Patents Assigned to T2 Biosystems, Inc.
  • COMPOSITIONS AND METHODS FOR DETECTION OF CANDIDA SPECIES
    Publication number: 20220154297
    Abstract: The invention features compositions and methods for the detection of Candida species in biological samples, such as human tissue samples. The invention features species specific nucleic acid probes that can hybridize to target nucleic acid molecules in Candida species and can be used in a variety of detection assays, such as fluorescence based assays or NMR based assays. The compositions and methods of the invention can be used to rapidly and accurately detect one or more Candida species in patients and can be used to assist in point-of care-decisions for treating Candida infections.
    Type: Application
    Filed: August 24, 2021
    Publication date: May 19, 2022
    Applicant: T2 Biosystems, Inc.
    Inventor: Lori Anne NEELY
  • NMR methods and systems for the rapid detection of tick-borne pathogens
    Patent number: 11326213
    Abstract: The invention features methods, systems, and panels for rapid detection of tick-borne pathogens in a sample (including Borrelia spp. such as B. burgdorferi, B. afzelii, and B. garinii) and for diagnosis and monitoring of tick-transmitted diseases, including Lyme disease, Rocky Mountain spotted fever, Q-fever, babesiosis, ehrlichiosis, tularemia, and anaplasmosis.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: May 10, 2022
    Assignee: T2 Biosystems, Inc.
    Inventors: Ulrich Hans Thomann, Lori Anne Neely, Rahul Krishan Dhanda, Frédéric Sweeney, Thomas Jay Lowery, Jr., Jessica Ann Townsend, Jessica Lee Snyder, Heidi Susanne Giese, Cheryl Ann Bandoski-Gralinski, Daniella Lynn Logan
  • Compositions and methods for detection of candida species
    Patent number: 11098378
    Abstract: The invention features compositions and methods for the detection of Candida species in biological samples, such as human tissue samples. The invention features species specific nucleic acid probes that can hybridize to target nucleic acid molecules in Candida species and can be used in a variety of detection assays, such as fluorescence based assays or NMR based assays. The compositions and methods of the invention can be used to rapidly and accurately detect one or more Candida species in patients and can be used to assist in point-of care-decisions for treating Candida infections.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: August 24, 2021
    Assignee: T2 Biosystems, Inc.
    Inventor: Lori Anne Neely
  • NMR methods for monitoring blood clot formation
    Patent number: 10697984
    Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: June 30, 2020
    Assignee: T2 Biosystems, Inc.
    Inventors: Thomas Jay Lowery, Jr., Vyacheslav Papkov, Walter W. Massefski, Jr., Rahul K. Dhanda, Edward Chris Thayer
  • NMR methods for endotoxin analysis
    Patent number: 10620205
    Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing endotoxi-induced clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the level of endotoxin present in the sample.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: April 14, 2020
    Assignee: T2 Biosystems, Inc.
    Inventors: Rahul K. Dhanda, Vyacheslav Papkov, Thomas Jay Lowery, Jr.
  • Containers for agitation of liquid samples and methods of use thereof
    Patent number: 10486118
    Abstract: The present invention relates to containers for holding liquid samples. The containers may be useful for mixing a liquid sample or lysing cells in a liquid sample. The invention also relates to methods of using the containers of the invention.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: November 26, 2019
    Assignee: T2 Biosystems, Inc.
    Inventors: Adam Suchocki, Mark John Audeh, Matthew Blanco, James Franklin Chepin, Vasiliki Demas, Marilyn Lee Fritzemeier, Thomas Jay Lowery, Jr., Michael Min, Lori Anne Neely, Charles William Rittershaus, Hwa-Tang Wang, Parris Wellman
  • Devices for control of condensation and methods of use thereof
    Patent number: 10330343
    Abstract: The present invention relates to devices including a heating element with an opening, which can control condensation of liquid samples during thermal incubation. The opening of the heating element can provide direct access to the samples in a process that may be automated. The invention also provides methods for heating containers.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: June 25, 2019
    Assignee: T2 Biosystems, Inc.
    Inventor: Adam Suchocki
  • RAPID ANTIMICROBIAL SUSCEPTIBILITY TESTING USING HIGH-SENSITIVITY DIRECT DETECTION METHODS
    Publication number: 20190032104
    Abstract: The invention features methods, panels, cartridges, kits, and systems for rapid and sensitive detection and identification of pathogens and determination of the pathogen's susceptibility to antimicrobial agents for diagnosis and treatment of disease, including bloodstream infection (e.g., bacteremia and fungemia), and sepsis.
    Type: Application
    Filed: January 20, 2017
    Publication date: January 31, 2019
    Applicant: T2 Biosystems, Inc.
    Inventors: Thomas Jay LOWERY, JR., Michael Andy PFALLER, Rahul Krishan DHANDA, John J. MCDONOUGH, Glenn MAGNUSON, Lori Anne NEELY, Ulrich Hans THOMANN, William Coulter HARRIS, Justin Layne BLACK
  • Magnetic nanosensor compositions and bioanalytical assays therefor
    Patent number: 10184907
    Abstract: Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: January 22, 2019
    Assignee: T2 Biosystems, Inc.
    Inventors: Thomas Jay Lowery, Jr., James Joseph Koziarz, Douglas Adam Levinson, David A. Berry, Tuan A. Elstrom, Sonia Kumar, Mark John Audeh
  • NMR detection of coagulation time
    Patent number: 10126314
    Abstract: The invention relates to detecting coagulation and coagulation-related activities including agglutination and fibrinolysis of samples. More particularly the invention relates to methods and apparatus for monitoring coagulation and/or obtaining a coagulation time of a sample using NMR-based detectors.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: November 13, 2018
    Assignee: T2 Biosystems, Inc.
    Inventors: Sonia Taktak, Brian M. Mozeleski, Thomas J. Lowery, Jr.
  • NMR methods for monitoring blood clot formation
    Patent number: 9797914
    Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: October 24, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Thomas Jay Lowery, Jr., Vyacheslav Papkov, Walter W. Massefski, Jr., Rahul K. Dhanda, Edward Chris Thayer
  • Methods for monitoring tight clot formation
    Patent number: 9739733
    Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: August 22, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Walter W. Massefski, Jr., Thomas Jay Lowery, Jr., Lynell R. Skewis
  • NMR SYSTEMS AND METHODS FOR THE RAPID DETECTION OF ANALYTES
    Publication number: 20170233798
    Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
    Type: Application
    Filed: December 22, 2016
    Publication date: August 17, 2017
    Applicant: T2 Biosystems, Inc.
    Inventors: Lori Anne NEELY, Mark John AUDEH, Rahul DHANDA, Marilyn Lee FRITZEMEIER, Daniella Lynn PLOURDE, Charles William RITTERSHAUS
  • NMR systems and methods for the rapid detection of analytes
    Patent number: 9714940
    Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: July 25, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Thomas Jay Lowery, Jr., Mark John Audeh, Matthew Blanco, James Franklin Chepin, Vasiliki Demas, Rahul Dhanda, Lori Anne Neely
  • Containers for agitation of liquid samples and methods of use thereof
    Patent number: 9707528
    Abstract: The present invention relates to containers for holding liquid samples. The containers may be useful for mixing a liquid sample or lysing cells in a liquid sample. The invention also relates to methods of using the containers of the invention.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: July 18, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Adam Suchocki, Mark John Audeh, Matthew Blanco, James Franklin Chepin, Vasiliki Demas, Marilyn Lee Fritzemeier, Thomas Jay Lowery, Jr., Michael Min, Lori Anne Neely, Charles William Rittershaus, Hwa-Tang Wang, Parris Wellman
  • NMR systems and methods for the rapid detection of analytes
    Patent number: 9702852
    Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: July 11, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Thomas Jay Lowery, Jr., Rahul K. Dhanda, Lori Anne Neely, Mark John Audeh
  • Small magnet and RF coil for magnetic resonance relaxometry
    Patent number: 9632154
    Abstract: Small and inexpensive probeheads for use in nuclear magnetic resonance systems, in particular, magnetic resonance relaxometry systems are provided. The design of the magnet-radiofrequency coil configurations within the probeheads is guided by an excitation bandwidth associated with radiofrequency pulses to be applied to a sample.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: April 25, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Pablo J. Prado, Thomas Jay Lowery, Jr.
  • NMR methods for monitoring blood clot formation
    Patent number: 9599627
    Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: March 21, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Thomas J. Lowery, Jr., Vyacheslav Papkov, Walter W. Massefski, Jr., Rahul K. Dhanda, Edward C. Thayer
  • Conduit-containing devices and methods for analyte processing and detection
    Patent number: 9568575
    Abstract: This invention features devices and methods for analyte processing and detection, and use of such methods, e.g., in the treatment and diagnosis of disease or determining the presence of a pathogen.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: February 14, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Thomas Jay Lowery, Jr., Parris S. Wellman, John J. McDonough, James Franklin Chepin, Charles William Rittershaus, Vasiliki Demas, Alison Skelley
  • Modular cartridge assembly
    Patent number: D852977
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: July 2, 2019
    Assignee: T2 Biosystems, Inc.
    Inventors: Adam Suchocki, Steven Anthony Scampini, Joseph D. Antocci, Thomas Cygan, William Peine, Uli Thomann, Chris Werner