Patents Assigned to Technische Universitat Muenchen
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Patent number: 11557327Abstract: The invention relates to a method for operating a memory assembly. A physical address is received. The physical address is associated with a first memory segment of a memory assembly. The physical address is modified to a modified physical address. The modified physical address is associated with a second memory segment of the memory assembly.Type: GrantFiled: October 1, 2019Date of Patent: January 17, 2023Assignee: TECHNISCHE UNIVERSITÄT MÜNCHENInventors: Alexandra Listl, Daniel Mueller-Gritschneder
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Patent number: 11513282Abstract: A sensor (10) comprises a waveguide (20) having a longitudinal axis and an end face (21), the waveguide (20) comprising a Bragg grating (23). The sensor comprises at least one reflector (24) on the end face (21) of the waveguide (20). An optical resonator (25) is formed by the Bragg grating (23), the at least one reflector (24), and an inner portion of the optical resonator (25) between the Bragg grating (23) and the at least one reflector (24). The inner portion of the optical resonator (25) extends within a portion of the waveguide (20). The sensor (10) comprises a detector (32) configured to detect at least one spectral characteristic of the optical resonator (25) or a change of at least one spectral characteristic of the optical resonator (25).Type: GrantFiled: March 8, 2019Date of Patent: November 29, 2022Assignee: TECHNISCHE UNIVERSITÄT MÜNCHENInventors: Rami Shnaiderman, Georg Michael Wissmeyer, Vasilis Ntziachristos
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Patent number: 11498943Abstract: The present invention relates to peptides, in particular amyloid inhibitory peptides, and to pharmaceutical compositions comprising such peptides. Furthermore, the present invention relates to such peptides, in particular such amyloid inhibitory peptides, for use in methods of treating or diagnosing neurodegenerative diseases such as Alzheimer's disease, or for use in a method of treating or diagnosing type 2 diabetes. Furthermore, the present invention also relates to a kit for the in-vitro or in-vivo detection and, optionally, quantification of amyloidogenic polypeptides, amyloid fibrils or amyloid aggregates, and/or for the diagnosis of Alzheimer's disease or type 2 diabetes in a patient.Type: GrantFiled: June 6, 2019Date of Patent: November 15, 2022Assignee: TECHNISCHE UNIVERSITÄT MÜNCHENInventors: Aphrodite Kapurniotu, Anna Spanopoulou, Luzia Heidrich, Jürgen Bernhagen
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Patent number: 11497819Abstract: The present invention relates to compounds which bind and/or inhibit prostate-specific membrane antigen (PSMA) comprising at least one group electron dense substituent (EDS), and at least one moiety which is amenable to radiolabeling; and therapeutic and diagnostic uses thereof.Type: GrantFiled: December 11, 2018Date of Patent: November 15, 2022Assignee: Technische Universität MünchenInventors: Hans-Jurgen Wester, Alexander Schmidt, Mara Parzinger
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Patent number: 11471532Abstract: The present invention relates to inhibitors of the interaction between H. pylori IIopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.Type: GrantFiled: July 20, 2017Date of Patent: October 18, 2022Assignees: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG, DER WISSENSCHAFT EN E.V., TECHNISCHE UNIVERSITÄT MÜNCHENInventors: Anahita Javaheri, Tobias Kruse, Markus Gerhard, Bernhard B. Singer, Daniel Hornburg, Han Remaut, Matthias Mann, Felix Meissner, Steffen Backert
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Patent number: 11459423Abstract: A process for polymerizing ?-butyrolactone that includes contacting racemic ?-butyrolactone or an enantiomer thereof with a catalyst/initiator system which includes a rare earth metal, a chiral ligand, at least one nucleophilic ligand, optionally at least one solvent ligand, and optionally an alkali based co-catalyst. The chiral ligand is an enantiomer of a unit of formula I Each Rz independently is substituted or unsubstituted linear C1-C20 alkyl, or substituted or unsubstituted branched, or cyclic C3-C20 alkyl, substituted or unsubstituted C6-C20 aryl, substituted or unsubstituted C5-C20 heteroaryl, or halogen. Each Ra independently is H, Me+, (MeZ)+, wherein Z is a charge equalizing anion, or wherein two Ra together are alkaline earth metal, wherein Me+ is alkali metal or alkaline earth metal.Type: GrantFiled: November 21, 2018Date of Patent: October 4, 2022Assignee: Technische Universität MünchenInventors: Friederike Adams, Bernhard Rieger
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Patent number: 11447801Abstract: The present invention relates to an enzymatic process for the modification of free fatty acids (FFAs) derived from renewable feedstocks of bio-based oils. Specifically, the invention describes the hydrolysis of any bio-based oil, such as high oleic sunflower oil (HOSO), to FFAs, containing high amounts of oleic acid (OA), which is further hydrated to 10-hydroxystearic acid (10-HSA).Type: GrantFiled: September 27, 2018Date of Patent: September 20, 2022Assignee: TECHNISCHE UNIVERSITÄT MÜNCHENInventors: Thomas Brück, Jan Lorenzen
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Patent number: 11437736Abstract: An antenna comprises a ground plane, a first antenna element and a second antenna element, wherein the first antenna element and the second antenna element are arranged for emitting and/or receiving electromagnetic radiation at a design wavelength with a first polarization direction and a second polarization direction, respectively, the second polarization direction being different from the first polarization direction, wherein the first and second antenna elements each comprise pairs of resonator elements having sidewalls facing a corresponding probe arranged in each pair of resonator elements, wherein one resonator element of each pair of resonator elements is shared between the first and second antenna elements and the respective probes of the first and second antenna elements are arranged on different sides of the shared resonator element.Type: GrantFiled: July 30, 2019Date of Patent: September 6, 2022Assignee: TECHNISCHE UNIVERSITÄT MÜNCHENInventor: Zafer Toprak
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Patent number: 11422032Abstract: Disclosed herein is a device (100) for multicolor optical imaging of a sample (102) with wavelength-dependent optical path length enhancement, the device (100) comprising an optical resonator (106) for enhancing an optical path length, wherein the optical resonator (106) has a first finesse at a first wavelength and a second finesse at a second wavelength; a sample holder (104) for mounting the sample (102) in the optical resonator (106), wherein the sample holder (104) is configured to hold the sample (102) such that an optical axis (112) of the optical resonator (106) intersects with the sample (102);a first imaging system (114) for imaging the sample (102) at the first wavelength with a first imaging technique, and a second imaging system (126) for imaging the sample (102) at the second wavelength with a second imaging technique, wherein the second wavelength is different from the first wavelength; wherein the first finesse and the second finesse are chosen such that the optical resonator (106) enhances aType: GrantFiled: October 25, 2019Date of Patent: August 23, 2022Assignee: Technische Universität MünchenInventors: Hristo Iglev, Oliver Hayden, Reinhard Kienberger, Markus Wurzer, Albert Schletter, Johann Riemensberger
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Patent number: 11420909Abstract: According to the present invention there is provided a method for enantiomeric enrichment of a mixture of two enantiomers of a chiral compound, the method comprises the application of the mixture of two enantiomers of a chiral compound onto a surface of a support material for producing a coated support, the determination a first value of an optical activity (OA0) of the coated support, the irradiation of the coated support with a light beam having an intensity at least higher than a desorption threshold of one of the enantiomers from the coated support, wherein, if the support material is achiral, the light beam is circularly polarized and, if the support material is chiral, the light beam is unpolarized, linearly polarized or circularly polarized, and the determination of a second value of the optical activity (OAe) of the coated support after said irradiation, wherein the second value of the optical activity (OAe) differs from the first value of the optical activity (OA0).Type: GrantFiled: July 17, 2019Date of Patent: August 23, 2022Assignee: TECHNISCHE UNIVERSITÄT MÜNCHENInventors: Aras Kartouzian, Ulrich Heiz, Farinaz Mortaheb, Katrin Oberhofer, Johann Riemensberger, Hristo Iglev, Reinhard Kienberger
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Patent number: 11413360Abstract: The present invention relates to a ligand-SIFA-chelator conjugate, comprising, within in a single molecule three separate moieties: (a) one or more ligands which are capable of binding to a disease-relevant target molecule, (b) a silicon-fluoride acceptor (SIFA) moiety which comprises a covalent bond between a silicon atom and a fluorine atom, and (c) one or more chelating groups, optionally containing a chelated nonradioactive or radioactive cation.Type: GrantFiled: July 30, 2018Date of Patent: August 16, 2022Assignees: Technische Universität München, Technische Universität München—Klinikum Rechts der IsarInventors: Alexander Josef Wurzer, Hans-Jürgen Wester, Matthias Johannes Eiber
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Patent number: 11401305Abstract: The present invention relates to a nucleic acid molecule comprising a low repetitive nucleotide sequence encoding a proline/alanine-rich amino acid repeat sequence. The encoded polypeptide comprises a repetitive amino acid sequence that forms a random coil. The nucleic acid molecule comprising said low repetitive nucleotide sequences can further comprise a nucleotide sequence encoding a biologically or pharmacologically active protein. Further, the present invention provides for selection means and methods to identify said nucleic acid molecule comprising said low repetitive nucleotide sequence. The present invention also relates to a method for preparing said nucleic acid molecules. Also provided herein are methods for preparing the encoded polypeptide or drug conjugates with the encoded polypeptide using the herein provided nucleic acid molecules. The drug conjugate may comprise a biologically or pharmacologically active protein or a small molecule drug.Type: GrantFiled: December 22, 2016Date of Patent: August 2, 2022Assignees: XL-PROTEIN GMBH, TECHNISCHE UNIVERSITÄT MÜNCHENInventors: Uli Binder, Stefan Achatz, Arne Skerra
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Patent number: 11398726Abstract: A method for identifying the switch topology of multiple energy storage module connected in parallel and/or in series, which respectively have at least one energy storage element, each module has a switch element for selectively activating and deactivating the module and a unique identifier, wherein each module is assigned to a module string in that a total current flowing across the switch topology is checked, and individual modules are activated successively via the switch element until the total current is detectable.Type: GrantFiled: July 10, 2018Date of Patent: July 26, 2022Assignee: Technische Universität MünchenInventor: Thomas Zimmermann
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Patent number: 11352254Abstract: A molecular machine comprising a movement part (2) including a first molecular element (4), a second molecular element (5), and a linking element (6) for constraining a relative movement of the first molecular element (4) and the second molecular element (5), and a control part configured to generate an electrical field around the movement part (2), wherein the first molecular element (4) is fixed relative to the control part, wherein the second molecular element (5) is movable relative to the first molecular element (4) in at least one degree of freedom, and wherein the second molecular element (5) is electrically charged such that the second molecular element (5) aligns to said electrical field.Type: GrantFiled: April 6, 2018Date of Patent: June 7, 2022Assignee: Technische Universität MünchenInventors: Enzo Kopperger, Jonathan List, Friedrich C. Simmel
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Patent number: 11324820Abstract: The present invention provides methods for the treatment of a subject having a Hepatitis B virus (HBV) infection, e.g., a chronic HBV infection, using a combination of an RNAi agent that targets HBV and an HBV vaccine. It is disclosed a RNAi agent and an HBV vaccine for use in treatment of HBV infection, comprising sequentially administering to the subject having an HBV infection: a) an RNAi agent that inhibits expression of at least three HBV transcripts, wherein the RNAi agent forms a double stranded region; b) a protein-based vaccine comprising a first HBV core antigen (HBcAg) polypeptide, and a first HBV surface antigen (HBsAg) polypeptide; and c) a nucleic acid-based vaccine comprising an expression vector construct encoding a second HBcAg polypeptide, and/or a second HBsAg polypeptide, wherein the second HBcAg polypeptide, and/or the second HBsAg polypeptide, shares at least one epitope with at least one of the first HBcAg polypeptide, and/or the first HBsAg polypeptide.Type: GrantFiled: April 18, 2018Date of Patent: May 10, 2022Assignees: ALNYLAM PHARMACEUTICALS, INC., TECHNISCHE UNIVERSITÄT MÜNCHENInventors: Laura Sepp-Lorenzino, Ulrike Protzer, Thomas Michler
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Publication number: 20220096669Abstract: A ligand-SiFA conjugate compound represented by formula (1) wherein: RL is a ligand moiety which is capable of binding to prostate-specific membrane antigen (PSMA); RSiFA is a silicon-fluoride acceptor (SiFA) moiety which can be labeled with 18F or which is labeled with 18F; L is a linking moiety; RH is a hydrophilic moiety which comprises (i) a linear or branched sequence of 2 to 10 hydrophilic amino acid units AH, each of which is independently derived from a natural or non-natural amino acid carrying a hydrophilic side chain, and optionally one amino acid unit AN derived from a natural or non-natural amino acid which is devoid of a hydrophilic side chain, wherein the hydrophilic amino acid units and, if present, the unit AN, are bound to each other via a direct covalent bond or via a coupling unit; and which optionally further comprises (ii) one or more hydrophilic residues RT, each of which may be bound to an amino group, a carboxylic acid group, or to a hydrophilic side chain of an amino acid unit; or aType: ApplicationFiled: January 29, 2020Publication date: March 31, 2022Applicant: Technische Universität MünchenInventors: Daniel DI CARLO, Hans-Jürgen WESTER
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Patent number: 11273415Abstract: A device and a method for detecting deposits in a membrane module which produces a permeate and which comprises at least one permeable or semipermeable membrane layer. At least one polymer optical fiber for detecting deposits on the membrane layer is integrated in the membrane module such that the polymer optical fiber is in contact with at least one membrane layer. A method of detecting deposits in a membrane module producing a permeate and to a membrane module for producing a permeate from a feed stream of a fluid, in particular an aqueous solution, with the membrane module comprising a plurality of adjacently disposed or stacked sheets of a permeable or semipermeable membrane layer and with at least one polymer optical fiber being embedded or integrated in the membrane module, which polymer optical fiber is in contact with at least one sheet of the membrane layer.Type: GrantFiled: April 18, 2018Date of Patent: March 15, 2022Assignee: TECHNISCHE UNIVERSITÄT MÜNCHENInventors: Simon Hager, Karl Glas, Martin Meinardus, Matthias Albert
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Patent number: 11264226Abstract: Disclosed herein is an ion guide for guiding an ion beam along an ion path, said ion guide having a longitudinal axis which corresponds to said ion path. Said ion guide comprises a plurality of electrode plates which are arranged perpendicularly to the longitudinal axis, each electrode plate having an opening and being arranged such that said longitudinal axis extends through its respective opening, wherein said openings collectively define an ion guide volume. The ion guide extends or is configured to extend through a separation wall separating adjacent first and second pumping chambers. The ion guide has a first portion, in which gaps are formed between at least some of said electrode plates such that uncharged gas can escape from said ion guide volume, wherein said first portion is completely located in said first pumping chamber.Type: GrantFiled: April 5, 2019Date of Patent: March 1, 2022Assignee: TECHNISCHE UNIVERSITÄT MÜNCHENInventors: Tobias Kaposi, Hartmut Schlichting, Johannes Barth, Andreas Walz
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Patent number: 11224949Abstract: The invention relates to a speed-changing shearing or forming active element insert which is designed to be detachably connected to an active element receptacle of a machine tool, the speed-changing shearing or forming active element insert having a speed-changing unit which is in the form of a hydraulic force/distance transducer, the force/distance transducer comprising a housing, the housing interior of which is supplied with a hydraulic fluid, and the force/distance transducer comprising a first piston which is in oo contact with the hydraulic fluid via one piston end and a second piston which is in contact with the hydraulic fluid via one piston end and the cross-sectional area of which is smaller than the cross-sectional area of the first piston. The invention also relates to the use of the speed-changing changing shearing or forming active element insert in a machine tool.Type: GrantFiled: July 26, 2017Date of Patent: January 18, 2022Assignee: Technische Universität MünchenInventors: Tim Benkert, Martin Feistle, Thomas Kopp, Roland Golle
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Patent number: 11222777Abstract: Disclosed herein is an ion guide for guiding an ion beam along an ion path, said ion guide having a longitudinal axis corresponding to said ion path, said ion guide-comprising a plurality of elongate electrodes arranged around and extending along said longitudinal axis wherein an inner envelope of the plurality of electrodes defines an ion guide volume. Said elongate electrodes are formed by electrode wires, wherein adjacent electrode wires are arranged at an inter-wire distance. The ion guide comprises holding structures for supporting and for straightening the electrode wires by applying a tension or maintaining a tension applied to them. Any portion of said holding structures which is separated from said ion guide volume by less than the local inter-wire distance is made from a material having a resistivity of less than 1012 Ohm·cm, preferably of less than 109 Ohm·cm, or has a sheet resistivity of less than 1014 Ohm, preferably of less than 1010 Ohm on a surface facing said ion guide volume.Type: GrantFiled: April 5, 2019Date of Patent: January 11, 2022Assignee: TECHNISCHE UNIVERSITÄT MÜNCHENInventors: Tobias Kaposi, Hartmut Schlichting, Johannes Barth, Andreas Walz