Abstract: Small and inexpensive probeheads for use in nuclear magnetic resonance systems, in particular, magnetic resonance relaxometry systems are provided. The design of the magnet-radiofrequency coil configurations within the probeheads is guided by an excitation bandwidth associated with radiofrequency pulses to be applied to a sample.
Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.
Type:
Grant
Filed:
July 13, 2012
Date of Patent:
March 21, 2017
Assignee:
T2 Biosystems, Inc.
Inventors:
Thomas J. Lowery, Jr., Vyacheslav Papkov, Walter W. Massefski, Jr., Rahul K. Dhanda, Edward C. Thayer
Abstract: This invention features devices and methods for analyte processing and detection, and use of such methods, e.g., in the treatment and diagnosis of disease or determining the presence of a pathogen.
Type:
Grant
Filed:
October 19, 2011
Date of Patent:
February 14, 2017
Assignee:
T2 Biosystems, Inc.
Inventors:
Thomas Jay Lowery, Jr., Parris S. Wellman, John J. McDonough, James Franklin Chepin, Charles William Rittershaus, Vasiliki Demas, Alison Skelley
Abstract: The invention features compositions and methods for the detection of Candida species in biological samples, such as human tissue samples. The invention features species specific nucleic acid probes that can hybridize to target nucleic acid molecules in Candida species and can be used in a variety of detection assays, such as fluorescence based assays or NMR based assays. The compositions and methods of the invention can be used to rapidly and accurately detect one or more Candida species in patients and can be used to assist in point-of care-decisions for treating Candida infections.
Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.
Type:
Application
Filed:
December 5, 2013
Publication date:
October 29, 2015
Applicant:
T2 Biosystems, Inc.
Inventors:
Walter W. MASSEFSKI, JR., Thomas Jay LOWERY, JR., Lynell R. SKEWIS
Abstract: The invention relates to detecting coagulation and coagulation-related activities including agglutination and fibrinolysis of samples. More particularly the invention relates to methods and apparatus for monitoring coagulation and/or obtaining a coagulation time of a sample using NMR-based detectors.
Type:
Grant
Filed:
October 29, 2009
Date of Patent:
October 13, 2015
Assignee:
T2 BIOSYSTEMS, INC.
Inventors:
Sonia Taktak, Brian M. Mozeleski, Thomas J. Lowery, Jr.
Abstract: The invention features a portable device for monitoring changes in the rheological state of multiple samples by NMR based measurement. The rheological changes can be, for example, gelation occurring during limulus amoebocyte lysate (LAL) testing for endotoxins or blood coagulation. The inventive method entails organization of individual NMR tubes in a disposable cartridge where the tubes are connected through a top cover, provided with movable actuators to push the reagent in the reagent compartments of the individual chambers to the reaction chambers in a predetermined sequence.
Type:
Application
Filed:
June 25, 2013
Publication date:
May 14, 2015
Applicant:
T2 BIOSYSTEMS, INC.
Inventors:
Parris S. Wellman, Matthew Blanco, William Peine
Abstract: This invention relates generally to NMR systems for in vivo detection of analytes. More particularly, in certain embodiments, the invention relates to systems in which superparamagnetic nanoparticles are exposed to a magnetic field and radio frequency (RF) excitation at or near the Larmor frequency, such that the aggregation and/or disaggregation of the nanoparticles caused by the presence and/or concentration of a given analyte in a biological fluid is detected in vivo from a monitored RF echo response.
Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.
Type:
Application
Filed:
July 13, 2012
Publication date:
July 31, 2014
Applicant:
T2 Biosystems, Inc.
Inventors:
Thomas J. Lowery, JR., Vyacheslav Papkov, Walter W. Massefski, JR., Rahul K. Dhanda, Edward C. Thayer
Abstract: This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid sample. The device may be used, for example, as a portable unit for point of care diagnosis and/or field use, or the device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a patient.
Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
Type:
Application
Filed:
October 17, 2013
Publication date:
April 17, 2014
Applicant:
T2 BIOSYSTEMS, INC.
Inventors:
THOMAS JAY LOWERY, JR., MARK JOHN AUDEH, MATTHEW BLANCO, JAMES FRANKLIN CHEPIN, VASILIKI DEMAS, RAHUL K. DHANDA, MARILYN LEE FRITZEMEIER, ISAAC KOH, SONIA KUMAR, LORI ANNE NEELY, BRIAN M. MOZELESKI, DANIELLA LYNN PLOURDE, CHARLES WILLIAM RITTERSHAUS, PARRIS S. WELLMAN
Abstract: This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid sample. The device may be used, for example, as a portable unit for point of care diagnosis and/or field use, or the device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a patient.