Abstract: Disclosed are compound exhibiting highly active and selective binding to ?v?6 integrin, which are represented by the following general formula (I): Cyclo-(Arg-X1-Asp-X2-X3-X4-X5-X6-X7) (I) wherein the variables groups X to X have the following meanings X1: Ser, Gly, Thr, X2: Leu, lie, Nle, Val, Phe, X3: Gly, Ala, X4: Leu, He, Nle, Val, Phe, Lys, Tyr, Trp, Arg, X5: D-Pro, N-Me-D-lipophilic amino acids, X6: Pro, N-Me-amino acids, N-Me-Lys, N-Me-Lys(Ac), and X7; Ala, Leu, He, Nle, Val, Phe, Tyr, Trp or wherein the sub-sequence -X5-X6- represents a ?-turn mimetic differing from the meanings above, or pharmaceutically acceptable salts, esters, solvates, polymorphs or modified forms thereof represented by the following general formula (II): (X0)n1L(X8)n2 wherein Xo represents the compound of the general formula (I) as specified above (excluding one hydrogen atom to allow bonding to the linker), L represents a linker, X8 represents the effector moiety and wherein n1 and n2 are each independently selected from the ra

Abstract: A solvothermal synthesis process for polyimides is provided. The process uses solution polymerization of monomers in an appropriate solvent, by mixing the solvent and the monomers and heating the mixture under pressure at temperatures exceeding the respective boiling point at normal pressure. The process produces essentially completely crystalline polyimides by a) mixing and heating the solvent and the monomers by either (i) heating the solvent up to solvothermal conditions and subsequently adding the monomers to initiate the reaction, or (ii) mixing the monomers with the solvent and heating the mixture up to solvothermal conditions within a period of 5 min, the reaction temperature TR being held below the solid-state polymerization temperature TP of the monomers during the polymerization; and b) carrying out the solution polymerization until essentially complete conversion is achieved.

Abstract: A method (C) for converting a data signal (U), comprising (i) providing an input symbol stream (B) representative of the data signal (U), (ii) demultiplexing (DMX) the input symbol stream (B) to consecutively decompose the input symbol stream (B) into a number m of decomposed partial symbol streams (B_1, . . . , B_m), (iii) applying on each of the decomposed partial symbol streams (B_1, . . . , B_m) an assigned distribution matching process (DM_1, . . . , DM_m), thereby generating and outputting for each decomposed partial symbol stream (B_1, . . . , B_m) a respective pre-sequence (bn_1, . . . , bn_m) or n_j symbols as an intermediate output symbol sequence, and (iv) supplying the pre-sequences (bn_1, . . . , bn_m) to at least one symbol mapping process (BM) to generate and output a signal representative for a final output symbol sequence (S) as a converted data signal. Each of the distribution matching processes (DM_1, . . .

Abstract: An apparatus and a method for analysing a solid specimen material by means of ablating particles of the solid specimen material by laser into a carrier liquid, having: a specimen holder for arranging the solid specimen material covered by the carrier liquid, a laser apparatus for irradiating the solid specimen material to produce a suspension of particles of the solid specimen material and the carrier liquid, an analysis apparatus for analysing the particles, an ablation cell with the specimen holder, having a liquid channel for the carrier liquid and having an entry window made of a material that transmits the laser beam, a supply line for supplying the carrier liquid into the liquid channel of the ablation cell and a discharge line for discharging the suspension of particles of the solid specimen material and the carrier liquid from the liquid channel of the ablation cell into the analysis apparatus.

Abstract: The invention relates to a method for producing a reference frequency ?f. According to the invention, the use of a first optical resonator (3a; 24) and of a second optical resonator (25) is provided, wherein the first resonator (3a; 24) has a first resonator mode having a first frequency f1 and the second resonator (25) has a second resonator mode having a second frequency f2, wherein the frequencies of the two resonator modes are functions of an operating parameter BP and assume the values f1 and f2 at a specified value BP0 of the operating parameter such that f1(BP0)=f1 and f2(BP0)=f2 apply, wherein the resonators (3a; 24, 25) are designed in such a way that the respective first derivatives of the frequencies f1(BP), f2(BP) with respect to BP or at least respective difference quotients around BP0 correspond within a deviation of at most ±0.

Abstract: The present invention relates to polypeptides for use in treating diseases or disorders of energy homeostasis such as obesity, dyslipidemia, diabetes, insulin resistance, hyperglycemia or the metabolic syndrome. The invention also relates to polynucleotides encoding said polypeptides for use in treating diseases or disorders of energy homeostasis. Also provided by the present invention are pharmaceutical compositions comprising said polypeptides and polynucleotides for use in treating diseases or disorders of energy homeostasis. Said polypeptides, polynucleotides and pharmaceutical compositions may be administered locally, in particular locally into the visceral adipose tissue. Another aspect of the invention relates to a cosmetic product and the use of said cosmetic product for reducing body weight, in particular for reducing abdominal adipose tissue.

Abstract: The present invention relates to a method of determining a distance or location of a remote device or reflector, the method comprising: receiving a signal from a remote signal transmitter associated with or contained in or attached to the remote device; estimating a first propagation delay associated with the received signal, wherein the first propagation delay represents a first candidate for a correct propagation delay; deriving a relationship between the first candidate and one or more other candidates for a correct propagation delay from the received signal; determining a plurality of other candidates for a correct propagation delay based on said relationship; generating a likelihood histogram based on said candidates for a correct propagation delay; selecting a propagation delay from said candidates based on the likelihood histogram; and determining a distance or location of the remote device or reflector using the selected propagation delay.

Abstract: The present invention provides means and methods for selectively detecting activated MALT1 in a sample. Moreover, the present invention provides a method for diagnosing diseases, which are characterized by an increased MALT1 activity. Finally, the present invention provides methods for identifying patients which are amenable to treatment with a therapeutic agent capable of inhibiting MALT1 activity.

Abstract: The invention relates to a method for the preparation of modified cellulose fibers for artificial clarification of active haze substances from liquids. In addition, the invention relates to a modified cellulose fiber obtained by the method according to the invention for artificial clarification of active haze substances from a liquid, and to auxiliary filtering means containing one or more of the modified cellulose fibers.

Abstract: The disclosure relates to a manually operable tactile input/output device for a data processing system, in particular a tactile computer mouse, which is configured with a housing and a plurality of actuators in operative connection with the housing and in which the actuators are arranged and jointly controlled in the housing to cause at least temporarily a tactile perception by a user in manual contact with the housing, by which simultaneously at least two and in particular all five tactile perception dimensions of microscopic roughness, macroscopic roughness, friction, hardness and heat are simulated. Furthermore, the disclosure relates to an operating method for a manually operable tactile input/output device and a data processing system.

Abstract: Computer implemented method for rendering an image of a three-dimensional scene on an image plane by encoding at least a luminosity in the image plane by a luminosity function. The value of the luminosity can be computed at substantially each point of the image plane by using a set of stored input data describing the scene. The method includes constructing the luminosity function as equivalent to a first linear combination involving the functions of a first set of functions, and computing at least the value of the coefficients of the first linear combination, by solving a first linear system, obtained by using at least the functions of the first linear combination, at least a subset of the first subset of the image plane, and the luminosity at the points of said subset. The method further includes storing the value of the coefficients of the first linear combination and at least the information needed to associate each coefficient to the function multiplying said coefficient in the first linear combination.

Abstract: A photoconducting layered material arrangement for producing or detecting high frequency radiation includes a semiconductor material including an alloy comprised of InGaAs, InGaAsSb, or GaSb, with an admixture of Al, which material is applied to a suitable support substrate in a manner such that the lattices are suitably adjusted, wherewith the semiconductor material comprised of InGaAlAs, InGaAlAsSb, or GaAlSb has a band gap of more than 1 eV, as a consequence of the admixed proportion of Al. The proportion x of Al in the semiconductor material InyGa1-y-xAlxAs is between x=0.2 and x=0.35, wherewith the proportion y of in may be between 0.5 and 0.55. The support substrate is InP or GaAs.

Abstract: A washing or cleaning agent that has MOFs (metal organic frameworks) in order to reduce offensive odor, a method for reducing malodors, and the use of MOFs to reduce malodors.

Abstract: The present disclosure refers to a rotor (1) comprising a rotor blade (3), a hub (2), on which the rotor blade (3) is held by means of a bearing, and an adjustment device (7, 8, 10), in which a coupling component (7) arranged at the foot (5) of the rotor blade (3) is mounted in a guide (10) arranged on an adjustment component (8), such that by means of a displacement of the adjustment component (8) axially with respect to the axis of rotation (11) of the rotor of the hub (2) a pitch angle of the rotor blade can be altered, wherein the guide (10) runs at an inclination to the axis of rotation (11) of the rotor, at least during the axial displacement of the adjustment component (8). Also disclosed is a method for adjusting a pitch angle of a rotor blade.

Abstract: The present invention relates to a prostate-specific membrane antigen (PSMA)-specific binding protein, wherein the PSMA-specific binding protein is a lipocalin 2 (Lcn2)-derived binding protein and binds to PSMA with a KD of 10 nM or lower. The present invention also relates to a nucleic acid molecule encoding the PSMA-specific binding protein of the invention, a vector comprising said nucleic acid molecule of the invention and a host cell transformed with the vector. Furthermore, the invention relates to a method of producing the PSMA-specific binding protein of the invention, the method comprising culturing the host cell of the invention under suitable conditions and isolating the PSMA-specific binding protein produced. The present invention further relates to a protein conjugate comprising the PSMA-specific binding protein of the invention, or the PSMA-specific binding protein produced by the method of the invention.

Abstract: The present disclosure presents a visuo-haptic sensor, which is based on a passive, deformable element whose deformation is observed by a camera. In particular, the improved simplified sensor may determine the force and/or torque applied to a point of the sensor in multiple spatial dimensions.

Abstract: An electrode for an electrochemical element with an organic electrolyte includes a polymeric material containing or composed of subunits according to general formulae (I) and/or (II): wherein n is an integer ?2, Y represents an amide group (—NH—CO— or —CO—NH—), an ester group (—O—CO— or —CO—O—) or a urethane group (—NH—CO—O— or —O—CO—NH—), R1, R2, R3 and R4 each independently represent H, alkyl (preferably —CH3, —C2H5), Alkoxy-(preferably —OCH3, —OC2H5), -halogen or —CN, Ar1 and Ar4 independently represent a bridging aryl group, Ar2 and Ar3 independently represent a non-bridging aryl group, and R5 is a bridging alkyl, alkene or aryl group, wherein Ar1 and Ar4 in structures (I) and (II) independently represent a bridging aryl group.

Abstract: The present invention relates to a novel method for the treatment and/or prophylaxis of a tau-mediated neurodegenerative disease and/or of a tau-mediated neurodegenerative pathological condition, especially of a neurodegenerative disease and/or of a neurodegenerative pathological condition associated with and/or accompanied by tau aggregation, and in particular for the treatment and/or prophylaxis of a tauopathy; compounds and/or agents and compositions for such treatment and/or prophylaxis, and the manufacture of the compounds and/or agents and compositions suitable for the said treatment and/or prophylaxis. In this regard, the present invention relates especially to the use of compounds acting as PERK activator, a prodrug thereof, a derivative thereof and/or a pharmaceutically acceptable salt of any thereof, as a medicament.

Abstract: Systems and methods for transmitting data using various Modulation on Zeros schemes are described. In many embodiments, a communication system is utilized that includes a transmitter having a modulator that modulates a plurality of information bits to encode the bits in the zeros of the z-transform of a discrete-time baseband signal. In addition, the communication system includes a receiver having a decoder configured to decode a plurality of bits of information from the samples of a received signal by: determining a plurality of zeros of a z-transform of a received discrete-time baseband signal based upon samples from a received continuous-time signal, identifying zeros that encode the plurality of information bits, and outputting a plurality of decoded information bits based upon the identified zeros.

Abstract: A reconfigurable field effect transistor (RFET) includes a nanowire, wherein the nanowire comprises two Schottky contacts, as well as two gate contacts partially enclosing the nanowire in cross section. An integrated circuit can be produced therefrom. The aim of producing CMOS circuits with enhanced functionality and a more compact design is achieved in that the nanowire is divided along the cross section thereof into two nanowire parts, wherein each nanowire part comprises a respective Schottky contact and a respective gate contact, and the two nanowire parts are connected electrically to one another via a common substrate and stand vertically on the substrate. In a nanowire-parts-array, between the nanowire parts, a respective top-gate contact and/or back-gate contact can be formed in a substrate defining a substrate plane.