Abstract: The present invention provides the modular design and assembly of novel targeting bio-conjugates, exclusively assembled by means of biotin-biotin binding element conjugation, comprising mono-biotinylated cell binding component, a tetrameric biotin-binding element, and mono-biotinylated payload for therapeutic and diagnostic purposes. In addition, there is provided a method of delivering the payload, such as therapeutic oligonucleotides, via mono-biotinylated targeting devices, such as antibodies or ligands, into eukaryotic cells by means of receptor-mediated endocytosis. The targeting bio-conjugates are suitable for use in the areas of medicine, pharmacy and biomedical research.

Abstract: A washing or cleaning agent that has MOFs (metal organic frameworks) in order to reduce offensive odor, a method for reducing malodors, and the use of MOFs to reduce malodors.

Abstract: A method and a fibre-optical system for illuminating and detecting an object by light includes in situ calibration of a fibre bundle and disturbance-corrected illumination or disturbance-corrected detection of an object, in particular for endoscopic and microscopic applications, and makes it possible to directly determine the single phase distortion of the light, caused by the transmission by the fibre bundle, in order to calibrate the fibre bundle, and thus provides a possibility for determining the system function of a fibre bundle that is improved compared with the prior art of measuring the double phase distortion. The system function is used for disturbance correction when illuminating or detecting the object.

Abstract: A reconfigurable field effect transistor (RFET) includes a nanowire, wherein the nanowire comprises two Schottky contacts, as well as two gate contacts partially enclosing the nanowire in cross section. An integrated circuit can be produced therefrom. The aim of producing CMOS circuits with enhanced functionality and a more compact design is achieved in that the nanowire is divided along the cross section thereof into two nanowire parts, wherein each nanowire part comprises a respective Schottky contact and a respective gate contact, and the two nanowire parts are connected electrically to one another via a common substrate and stand vertically on the substrate. In a nanowire-parts-array, between the nanowire parts, a respective top-gate contact and/or back-gate contact can be formed in a substrate defining a substrate plane.

Abstract: The present invention relates to a method and a device for monitoring the process for a welding seam formed by means of collision welding, in which a first joining partner (1) and a second joining partner (2) are moved toward one another by an introduction of energy and are welded to one another to form the welding seam. A light flash between the first joining partner (1) and the second joining partner (2) is detected during the welding by an optical capture unit (6), which measures in a time-resolved manner, having at least one detector (19, 20, 24) and an actual value of a beginning of the light flash, a duration of the light flash, an intensity of the light flash, and/or an intensity distribution over time of the light flash is determined by an analysis unit (16) and compared to a respective target value of the beginning of the light flash, the duration of the light flash, the intensity of the light flash, and/or the intensity distribution over time of the light flash.

Abstract: The invention relates to a device for isolating stem cells from fetal tissues, which device has an incubation chamber, at least one pump, at least one reservoir for a tissue break-down solution, at least one reservoir for a rinsing solution, optionally a control unit, optionally a means for removing contaminants, and optionally a means for expansion of the isolated stem cells. The invention further relates to a method for isolating stem cells from fetal tissue, which method comprises, among other things, the mechanical dissociation and the enzymatic digestion of the fetal tissue and optionally density gradient centrifugation for removing contaminants. The device and the method according to the invention are particularly suitable for isolating mesenchymal stem cells from fetal tissues, such as umbilical cord tissue, placenta tissue, or fetal lung tissue.

Abstract: Method for managing available communication resources in a communication network and node (100, 200) for a communication network The invention concerns a method for managing signaling duties in a communication network and a node for a communication network, the node comprising a resource management. The method comprises using at least one signaling duty concerning a requested service for allocating corresponding communication resource of one of the nodes (200), the signaling duty being assigned to a different, further node (100) and the one node (200) being capable for at least partly providing the service. The method further comprises using the one node and the further node for determining a compensation and providing the compensation to said one node.

Abstract: The invention relates to the use of a protein with recombinase activity to catalyze a site-specific DNA recombination and a method for producing a site-specific DNA recombination. The invention is applicable alone or in combination with other recombinase systems for genetic manipulation, for example in medical research. The objective of the invention is solved by the use of a protein with recombinase activity to catalyze a site-specific DNA recombination at, preferably at two, recognition sites that are identical or reverse complementary to each other. The invention also includes a method for producing a site-specific DNA recombination comprising the steps of a) providing a cell comprising at least two recognition sites that are identical or reverse complementary to each other; and b) contacting a protein with recombinase activity with the recognition sites, thereby producing the site-specific DNA-recombination.

Abstract: A solution for synchronizing a network comprising a plurality of interconnected nodes provides a stable synchronized state, especially for large scale networks. Signal transmission speed and the length of each interconnection of the network is configured to cause a delay of the signals received by a node from the other node of the interconnection which is larger than one millionth of the free-running period of the controllable oscillator of the receiving node such that Network-wide synchronization of oscillators is achieved for all nodes of the network in a continuous self-organized process in interaction with the other node of the network.

Abstract: A device for adjusting and determining the blood flow plateau at a patient's limb, wherein the device includes an chamber the wall of which surrounds an inner space, and at least one opening for inserting at least a part of the limb into the inner space as well as at least one recess, that allows access to the part of the limb that is located inside the inner space, are formed in the chamber, and wherein the device includes at least one heating element that is in thermal contact with the inner space. In this context, it is provided that the device further includes an apparatus for determining the blood flow plateau at the part of the limb that is located inside the inner space.

Abstract: The invention relates to a method and means for diagnosing tumors, in particular for an early diagnosis (prevention) and for differentiating between benign and malignant tumors using a PCR, in particular in bodily fluids. The method according to the invention is characterized by a combination of a pre-amplification process using a PCR, wherein methylated DNA sequences are amplified more strongly than non-methylated DNA sequences, and a subsequent quantification process using a special digital PCR, in which significantly more DNA is used than normally in the prior art. As comparison data indicates, the invention advantageously allows a clear reliable conclusion as to whether a malignant tumor disease is present or not. The invention is suitable for screening (prevention), monitoring the progress of a tumor disease, in particular to order to exclude a minimal residual disease (MRD), and for a differential diagnosis between malignant carcinoma and benign tumors.

Abstract: The present invention relates to a method for preparing an expression vector encoding a well-tolerated and highly specific tailored recombinase, which tailored recombinase is capable of recombining asymmetric target sequences within the long terminal repeat (LTR) of proviral DNA of a plurality of retrovirus strains which may be inserted into the genome of a host cell, as well as to the obtained expression vector, cells transfected with these, expressed recombinase and pharmaceutical compositions comprising the expression vector, cells and/or recombinase. Pharmaceutical compositions are useful, e.g., in treatment and/or prevention of retrovirus infection, in particular, HIV infection. In particular, the invention relates to well-tolerated and highly specific tailored recombinases capable of combining asymmetric target sequences in a more than 90% of HIV-strains, thereby excising the HIV-1 sequences, and expression vectors encoding them.

Abstract: Apparatus for spectrometrically capturing light includes a wavelength-adjustable filter for converting spectral information into location information and an organic photodiode for converting the location information into electrical signals which can be forwarded, wherein the filter and the organic photodiode form a one-piece monolith, the organic photodiode is connected to the filter or the organic photodiode is integrated in the filter, the filter consists of at least one spectrally resolving element in the form of at least one layer-like photonic crystal which constitutes the monolith and in which two layers of variable thickness D are formed along a direction perpendicular to the incidence of light. A resonant layer is arranged between the two layers. The organic photodiode includes: a photoactive layer, a first electrode, and a second electrode sandwiching the photoactive layer, and one of the electrodes is in contact with the photonic crystal.

Abstract: The present invention relates to a new fusion gene, KIAA0368-ROBO2, and the use thereof in methods for diagnosing cancer, in particular a glioblastoma in a subject, wherein the presence and/or expression of said fusion gene in a sample derived from said subject is determined, and wherein the presence or expression of said fusion gene is attributed to the presence of a glioblastoma in said patient. Also methods for the identification of compounds useful in the medical intervention of glioma, in particular glioblastoma, are provided. Accordingly, the present invention also relates to diagnostic means as well as to the medical intervention in cancer, like glioma and in particular glioblastoma. The invention further relates to the use of the fusion gene for diagnosing and/monitoring of tumor progression, preferably of the progression of brain tumors, as well as for the subclassification of brain tumors and other proliferative diseases.

Abstract: A direction-selective interferometric optical filter for spectrometric devices, at least includes an arrangement of two layered one-dimensional photonic structures. Each of the two structures contains a defect layer, and each photonic structure has a dispersion function in the energy momentum space (E, kx, ky), wherein kx and ky are momentum components of transmitted photons of the photonic structures for a defined energy (frequency/wavelength) E in the energy momentum space. Both photonic structures have opposite interfaces which are at a plane-parallel distance from one another. In this case, the dispersion functions of both photonic structures cross or intersect in the energy momentum space and produce a cut set of rays of waves on the surfaces of the dispersion functions at a particular energy, wherein a ray of waves contains waves selectively chosen through the filter at an angle, while other waves are reflected by the filter at other angles.

Abstract: A method for detecting infrared electromagnetic radiation and for converting same into an electrical signal, an optoelectronic component, in particular an organic infrared detector for (near) infrared detection, and use thereof for detecting an electromagnetic signal in the wavelength range of 780 nm to 10 ?m, are provided.

Abstract: An optical filter element for devices for converting spectral information into location information, uses a connected detector for detecting signals. The element has at least two microresonators, each comprising at least two superposed reflective layer structures of a material layer having a high refractive index and a material layer having a low refractive index in an alternating sequence, and at least one superposed resonance layer arranged between the two superposed reflective layer structures. The filter element comprises at least one transparent plane-parallel substrate for optically decoupling the two microresonators; the first microresonator being located on a first of two opposing surfaces of said substrate, and the second microresonator being located on said substrate on a second surface thereof that lies opposite the first surface.

Abstract: The invention relates to methods for coating a substrate with at least one monolayer of self-assembling proteins, using stabilized aqueous solutions with self-assembling proteins, and also to substrates obtainable as a result. Methods for stabilizing solutions with self-assembling proteins, and the stabilized solutions obtainable therefrom, are likewise provided by the invention. According to the coating method, at least one monolayer of a self-assembling protein is produced on a substrate by first providing a stabilized aqueous solution which comprises at least one self-assembling protein.

Abstract: The invention relates to methods for producing hydrophobized, doped or non-doped mixed metal oxide nanoparticles or doped metal oxide nanoparticles by flame spray pyrolysis, wherein a combustible precursor solution A, containing at least two metal alkyloates of general formula Me(OOC—R)x with differing metals Me, or a combustible precursor solution B containing at least one metal alkyloate of general formula Me(OOC—R)x and at least one metal salt containing a metal ion Me and at least one metal salt containing a metal ion Me, with Me selected from metal ions of the subgroups of the periodic system of the elements, with R=alkyl or aryl, wherein the alkyl chain is branched or straight, and wherein x corresponds to the oxidation step of the metal ion, is used in stoichiometric excess relative to a quantity of oxygen, and wherein a combustion ratio c of 3.5 bis 0.4 is established, and hydrophobized nanoparticles and the use thereof.

Abstract: The invention relates to a system and a method for haptic interaction with virtual objects. The system of the invention is based on the idea that, for the haptic representation of any virtual three-dimensional object—synchronized with the visual representation—only the tangible haptic characteristics of the surface area of the object at the collision point or the area of contact are important. The haptic display system (morphling) of the invention that displays these characteristics comprises in principle three functional groups, which operate in synchronism with one another and with a visual subsystem. The individual subsystems can be operated statically or dynamically. In dynamic operation, users can change the position and/or shape, for example, of the tactile display by touching it. With regard to the real-time representation of the three-dimensional data of the user, at least the body part that is interacting with the object, e.g.