Patents Assigned to T2 Biosystems, Inc.
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Publication number: 20220154297Abstract: The invention features compositions and methods for the detection of Candida species in biological samples, such as human tissue samples. The invention features species specific nucleic acid probes that can hybridize to target nucleic acid molecules in Candida species and can be used in a variety of detection assays, such as fluorescence based assays or NMR based assays. The compositions and methods of the invention can be used to rapidly and accurately detect one or more Candida species in patients and can be used to assist in point-of care-decisions for treating Candida infections.Type: ApplicationFiled: August 24, 2021Publication date: May 19, 2022Applicant: T2 Biosystems, Inc.Inventor: Lori Anne NEELY
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Patent number: 11326213Abstract: The invention features methods, systems, and panels for rapid detection of tick-borne pathogens in a sample (including Borrelia spp. such as B. burgdorferi, B. afzelii, and B. garinii) and for diagnosis and monitoring of tick-transmitted diseases, including Lyme disease, Rocky Mountain spotted fever, Q-fever, babesiosis, ehrlichiosis, tularemia, and anaplasmosis.Type: GrantFiled: January 21, 2016Date of Patent: May 10, 2022Assignee: T2 Biosystems, Inc.Inventors: Ulrich Hans Thomann, Lori Anne Neely, Rahul Krishan Dhanda, Frédéric Sweeney, Thomas Jay Lowery, Jr., Jessica Ann Townsend, Jessica Lee Snyder, Heidi Susanne Giese, Cheryl Ann Bandoski-Gralinski, Daniella Lynn Logan
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Patent number: 11098378Abstract: The invention features compositions and methods for the detection of Candida species in biological samples, such as human tissue samples. The invention features species specific nucleic acid probes that can hybridize to target nucleic acid molecules in Candida species and can be used in a variety of detection assays, such as fluorescence based assays or NMR based assays. The compositions and methods of the invention can be used to rapidly and accurately detect one or more Candida species in patients and can be used to assist in point-of care-decisions for treating Candida infections.Type: GrantFiled: January 12, 2017Date of Patent: August 24, 2021Assignee: T2 Biosystems, Inc.Inventor: Lori Anne Neely
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Patent number: 10697984Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.Type: GrantFiled: September 27, 2017Date of Patent: June 30, 2020Assignee: T2 Biosystems, Inc.Inventors: Thomas Jay Lowery, Jr., Vyacheslav Papkov, Walter W. Massefski, Jr., Rahul K. Dhanda, Edward Chris Thayer
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Patent number: 10620205Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing endotoxi-induced clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the level of endotoxin present in the sample.Type: GrantFiled: September 20, 2012Date of Patent: April 14, 2020Assignee: T2 Biosystems, Inc.Inventors: Rahul K. Dhanda, Vyacheslav Papkov, Thomas Jay Lowery, Jr.
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Patent number: 10486118Abstract: The present invention relates to containers for holding liquid samples. The containers may be useful for mixing a liquid sample or lysing cells in a liquid sample. The invention also relates to methods of using the containers of the invention.Type: GrantFiled: March 8, 2017Date of Patent: November 26, 2019Assignee: T2 Biosystems, Inc.Inventors: Adam Suchocki, Mark John Audeh, Matthew Blanco, James Franklin Chepin, Vasiliki Demas, Marilyn Lee Fritzemeier, Thomas Jay Lowery, Jr., Michael Min, Lori Anne Neely, Charles William Rittershaus, Hwa-Tang Wang, Parris Wellman
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Patent number: 10330343Abstract: The present invention relates to devices including a heating element with an opening, which can control condensation of liquid samples during thermal incubation. The opening of the heating element can provide direct access to the samples in a process that may be automated. The invention also provides methods for heating containers.Type: GrantFiled: February 21, 2013Date of Patent: June 25, 2019Assignee: T2 Biosystems, Inc.Inventor: Adam Suchocki
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Publication number: 20190032104Abstract: The invention features methods, panels, cartridges, kits, and systems for rapid and sensitive detection and identification of pathogens and determination of the pathogen's susceptibility to antimicrobial agents for diagnosis and treatment of disease, including bloodstream infection (e.g., bacteremia and fungemia), and sepsis.Type: ApplicationFiled: January 20, 2017Publication date: January 31, 2019Applicant: T2 Biosystems, Inc.Inventors: Thomas Jay LOWERY, JR., Michael Andy PFALLER, Rahul Krishan DHANDA, John J. MCDONOUGH, Glenn MAGNUSON, Lori Anne NEELY, Ulrich Hans THOMANN, William Coulter HARRIS, Justin Layne BLACK
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Patent number: 10184907Abstract: Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors.Type: GrantFiled: October 8, 2015Date of Patent: January 22, 2019Assignee: T2 Biosystems, Inc.Inventors: Thomas Jay Lowery, Jr., James Joseph Koziarz, Douglas Adam Levinson, David A. Berry, Tuan A. Elstrom, Sonia Kumar, Mark John Audeh
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Patent number: 10126314Abstract: The invention relates to detecting coagulation and coagulation-related activities including agglutination and fibrinolysis of samples. More particularly the invention relates to methods and apparatus for monitoring coagulation and/or obtaining a coagulation time of a sample using NMR-based detectors.Type: GrantFiled: September 1, 2015Date of Patent: November 13, 2018Assignee: T2 Biosystems, Inc.Inventors: Sonia Taktak, Brian M. Mozeleski, Thomas J. Lowery, Jr.
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Patent number: 9797914Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.Type: GrantFiled: July 20, 2015Date of Patent: October 24, 2017Assignee: T2 Biosystems, Inc.Inventors: Thomas Jay Lowery, Jr., Vyacheslav Papkov, Walter W. Massefski, Jr., Rahul K. Dhanda, Edward Chris Thayer
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Patent number: 9739733Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.Type: GrantFiled: December 5, 2013Date of Patent: August 22, 2017Assignee: T2 Biosystems, Inc.Inventors: Walter W. Massefski, Jr., Thomas Jay Lowery, Jr., Lynell R. Skewis
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Publication number: 20170233798Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.Type: ApplicationFiled: December 22, 2016Publication date: August 17, 2017Applicant: T2 Biosystems, Inc.Inventors: Lori Anne NEELY, Mark John AUDEH, Rahul DHANDA, Marilyn Lee FRITZEMEIER, Daniella Lynn PLOURDE, Charles William RITTERSHAUS
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Patent number: 9714940Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.Type: GrantFiled: October 19, 2011Date of Patent: July 25, 2017Assignee: T2 Biosystems, Inc.Inventors: Thomas Jay Lowery, Jr., Mark John Audeh, Matthew Blanco, James Franklin Chepin, Vasiliki Demas, Rahul Dhanda, Lori Anne Neely
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Patent number: 9707528Abstract: The present invention relates to containers for holding liquid samples. The containers may be useful for mixing a liquid sample or lysing cells in a liquid sample. The invention also relates to methods of using the containers of the invention.Type: GrantFiled: October 12, 2012Date of Patent: July 18, 2017Assignee: T2 Biosystems, Inc.Inventors: Adam Suchocki, Mark John Audeh, Matthew Blanco, James Franklin Chepin, Vasiliki Demas, Marilyn Lee Fritzemeier, Thomas Jay Lowery, Jr., Michael Min, Lori Anne Neely, Charles William Rittershaus, Hwa-Tang Wang, Parris Wellman
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Patent number: 9702852Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.Type: GrantFiled: October 17, 2013Date of Patent: July 11, 2017Assignee: T2 Biosystems, Inc.Inventors: Thomas Jay Lowery, Jr., Rahul K. Dhanda, Lori Anne Neely, Mark John Audeh
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Patent number: 9632154Abstract: Small and inexpensive probeheads for use in nuclear magnetic resonance systems, in particular, magnetic resonance relaxometry systems are provided. The design of the magnet-radiofrequency coil configurations within the probeheads is guided by an excitation bandwidth associated with radiofrequency pulses to be applied to a sample.Type: GrantFiled: August 23, 2013Date of Patent: April 25, 2017Assignee: T2 Biosystems, Inc.Inventors: Pablo J. Prado, Thomas Jay Lowery, Jr.
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Patent number: 9599627Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.Type: GrantFiled: July 13, 2012Date of Patent: March 21, 2017Assignee: T2 Biosystems, Inc.Inventors: Thomas J. Lowery, Jr., Vyacheslav Papkov, Walter W. Massefski, Jr., Rahul K. Dhanda, Edward C. Thayer
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Patent number: 9568575Abstract: This invention features devices and methods for analyte processing and detection, and use of such methods, e.g., in the treatment and diagnosis of disease or determining the presence of a pathogen.Type: GrantFiled: October 19, 2011Date of Patent: February 14, 2017Assignee: T2 Biosystems, Inc.Inventors: Thomas Jay Lowery, Jr., Parris S. Wellman, John J. McDonough, James Franklin Chepin, Charles William Rittershaus, Vasiliki Demas, Alison Skelley
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Patent number: D852977Type: GrantFiled: November 28, 2016Date of Patent: July 2, 2019Assignee: T2 Biosystems, Inc.Inventors: Adam Suchocki, Steven Anthony Scampini, Joseph D. Antocci, Thomas Cygan, William Peine, Uli Thomann, Chris Werner