Abstract: The present invention discloses a photon enhancement apparatus comprising a reflective component and 4f coherent imaging system, which increases a photon collection efficiency. The present invention also provides a microscope comprising said photon enhancement apparatus and methods of improving photon collection efficiency, signal-to-noise ratio, and/or optical resolution using the said photon enhancement apparatus.
Type:
Grant
Filed:
November 25, 2020
Date of Patent:
April 22, 2025
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.
Type:
Grant
Filed:
November 2, 2021
Date of Patent:
April 8, 2025
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Inventors:
Daniel J. Canney, Benjamin E. Blass, Rong Gao, Magid Abou-Gharbia
Abstract: Compositions and methods for the promotion of wound healing and tissue regeneration are described. The compositions and methods make use of water-soluble soy protein isolates (WSsoy), Fraction 5, Fraction 9, and/or bioactive peptide components of soy protein isolates. The invention also relates to the unexpected discovery that purified WSsoy forms gel-like matrices when suspended within certain concentration ranges in an aqueous environment. The compositions of the invention comprising WSsoy promote natural healing and have a low risk profile.
Type:
Grant
Filed:
August 2, 2021
Date of Patent:
March 18, 2025
Assignee:
Temple University—Of The Commonwealth System of Higher Education
Inventors:
Peter I. Lelkes, Yah-el H. Har-el, Cezary Marcinkiewicz, Philip Lazarovici, Sogol Moaiyed Baharlou, Jonathan A. Gerstenhaber
Abstract: Compositions for specifically cleaving target sequences in retroviruses include nucleic acids encoding a Clustered Regularly Interspace Short Palindromic Repeat (CRISPR) associated endonuclease and a guide RNA sequence complementary to one or more target nucleic acid sequences in a retrovirus genome.
Type:
Grant
Filed:
September 10, 2020
Date of Patent:
March 18, 2025
Assignee:
Temple University—of the Commonwealth System of Higher Education
Abstract: A method of assessing the balance impairment of a subject includes the steps of presenting the subject with a static scene on a display, collecting a first set of orientation measurements, presenting the subject with an unstable scene on a display, collecting a second set of orientation measurements, storing the first and second sets of orientation measurements on a computing device, referenced to a set of time indices, and calculating a balance score for the subject by comparing the second set of orientation measurements with the first set of orientation measurements. A system for assessing the balance impairment of a subject is also disclosed.
Type:
Grant
Filed:
January 16, 2018
Date of Patent:
January 28, 2025
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Abstract: The present invention features compositions comprising an anti-amyloid antibody and methods of treating microbial infection and treating or preventing microbial biofilms using the composition.
Type:
Grant
Filed:
January 20, 2022
Date of Patent:
January 21, 2025
Assignees:
Temple University-of The Commonwealth System of Higher Education, LANKENAU INSTITUTE OF MEDICAL RESEARCH
Abstract: The present application provides compounds and methods of treating bacterial infection, including bacterial infection caused by P. acnes.
Type:
Grant
Filed:
November 23, 2021
Date of Patent:
January 14, 2025
Assignees:
The General Hospital Corporation, Rhode Island Hospital, A Lifespan-Partner, Temple University—Of The Commonwealth System of Higher Education
Inventors:
Frederick M. Ausubel, Wooseong Kim, Eleftherios Mylonakis, William M. Wuest
Abstract: The present invention relates in part to a filter comprising a tubular housing having a proximal end, a distal end and a housing lumen therethrough; a tubular membrane having a proximal end, a distal end and a membrane lumen therethrough, wherein the tubular membrane is positioned within the housing lumen; a contaminated fluid sample inlet fluidly connected to the proximal end of the membrane, and a contaminated fluid sample outlet fluidly connected to the distal end of the membrane, thereby creating a sample flow-path from the sample inlet through the membrane lumen to the sample outlet; and a purification material inlet fluidly connected to a distal region of the housing lumen, and a purification material outlet fluidly connected to a proximal region of the housing lumen, thereby creating a purification material flow-path from the purification material inlet through the housing lumen to the purification material outlet; wherein the direction of the sample flow-path is in the opposite direction of the purifi
Type:
Grant
Filed:
February 4, 2020
Date of Patent:
December 10, 2024
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Abstract: Compositions for the in vivo delivery of a gene editing CRISPR/Cas9 complex was developed to eliminate integrated retroviral DNA sequences from latently infected human cells and animal disease models.
Type:
Grant
Filed:
February 13, 2017
Date of Patent:
October 22, 2024
Assignee:
Temple University—of the Commonwealth System of Higher Education
Abstract: The present invention relates to pyrazolylbenzene-1,3-diols as cannabidiol derivatives, its use for the manufacture of a medicament, and more particularly, to the use of this medicament for the treatment and/or prevention of a disorder associated with the GPR18 and/or TRPV1 receptors and the use of these compounds for pharmacological assays related to GPR18 and/or TRPV1.
Type:
Grant
Filed:
April 16, 2021
Date of Patent:
September 17, 2024
Assignees:
Temple University Of The Commonwealth System of Higher Education, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, University of North Carolina Greensboro
Inventors:
Mary Ellen Abood, Eugen Brailoiu, Luciana Magalhaes Leo, Pingwei Zhao, Nadine Jagerovic, Ana Lago Fernández, Paula Morales Lazaro, Patricia Hodapp Reggio, Dow Preston Hurst, Nouroddin Sotoudeh Chafi
Abstract: The present invention relates in part to a method of fabricating a ceramic-polymer composite by contacting a polymer material with an acid solution and depositing a ceramic on the polymer material. The invention also relates in part to ceramic-polymer composites produced using said method and ballistic resistant materials comprising said ceramic-polymer composites.
Type:
Grant
Filed:
November 29, 2018
Date of Patent:
September 17, 2024
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Abstract: The present invention provides portable devices and systems for electrofocused blow spinning, and methods for using the same. The devices of the invention are convenient to carry and use and are able to aerodynamically spin a variety of materials in a mobile setting.
Type:
Grant
Filed:
September 29, 2016
Date of Patent:
July 9, 2024
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Inventors:
Sogol M. Baharlou, Jonathan A. Gerstenhaber, Yah-el H. Har-el, Peter I. Lelkes
Abstract: The invention provides compositions and methods for generating improved T cells having increased Ezh2 activity and methods of use thereof in the treatment of cancer and chronic infection.
Type:
Grant
Filed:
November 7, 2018
Date of Patent:
July 2, 2024
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Abstract: The invention provides AML-specific methylation biomarkers (SP140, MCCC1, EHMT1 and MTSS1). In one embodiment, a biomarker is differentially methylated, specifically in AML.
Type:
Grant
Filed:
October 19, 2016
Date of Patent:
June 25, 2024
Assignee:
Temple University—Of The Commonwealth System of Higher Education
Abstract: The present invention provides a semi-quantitative phage-based assay for Mycobacterial infection, in which the phage assay plaque count correlates to the number of viable Mycobacterial organisms in the subject sample, and methods of use thereof for diagnosing, treating or monitoring Mycobacterial infection.
Type:
Grant
Filed:
September 27, 2019
Date of Patent:
June 11, 2024
Assignee:
Temple University—Of The Commonwealth System of Higher Education
Inventors:
Irene Grant, Antonio Foddai, John Todd Kuenstner, Raghava Potula, Tim Bull, Saleh Naser, Ira Shafran
Abstract: The invention provides compositions and methods for modifying the 3?-terminal ends of nucleic acids using DNA polymerase ? terminal transferase activity.
Type:
Grant
Filed:
December 14, 2020
Date of Patent:
May 28, 2024
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Abstract: A light detection and measurement device comprises a silicon photomultiplier, at least one thermoelectric cooler thermally coupled to the silicon photomultiplier, a sealed enclosure surrounding the silicon photomultiplier and the at least one thermoelectric cooler, the enclosure including a substantially transparent window thermally coupled to the silicon photomultiplier, and a heat sinking device thermally coupled to the enclosure configured to remove waste heat. A method of cooling a silicon photomultiplier is also described.
Type:
Grant
Filed:
September 27, 2019
Date of Patent:
May 28, 2024
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Inventors:
C. J. Martoff, Donald Jones, Andrew Ponento
Abstract: A method for quantifying the professional development of a subject includes storing, on a non-transitory computer-readable medium, a base professional development score for a subject, receiving a submission pertaining to a professional development activity of the subject, approving the submission based on at least one professional development criteria, assigning a value to the approved submission, adjusting the base professional development score according to the approved submission value, comparing the adjusted professional development score to a threshold value, and determining that the subject has achieved a professional development goal when the adjusted professional development score is greater than the threshold value. A system for quantifying the professional development, a system for network-assisted recruitment, and a system for network-assisted learning are also described.
Type:
Grant
Filed:
February 27, 2019
Date of Patent:
May 21, 2024
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Inventors:
Munir Y. Mandviwalla, Manoj J. Chacko, Laurel A. Miller
Abstract: The invention relates to compositions for preventing or delaying the onset of hepatocellular cancer. The compositions of the invention may comprise short chain fatty acids. The compositions of the invention may also comprise probiotic bacteria. The compositions of the invention include compositions for preventing or delaying the onset of hepatocellular cancer by treating or preventing liver inflammation, liver disease, and precancerous lesions.
Type:
Grant
Filed:
July 19, 2021
Date of Patent:
April 23, 2024
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Abstract: Apparatus for increasing burning efficiency including a bottom shell having a plate defining a first opening for receiving a fuel source and a side wall extending in an upward direction. The side wall has a first side wall end coupled to the plate and a second side wall end spaced from the first side wall end in the upward direction. Additionally, the apparatus includes a top shell having inner and outer walls defining a cavity for receiving the second side wall end of the side wall of the bottom shell. The inner wall has a first inner end and a second inner end and the outer wall has a first outer end and a second outer end. The first inner end is coupled to the first outer end and the second inner end is spaced from the second outer end to receive at least the second side wall end.
Type:
Application
Filed:
September 15, 2022
Publication date:
March 21, 2024
Applicant:
Temple University of the Commonwealth System of Higher Education