Abstract: Disclosed is a method for activating a surface of metals, such as self-passivated metals, and of metal-oxide dissolution, effected using a fluoroanion-containing composition. Also disclosed is an electrochemical cell utilizing an aluminum-containing anode material and a fluoroanion-containing electrolyte, characterized by high efficiency, low corrosion, and optionally mechanical or electrochemical rechargeability. Also disclosed is a process for fusing (welding, soldering etc.) a self-passivated metal at relatively low temperature and ambient atmosphere, and a method for electrodepositing a metal on a self-passivated metal using metal-oxide source.
Type:
Application
Filed:
April 7, 2020
Publication date:
July 23, 2020
Applicant:
Technion Research & Development Foundation Limited
Inventors:
Yair EIN-ELI, Danny GELMAN, Boris SHVARTSEV, Alexander KRAYTSBERG
Abstract: A fragment of a virulent peptide named phenol-soluble modulin (PSM) having anti-bacterial activity and methods for eliminating bacteria are provided.
Type:
Grant
Filed:
August 22, 2017
Date of Patent:
July 21, 2020
Assignee:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Abstract: A method for the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also discloses.
Type:
Grant
Filed:
June 26, 2016
Date of Patent:
July 21, 2020
Assignees:
Technion Research & Development Foundation Limited, Yeda Research and Development Co. Ltd.
Abstract: Provided is an isolated population of human pluripotent stem cells comprising at least 50% human pluripotent stem cells characterized by an OCT4+/TRA1-60?/TRA1-81?/SSEA1+/SSEA4? expression signature, and novel methods of generating and maintaining same in a pluripotent, undifferentiated state a suspension culture devoid of cell clumps. Also provided are novel culture media, cell cultures and methods for culturing pluripotent stem cells in a suspension culture or a two-dimensional culture system while maintaining the cells in a proliferative, pluripotent and undifferentiated state. The novel culture media comprise interleukin 11 (IL11) and Ciliay Neurotrophic Factor (CNTF); bFGF at a concentration of at least 50 ng/ml and an IL6RIL6 chimera; or an animal contaminant-free serum replacement and an IL6RIL6 chimera. Also provided are methods for generating lineage-specific cells from the pluripotent stem cells.
Type:
Application
Filed:
March 5, 2020
Publication date:
July 16, 2020
Applicant:
Technion Research & Development Foundation Limited
Abstract: The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53 amino acid sequences.
Type:
Grant
Filed:
October 7, 2016
Date of Patent:
July 14, 2020
Assignees:
UNIVERSITY OF UTAH RESEARCH FOUNDATION, TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Inventors:
Joshua Schiffman, Avi Schroeder, Lisa Abegglen
Abstract: Apparatus and method for hashing a message, comprises using an array of individually selectable memristor cells. The memristor cells are subject to write disturb that affects cells neighboring a selected cell so that a write operation into one cell has a knock-on effect on the neighbors. The array is initiated into a known stable state so that these changes to neighboring cells are predictable according to proximity to the currently selected cell. An inserter sequentially mixes bits with the hash so far to insert bits into successively selected cells of the memristor array and forms a succession of memristor array states including the knock on effects on the neighboring cells. A final resulting memristor array state following input of the bits forms the hash of the message.
Type:
Grant
Filed:
April 29, 2018
Date of Patent:
July 7, 2020
Assignee:
Technion Research & Development Foundation Limited
Abstract: Yeast strains are disclosed that are capable of surviving high ethanol concentrations and propagating in high ethanol concentrations. Genes that are involved in ethanol tolerance are disclosed as well.
Type:
Application
Filed:
August 23, 2018
Publication date:
June 25, 2020
Applicant:
Technion Research & Development Foundation Limited
Abstract: According to an aspect of some embodiments of the present invention there is provided a method for converting energy. The method comprises receiving energy from an external source, using the received energy for inducing a mass exchange process to release thermodynamic energy, and converting the thermodynamic energy directly into electrical energy at sufficient amount for performing work therewith. In some embodiments of the present invention, a portion of the released energy is converted to a pressure wave, and the mechanical energy constituted by the pressure wave is converted to non-mechanical energy.
Type:
Grant
Filed:
January 25, 2017
Date of Patent:
June 16, 2020
Assignee:
Technion Research & Development Foundation Limited
Inventors:
Yehuda Agnon, Guy Ramon, Carlos Dosoretz
Abstract: New exemplary heat exchange configurations that incorporate internal or external surfaces equipped with perturbators, for changing the thermal behavior of the system, or for modulating the surface temperature distribution of the flow surfaces. This is achieved by applying an acoustic wave to the fluid flow in a heat exchange passage, and selecting the frequency of the acoustic exciting wave to be the same as the acoustic resonance frequency of the heat exchange passage itself. As the traveling waves interact with the boundaries confining the heat exchange passages, constructive interference of the incident and reflected waves give rise to a standing wave. Thus, the heat exchange passages act as a resonator, and by superimposing this standing wave on the separating and reattaching fluid flow, significant heat transfer improvement can be achieved. This is accomplished without the need to significantly increase the pressure required to achieve the desired through flow.
Type:
Grant
Filed:
December 15, 2015
Date of Patent:
June 9, 2020
Assignee:
Technion Research & Development Foundation Limited
Abstract: A computer implemented method of estimating a similarity of binary records comprising executable code, comprising converting a first binary record and a second binary record to a first intermediate representation (IR) and a second IR respectively, decomposing each of the first IR and the second IR to a plurality of strands which are partial dependent chains of program instructions, calculating a probability score for each of the plurality of strands of the first IR to have an equivalent counterpart in the second IR by comparing each strand of the first IR to one or more strands of the second IR, adjusting the probability score for each strand according to a significance value calculated for each strand and calculating a similarity score defining a functional similarity between the first IR and the second IR by aggregating the adjusted probability score of the plurality of strands.
Type:
Application
Filed:
December 23, 2019
Publication date:
June 4, 2020
Applicant:
Technion Research & Development Foundation Limited
Inventors:
Eran YAHAV, Nimrod Sebban PARTUSH, Moshe Yaniv DAVID
Abstract: Agents which inhibit Gads dimerization are provided. Accordingly there is provided an agent which inhibits Gads (SEQ ID NO: 1) dimerization, the agent interacting with a pharmacophore binding site comprising an amino acid selected from the group consisting of F55, P56, W58, F59, E61, G62, A84-F92, V107-N111, Y115, F116, L125 and N126 of SEQ ID NO: 1. Also provided an agent which inhibits Gads (SEQ ID NO: 1) dimerization, the agent interacting with a pharmacophore binding site comprising an amino acid sequence of an SH3 domain of SEQ ID NO: 1. Also provided are methods of inhibiting activation of a T cell and/or a mast cell and methods of treating or preventing a disease associated with activation of T cells or an allergic response.
Type:
Application
Filed:
May 22, 2018
Publication date:
June 4, 2020
Applicant:
Technion Research & Development Foundation Limited
Abstract: An article comprised of an oxidized carbon nanotube (CNT) membrane is disclosed. Incorporation of the article in a filtration system is further disclosed. A method for oxidizing a surface of a CNT membrane, e.g., by applying a direct-current (DC) potential in/on said CNT membrane is further disclosed.
Type:
Application
Filed:
July 23, 2018
Publication date:
May 21, 2020
Applicant:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Abstract: Doubly-crosslinked hydrogel polyHIPEs (DC-PHs), which exhibit rapid water absorption, enhanced mechanical properties, and shape memory behavior, are provided herein, as well as processes of producing the same and uses thereof. DC-PHs comprise a continuous HIPE-templated doubly-crosslinked hydrogel, formed from hydrogel-forming monomers, ligand-bearing monomers, and crosslinking monomers.
Type:
Application
Filed:
January 21, 2020
Publication date:
May 14, 2020
Applicant:
Technion Research & Development Foundation Limited
Abstract: A method for estimating a plurality of camera, comprising using at least one processor executing a code for: extracting a plurality of image features of a plurality of landmarks from a plurality of images captured by at least one camera from at least one pose, the plurality of landmarks calibrated with respect to a certain coordinate system; identifying among the plurality of image features at least one image feature documented in at least some of the images; producing scale values of at least one common image feature by analyzing the at least some of the images; determining a plurality of estimated poses of the at least one camera with respect to the certain coordinate system by using the scale values in calculating a minimal re-projection error between the plurality of image features and a plurality of predicted image features; and outputting the plurality of estimated poses.
Type:
Application
Filed:
January 20, 2020
Publication date:
May 14, 2020
Applicant:
Technion Research & Development Foundation Limited
Abstract: A method for locating a vessel, the method comprising illuminating at least a portion of the vessel with a background light having a substantially high susceptibility to absorption by particles in said portion of the vessel; detecting backscattered light from said illuminated portion of the vessel; reproducing an image from said backscattered light; and identifying dark regions within said reproduced image.
Type:
Grant
Filed:
January 17, 2013
Date of Patent:
May 12, 2020
Assignee:
Technion Research & Development Foundation Limited
Abstract: Disclosed is a method for activating a surface of metals, such as self-passivated metals, and of metal-oxide dissolution, effected using a fluoroanion-containing composition. Also disclosed is an electrochemical cell utilizing an aluminum-containing anode material and a fluoroanion-containing electrolyte, characterized by high efficiency, low corrosion, and optionally mechanical or electrochemical rechargeability. Also disclosed is a process for fusing (welding, soldering etc.) a self-passivated metal at relatively low temperature and ambient atmosphere, and a method for electrodepositing a metal on a self-passivated metal using metal-oxide source.
Type:
Grant
Filed:
March 31, 2015
Date of Patent:
May 5, 2020
Assignee:
Technion Research & Development Foundation Limited
Inventors:
Yair Ein-Eli, Danny Gelman, Boris Shvartsev, Alexander Kraytsberg
Abstract: Provided are compositions-of-matter comprising a continuous elastomeric matrix that is structurally-templated by an external phase of a high internal phase emulsion (HIPE), and a liquid dispersed and entrapped in the elastomeric matrix in a form of a plurality of discrete liquid-filled voids. Also provided are processes for obtaining said compositions-of-matter and uses thereof.
Type:
Application
Filed:
July 10, 2018
Publication date:
April 23, 2020
Applicant:
Technion Research & Development Foundation Limited
Abstract: A system comprising: a camera configured to capture one or more images of a user's hand; and a computer configured to: receive the one or more captured images, apply a mapping function to the received one or more images, thereby yielding one or more coordinates associated with at least one feature of the user's hand, wherein the mapping function is derived from a set of labeled images that are produced by applying a machine learning algorithm to training data which comprises images of a trainer's hand, wherein the images are labeled with coordinates obtained from multiple magnetic sensors attached to the trainer's hand.
Type:
Grant
Filed:
February 22, 2016
Date of Patent:
March 31, 2020
Assignee:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Abstract: Provided is an isolated population of human pluripotent stem cells comprising at least 50% human pluripotent stem cells characterized by an OCT4+/TRA1-60?/TRA1-81?/SSEA1+/SSEA4? expression signature, and novel methods of generating and maintaining same in a pluripotent, undifferentiated state a suspension culture devoid of cell clumps. Also provided are novel culture media, cell cultures and methods for culturing pluripotent stem cells in a suspension culture or a two-dimensional culture system while maintaining the cells in a proliferative, pluripotent and undifferentiated state. The novel culture media comprise interleukin 11 (IL11) and Ciliay Neurotrophic Factor (CNTF); bFGF at a concentration of at least 50 ng/ml and an IL6RIL6 chimera; or an animal contaminant-free serum replacement and an IL6RIL6 chimera. Also provided are methods for generating lineage-specific cells from the pluripotent stem cells.
Type:
Grant
Filed:
January 11, 2017
Date of Patent:
March 24, 2020
Assignee:
Technion Research & Development Foundation Limited
Abstract: The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.
Type:
Grant
Filed:
September 3, 2018
Date of Patent:
March 17, 2020
Assignee:
Technion Research & Development Foundation Limited