Abstract: The present invention relates to novel inhibitors of adipose triglyceride lipase (ATGL) having an improved inhibitory activity against human ATGL (hATGL) as well as pharmaceutical compositions comprising these inhibitors, and their therapeutic use, particularly in the treatment or prevention of a lipid metabolism disorder, including, e.g., obesity, non-alcoholic fatty liver disease, type 2 diabetes, insulin resistance, glucose intolerance, hypertriglyceridemia, metabolic syndrome, cardiac and skeletal muscle steatosis, congenital generalized lipodystrophy, familial partial lipodystrophy, acquired lipodystrophy syndrome, atherosclerosis, or heart failure.

Abstract: Disclosed herein is a device (100) for multicolor optical imaging of a sample (102) with wavelength-dependent optical path length enhancement, the device (100) comprising an optical resonator (106) for enhancing an optical path length, wherein the optical resonator (106) has a first finesse at a first wavelength and a second finesse at a second wavelength; a sample holder (104) for mounting the sample (102) in the optical resonator (106), wherein the sample holder (104) is configured to hold the sample (102) such that an optical axis (112) of the optical resonator (106) intersects with the sample (102);a first imaging system (114) for imaging the sample (102) at the first wavelength with a first imaging technique, and a second imaging system (126) for imaging the sample (102) at the second wavelength with a second imaging technique, wherein the second wavelength is different from the first wavelength; wherein the first finesse and the second finesse are chosen such that the optical resonator (106) enhances a

Abstract: A method and apparatus decode packetized data in the presence of packet erasures using a finite sliding window technique. A decoder receives packets containing uncoded and coded symbols. When a packet with a coded symbol is received, the decoder determines whether a packet sequence number is within a sliding window of w consecutive sequence numbers that are no greater than a decoder sequence number, where the number w is fixed prior to encoding. When this is the case, the decoder decodes the coded symbol into one or more of the w input symbols using the coefficient vector. Decoding may use a forward error correcting (FEC) window within the finite sliding window. Decoding also may use a technique of Gaussian elimination to produce a “shifted” row echelon coefficient matrix.

Abstract: The present invention relates to a method for monitoring a vehicle convoy containing at least two vehicles (1.1, 1.2), wherein the at least two vehicles (1.1, 1.2) in the vehicle convoy are each formed with a communication system, which is configured to use vehicle-to-vehicle communication to send and/or receive information, and a measuring apparatus, which is configured to capture values for at least one kinematic state parameter. The method involves kinematic state parameters being ascertained and regulated for at least one pair of vehicles (1.1, 1.2) in the vehicle convoy, which pair is formed by a first vehicle (1.1) in the vehicle convoy and a second vehicle (1.2) in the vehicle convoy arranged directly after the first vehicle (1.1) in the vehicle convoy, by means of allocated time and frequency resources.

Abstract: The present invention relates to a ligand-SIFA-chelator conjugate, comprising, within in a single molecule three separate moieties: (a) one or more ligands which are capable of binding to a disease-relevant target molecule, (b) a silicon-fluoride acceptor (SIFA) moiety which comprises a covalent bond between a silicon atom and a fluorine atom, and (c) one or more chelating groups, optionally containing a chelated nonradioactive or radioactive cation.

Abstract: The present disclosure provides methods and composition including vaccines, monoclonal antibodies, polyclonal antibodies, chimeric molecule of an extracellular fibrinogen binding protein (Efb) and targeted agent delivery pharmaceutical composition comprising at least a portion of a modified N-terminus region, at least a portion of a modified C-terminus region, or both, wherein the modified extracellular fibrinogen binding protein results in inhibiting the fibrinogen binding, C3 binding, or both or administering to a subject a pharmacologically effective amount of a vaccine in a pharmaceutically acceptable excipient, comprising a modified extracellular fibrinogen binding protein comprising at least a portion of a modified N-terminus region, at least a portion of a modified C-terminus region, or both, wherein the modified extracellular fibrinogen binding protein results in not shielding the staphylococcus bacterium from recognition by a phagocytic receptor.

Abstract: Method and apparatus to produce a wideband RF signal covering an increased first bandwidth, utilizing at least one narrowband transceiver (1) capable of producing an output RF signal with a base frequency fbase and a second bandwidth, wherein the second bandwidth is lower than the first bandwidth, and wherein the base frequency Case depends on the setting of at least one frequency register (2, 2?, 2?), which is adjustable by a control unit, as well as method to estimate the position of a narrowband RF transceiver (1) using a multitude of coherent wideband RF receivers (12) and computer-readable medium comprising computer-executable instructions causing an electronic device to perform the method.

Abstract: A method for identifying the switch topology of multiple energy storage module connected in parallel and/or in series, which respectively have at least one energy storage element, each module has a switch element for selectively activating and deactivating the module and a unique identifier, wherein each module is assigned to a module string in that a total current flowing across the switch topology is checked, and individual modules are activated successively via the switch element until the total current is detectable.

Abstract: An arrangement for determining an energy spectrum of a beam of radiation or particles is disclosed. The arrangement comprises a plurality of polymeric bodies. Each of the plurality of polymeric bodies includes an optical waveguide. Each of the plurality of polymeric bodies has a scintillator disposed at a respective end of the optical waveguide. The scintillators are arranged relative to each other such that an energy resolution of a particle beam incident on the arrangement can be determined. Furthermore, a particle detector with the arrangement and an evaluation unit for reading out the particle detector are disclosed.

Abstract: A method for in-ova fertilisation determination and gender determination on a closed egg. The aim is to specify a method for the in-ovo fertilisation determination and gender determination on a closed egg. This aim is achieved by a method in which a closed egg is positioned, candled and/or illuminated, next an image of the closed egg is recorded, then the captured data are evaluated and the position of the cardiovascular system located in the egg is calculated. A detection unit is adjusted via the calculated position of the cardiovascular system by means of a positioning unit and subsequently the blood is stimulated, then the blood-specific and blood-foreign absorption spectra are detected and selected, the fertilisation is ascertained and then the spectra containing blood-foreign information are compensated by a compensation method and the spectra are classified for sex determination.

Abstract: Communication systems and methods in accordance with various embodiments of the invention utilize modulation on zeros. Carrier frequency offsets (CFO) can result in an unknown rotation of all zeros of a received signal's z-transform. Therefore, a binary MOCZ scheme (BMOCZ) can be utilized in which the modulated binary data is encoded using a cycling register code (e.g. CPC or ACPC), enabling receivers to determine cyclic shifts in the BMOCZ symbol resulting from a CFO. Receivers in accordance with several embodiments of the invention include decoders capable of decoding information bits from received discrete-time baseband signals by: estimating a timing offset for the received signal; determining a plurality of zeros of a z-transform of the received symbol; identifying zeros from the plurality of zeros that encode received bits by correcting fractional rotations resulting from the CFO; and decoding information bits based upon the received bits using a cycling register code.

Abstract: A method for influencing an auditory direction perception of a listener, and to an arrangement for it the method is disclosed, to provide a solution, by means of which the improvement of the suppression of the auditory localization of a direction of one or more real sources S1 of a sound projecting audio playback system is achieved in that a localization-masking additionally generated sound entity is provided and is radiated by the real source S1 with a directional effect in a defined direction.

Abstract: A method for rendering material surfaces inert is provided. Exemplary surfaces include ceramic, metal or plastic surfaces. The method is accomplished with functionalized perfluorinated compounds for the formation of hyperhydrophobic structures on the surfaces to create inert surfaces. The inert surfaces produced or can be produced in this way have an extremely low surface energy, are resistant to deposits of substances or cells and have a very low coefficient of friction. Practical uses of the inert surfaces are also provided.

Abstract: A molecular machine comprising a movement part (2) including a first molecular element (4), a second molecular element (5), and a linking element (6) for constraining a relative movement of the first molecular element (4) and the second molecular element (5), and a control part configured to generate an electrical field around the movement part (2), wherein the first molecular element (4) is fixed relative to the control part, wherein the second molecular element (5) is movable relative to the first molecular element (4) in at least one degree of freedom, and wherein the second molecular element (5) is electrically charged such that the second molecular element (5) aligns to said electrical field.

Abstract: The invention relates to a method for detecting a measured value (d?/dx, M).

Abstract: Disclosed is a mussel adhesive protein including at least one photocaged 3,4-dihydroxyphenylalanine derivative residue including a protecting group on at least one hydroxyl residue of its catechol moiety. The photocaged 3,4-dihydroxyphenylalanine derivative residue replaces a naturally occurring amino acid and the protecting group can be cleaved from the 3,4-dihydroxyphenylalanine derivative residue by irradiation with UV light.

Abstract: The invention relates to a method for manufacturing an elastic and flexible fiber with a pre-de-termined non-circular cross-sectional geometry, the method comprising extrusion of an elasto-mer from a nozzle onto a substrate, wherein the pre-determined non-circular cross-sectional geometry of the fiber is determined by the height and velocity of the nozzle relative to the sub-strate. The invention relates to an elastic and flexible fiber produced using the method, wherein the fiber comprises an elongated indentation along a length of the fiber (groove). The invention relates to methods for producing preferably biocompatible microfluidic, electrically conducting or light-guiding fibers using the methods of the invention. The invention further re-lates to elastic and flexible fibers produced by the method.

Abstract: Disclosed are compounds represented by the following general formula (I): Cyclo-(Arg-Gly-Asp-X1-X2-X3-X4-X5) (I) wherein the variables groups X1 to X5 have the following meanings X1: Leu, Ile, Nle, Val, Tyr, Phe; X2: D-amino acid such as D-Pro, N-Me-D-Phe; X3: Pro, N-Me-amino acid such as N-Me-Lys, N-Me-Lys(Ac); Pro-Rx3, N-Me-Lys-Rx4; X4: Gly, Ala, Ser, Thr; X5: Leu, Ala, Tyr, His, Ile, Nle, Val, Phe wherein Pro-Rx3 represents a proline residue that carries at the C-3, C-4 or C-5 carbon atom and preferably the C-4 carbon atom a functional group selected from —NH2, —OH, —NH—Ac, —NH-hexyne, and wherein Lys-Rx4 represents a lysine residue, wherein the ?-amino nitrogen atom carries a group of the formula -L4-R4, wherein L4 is selected from the group consisting of covalent bond, —C(O)—, and —C(O)—O—, . . .

Abstract: A method for automatic detection of a functional primitive in a model of a hardware system, the model being a netlist having cells and net links therebetween, comprising the steps: a) mapping the cells to target nodes, each of which having a target node type, and the net links to edges of a target graph, and mapping the functional primitive to a search pattern having search nodes and connections therebetween; b) selecting candidates from those target nodes the target node types of which match a search node type, and selecting a candidate structure from those selected candidates the target nodes and edges of which match the search nodes and connections of the search pattern; c) reverse-mapping the target nodes and edges of the selected candidate structure to the cells and net links of the netlist; and d) outputting said cells and net links as detected functional primitive.

Abstract: The operation of a hybrid powertrain system is optimized with respect to a desired state-of-charge trajectory, taking account of the estimated anticipated vehicle drive power. The hybrid powertrain system has an internal combustion engine and an electrically operated torque machine. The internal combustion engine and the torque machine are controlled by a control device and are connected to an output element via a hybrid transmission. Before the start of the prediction period ?t, an experience-based state-of-charge trajectory for the anticipated route, covering at least the prediction period ?t, is retrieved from an external database. The desired state-of-charge trajectory is established based on the experience-based state-of-charge trajectory by modifying it with at least one optimization constraint.