Patents Assigned to System of Higher Education
  • SUPERCONDUCTING MATERIALS AND METHODS OF MAKING THE SAME
    Publication number: 20230371403
    Abstract: Superconductive materials and methods of making the same are described, in which the superconductive materials are grown on a crystalline substrate having lattice parameters that impart a strain on the superconductive materials that reduces an applied pressure at which the superconductive materials exhibit superconductivity.
    Type: Application
    Filed: July 29, 2021
    Publication date: November 16, 2023
    Applicants: University of Rochester, THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA,
    Inventors: Liyanagamage R. Dias, Ashkan Salamat
  • Therapy for mitochondrial fatty acid beta-oxidation and transport disorders
    Patent number: 11813258
    Abstract: Methods of treating mitochondrial fatty acid ?-oxidation and/or transport disorders arising from mutant proteins in the mitochondrial fatty acid ?-oxidation and transport metabolic pathways in patients are provided. The methods modulate the mitochondrial fatty acid ?-oxidation pathway at the last step so that the product of the mutant protein accumulates and stabilizes the mutant protein and/or the substrate(s)/product(s) of the down stream reactions accumulate and possibly bind to allosteric sites on the mutant protein to stabilize it. Trimetazidine pharmacodynamics function as such in the ?-oxidation pathway. Further, a synergistic effect is observed where trimetazidine and PPAR? agonist combination enhanced enzyme activity and presence significantly more than either alone.
    Type: Grant
    Filed: June 10, 2021
    Date of Patent: November 14, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Al-Walid A. Mohsen, Gerard Vockley
  • BIOCARPET: A LOW PROFILE, MECHANICALLY OPTIMIZED, AND FULLY BIODEGRADABLE ENDOVASCULAR DEVICE FOR TREATMENT OF PERIPHERAL VASCULAR DISEASES
    Publication number: 20230355848
    Abstract: The invention relates to biodegradable endovascular devices, and methods for their preparation and use as medical implant devices. The invention includes flexible, drug-eluting, biodegradable endovascular devices that provide optimum treatment of peripheral arterial disease in small arteries and across joints. According to the invention, the biodegradable endovascular medical implant devices include a thermoformed tube or cylinder constructed of a flexible polymeric material, positioned in a vascular region of a patient, wherein the thermoformed tube or cylinder conforms to the geometry or anatomy of the vascular region to treat peripheral arterial disease.
    Type: Application
    Filed: October 13, 2021
    Publication date: November 9, 2023
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Jonathan VANDE GEEST, William R. WAGNER, John J. PACELLA
  • RNF167 AND CASTOR1 AS NOVEL MTOR TARGETS
    Publication number: 20230357430
    Abstract: The present subject matter relates to the use of one or more inhibitors to treat a disease, e.g., cancer, in a subject. It is based, at least in part, on the discovery that protein kinase B (AKT) and ring finger protein 167 (RNF167)-mediated CASTOR1 degradation activates the mammalian target of rapamycin complex 1 (mTORC1) independent of arginine and promotes cancer progression. Accordingly, the presently disclosed subject matter provides for compositions, methods, and kits for treating a subject using an RNF167 inhibitor, an inhibitor that reduces phosphorylation of CASTOR1 at S14, ubiquitination and/or degradation of CASTOR1, or a combination thereof.
    Type: Application
    Filed: June 15, 2023
    Publication date: November 9, 2023
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventor: Shou-Jiang Gao
  • 5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents
    Patent number: 11807642
    Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.
    Type: Grant
    Filed: December 3, 2021
    Date of Patent: November 7, 2023
    Assignee: Temple University—Of The Commonwealth System of Higher Education
    Inventors: Benjamin E. Blass, Daniel J. Canney, Kevin M. Blattner
  • Ultrasound devices and systems for determining constitutive relations and fiber orientation of soft tissues
    Patent number: 11808754
    Abstract: The systems and methods provided herein relate to the performance of inverse reconstruction algorithms from ultrasound radiofrequency data and stress-strain data. These systems and methods can be applied to any soft tissue mechanical measurements, providing information about both mechanical properties and fiber orientation, and the relationships between them.
    Type: Grant
    Filed: December 26, 2019
    Date of Patent: November 7, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Kang Kim, Choon Hwai Yap
  • CATHETER INSERTION SYSTEMS
    Publication number: 20230347111
    Abstract: Disclosed catheter insertion systems enable the user to identify the location of the needle based on the electrical properties of subcutaneous tissue relative the electrical properties of other fluids such as blood or air. Disclosed systems can include one or more of the following features: 1) the catheter assembly is modular (e.g., the catheter can be connected and disconnected from the detection unit at will); 2) the detection unit employs an electrical circuit that allows for the discernment between subcutaneous tissue and blood; 3) the system assists the end user with catheter advancement. Some embodiments can be used to insert catheters into a spaces where the needle passes first through subcutaneous fat and muscle before entering fluid or air.
    Type: Application
    Filed: June 2, 2023
    Publication date: November 2, 2023
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Cameron Dezfulian, William W. Clark, Ehsan Qaium, Dennis Wist
  • Mitochondrial health parameters as clinical predictors of Parkinson's disease
    Patent number: 11802313
    Abstract: Methods are disclosed for detecting peripheral mitochondrial DNA damage and dysfunction. Methods are also disclosed that utilize blood samples to detect a neurodegenerative disease, such as Parkinson's disease, and determine the efficacy of therapy.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: October 31, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Laurie H. Andolina, John T. Greenamyre, Sruti Shiva
  • A SELF-CLEANING POROUS LAYER TO MINIMIZE THROMBUS FORMATION ON BLOOD CONTACTING DEVICES
    Publication number: 20230338627
    Abstract: The invention relates to self-cleaning porous structures, e.g., layers or coatings, fabricated within, applied to, or deposited on a blood contacting surface of a medical device, to prevent activation and aggregation of platelets thereon. In certain embodiments, the layer or coating is composed of multi-layered fibers. The porous structure is applied to or deposited such as to form a permeable wall on the blood contacting surface. The blood travels into the wall and subsequently back out (reversing back into the lumen) during a cardiac cycle. Reversal flow is controlled during the diastole phase such that the backward flow repels the platelets and prevents their activation and aggregation and therefore, minimizes thrombus formation.
    Type: Application
    Filed: June 16, 2021
    Publication date: October 26, 2023
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Jonathan VANDE GEEST, Ali BEHRANGZADE
  • PERFUSION DEVICE FOR A BLOOD VESSEL
    Publication number: 20230338034
    Abstract: A medical assembly includes a perfusion device that has a self-expandable stent. The stent has a proximal end portion and a distal end portion. The proximal end portion tapers from the distal end to a proximal end thereof. A blood-impermeable cover extends at least partially over the distal end portion and the proximal end portion of the stent. The perfusion device further includes an elongated shaft having a proximal end a distal end, wherein the distal end is fixedly secured to the proximal end of the proximal end portion of the stent. The assembly further includes a sheath configured to retain the stent and the cover is a radially collapsed state for insertion into a vessel of a patient, wherein the stent and the cover are expandable from the radially collapsed state to a radially expanded, deployed state within the vessel when deployed from the sheath.
    Type: Application
    Filed: June 30, 2023
    Publication date: October 26, 2023
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Bryan W. Tillman, William W. Clark, Sung Kwon Cho, Youngjae Chun
  • METHODS OF TREATING CANCER
    Publication number: 20230338384
    Abstract: The present disclosure relates to the use of a KRAS inhibitor and an oncolytic virus to prevent and/or treat cancer. The methods include prevention and/or treatment of cancer with the administration of a KRAS inhibitor and an oncolytic virus to a subject. The present disclosure further provides kits for performing such methods.
    Type: Application
    Filed: May 30, 2023
    Publication date: October 26, 2023
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Zong Sheng GUO, Binfeng LU, Zhi ZHU, Hongqi CHEN
  • Devices, systems and methods for treating urological and gastrointestinal disorders by electrical stimulation of the foot
    Patent number: 11794009
    Abstract: Provided herein are devices, systems, and methods for treating urological and gastrointestinal disorders, including bedwetting, through stimulation of the dorsal or plantar surface of the foot, including the superficial peroneal nerve and branches thereof, such as the dorsal intermediate and medial cutaneous nerves, or the medial and/or and lateral plantar nerves. The device facilitates placement of electrodes on the foot. Also provided herein is a system including the device, a pulse generator, and a controller, and methods of manufacturing and using the same.
    Type: Grant
    Filed: May 12, 2021
    Date of Patent: October 24, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventor: Changfeng Tai
  • Vaginal films
    Patent number: 11793765
    Abstract: Provided herein are stable, dissolvable films containing active ingredients, such as antimicrobial composition, antiviral compositions, or anti-retroviral compositions for intravaginal or intrarectal placement to provide prophylaxis against viral infections.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: October 24, 2023
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventor: Lisa Cencia Rohan
  • Functionalized microbubble embodiments for ultrasound-mediated treatment and methods of making and using the same
    Patent number: 11793863
    Abstract: Disclosed herein are embodiments of a functionalized microbubble designed for treating and/or preventing vascular obstructions, including microvascular obstructions. The functionalized microbubble embodiments comprise a microbubble that can be activated upon exposure to ultrasound and further that has a lipid-based shell that is attached to an exteriorly-attached therapeutically active agent, such as a thrombolytic agent. Also disclosed herein are embodiments of a method for making and using the functionalized microbubble embodiments.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: October 24, 2023
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMC
    Inventors: John J. Pacella, Xucai Chen, Francois Tchi Ho Yu, Thiruganesh Ramasamy, Stephen D'Auria
  • Esophageal temporary occlusion device and method for endotracheal intubation and orogastric tube insertion
    Patent number: 11793961
    Abstract: A temporary esophagus occlusion device for providing temporary occlusion of the esophagus during intubation of a in patient includes a frame configured to transition between a contracted state, in which it can be swallowed by the patient, and an expanded state, wherein in the expanded state, the frame has a maximum outer diameter sufficient to span an inner diameter of the esophagus of the patient. The device also includes a flexible cover connected to and extending over at least a portion of the frame when the frame is in the expanded state to at least partially block flow of fluid and/or solid materials through the esophagus and a guidewire attached to the frame, sized to be swallowed by the patient along with the frame and having a proximal end portion configured to remain external to the patient's body and a distal end connected to the frame.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: October 24, 2023
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMC
    Inventors: Youngjae Chun, Philip Charles Carullo
  • Sonodynamic therapy using microbubbles and pulsed wave ultrasound methods and systems
    Patent number: 11793983
    Abstract: The systems and methods disclosed herein relate generally to microbubble-assisted delivery of a therapeutic agent, such as a chemotherapeutic agent, to cells or tissue of interest, either in vitro or in vivo, that can be activated by directed ultrasound irradiation. For example, hydrophobic sonosensitizers can be incorporated in microbubble complexes to provide improved sonodynamic therapies.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: October 24, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Xucai Chen, Qin Bin, Villanueva Flordeliza
  • PEROVSKITE SOLAR CELL CONFIGURATIONS
    Publication number: 20230335344
    Abstract: Various perovskite solar cell embodiments include a flexible metal substrate (e.g., including a metal doped TiO2 layer), a perovskite layer, and a transparent electrode layer (e.g., including a dielectric/metal/dielectric structure), wherein the perovskite layer is provided between the flexible metal substrate and the transparent electrode layer. Also, various tandem solar cell embodiments including a perovskite solar cell and either a quantum dot solar cell, and organic solar cell or a thin film solar cell.
    Type: Application
    Filed: June 7, 2023
    Publication date: October 19, 2023
    Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Jung-Kun Lee, Gillsang Han
  • EphA2 T-cell epitope agonists and uses therefore
    Patent number: 11787846
    Abstract: EphA2 T-cell epitope are provided herein. The epitopes include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell epitopes, and conservative derivatives thereof. The EphA2 T-cell epitopes are useful in an assay, such as an ELISPOT assay, that may be used to determine and/or quantify a patient's immune responsiveness to EphA2. The epitopes also are useful in methods of modulating a patient's immune reactivity to EphA2, which has substantial utility as a treatment for cancers that overexpress EphA2, such as renal cell carcinoma (RCC). The EphA2 epitopes also can be used to vaccinate a patient against EphA2, by in vivo or ex vivo methods.
    Type: Grant
    Filed: August 19, 2020
    Date of Patent: October 17, 2023
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Walter J. Storkus, Michael S. Kinch
  • Aminothiazole compounds and methods using same
    Patent number: 11787794
    Abstract: The present invention includes novel aminothiazole compounds of formula (I), which are useful in preventing or treating cancer in a subject in need thereof.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: October 17, 2023
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Jean-Pierre J. Issa, Hanghang Zhang, Magid Abou-Gharbia, Wayne E. Childers, George C. Morton
  • Expression of metabolic modulators in tumor microenvironment to improve tumor therapy
    Patent number: 11786569
    Abstract: Recombinant oncolytic viruses (OVs) that express one or more metabolic modulator proteins, such as an adipokine (e.g., leptin or chemerin), insulin, and/or IGF-1, and methods of their use to treat cancer, for example in immunotherapy anti-cancer treatments. In some examples, such recombinant OVs and methods increase T cell infiltration into the tumor or tumor microenvironment.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: October 17, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Greg M. Delgoffe, Dayana Rivadeneira, Padmavathi Sampath, Stephen H. Thorne