Patents Assigned to Temple University
  • Patent number: 11406840
    Abstract: Systems and methods for reducing blood viscosity along a flow direction, suppressing turbulence in blood flow, and treating rouleaux are disclosed. One method includes applying a unidirectional magnetic field to a flow of blood in a direction parallel or antiparallel to a direction of the flow of blood, and maintaining the application of the unidirectional magnetic field to the flow of blood until a blood viscosity along the direction of the flow of blood is reduced and/or the turbulence in the blood flow is suppressed. One system includes an annular magnet sized to encircle a portion of a patient's body. The magnet is adapted to generate a unidirectional magnetic field in a region within the annular magnet. The unidirectional magnetic field has a strength sufficient to reduce the blood viscosity in the portion of the patient's body and/or suppress turbulence in the blood flow by a predetermined amount. The system will also break rouleaux for patients with rouleaux, but the process will take more time.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: August 9, 2022
    Assignee: Temple University of the Commonwealth System of Higher Education
    Inventors: Rongjia Tao, Hong Tang, Xiaojun Xu, Kazi M. Tawhid-Al-Islam, Enpeng Du
  • Patent number: 11387520
    Abstract: The invention provides a novel ceramic-metal oxide-polymer composite material. A functionalized metal oxide nanolayer coating can be bonded between LICGCs and polymers/oligomers, which protects the LICGC from corrosion, has a low interfacial resistance to Li+ migration, and can be a SIC. Hybrid ceramic-polymer electrolytes were formed by engineering the interface between a LICGC and a polymer, polyethylene oxide (PEO), by sputter coating a 200 nm thick SiO2 layer onto a lithium ion conducting glass ceramic (LICGC) and silanating the SiO2 with a functionalized PEG in the presence of LiTFSI. A low interfacial resistance (Rinterfacial) was measured, the same as that obtained for a SiO2 interface soaked with liquid tetraglyme/LiTFSI. The pegylated SiO2 interface (unlike the tetraglyme/LiTFSI interface) protected the LICGC from corrosion by Li0 metal. The (PEG-LiTFSI)—SiO2-LICGC could be bonded with polyethylene oxide/LiTFSI.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: July 12, 2022
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Stephanie Wunder, Mike Zdilla, Parameswara Rao Chinnam
  • Publication number: 20220160464
    Abstract: The present invention provides novel multi-functional (e.g., repelling biofilms, promoting formation of minerals, and having anti-infection properties) biocomposites and methods of use thereof. In various embodiments, the present invention also provides method for simultaneously treating biofilms, promoting mineralization, treating infection, or any combination thereof.
    Type: Application
    Filed: March 26, 2020
    Publication date: May 26, 2022
    Applicant: Temple University-Of The Commonwealth System of Higher Education
    Inventor: Santiago ORREGO
  • Patent number: 11332789
    Abstract: The invention provides compositions and methods for the diagnosis, treatment, assessment, and characterization of hyperlipidemia-related diseases and disorders, including atherosclerosis, non-alcoholic fatty liver disease, obesity and diabetes mellitus in a subject in need thereof, based on the expression level of at least one miRNA that is associated with these diseases and disorders.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: May 17, 2022
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventor: Xiao-Feng Yang
  • Patent number: 11278025
    Abstract: The present application provides compounds and methods of treating bacterial infection, including bacterial infection caused by P. acnes.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: March 22, 2022
    Assignees: The General Hospital Corporation, Rhode Island Hospital, A Lifespan-Partner, Temple University-Of The Commonwealth System of Higher Education
    Inventors: Frederick M. Ausubel, Wooseong Kim, Eleftherios Mylonakis, William M. Wuest
  • Patent number: 11236389
    Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: February 1, 2022
    Assignee: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Arthur M. Feldman, Douglas G. Tilley, Weizhong Zhu, Kamel Khalili, Walter J. Koch
  • Patent number: 11235029
    Abstract: The present invention relates to compositions and methods for the treatment of heart failure.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: February 1, 2022
    Assignees: Temple University-Of The Commonwealth System of Higher, Education Johns Hopkins Technology Ventures, Universita di Napoli Federico II
    Inventors: Alessandro Cannavo, Ning Feng, Giuseppe Rengo, Nazareno Paolocci, Walter J. Koch
  • Patent number: 11220505
    Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: January 11, 2022
    Assignee: Temple University-Of the Commonwealth System of Higher Education
    Inventors: Benjamin E. Blass, Daniel J. Canney, Kevin M. Blattner
  • Patent number: 11210396
    Abstract: A behavioral malware detection involves extracting features from prefetch files, wherein prefetch files; classifying and detecting benign applications from malicious applications using the features of the prefetch files; and quarantining malicious applications based on the detection.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: December 28, 2021
    Assignees: Drexel University, Temple University
    Inventors: Bander Mohamed Alsulami, Spiros Mancoridis, Avinash Srinivasan
  • Patent number: 11192871
    Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: December 7, 2021
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Daniel J. Canney, Benjamin E. Blass, Rong Gao, Magid Abou-Gharbia
  • Patent number: 11154569
    Abstract: A method for treating or preventing a disease or condition that operates by calcium transport through the mitochondrial calcium uniporter (MCU), the method comprising administering to a subject a therapeutically effective amount of an MCU inhibitor having the following structure: wherein L1, L2, L3, L4, L5, L6, L7, L8, X1, and X2 are independently selected from halide, amine groups —NR1R2R3, phosphine groups —PR5R6R7, carboxylate groups R4C(O)O—, and solvent molecules, and provided that at least one of L1, L2, L3, L4, L5, L6, L7, L8, X1, and X2 is selected from amine or phosphine groups; wherein R1, R2, R3, and R4 are independently selected from hydrogen atoms and hydrocarbon groups having up to six carbon atoms, wherein two of R1, R2, and R3 within a —NR1R2R3 group are optionally interconnected to form an N-containing ring; and R groups in adjacent amino or phosphine groups may optionally interconnect.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: October 26, 2021
    Assignees: CORNELL UNIVERSITY, TEMPLE UNIVERSITY
    Inventors: Justin Wilson, Madesh Muniswamy, Sarah R. Nathan
  • Patent number: 11111216
    Abstract: The present invention includes novel polycationic amphiphilic compounds useful as antimicrobial agents. The present invention further includes methods useful for removing microorganisms and/or biofilm-embedded microorganisms from a surface. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and/or biofilm-embedded microorganisms on a surface.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: September 7, 2021
    Assignees: Temple University-Of The Commonwealth System of Higher Education, Villanova University
    Inventors: William M. Wuest, Kevin P. C. Minbiole
  • Publication number: 20210254159
    Abstract: Identification of BAG3 (Bcl2-associated anthanogene 3) genetic variants were associated with the prevalence non-ischemic or ischemic dilated cardiomyopathy (DCM) and DCM outcomes in individuals of African ancestry.
    Type: Application
    Filed: June 7, 2019
    Publication date: August 19, 2021
    Applicant: TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventor: Arthur M. FELDMAN
  • Patent number: 11090309
    Abstract: The present invention is related to compositions and methods for treating platelet-related diseases.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: August 17, 2021
    Assignees: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Molecular Targeting Technologies. Inc.
    Inventors: Parkson L-G Chong, Lawrence E. Goldfinger, Koon Y. Pak, Brian D. Gray
  • Patent number: 11077169
    Abstract: Compositions and methods for the promotion of wound healing and tissue regeneration are described. The compositions and methods make use of water-soluble soy protein isolates (WSsoy), Fraction 5, Fraction 9, and/or bioactive peptide components of soy protein isolates. The invention also relates to the unexpected discovery that purified WSsoy forms gel-like matrices when suspended within certain concentration ranges in an aqueous environment. The compositions of the invention comprising WSsoy promote natural healing and have a low risk profile.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: August 3, 2021
    Assignee: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Peter I. Lelkes, Yah-El H. Har-el, Cezary Marcinkiewicz, Philip Lazarovici, Sogol Moaiyed Baharlou, Jonathan A. Gerstenhaber
  • Patent number: 10961249
    Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma-2 receptor activity.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: March 30, 2021
    Assignee: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Benjamin E. Blass, Daniel J. Canney, Kevin M. Blattner
  • Patent number: 10962555
    Abstract: The present invention provides for the first time the identification of fetal neural exosomal biomarkers isolated from maternal plasma useful in diagnosing fetal neurodevelopmental outcomes. The invention also provides the identification of neonatal neural exosomal biomarkers isolated from neonatal plasma useful in diagnosing neonatal neurodevelopmental outcomes The present invention therefore provides methods, kits and systems for diagnosing fetal neurodevelopmental outcomes, by examining relevant proteins and RNA in fetal neural exosomes isolated from a maternal plasma and neonatal neural exosomes isolated from neonatal plasma.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: March 30, 2021
    Assignee: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Laura Goetzl, Edward Goetzl
  • Patent number: 10941126
    Abstract: The present invention includes novel bridged bicycloalkyl-substituted aminothiazole compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: March 9, 2021
    Assignee: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Wayne C. Childers, Magid A. Abou-Gharbia, George C. Morton, Jean-Pierre J. Issa, Hanghang Zhang
  • Publication number: 20210060138
    Abstract: Methods of eliminating a retrovirus from a subject utilize nanoformulated anti-retroviral compounds and gene editing agents. Compositions comprise at least one anti-retroviral compounds, at least one gene-editing agent, or combinations thereof.
    Type: Application
    Filed: March 6, 2020
    Publication date: March 4, 2021
    Applicants: Temple University - of the Commonwealth System of Higher Education, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Kamel Khalili, Howard E. Gendelman, Benson Edagwa
  • Publication number: 20210052532
    Abstract: In certain embodiments, this disclosure relates to methods of treating or preventing type 2 diabetes, pre-diabetes and conditions characterized by an increase in the levels of A1C, glucose, insulin, homeostasis model of assessment of insulin resistance HOMA-IR), oxidative stress in adipose tissue, and earbonvlation of GLUT4 comprising administering an effective amount of a compound of Formula I-III as described herein, to a subject in need thereof.
    Type: Application
    Filed: March 7, 2019
    Publication date: February 25, 2021
    Applicant: Temple University - Of The Commonwealth System Of Higher Education
    Inventors: Salim MERALI, Carlos A. BARRERO, Wayne E. CHILDERS, George C. MORTON