Abstract: A new and distinct apple variety is described. The variety results from crossing the apple varieties ‘Cripps Pink’ (U.S. Plant Pat. No. 7,880) and ‘Scilate’ (U.S. Plant Pat. No. 20,477) in Havelock North, New Zealand. The fruit of the apple tree of this new variety have an attractive appearance characterized by its dark red color and it notable for its long storage life. This new variety has been named ‘HOT141A1’.

Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof. It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular to modulate CFTR protein or ABC protein activities.

Abstract: Isolated VHH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.

Abstract: A floating offshore structure includes a buoyant hull including a first column, a second column, and a pontoon coupled to the first column and the second column. The pontoon extends horizontally from the first column to the second column. The pontoon includes a first tubular member, a second tubular member positioned laterally adjacent to the first tubular member, a first edge plate extending horizontally from the first tubular member, and a second edge plate extending horizontally from the second tubular member. The first tubular member and the second tubular member are disposed between the first edge plate and the second edge plate. Each tubular member has a central axis, a first end coupled to the lower end of the first column, and a second end coupled to the lower end of the second column. The longitudinal axis of the first tubular member and the longitudinal axis of the second tubular member are disposed in a common horizontal plane.

Abstract: Tracers for oil recovery, particularly fluorescent nanotracers conservative in aqueous phases. The tracer comprises a core-shell nanoparticle tailored according to the operation to be traced. It contains a fluorescent core that allows the detection thereof in the field and a functionalized polymeric shell that provides increased stability in high salinity aqueous phases. A method for preparing said nanotracer. Given the nanotracer versatility, it can be used both for tracing fracking steps as well as meshes of secondary and tertiary recovery.

Abstract: A driving assistance system for reversing a mining haulage vehicle, particularly for reversing a haul truck into a defined target position in a loading or dumping area, wherein the driving assistance system is configured that the target position is determined based on a logged loading tool position of the earthmoving machine, wherein steering instructions are provided to a light indicator when the transmission of the haulage vehicle is shifted to reverse.

Abstract: The present invention concerns 4-amino-2-pyrido-bicyclic pyrimidines of Formula (I) that function as type II topoisomerase inhibitors and their use thereof as medicaments especially in the treatment of cancer. The invention also provides a method for the manufacture of 4-amino-2-pyrido bicyclic pyrimidines of Formula (I).

Abstract: Method for identifying a person through an electrocardiogram, ECG, waveform, said method comprising: capturing ECG signals from a sample population including the person to be identified; computing sample population ECG distances ST, RT and QT from the captured ECG signals; training a computer classification model on the computed sample population ECG distances, provided that no other ECG distances are used; capturing an ECG signal from the person to be identified; computing the person's ECG distances ST, RT and QT from the person's captured ECG signal; using the classification model with the person's computed ECG distances to identify the person to be identified within the sample population. Device for identifying a person through an electrocardiogram, ECG, waveform, said device comprising means for carrying out said method.

Abstract: This invention consists of a consortium of plant-growth promoting microorganisms including Pseudomonas stutzeri, Pseudomonas denitrificans, Pseudomonas resinovorans, Pseudomonas brassicacearum, Pseudomonas fluorescens, Shimwellia blattae and Klebsiella oxytoca. The bacterial consortium along with a vehicle suitable for agricultural application, form a biofertilizer useful to enhance agricultural yield when applied to cultivation plants. The biofertilizer described present a long shelf life and preserve a high cell density along the time.

Abstract: An actuation device (1) comprising a threaded shaft (2) connected at one end to driving means adapted to allow the threaded shaft (2) to rotate about its longitudinal axis (a). A movable element (3) is provided with a cylindrical cavity (30) adapted to receive the threaded shaft (2), and configured so that a rotation of the threaded shaft (2) corresponds to a translation the movable element (3) along the longitudinal axis (a). The device (1) has two guiding rods (4,4?) coupled to the movable element (3) and adapted to constrain the translation of the latter along a direction parallel to the longitudinal axis (a). Element (3) comprises a first (31) and a second (32) element constrained to each other, wherein the first element (31) is coupled to the threaded shaft (2) and the second element (32) is coupled to the two guiding rods (4,4?).

Abstract: Isolated VHH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.

Abstract: A display including: a plurality of light sources that emit light beams; a plurality of optical cores having an elongated shape, each optical core having a respective first end, which is optically coupled to a corresponding light source, each optical core further being such that the light beam emitted from the corresponding light source propagates in a guided manner inside the optical core; and a screen, each optical core having a respective second end, which is optically coupled to the screen. The display further includes an optical separation element, which forms a plurality of cavities that house corresponding optical cores, each cavity and the corresponding optical core forming a corresponding waveguide. The optical separation element absorbs visible light and laterally surrounds at least the first end of each optical core.

Abstract: The present invention is directed to an anode for a lithium-ion battery and a method of manufacturing the same. The anode is manufactured from a material composed of Si and C known as SBA-15/C having a porous structure of mesopores interconnected by micropores, wherein carbon nanofibers occupy the pore space of the porous structure. The anode has improved conductivity properties and allows to mitigate the drawbacks linked to the volumetric expansion of the anode during the operation of a lithium-ion battery.

Abstract: Described is a device for use in scanning probe microscopy and to a method for manufacturing same. The metallic device has a single body with two parts, wherein the second part has a submicrometric point that defines a nanoscale apex. Also provided is a method for manufacturing a high optical efficiency probe for scanning probe microscopy.

Abstract: Disclosed herein, inter alia, are compositions and methods for modulating the activity of N-acylethanolamine acid amidase for the treatment of a pathological state, including pain, an inflammatory condition, or a neurodegenerative disorder.

Abstract: The present invention relates to an epicyclic speed reducer (1), comprising a casing (4) comprising a first (2a) and a second opening (2b) arranged on opposite faces of said casing (4).

Abstract: The inventors provide a composition comprising an antimicrobial polypeptide comprising Blad or an active variant thereof for use in a method of treatment of the human or animal body by therapy or prophylaxis, such as for use in a method of treating or preventing an infection in or on a subject by a microorganism. Also provided is the use of a composition comprising an antimicrobial polypeptide comprising Blad or an active variant thereof to kill, or inhibit the growth of, a microorganism that is pathogenic to a human or an animal at a site that is not on or in the human or animal body.

Abstract: Method of making BTX compounds including benzene, toluene, and xylene, including feeding heavy reformats to a reactor containing a composite zeolite catalyst. The composite zeolite catalyst includes a mixture of nanocrystalline Beta zeolite (Nano-Beta) comprising crystal size in the range of 10 to 40 nm and ZSM-5. The Nano-Beta, the ZSM-5, or both include one or more impregnated metals. The method further includes producing the BTX compounds by simultaneously performing transalkylation and dealkylation of the heavy reformate in the reactor. The composite zeolite catalyst is able to simultaneously catalyze both the transalkylation and dealkylation reactions.

Abstract: A system for the exfoliation of a layered material is described, comprising in combination: an exfoliation station (14-22) operating on a volume of a dispersion of a layered precursor material, including a wet-jet milling device (10); and a collecting station (30, 40), located downstream of the exfoliation station (14-22), operating on a volume of a dispersion of the at least partly exfoliated material, in which the exfoliation station (14-22) and the collecting station (30, 40) are connected to each other through a fluid communication path (20) along which there are interposed flow regulating means (50) adapted to assume a first operating configuration in which the communication path (20) between the exfoliation station (14-22) and the collecting station (30, 40) is discontinued, where the exfoliation station (14-22) is adapted to subject a volume of dispersion of layered precursor material to a predetermined number of wet jet milling cycles; and a second operating configuration in which the communication pa

Abstract: The present invention provides a water tension sensor with a non-sintered core that allows batches of similar and standard sensors to be manufactured in a simple manner, for operation with air and with an air flow outlet, which sensor can be used to read water tension and trigger dripping. The sensor according to the invention is ideal for manually reading soil water tension and for automating irrigation systems based on a static pressure or gas propulsion mechanism.