Patents Assigned to T2 Biosystems, Inc.
  • NMR systems and methods for the rapid detection of analytes
    Patent number: 9714940
    Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: July 25, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Thomas Jay Lowery, Jr., Mark John Audeh, Matthew Blanco, James Franklin Chepin, Vasiliki Demas, Rahul Dhanda, Lori Anne Neely
  • Containers for agitation of liquid samples and methods of use thereof
    Patent number: 9707528
    Abstract: The present invention relates to containers for holding liquid samples. The containers may be useful for mixing a liquid sample or lysing cells in a liquid sample. The invention also relates to methods of using the containers of the invention.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: July 18, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Adam Suchocki, Mark John Audeh, Matthew Blanco, James Franklin Chepin, Vasiliki Demas, Marilyn Lee Fritzemeier, Thomas Jay Lowery, Jr., Michael Min, Lori Anne Neely, Charles William Rittershaus, Hwa-Tang Wang, Parris Wellman
  • NMR systems and methods for the rapid detection of analytes
    Patent number: 9702852
    Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: July 11, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Thomas Jay Lowery, Jr., Rahul K. Dhanda, Lori Anne Neely, Mark John Audeh
  • Small magnet and RF coil for magnetic resonance relaxometry
    Patent number: 9632154
    Abstract: Small and inexpensive probeheads for use in nuclear magnetic resonance systems, in particular, magnetic resonance relaxometry systems are provided. The design of the magnet-radiofrequency coil configurations within the probeheads is guided by an excitation bandwidth associated with radiofrequency pulses to be applied to a sample.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: April 25, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Pablo J. Prado, Thomas Jay Lowery, Jr.
  • NMR methods for monitoring blood clot formation
    Patent number: 9599627
    Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: March 21, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Thomas J. Lowery, Jr., Vyacheslav Papkov, Walter W. Massefski, Jr., Rahul K. Dhanda, Edward C. Thayer
  • Conduit-containing devices and methods for analyte processing and detection
    Patent number: 9568575
    Abstract: This invention features devices and methods for analyte processing and detection, and use of such methods, e.g., in the treatment and diagnosis of disease or determining the presence of a pathogen.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: February 14, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Thomas Jay Lowery, Jr., Parris S. Wellman, John J. McDonough, James Franklin Chepin, Charles William Rittershaus, Vasiliki Demas, Alison Skelley
  • Compositions and methods for detection of species
    Patent number: 9562271
    Abstract: The invention features compositions and methods for the detection of Candida species in biological samples, such as human tissue samples. The invention features species specific nucleic acid probes that can hybridize to target nucleic acid molecules in Candida species and can be used in a variety of detection assays, such as fluorescence based assays or NMR based assays. The compositions and methods of the invention can be used to rapidly and accurately detect one or more Candida species in patients and can be used to assist in point-of care-decisions for treating Candida infections.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: February 7, 2017
    Assignee: T2 Biosystems, Inc.
    Inventor: Lori Anne Neely
  • NMR systems and methods for the rapid detection of analytes
    Patent number: 9488648
    Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: November 8, 2016
    Assignee: T2 Biosystems, Inc.
    Inventors: Lori Anne Neely, Mark John Audeh, Matthew Blanco, James Franklin Chepin, Vasiliki Demas, Rahul K. Dhanda, Thomas Jay Lowery, Jr.
  • NMR systems and methods for the rapid detection of analytes
    Patent number: 9360457
    Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: June 7, 2016
    Assignee: T2 Biosystems, Inc.
    Inventors: Lori Anne Neely, Mark John Audeh, Rahul K. Dhanda, Marilyn Lee Fritzemeier, Daniella Lynn Plourde, Charles William Rittershaus
  • METHODS FOR MONITORING TIGHT CLOT FORMATION
    Publication number: 20150308970
    Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.
    Type: Application
    Filed: December 5, 2013
    Publication date: October 29, 2015
    Applicant: T2 Biosystems, Inc.
    Inventors: Walter W. MASSEFSKI, JR., Thomas Jay LOWERY, JR., Lynell R. SKEWIS
  • NMR detection of coagulation time
    Patent number: 9157974
    Abstract: The invention relates to detecting coagulation and coagulation-related activities including agglutination and fibrinolysis of samples. More particularly the invention relates to methods and apparatus for monitoring coagulation and/or obtaining a coagulation time of a sample using NMR-based detectors.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: October 13, 2015
    Assignee: T2 BIOSYSTEMS, INC.
    Inventors: Sonia Taktak, Brian M. Mozeleski, Thomas J. Lowery, Jr.
  • NMR systems and methods for the rapid detection of analytes
    Patent number: 9046493
    Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: June 2, 2015
    Assignee: T2 Biosystems, Inc.
    Inventors: Lori Anne Neely, Mark John Audeh, Matthew Blanco, James Franklin Chepin, Vasiliki Demas, Rahul K. Dhanda, Thomas Jay Lowery, Jr.
  • PORTABLE DEVICE FOR NMR BASED ANALYSIS OF RHEOLOGICAL CHANGES IN LIQUID SAMPLES
    Publication number: 20150130463
    Abstract: The invention features a portable device for monitoring changes in the rheological state of multiple samples by NMR based measurement. The rheological changes can be, for example, gelation occurring during limulus amoebocyte lysate (LAL) testing for endotoxins or blood coagulation. The inventive method entails organization of individual NMR tubes in a disposable cartridge where the tubes are connected through a top cover, provided with movable actuators to push the reagent in the reagent compartments of the individual chambers to the reaction chambers in a predetermined sequence.
    Type: Application
    Filed: June 25, 2013
    Publication date: May 14, 2015
    Applicant: T2 BIOSYSTEMS, INC.
    Inventors: Parris S. Wellman, Matthew Blanco, William Peine
  • NMR systems and methods for the rapid detection of analytes
    Patent number: 8883423
    Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: November 11, 2014
    Assignee: T2 Biosystems, Inc.
    Inventor: Lori A. Neely
  • NMR systems for in vivo detection of analytes
    Patent number: 8836334
    Abstract: This invention relates generally to NMR systems for in vivo detection of analytes. More particularly, in certain embodiments, the invention relates to systems in which superparamagnetic nanoparticles are exposed to a magnetic field and radio frequency (RF) excitation at or near the Larmor frequency, such that the aggregation and/or disaggregation of the nanoparticles caused by the presence and/or concentration of a given analyte in a biological fluid is detected in vivo from a monitored RF echo response.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: September 16, 2014
    Assignee: T2 Biosystems, Inc.
    Inventors: W. David Lee, David A. Berry
  • NMR METHODS FOR MONITORING BLOOD CLOT FORMATION
    Publication number: 20140212901
    Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.
    Type: Application
    Filed: July 13, 2012
    Publication date: July 31, 2014
    Applicant: T2 Biosystems, Inc.
    Inventors: Thomas J. Lowery, JR., Vyacheslav Papkov, Walter W. Massefski, JR., Rahul K. Dhanda, Edward C. Thayer
  • NMR SYSTEMS AND METHODS FOR THE RAPID DETECTION OF ANALYTES
    Publication number: 20140120523
    Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
    Type: Application
    Filed: October 17, 2013
    Publication date: May 1, 2014
    Applicant: T2 BIOSYSTEMS, INC.
    Inventors: THOMAS JAY LOWERY, JR., RAHUL K. DHANDA
  • Modular cartridge assembly
    Patent number: D717470
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: November 11, 2014
    Assignee: T2 Biosystems, Inc.
    Inventors: Vasiliki Demas, Trevor Beckett, Michael Withers, Robin Lee, Parris S. Wellman
  • Tube cap
    Patent number: D730185
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: May 26, 2015
    Assignee: T2 Biosystems, Inc.
    Inventors: Matthew Blanco, Mark John Audeh, Vasiliki Demas, Michael Min, Charles William Rittershaus, Adam Suchocki, Parris Wellman
  • Modular cartridge assembly
    Patent number: D776297
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: January 10, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Vasiliki Demas, Trevor Beckett, Michael Withers, Robin Lee, Parris S. Wellman