Patents Assigned to Temple University
  • Patent number: 11896037
    Abstract: The present invention relates to compositions and methods for masking the taste of an agent. In certain aspects, the invention comprises a microsphere and at least one sweetener therein. In another aspect, the invention comprises an edible material comprising at least one microsphere comprising an agent and at least one microsphere comprising a sweetener.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: February 13, 2024
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Gregory S. Smutzer, Kevin Lee, Dhruti Patel
  • Patent number: 11897870
    Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: February 13, 2024
    Assignee: Temple University-Of The Commonwealth System Higher Education
    Inventors: Daniel J. Canney, Benjamin E. Blass, Rong Gao, Magid Abou-Gharbia
  • Patent number: 11873267
    Abstract: Pharmaceutical compositions of the invention comprise functionalized N,N-dialkylamino phenyl ethers derivatives having a disease-modifying action in the treatment of diseases associated with lysosomal storage dysfunction that include Gaucher's disease, and any disease or condition involving lysosomal storage dysfunction.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: January 16, 2024
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Magid A. Abou-Gharbia, Wayne E. Childers, Marlene A. Jacobson, Rong Fan, Rogelio L. Martinez
  • Publication number: 20230390357
    Abstract: The invention provides methods of treating ischemia/reperfusion injury in a subject. In one example, a method comprises administering a therapeutically effective amount of a pharmaceutical composition that increases levels of Bcl2-associated athanogene 3 (BAG3) polypeptide in ischemic tissue. The invention also provides methods of treating a subject at risk of ischemia/reperfusion injury. In one example, a method comprises administering a therapeutically effective amount of a pharmaceutical composition that increases levels of Bcl2-associated athanogene 3 (BAG3) polypeptide. In the invention methods, in one example, a pharmaceutical composition comprises a nucleic acid encoding BAG3 polypeptide.
    Type: Application
    Filed: November 4, 2022
    Publication date: December 7, 2023
    Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Arthur M. FELDMAN, Joseph Y. CHEUNG, Kamel KHALILI
  • Patent number: 11821625
    Abstract: Aspects of the invention are directed to systems and apparatuses for efficiently burning fuels. According to one aspect of the invention, apparatus for efficiently burning hydrocarbons includes a housing having a first opening for receiving a fuel, a second opening for expelling the fuel, and a tubular passageway extending between the first opening and the second opening. The tubular passageway includes a central region and an outer region surrounding the central region. The apparatus also includes a plurality of magnets disposed within the passageway. Each of the magnets has a spherical or an ovoid shape. The plurality of magnets define void spaces for passing the fuel such that a central flow rate of the fuel in the central region of the passageway is equivalent to the an outer flow rate of the fuel in an outer region of the passageway.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: November 21, 2023
    Assignee: Temple University of the Commonwealth System of Higher Education
    Inventors: Oleksandr Diloyan, Haykazuni Andreasyan
  • Patent number: 11787794
    Abstract: The present invention includes novel aminothiazole compounds of formula (I), which are useful in preventing or treating cancer in a subject in need thereof.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: October 17, 2023
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Jean-Pierre J. Issa, Hanghang Zhang, Magid Abou-Gharbia, Wayne E. Childers, George C. Morton
  • Patent number: 11759442
    Abstract: The invention relates to compositions and methods that include short chain fatty acids (SCFAs), related therapeutic compounds, and other compounds, including combinations thereof, for the treatment or prevention of diseases or disorders.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: September 19, 2023
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Ira C. Spector, Mark A. Feitelson, Alla Arzumanyan
  • Patent number: 11739323
    Abstract: The invention includes compositions and methods useful for the diagnosis and treatment of head or brain injury in a subject in need thereof, based upon the expression level of at least one miRNA that is associated with head or brain injury.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: August 29, 2023
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Matthew B. Hudson, Dianne Langford, John Jeka, Ryan Tierney
  • Patent number: 11672830
    Abstract: The invention provides one or more of miR-290 family and Lin28a modified cardiac progenitor cell based therapies for the treatment of myocardial infarction. Exosomes derived from one or more of miR-290 family and Lin28a modified cardiac progenitor cells can also be used in cardiac therapy.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: June 13, 2023
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Mohsin Khan, Raj Kishore
  • Publication number: 20230107743
    Abstract: Smart dental implant systems and methods for ambulatory dental care are provided. In some embodiments, the disclosed subject matter includes a crown, adapted to mimic a patient's anatomy and location of the smart dental implant system. The crown can include piezoelectric nanoparticles, disposed on a surface of the crown and adapted to generate electricity from a patient's oral motion. In some embodiments, the disclosed subject matter includes an abutment, coupled to the crown. The abutment can include an energy harvesting circuit, operationally coupled to the piezoelectric nanoparticles and adapted to harvest the electricity, and a micro LED array, operationally coupled to the energy harvesting circuit and adapted to photobiomodulate surrounding peri-implant soft tissue.
    Type: Application
    Filed: December 12, 2022
    Publication date: April 6, 2023
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, TEMPLE UNIVERSITY
    Inventors: Geelsu Hwang, Hye-Eun Kim, Jonathan Korostoff, Albert Kim
  • Patent number: 11618158
    Abstract: The present invention relates to a new pneumatic-actuated multifunctional doming actuator. The doming actuator can be used as a doming actuator, which can maintain machine/robotic operation on vertical surfaces without falling. The doming actuators exhibit rapid switchable adhesion/deadhesion on target surfaces upon pressurizing/depressurizing the embedded spiral pneumatic channels. The present invention also relates to novel load-carrying and climbing soft robots using the doming actuators. The soft robots are operable on a wide range of horizontal and vertical surfaces including dry, wet, slippery, smooth, and semi-smooth surfaces. In addition, the doming actuators can be used as a driving actuator for swimming soft robotics and as an actuator for soft grippers.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: April 4, 2023
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Yichao Tang, Jie Yin
  • Publication number: 20230073246
    Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.
    Type: Application
    Filed: October 5, 2022
    Publication date: March 9, 2023
    Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Arthur M. Feldman, Douglas G. Tilley, Weizhong Zhu, Kamel Khalili, Walter J. Koch
  • Publication number: 20230037458
    Abstract: A mobile-platform imaging device uses compression of the target region to generate an image of an object. A tactile sensor has an optical waveguide with a flexible, transparent first layer. Light is directed into the waveguide. Light is scattered out of the first layer when the first layer is deformed. The first layer is deformed by the tactile sensor being pressed against the object. A force sensor detects a force pressing the tactile sensor against the object and outputs corresponding force information. A first communication unit receives the force information from the force sensor. A receptacle holds a mobile device with a second communication unit and an imager that can generate image information using light scattered out of the first layer. The first communication unit communicates with the second communication unit and the mobile device communicates with an external network.
    Type: Application
    Filed: September 30, 2022
    Publication date: February 9, 2023
    Applicant: Temple University - Of The Commonwealth System Of Higher EducationB
    Inventor: Chang-Hee WON
  • Patent number: 11547776
    Abstract: The present invention provides porous biomimetic scaffolds and methods for making the same. The scaffolds have graded pore sizes for enhanced cell penetration. The scaffolds are useful for wound regeneration by facilitating cell penetration into the scaffold interior and due to their inherent immunomodulatory effects. The scaffolds have tissue modeling specification by mimicking the inherent stratified structure of certain tissues.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: January 10, 2023
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Azadeh Timnak, Peter I. Lelkes, Yah-el H. Har-el
  • Patent number: 11542555
    Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.
    Type: Grant
    Filed: May 21, 2020
    Date of Patent: January 3, 2023
    Assignee: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Arthur M. Feldman, Douglas G. Tilley, Weizhong Zhu, Kamel Khalili, Walter J. Koch
  • Patent number: 11484712
    Abstract: The present invention provides in part wearable devices for balance control. The wearable devices are capable of non-invasively monitoring and stimulating the wearer's vestibular system such that it produces postural responses. The wearable devices deliver low levels of electrical current to the vestibular system of a user to maintain balance. In one example, the wearable device is in the form of a pair of glasses.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: November 1, 2022
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Peter Igoche Agada, John Jeka
  • Patent number: 11464420
    Abstract: A magnetometer-based metal detection device and methods of use are described. The device includes a proximal portion, a central body and a distal portion, and at least one magnetometer positioned within or on the distal portion. The at least one magnetometer includes at least one sensor capable of sensing a magnetic field in three orthogonal axes. Also described is a method of calibrating the device to achieve rotational invariance, and a method of determining a directionality or directional line along which a target metal object lies.
    Type: Grant
    Filed: December 28, 2020
    Date of Patent: October 11, 2022
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Samuel Alex Weprin, John Noel, Daniel D. Eun
  • Patent number: 11406840
    Abstract: Systems and methods for reducing blood viscosity along a flow direction, suppressing turbulence in blood flow, and treating rouleaux are disclosed. One method includes applying a unidirectional magnetic field to a flow of blood in a direction parallel or antiparallel to a direction of the flow of blood, and maintaining the application of the unidirectional magnetic field to the flow of blood until a blood viscosity along the direction of the flow of blood is reduced and/or the turbulence in the blood flow is suppressed. One system includes an annular magnet sized to encircle a portion of a patient's body. The magnet is adapted to generate a unidirectional magnetic field in a region within the annular magnet. The unidirectional magnetic field has a strength sufficient to reduce the blood viscosity in the portion of the patient's body and/or suppress turbulence in the blood flow by a predetermined amount. The system will also break rouleaux for patients with rouleaux, but the process will take more time.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: August 9, 2022
    Assignee: Temple University of the Commonwealth System of Higher Education
    Inventors: Rongjia Tao, Hong Tang, Xiaojun Xu, Kazi M. Tawhid-Al-Islam, Enpeng Du
  • Patent number: 11387520
    Abstract: The invention provides a novel ceramic-metal oxide-polymer composite material. A functionalized metal oxide nanolayer coating can be bonded between LICGCs and polymers/oligomers, which protects the LICGC from corrosion, has a low interfacial resistance to Li+ migration, and can be a SIC. Hybrid ceramic-polymer electrolytes were formed by engineering the interface between a LICGC and a polymer, polyethylene oxide (PEO), by sputter coating a 200 nm thick SiO2 layer onto a lithium ion conducting glass ceramic (LICGC) and silanating the SiO2 with a functionalized PEG in the presence of LiTFSI. A low interfacial resistance (Rinterfacial) was measured, the same as that obtained for a SiO2 interface soaked with liquid tetraglyme/LiTFSI. The pegylated SiO2 interface (unlike the tetraglyme/LiTFSI interface) protected the LICGC from corrosion by Li0 metal. The (PEG-LiTFSI)—SiO2-LICGC could be bonded with polyethylene oxide/LiTFSI.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: July 12, 2022
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Stephanie Wunder, Mike Zdilla, Parameswara Rao Chinnam
  • Publication number: 20220160464
    Abstract: The present invention provides novel multi-functional (e.g., repelling biofilms, promoting formation of minerals, and having anti-infection properties) biocomposites and methods of use thereof. In various embodiments, the present invention also provides method for simultaneously treating biofilms, promoting mineralization, treating infection, or any combination thereof.
    Type: Application
    Filed: March 26, 2020
    Publication date: May 26, 2022
    Applicant: Temple University-Of The Commonwealth System of Higher Education
    Inventor: Santiago ORREGO