Abstract: A system and method of detecting acoustic waves including directing a continuous-wave source laser beam to an optical resonator that is impinged by acoustic the waves. Optionally, the source laser beam can propagate through the optical resonator, thereby generating a propagated laser beam. Using an interferometer, the acoustic waves can be detected by monitoring transients in an optical phase of the propagated laser beam.

Abstract: A semiconductor laser element a first ring resonator. The first ring resonator includes a first semiconductor stack including a first n-side semiconductor layer, a first p-side semiconductor layer, and a first active layer located between the first n-side semiconductor layer and the first A-side semiconductor layer, wherein the first ring resonator comprises a diffraction grating. The semiconductor laser element further includes a second ring resonator optically coupled to the first ring resonator by evanescent field coupling. The second ring resonator includes a second semiconductor stack including a second n-side semiconductor layer, a second p-side semiconductor layer, and a second active layer located between the second n-side semiconductor layer and the second p-side semiconductor layer, wherein a peak wavelength of light emitted by the second ring resonator is the same as a peak wavelength of light emitted by the first ring resonator.

Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.

Abstract: A composition comprising a carbon material comprising a first channel with a width in the range of 50 nm to 1000 nm and a second channel with a width in the range of 20 nm to 200 nm, wherein the second channel comprises branches and is in fluid communication with the first channel, is provided. Further, articles comprising the composition are provided. A method for making a templated carbon material with hierarchical porosity is also provided.

Abstract: A system and method to measure blood oxygenation levels and total hemoglobin on individually selected blood vessels, to provide a representation of the subject condition and of tissue perfusion that may be used for diagnosing specific tissue conditions. Reflection spectra from individual blood vessels or a collection of vessels are measured by using wide-field imaging for selecting target vessels and a narrow-field confocal detection system to enable measuring local blood oxygenation and hemoglobin. Optical fibers may be used to illuminate the target vessel and to detect light diffusively reflected therefrom. The reflection spectra may be analyzed in a spectrometer to extract the ratio of the deoxy- to oxyhemoglobin and to determine their absolute concentration for computing total hemoglobin levels. An alternative implementation uses image processing on camera images of a blood vessel, generated at an isosbestic wavelength of the deoxy- and oxyhemoglobin, and optionally also at neighboring wavelengths.

Abstract: Provided herein is a porous PLA-based monolith having a microstructure templated by an external phase of a HIPE, as well as processes of manufacturing the same and uses thereof.

Abstract: A monolithic solid state system comprises a ferroelectric crystal and a semiconductor crystal arranged laterally to define a nanolayer having a heterojunction between the two crystals. In some embodiments, the ferroelectric crystal exhibits in-plane polarization.

Abstract: Anion exchange membrane electrode assemblies, fuel cells and electrochemical cells comprising such assemblies, which comprise an anion exchange membrane sandwiched between an anode compartment and a cathode compartment, and which are operable at a temperature of at least 100° C., are provided. Systems, devices, articles and methods that utilize such assemblies at an operating temperature of at least 100° C. are also provided.

Abstract: The present invention relates to an heparanase-binding and heparanase-neutralizing monoclonal antibody (IgG-1 mAb A54), including its epitope (HBD-II) and mode of interaction with heparanase, pharmaceutical composition comprising same, and uses thereof e.g. for inhibiting or treating a disease or disorder associated with heparanase activity, including but not limited to cancer, inflammation, viral infection, diabetes and related complications. The present invention further provides combinatorial cancer therapies, comprising the heparanase-neutralizing mAb and an additional anti-cancer treatment such as chemotherapy or radiation.

Abstract: The present invention provides a flow-gate design that utilizes chemo-responsive colloidal particles to control the flow rate therethrough. The flow-gate operates by changing the compactness of the colloidal particles, which changes in response to changes in pH or ionic strength in the flow medium or the surrounding environment. The design also allows the flow-gate as a size-discriminating filter. The ability to control the flow rate in response to changes in the flow medium or the environment makes the presently provided flow-gate useful for a variety of applications, including those that require automatic control of the flow rate, and automatic irrigation.

Abstract: The present invention is directed to a method for treating a bowel disease in a subject in need thereof, the method comprising inhibiting the activity of neurons of the insular cortex of the subject. Further provided is a system comprising a transcranial stimulation transducing coil for transcranial stimulation configured to provide a series of pulses to neurons of the insular cortex.

Abstract: Provided is a superabsorbent structure based on a covalently crosslinked copolymer having a microstructure of a HIPE, and characterized by hydrophobic and hydrophilic segments of at least five residues; the unique chemical and structural properties of the copolymer afford a polymeric superabsorbent structure that is capable of swelling in polar as well as apolar media. Also provided are processes of manufacturing the superabsorbent structure, and uses thereof.

Abstract: An analog to digital converter comprises an input for receiving an analog input signal; a plurality of outputs for outputting parallel bits of a digital signal that represents said analog input signal; and a neural network layer providing connections between each of said outputs respectively, each connection having an adjustable weighting. The synapses of the neural networks may be memristors and training may use online gradient descent.

Abstract: A method of fabricating an optical element, comprises fabricating a three-dimensional mold having a relief pattern complementary to a pattern of the optical element to be fabricated, contacting the relief pattern with a solidifiable transmissive material, and solidifying the material thereby forming a transmissive substrate having the pattern thereupon. The method also comprises contacting the transmissive substrate with one or more substances wherein a difference in refractive indices between the substance(s) and the transmissive substrate is less than about 0.1.

Abstract: Yeast strains are disclosed that are capable of surviving high ethanol concentrations and propagating in high ethanol concentrations. Genes that are involved in ethanol tolerance are disclosed as well.

Abstract: A method comprising receiving, as input, a data stream representing events; receiving a complex event pattern (CEP) specification representing an occurrence of a CEP in said data stream based on a set of conditions and set of event attributes; applying an algorithm to generate a current CEP plan configured to determine said occurrence of said CEP, wherein said current CEP plan comprises of a series of execution steps; optimize said current CEP plan by, iteratively: (i) executing said current CEP plan, (ii) identifying, with respect to each of said execution steps, one of said conditions whose verification causes said execution step to be included in said current CEP plan, and (iii) performing a re-verification of all of said identified conditions using said updated current values; and re-applying said algorithm when said re-verification fails with respect to at least one of said identified conditions, to generate an updated CEP plan.

Abstract: There is provided a computer implemented method of manufacturing a truss of a three dimensional (3D) object representation, comprising: receiving a definition of the 3D object representation, arranging within an interior space of the 3D object representation, a plurality of instances of a sphere having a common radius to create a packed sphere arrangement, computing nodes of a truss for the 3D object representation, each respective node positioned at a center of each respective instance of each sphere of the packed sphere arrangement, computing beams of the truss by connecting adjacent nodes with respective beams, and providing code instructions for execution by a manufacturing device controller of a manufacturing device for manufacturing the truss.

Abstract: A system for directional detection of radiation, comprises a plurality of scintillating crystals, responsive to the radiation and being arranged three-dimensionally, with voids between adjacent crystals, such that there are crystals that are inner and crystals that are outer within the arrangement. The system also comprises a plurality of light sensors coupled to the crystals for receiving optical signals from the crystals and responsively generating electrical signals, and a data processor receiving an electrical signal separately from each light sensor and calculating a direction of the radiation based on relative intensities of the signals and mutual occultation among different crystals.

Abstract: The present disclosure describes an interferometer interfering a plurality of bosonic particles at one or more inputs so as to form one or more first outputs, one or more second outputs, and one or more third outputs. The one or more third outputs output one or more purified bosonic particles depending on the presence of absence of bosonic particles at the first outputs and second outputs.

Abstract: Disclosed is a method for activating a surface of metals, such as self-passivated metals, and of metal-oxide dissolution, effected using a fluoroanion-containing composition. Also disclosed is an electrochemical cell utilizing an aluminum-containing anode material and a fluoroanion-containing electrolyte, characterized by high efficiency, low corrosion, and optionally mechanical or electrochemical rechargeability. Also disclosed is a process for fusing (welding, soldering etc.) a self-passivated metal at relatively low temperature and ambient atmosphere, and a method for electrodepositing a metal on a self-passivated metal using metal-oxide source.