Patents Assigned to Technion Research & Development
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Patent number: 6465804Abstract: A heterojunction bipolar transistor (HBT) having an emitter structure capable of reducing the current crowding effect and preventing thermal instabilities is disclosed, wherein a negative differential resistance. (NDR) element is added to the layer structure of the conventional emitter. In accordance with the invention, the NDR element can be implemented, for example, by a Resonant Tunnel Diode (RTD) or an Esaki Diode structure. The NDR element is designed to limit the tunneling current to the maximal emitter current density required for safe transistor operation, thereby also reducing the current crowding effect.Type: GrantFiled: July 10, 2000Date of Patent: October 15, 2002Assignee: Technion Research & Development Foundation Ltd.Inventors: Nachum Shamir, Dan Ritter
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Patent number: 6389047Abstract: A wavelength-selectable laser system (10) is achieved by addressing the suitable mode-locked frequency of a multi-length laser cavity formed by multiple wavelength-selective mirrors (20) such as fiber gratings. This is useful for fiber optic communication and WDM (wavelength division multiplexing) networks where there is incorporated an information encoder/modulator (22) of the light in the sending side and a detector in the receiving side, which are matched to the laser system.Type: GrantFiled: July 25, 2000Date of Patent: May 14, 2002Assignee: Technion Research & Development Foundation Ltd.Inventor: Baruch Fischer
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Patent number: 6251608Abstract: Methods for determining a potential of a hyperglycemic patient to develop vascular complications in response to oxidative stress and for determining the importance of reducing oxidative stress in a specific hyperglycemic patient are disclosed. Each method includes the step of determining a haptoglobin phenotype of the patient. A variety of means of making this determination are further disclosed.Type: GrantFiled: April 20, 2000Date of Patent: June 26, 2001Assignee: Technion Research & Development Foundation, Ltd.Inventor: Andrew P. Levy
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Patent number: 6207324Abstract: An electric storage cell (10) comprises a zinc anode (12) and a sulfur cathode (14), wherein the zinc and the sulfur are in contact with an aqueous solution (22) containing sulfur during the process of battery discharge. In this invention, specific conditions for the aqueous sulfur electrolyte are chosen to overcome the normal ineffectiveness of zinc oxidation in the presence of aqueous zero valent sulfur. Normally, a zinc anode (12) cannot be oxidized in an aqueous solution containing sulfur, because the product of the discharge would be zinc sulfide. This zinc sulfide is a highly insoluble salt and creates a layer which passivates the zinc and renders it completely ineffective to battery discharge. The performance of the battery is made possible by high OH- and HS-ion concentrations formed by the addition of salts to the aqueous zero valent sulfur solution, and permits effective and efficient battery discharge.Type: GrantFiled: December 22, 1999Date of Patent: March 27, 2001Assignee: Technion Research & Development Foundation, Ltd.Inventor: Stuart Licht
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Patent number: 6148926Abstract: Ground clearing apparatus (10) and a method for transporting the apparatus are provided. The ground clearing apparatus (10) includes a plurality of ground clearing tools (20) attached to a rotating shaft (18). The ground clearing tools include a chain (22) having a plurality of links and a hammer (24) attached to one end of the chain (22). The rotation of the shaft (18) causes the hammer (24) to strike objects in its path and generally mill the ground surface.Type: GrantFiled: February 3, 1999Date of Patent: November 21, 2000Assignee: Technion Research & Development Foundation Ltd.Inventors: Gedalyahu Manor, Dan Wolf
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Patent number: 6088495Abstract: An optical coupler, for coupling two waveguides, and an optical switch based on the optical coupler. The indices of refraction of parallel sections of the two waveguides are reversibly perturbed periodically in space to couple low order modes in the two waveguides via a high order mode common to the two waveguides. The waveguides are thus couples with a beat length that may be five or more orders of magnitude shorter than it would be without the periodic perturbations.Type: GrantFiled: April 21, 1998Date of Patent: July 11, 2000Assignee: Technion Research & Development Foundation Ltd.Inventors: Ilya Vorobeichik, Nimrod Moiseyev, Meir Orenstein
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Patent number: 6013780Abstract: The present invention relates to a novel VEGF protein product, and nucleic acid encoding the novel protein product, comprising exons 1-6 and 8 of the VEGF gene, and its use thereof in treating the cardiovascular system and its diseases through effects on anatomy, conduit function, and permeability. VEGF.sub.145 has been found to be an active mitogen for vascular endothelial cells and to function as an angiogenic factor in-vivo. VEGF.sub.145 has novel properties compared with previously characterized VEGF species with respect to cellular distribution, susceptibility to oxidative damage, and extra-cellular matrix (ECM) binding ability. The present invention provides methods of treating the cardiovascular system, enhancing endothelialization of diseased vessels, and enhancing drug permeation by providing the novel VEGF protein product. The invention also provides expression vectors, compositions, and kits for use in the methods of the invention.Type: GrantFiled: January 21, 1997Date of Patent: January 11, 2000Assignee: Technion Research & Development Co. Ltd.Inventors: Gera Neufeld, Eli Keshet, Israel Vlodavsky, Zoya Poltorak
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Patent number: 5994408Abstract: Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of mandelic acid.Type: GrantFiled: October 16, 1997Date of Patent: November 30, 1999Assignees: Teva Pharmaceutical Industries, Ltd., Technion Research & Development Foundation, Ltd.Inventors: Sasson Cohen, Yaacov Herzig, Ruth Levy, Tzipora Speiser, Jeff Sterling, Alex Veinberg, Moussa B. H. Youdim, John P. M. Finberg
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Patent number: 5811680Abstract: A method of testing the quality of a fruit including applying a dynamic impact force to the fruit, detecting the mechanical response of the fruit to the dynamic force via a piezoelectric film transducer supported on a displaceable resilient base member such that the film transducer is bent by the dynamic impact force, to induce a strain in the film transducer, and the film transducer outputs an electrical signal corresponding to the change of the induced strain in the film transducer caused by the dynamic force and analyzing the electrical signal to indicate the quality of the fruit. Apparatus for carrying out the method is also described and claimed.Type: GrantFiled: March 20, 1996Date of Patent: September 22, 1998Assignee: Technion Research & Development Foundation Ltd.Inventors: Naftali Galili, Itzhak Shmulevich, David Rosenfeld
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Patent number: 5691829Abstract: A method and apparatus for fixing images, holograms and domain gratings in crystals by application of an electric field on a crystal and simultaneous illumination of it with a light pattern. The fixing procedure is based on a screening effect. The modulation of the domains may be perpendicular to the c-axis. Another application of the method is in frequency mixing such as second harmonic generation and parametric processes, by overcoming the problem of phase matching using the domain gratings. Thus, it is possible to obtain controllable broadband mixing and tailored quasi-phase matching for several wavelengths or for prespecified wavelength tuning ranges and frequency widths.Type: GrantFiled: October 17, 1995Date of Patent: November 25, 1997Assignee: Technion Research & Development Foundation Ltd.Inventors: Baruch Fischer, Moshe Horowitz
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Patent number: 5671168Abstract: A method for the digital frequencey domain implementation of receiving arrays. The steps of the method are as follows: a discrete time input signal is transformed into its spectral components and the redundant spectral components are removed. Products of the non-redundant spectral components with a scaled set of acquired weights are computed. From the so-computed products a first set of spectral sums is calculated wherefrom a second set of spectral sums is derived. Thereafter, the first and second sets of spectral sums are converted to the discrete time domain thereby obtaining a discrete time output signal. The invention also provides a system having receiving components operating in accordance with the method. In another embodiment the invention also provides a method and system for the digital frequency domain implementation of transmitting arrays.Type: GrantFiled: July 6, 1995Date of Patent: September 23, 1997Assignee: Technion Research & Development Foundation Ltd.Inventors: Chen Liu, Samuel Sideman
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Patent number: 5646951Abstract: A method of using a distributed saturable absorber added to a laser cavity, which by nonlinear wave-mixing of the counterpropagating beams (or spatial hole-burning) promotes a reduction of the linewidth and a single mode operation.Type: GrantFiled: March 21, 1995Date of Patent: July 8, 1997Assignee: Technion Research & Development Foundation Ltd.Inventors: Baruch Fischer, Ron Daisy, Moshe Horowitz
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Patent number: 5608208Abstract: A method for producing a photodiode with a simplified planar device architecture based on a single layer of HgCdTe using a mature, established growth technology for the sensing material, combined with an implanted homojunction which is at least partially activated during MOCVD CdTe passivation. The device architecture is based on a planar structure, a p-on-n homojunction for sensing the infrared radiation, and a CdTe or CdZnTe/HgCdTe heterostructure for passivation. The MOCVD CdTe passivation can be applied ex-situ, irrespective of the growth technology of the sensing material, and the homojunction is at least partially activated while applying the CdTe passivation. Thus, a major simplification in device architecture is achieved, based on a single layer in contrast to known, double layer heterostructures.Type: GrantFiled: January 25, 1995Date of Patent: March 4, 1997Assignee: Technion Research & Development Foundation Ltd.Inventor: Yael Nemirovsky
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Patent number: 5560912Abstract: The invention relates to the use of an organic extract of the plant Cinnamon or a chemical constituent present in said plant, to prepare a pharmaceutical composition useful to inhibit the growth of Helicobacter pylori and the urease activity of Helicobacter pylori. Most preferred chemical constituents are cinnamaldehyde and methoxycinnamaldehyde. The extract may be used either as a drink, with or without additional flavoring ingredients or transformed into a capsule. The invention also relates to in-vitro method for determininig the inhibition of urease activity of Helicobacter pylori using said organic extract of the plant or chemical constituents present in said plant.Type: GrantFiled: June 27, 1994Date of Patent: October 1, 1996Assignee: Technion Research & Development Foundation Ltd.Inventors: Itzhak Neeman, Mina Tabak, Robert Armon
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Patent number: 5538645Abstract: A process for the removal of species containing metallic ions from effluents by yeast cell walls. The yeasts used are selected from Saccharomyces cerevisae, Saccharomyces uvarum and Saccharomyces lipolytica. According to the process, the washed yeast cell walls are first treated by a water soluble aldehyde and after sorbing the metallic ions, the yeast cell walls may regenerated by a mineral acid or a chelate solution such as ethylene-diamine tetraacetic acid, releasing the sorbed metal ions. According to a preferred embodiment, water containing acetone or alcohol is used for washing the yeast cell walls. The sorption by the yeast cell walls is carried out at a pH in the range of 1 to 13 and preferably in the range of 4 to 7. The most preferred aldehyde is selected from formaldehyde and glutaraldehyde or any mixture thereof. The metal sorption process may be carried out batchwise or continuously. In the continuous process, the yeast cell walls are immobilized on porous glass, purified sand or polymers.Type: GrantFiled: November 22, 1993Date of Patent: July 23, 1996Assignee: Technion Research & Development Foundation Ltd.Inventors: Shmuel Yannai, Galit Meshulam
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Patent number: 5520700Abstract: A stapler device includes a manually grippable handle containing a drive and a trigger to activate the drive mechanism, a barrel fixed to the handle, a guide for holding a staple to be ejected and formed to accommodate a suture thread fixed to the staple, and an ejector driven by the drive through the barrel for ejecting a staple out through the guide into a bone to enable the suture, so anchored to the bone, to be used for various medical operations.Type: GrantFiled: November 10, 1993Date of Patent: May 28, 1996Assignee: Technion Research & Development Foundation, Ltd.Inventors: Mordechai Beyar, Amnon Foux
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Patent number: 5496854Abstract: The invention relates to novel titanocene derivatives possessing chemotherapeutic activity and method for their preparation. These compounds possess two cyclopentadiene rings linked to titanium as a central atom and bound covalently to two phenoxy groups which possess a substituent R selected from the group consisting of COOCH.sub.3, COOC.sub.2 H.sub.5, H, COOCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 and are free from amino, nitro, chloride and fluoride groups. The novel compounds represent a compromise between the main properties for an antitumor agent, i.e., electrophilicity and stability, being water soluble. Cytotoxicity measurements of these compounds showed significant growth inhibition properties, expressed in terms of IC.sub.50 [M] values.Type: GrantFiled: February 17, 1995Date of Patent: March 5, 1996Assignees: Technion Research & Development Foundation Ltd., Ehud KeinanInventor: Ehud Keinan
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Patent number: 5365185Abstract: A method and apparatus for producing a frequency-controlled loop in a phase-diversity receiver for demodulating received ON-OFF-keyed (OOK) and phase shift keying (PSK) signals, by feeding a reference frequency signal and the received signals to a quadrature mixer (QM) which produces two output signals in phase quadrature at nominally zero intermediate frequency. Quadrature continuous wave signals void of the modulation are produced from the phase quadrature output signals. A voltage proportional to the frequency of the quadrature continuous wave signals is generated and is utilized for controlling the frequency of the generated reference frequency signal.Type: GrantFiled: July 30, 1993Date of Patent: November 15, 1994Assignee: Technion Research & Development FoundationInventor: Israel Bar-David
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Patent number: 5344434Abstract: The invention relates to an apparatus for an efficient photodynamic therapy treatment. The apparatus comprises the following parts: (a) a lamp possessing a narrow beam light with half angle divergence up to 10.degree., possessing an intensity of at least 2 mW/nm with a spectral region in the range of 610 to 750 nm; (b) a glass lens to focus the beams of the light; (c) a red filter possessing a transmittance of 0.95 which provides a spectral region of above 610 nm, and (c) a light guide in the range of 3 to 12 mm diameter, which provides a minimum irradiance of 50 mW/cm.sup.2. According to a preferred embodiment the lamp is provided with a fixed internal reflector. In order to transmit the useful radiation and to remove the heat produced by the infra-red radiation, a 45.degree. dicroic mirror is attached to the apparatus.Type: GrantFiled: December 21, 1992Date of Patent: September 6, 1994Assignee: Technion Research & Development Foundation, Ltd.Inventor: Eli T. Talmore
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Patent number: 5274092Abstract: Novel discogens based on tricycloquinazoline derivatives and methods for their preparation are described. One method for their preparation is to nitrate veratraldehyde and after reducing the resulting nitrate to dimethoxy anthranil to obtain its trimerization thus producing a trisubstituted tricycloquinazoline. Another method is to start with dichlorotoluene and after its nitration to oxidize the nitrate into dichloronitrodiacetoxytoluene, its hydrolysis into benzaldehyde followed by a partial reduction to anthranil and finally by the trimerization of the anthranil to obtain the hexachlorotricycloquinazoline. The novel compounds are useful as fluorescent indicators for high performance oxygen sensors, organic conductors, liquid crystals and polymeric liquid crystals.Type: GrantFiled: July 13, 1992Date of Patent: December 28, 1993Assignee: Technion Research & Development Foundation Ltd.Inventor: Ehud Keinan