Abstract: A method for detecting free metal ions in a sample includes, providing a liquid sample potentially comprising free metal ions. A fluorescent probe comprising an organic fluorescent core and one or more metal binding functional group is added to the sample. The one or more metal binding functional group is selected from a group comprising a phosphonic acid group and an arsonic acid group and is covalently linked to a sp or sp2-carbon atom or a nitrogen atom of the fluorescent core via a P or As atom. A fluorescence of the sample is measured. A presence of the metal ions leads to a concentration-dependent decrease, increase or shift of fluorescence compared to a reference sample. The method preferably involves determining a concentration of the metal ions in the sample. The liquid sample may be a biological sample, such as a bodily fluid, a tissue sample or a sample comprising cells.

Abstract: The present invention provides N-methylated cyclic hexapeptides comprising RGD and at least one alanine residue. The present invention further provides prodrugs comprising the cyclic hexapeptides. Pharmaceutical compositions comprising said cyclic hexapeptides are also disclosed as well as methods of their production and use in treating integrin related conditions and diseases.

Abstract: A semiconductor device for emitting electromagnetic radiation, and to a method of producing the same, which can be used as a semiconductor-based, structured light source. The semiconductor device comprises a layer stack structure composed of an n-doped layer, an active layer and a p-doped layer, as well as a connection structure comprising conductor layers and at least one insulator layer, the conductor layers being arranged, parallel to and spaced apart from one another, along a first direction that is parallel to the active layer of the layer stack structure, and at least one insulator layer being arranged between at least two conductor layers, one or more conductor layers being electrically connected to the p-doped layer of the layer stack structure.

Abstract: In a method of controlling a lithography-based additive manufacturing device capable of manufacturing a three-dimensional component from a plurality of volume elements, a check is made to determine whether the volume elements are entirely within the three-dimensional virtual model by identifying at least first and second boundary points of the volume element or virtual model in x-y planes spaced apart in the z-direction, and the volume element in question is provided for the manufacturing process only if it is within the model with respect to the first and second boundary points.

Abstract: The present invention pertains to a method for the identification of genetic variants that are associated with the severity of an infectious disease. The invention further pertains to a set of genetic factors associated with the severity of Human respiratory syncytial virus (HRSV) infection, for example in human infants. The genetic polymorphisms identified according to the present invention are for use in the diagnostic of infectious diseases and patient stratification in order to avoid or reduce the occurrence of fatal events during infection or to elect the most appropriate therapeutic approach to treat the disease.

Abstract: A radar assembly and a method for operating the radar assembly is disclosed, where a first frequency comb generator is arranged in the transmitting unit between the first oscillator and the transmitting antenna and a second frequency comb generator is arranged in the receiving unit between the second oscillator and the first mixer. On the transmitter side a first frequency comb generator is controlled with the first oscillator frequency in order to generate a primary signal containing a plurality of frequency components, on the receiver side a second frequency comb generator is controlled with a second oscillator frequency in order to generate an output signal containing a plurality of frequency components, the output signal generated in such a way is mixed with a third oscillator frequency, and the intermediate frequency is generated by mixing the received reflected signal with the mixed signal.

Abstract: A method for demodulation including the following steps: exciting a vibrationally mounted, at least sectionally bar-shaped oscillating element for oscillating in the range of a resonance frequency of the oscillating element, wherein a temporally varying, in particular periodic, excitation signal is used for excitation, and wherein at least the temporal variation of the excitation signal is known or determined; detecting a modulated oscillation of the oscillating element by means of at least one sensor, wherein the sensor supplies a sensor measurement variable that varies versus time as a function of an amplitude and a phase of the modulated oscillation of the oscillating element. According to the present teaching, it is provided that the method includes the following step: generate a first comparison signal by amplitude modulating a known temporally varying, in particular periodic, demodulation signal by means of the temporally varying sensor measurement variable.

Abstract: The present disclosure relates to imaging and endoradiotherapy of diseases involving chemokine receptor 4 (CXCR4). Provided are compounds which bind or inhibit hCXCR4 and mCXCR4 and furthermore carry at least one moiety which is amenable to labeling. Provided are also medical uses of such compounds.

Abstract: A shaped article, a method for making it, and its use. The shaped article is formed from flat fiber material and has a bottom (2), a body (4), and an opening, which is surrounded by a circumferential flange (6). The shaped article (1) comprises a flange stabilizer (10) attached to the second flat side (18) of the flange (6) facing the bottom (2). The flange stabilizer (10) is disc-shaped and has an inner contour (12) corresponding to the desired cross-sectional shape of the shaped article (1) in the region of the opening and can be slipped over the body (4) in the region of the bottom (2) and up to the flange (6). The flat sides (16, 18) of the flange stabilizer (10) extend essentially parallel to the flange (6), defining and stabilizing the cross-sectional shape of the body (4) in the region of the opening and the flange.

Abstract: The present invention relates to a method for producing a sport beverage, comprising the steps of providing malt and/or unmalted grains, providing mashing liquor produced from spent grains, processing the malt and the mashing liquor to obtain a wort, fermenting the wort by using a yeast and optionally, blending with flavour(s) and/or vitamin(s); and/or adding of sugar(s). The present invention further relates to a sport beverage obtained by said method, wherein said sport beverage is non-alcoholic or has an alcohol content of less than about 1.2 vol-%, preferably less than about 0.5 vol-%. The present invention also relates to the use of the sport beverage before and/or after physical activities.

Abstract: A redirecting rotating mirror arrangement includes a directional antenna subcomponent having a direction of maximum received or transmitted beam intensity. The redirecting rotating mirror arrangement also includes a rotatable mirror that reflects an electromagnetic beam to or from the directional antenna subcomponent. The rotatable mirror is inclined at an inclination angle with respect to a horizontal plane. The arrangement also includes a motor that rotates the rotatable mirror about the direction of maximum received or transmitted beam intensity such that the electromagnetic beam is either received from or transmitted to a range of angles as the rotatable mirror rotates.

Abstract: A method is presented for determining a setpoint signal of a wind energy conversion system. The method includes: providing a first input signal, comprising system frequency values of an electric power system, and a second input signal comprising an angular speed value of a wind energy conversion system; determining, from the first input signal, an intermediate signal comprising system frequency deviation values, the system frequency deviation values indicating deviations between the system frequency values and a target frequency value; determining, from the intermediate signal and the first input signal, a power correction signal comprising a first power value; determining, from the second input signal, a first reference signal comprising a second power value corresponding to a point of maximum power extraction of the wind energy conversion system; and determining a setpoint signal for setting an output power value of the wind energy conversion system.

Abstract: An arrangement of carbon nanotubes (CNTs) is disclosed. The arrangement includes: a substrate (100); a first CNT block (110) rising up from the substrate (100); a second CNT block (120) rising up from the substrate (100), the first CNT block (110) and the second CNT block (120) being spaced apart from each other; and a CNT link (130) connecting the first CNT block (110) to the second CNT block (120). The CNTs of the CNT link (130) are aligned in a same direction as the CNTs of the first CNT block (110) and the second CNT block (120), and the CNT link (130) is configured as a CNT bridge.

Abstract: IN The present invention relates to a method for the recombinant production of DNA single stranded molecules, comprising the steps of (1) providing a pseudogene nucleic acid; (2) integrating the pseudogene nucleic acid into a vector, transforming bacterial cells with said vector and producing a precursor ssDNA from said vector under bacterial culture conditions; (3) isolating the precursor ssDNA from the bacterial culture; (4) digesting the precursor ss DNA under reaction conditions where self-cleaving DNA sequences become active; and (5) separating and obtaining the target single stranded DNA oligo- or polynucleotide(s). The method of the present invention is suitable for the mass production of DNA single stranded molecules. The present invention further relates to the use of the target single stranded DNA oligo- or polynucleotide(s), in particular in DNA nanotechnology, or as research tools.

Abstract: The invention relates to a Gunn diode comprising a first contact layer (110); a second contact layer (120); an active layer (130) based on a gallium nitride (GaN)-based semiconductor material, said active layer being formed between the first contact layer (110) and the second contact layer (120); a substrate (140) on which the active layer (130) is formed together with the first contact layer (110) and the second contact layer (120); and an optical inlet (150) for a laser (50) in order to facilitate or trigger a charge carrier transfer between extrema (210, 220) of the energy bands of the active layer (130) by means of laser irradiation.

Abstract: The person invention relates to a method for the electro-decarboxylation of at least one diene with carbon dioxide CO2 in the presence of hydrogen H2, forming at least one unsaturated dicarboxylic acid, wherein the reaction is carried out in a reactor comprising at least one cathode as the working electrode for the cathodic activation of CO2, at least one anode as the counterelectrode for the anodic oxidation of H2, with a volumetric ration of hydrogen H2 to carbon dioxide CO2 between 1:1 and 1:3, a total pressure pg in the reactor between 2 and 4 MPa, particularly preferably between 3 and 4 MPa, and an average current density j between 5 and 15 mA/cm2, particularly preferably between 10 and 12.5 mA/cm2.

Abstract: A laser assembly comprising: a semiconductor laser with a fast gain medium, wherein the gain relaxation time of the gain medium is smaller than the round-trip time in a standing wave cavity; a DC source coupled to the standing wave cavity; and an AC injection device for injecting an electrical AC signal within a range and/or within an integer multiple of the range into the standing wave cavity, the range within ±1% of the natural round-trip frequency in the standing wave cavity, comprising at least a first and second electric contact section extending along a first longitudinal side of the longitudinal extension of the standing wave cavity, the AC injection device coupled to the first and/or second electric contact section such that the complex amplitude of the electrical AC signal differs for the first and second longitudinal electric contact section.

Abstract: The present invention relates to a coated membrane containing: a membrane with a front and a rear face, a catalyst-containing coating which is provided on the front face of the membrane, the catalyst containing a support material which has a BET surface area of maximally 80 m2/g, an iridium-containing coating which is provided on the support material and contains an iridium oxide, an iridium hydroxide or an iridium hydroxide oxide or a mixture of at least two of these iridium compounds, wherein the catalyst contains iridium in a quantity of maximally 60 wt. %, and the coating provided on the membrane front face has an iridium content of maximally 0.4 mg iridium/cm2.

Abstract: The invention relates to a method for coaxially extruding an extruded product. Hereby, an extruding device comprises the following: a receiver (7); a first receiver bore (5) which is formed in the receiver (7) and in which a first punch (10) is arranged; a second receiver bore (6) which is formed in the receiver (7) inside the first receiver bore (5) and coaxially therewith and in which a second punch (11) is arranged; and a mold (15) having a mold cavity (14) which is connected to the first and the second receiver bore (5, 6). In the method, the following is provided: arranging a first material billet (8) of a first material (2) in the first receiver bore (5); arranging a second material billet (9) of a second material (3) in the second receiver bore (6); and extruding an extruded product (1) in which the first and the second material (2, 3) are connected in a form-fitting and integrally bonded manner.

Abstract: An arrangement for adjusting a powder flow in relation to the central longitudinal axis of an energy beam for a working head which is formed for powder application welding. There is a device for the two-dimensional or three-dimensional alignment of the powder supply in relation to the central longitudinal axis of the energy beam in a plane oriented at right angles to the central longitudinal axis of the energy beam. From one side, a linear beam is directed to the region in which the particles of the powdery material meet one another. At right angles thereto, there is arranged an optical detector array for locally resolved detection of intensities connected to an electronic evaluation unit designed to determine the shape, size and/or length of an irradiated region in which locally resolved intensities which exceed a predefinable threshold have been detected with the optical detector array.