conditions utilizing a histone/protein deacetylase inhibitor
    Patent number: 11844862
    Abstract: A method for treating an ocular disorder in a subject comprising administering a therapeutic agent-loaded carrier to an ocular site of the subject in need thereof, wherein the therapeutic agent is a histone deactylase inhibitor.
    Type: Grant
    Filed: January 7, 2022
    Date of Patent: December 19, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Steven R. Little, Michelle L. Ratay
  • Method of treating fatty acid oxidation disorders using Omega3/Omega6 unsaturated or branched chain fatty acids
    Patent number: 11844775
    Abstract: A method of treating medium chain acyl-CoA dehydrogenase deficiency, very long chain acyl-CoA dehydrogenase deficiency, long chain hydroxyacyl-CoA dehydrogenase deficiency, trifunctional protein deficiency, or CPT II deficiency in a patient is provided comprising administering to the patient a therapeutic amount of a triglyceride or other conjugated fatty acid, that bypasses or leads to an intermediate that bypasses the deficient enzyme. Amino acid-conjugated fatty acids also are provided as well as compositions comprising the amino acid-conjugated fatty acids.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: December 19, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventor: Al-Walid A. Mohsen
  • ISCHEMIA/REPERFUSION INJURY
    Publication number: 20230390357
    Abstract: The invention provides methods of treating ischemia/reperfusion injury in a subject. In one example, a method comprises administering a therapeutically effective amount of a pharmaceutical composition that increases levels of Bcl2-associated athanogene 3 (BAG3) polypeptide in ischemic tissue. The invention also provides methods of treating a subject at risk of ischemia/reperfusion injury. In one example, a method comprises administering a therapeutically effective amount of a pharmaceutical composition that increases levels of Bcl2-associated athanogene 3 (BAG3) polypeptide. In the invention methods, in one example, a pharmaceutical composition comprises a nucleic acid encoding BAG3 polypeptide.
    Type: Application
    Filed: November 4, 2022
    Publication date: December 7, 2023
    Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Arthur M. FELDMAN, Joseph Y. CHEUNG, Kamel KHALILI
  • Predicting cancer recurrence from spatial multi-parameter cellular and subcellular imaging data
    Patent number: 11836998
    Abstract: A method of predicting cancer recurrence risk for an individual includes receiving patient spatial multi-parameter cellular and sub-cellular imaging data for a tumor of the individual, and analyzing the patient spatial multi-parameter cellular and sub-cellular imaging data using a prognostic model for predicting cancer recurrence risk to determine a predicted cancer recurrence risk for the individual, wherein the joint prognostic model is based on spatial correlation statistics among features derived for a plurality of intra-tumor spatial domains from spatial multi-parameter cellular and sub-cellular imaging data obtained from a plurality of cancer patients.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: December 5, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Srinivas C. Chennubhotla, Douglass L. Taylor, Shikhar Uttam Fnu
  • Touch-sensing via excitation of a surface with a waveform
    Patent number: 11836319
    Abstract: Disclosed herein are systems, methods, and devices for sensing touch at a surface. Sensing touch can be achieved while decreasing the number of sensors at a surface as well as data and computation complexity, but maintaining accuracy. Such sensing touch can be achieved via applying excitation and detecting emission waveforms at a surface that are associated with touch at a surface.
    Type: Grant
    Filed: August 6, 2020
    Date of Patent: December 5, 2023
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMC
    Inventor: David A. Anderson
  • REDIRECTING GLUCOSE METABOLISM TO LIMIT STRESS AND IMPROVE ADOPTIVE CELL THERAPY
    Publication number: 20230381312
    Abstract: Provided are improved methods for making immune effector cells, as well as improved immune effector cells generated using the methods. The improved T cells have improved respiratory capacity and mitochondrial mass. Adoptive T cell immunotherapies using such cells demonstrate improved survival, expansion, and persistence in vivo.
    Type: Application
    Filed: October 27, 2021
    Publication date: November 30, 2023
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Greg M. Delgoffe, Andrew Tyler Frisch
  • DEGRADABLE MAGNESIUM-BASED IMPLANT DEVICES FOR BONE FIXATION
    Publication number: 20230381382
    Abstract: The invention relates to biodegradable, magnesium alloys, compositions and composites, methods for their preparation and applications for their use as implantable medical devices in load-bearing conditions. The magnesium alloys are composed of alloying elements selected from yttrium, calcium, zirconium, zinc, and strontium, with the remainder being magnesium and impurities arising due to production, and preparation of the alloy by melting together the elements and casting the resulting melted mixture. In certain embodiments, the methods of preparation include solution treatment and hot extrusion.
    Type: Application
    Filed: June 1, 2023
    Publication date: November 30, 2023
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: PRASHANT N. KUMTA, ABHIJIT ROY, DA-TREN CHOU, DAEHO HONG, VIJAY S. GORANTLA
  • Nerve block by electrical pulses at sub-threshold intensity
    Patent number: 11826572
    Abstract: A method of blocking a nerve or neuron by applying an electrical stimulation to the nerve or neuron, wherein the electrical stimulation is of an intensity below the excitation threshold of the nerve or neuron for a length of time sufficient to produce a block of nerve conduction or neuron excitation.
    Type: Grant
    Filed: May 26, 2021
    Date of Patent: November 28, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventor: Changfeng Tai
  • System and method for integrated time-resolved 4D functional and anatomical MRI
    Patent number: 11828825
    Abstract: A magnetic resonance imaging method is includes collecting spatially encoded data from a subject using an MRI system, and directly extracting a number of temporal basis functions using at least a first portion of the spatially encoded data. The method further includes, after directly extracting the number of temporal basis functions, iteratively calculating a number of coefficient images using the number of temporal basis functions and at least a second portion of the spatially encoded data. Finally, the method includes generating a 4D image based on the number of temporal basis functions and the number of coefficient images.
    Type: Grant
    Filed: April 30, 2021
    Date of Patent: November 28, 2023
    Assignees: University of Pittsburgh—Of the Commowealth System of Higher Education, Cedars-Sinai Medical Center
    Inventors: Yijen Lin Wu, Anthony Christodoulou
  • Infusion catheter and method of use
    Patent number: 11826065
    Abstract: An infusion catheter has an elongate flexible shaft including a wall and a lumen extending between a proximal end and a distal end. The catheter also has a sealing member within the shaft lumen including a wall and a lumen. The catheter also has a slidable, retractable elongate central axis member extending through the shaft and sealing member lumens connected to an end cap. The catheter also has a plurality of eluting arms extending radially around the central axis member, including lumens fluidly connected to the shaft lumen and the distal end cap. A method for treating a thrombus is also disclosed.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: November 28, 2023
    Assignees: Temple University—Of The Commonwealth System of Higher Education, Thrombolex
    Inventors: Riyaz Bashir, Nicholas A. Green
  • INTERPOSITIONAL IMPLANT FOR GROWTH PLATE INJURY
    Publication number: 20230372589
    Abstract: Disclosed herein implantable material and methods for treatment of growth plate injuries and other purposes. These materials can be particularly useful for treating children whose growth plates are active, and can help encourage proper healing and inhibit unwanted bone formations. Exemplary compositions can comprise poly (ethylene glycol) (“PEG”), gelatin (“GEL”), and heparin (“HEP”). The PEG, GEL, and HEP components can be present in various forms of these materials, such as methacrylated forms, etc. The implanted materials can be anti-osteogenic and/or ant-mineralization, and can help prevent unwanted bone growth in the implanted area, such as boney tethers, which can inhibit desirable growth plate healing and overall bone growth.
    Type: Application
    Filed: September 20, 2021
    Publication date: November 23, 2023
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Juan M. Taboas, Jingming Chen
  • Modulators of the sigma-2 receptor and their method of use
    Patent number: 11820774
    Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma-2 receptor activity.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: November 21, 2023
    Assignee: Temple University—Of The Commonwealth System of Higher Education
    Inventors: Benjamin E. Blass, Daniel J. Canney, Kevin M. Blattner
  • Systems and apparatuses for efficiently burning fuels
    Patent number: 11821625
    Abstract: Aspects of the invention are directed to systems and apparatuses for efficiently burning fuels. According to one aspect of the invention, apparatus for efficiently burning hydrocarbons includes a housing having a first opening for receiving a fuel, a second opening for expelling the fuel, and a tubular passageway extending between the first opening and the second opening. The tubular passageway includes a central region and an outer region surrounding the central region. The apparatus also includes a plurality of magnets disposed within the passageway. Each of the magnets has a spherical or an ovoid shape. The plurality of magnets define void spaces for passing the fuel such that a central flow rate of the fuel in the central region of the passageway is equivalent to the an outer flow rate of the fuel in an outer region of the passageway.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: November 21, 2023
    Assignee: Temple University of the Commonwealth System of Higher Education
    Inventors: Oleksandr Diloyan, Haykazuni Andreasyan
  • Fuse cover
    Patent number: D1009804
    Type: Grant
    Filed: June 4, 2020
    Date of Patent: January 2, 2024
    Assignees: United States Goverment As Represented By The Department Of Veterans Affairs, University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Jonathan Aaron Duvall, Rory A. Cooper, Garrett G. Grindle, Joshua David Kanode, Douglas A. Hilliard