Patents Assigned to Temple University of the Commonwealth System of Higher Education
  • Assay for screening/ranking antioxidants based on their effects on membrane sterol lateral organization
    Patent number: 8183048
    Abstract: A method of screening an antioxidant for potency and/or toxicity in vitro, the method includes contacting the antioxidant with a model system containing a sterol superlattice formation capable of generating a detectable signal, wherein the detectable signal changes in a parameter representative of an integrity of the sterol superlattice formation; and detecting and/or measuring disruption of the sterol superlattice formation, wherein the disruption is caused by the insertion of the antioxidant into membranes and thereby screening the antioxidant for potency and/or toxicity.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: May 22, 2012
    Assignee: Temple University- Of the Commonwealth System of Higher Education
    Inventors: Parkson Lee-Gau Chong, Michelle Olsher, Su-In Yoon
  • TREATMENT OF DISORDERS ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 35 (GPR35)
    Publication number: 20120122987
    Abstract: Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke or ischemia, or treating gastric inflammation.
    Type: Application
    Filed: July 14, 2010
    Publication date: May 17, 2012
    Applicants: Temple University of the Commonwealth System of Higher Education, Research Triangle Institute, Duke University
    Inventors: Mary E. Abood, Pingwei Zhao, Lawrence S. Barak, Herbert H. Seltzman
  • Method and apparatus for treatment of a fluid
    Patent number: 8173023
    Abstract: An apparatus for the magnetic treatment of a fluid which produces at least one magnetic field for a period of time, Tc at or above a critical magnetic field strength, Hc, the period Tc and the field strength Hc determined relative to one another and dependant upon the properties of the fluid.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: May 8, 2012
    Assignee: Temple University of the Commonwealth System of Higher Education
    Inventors: Rongjia Tao, Xiaojun Xu
  • LEPTIN AGONIST AND METHODS OF USE
    Publication number: 20120108504
    Abstract: Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, type II diabetes, appetite control after bariatric surgery, insulin resistance, lipodystrophy and hypothalamic amenorrhea, obesity-related infertility, among other diseases and conditions related to leptin deficiency and/or leptin resistance.
    Type: Application
    Filed: June 25, 2010
    Publication date: May 3, 2012
    Applicant: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventor: Laszlo Otvos, JR.
  • Method for reduction of crude oil viscosity
    Patent number: 8156954
    Abstract: The present invention relates to a method for reducing the viscosity and facilitating the flow of petroleum-based fluids. The method includes the step of applying an electric field of sufficient strength and for a sufficient time to the petroleum-based fluid to cause a reduction in viscosity of the fluid.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: April 17, 2012
    Assignee: Temple University of the Commonwealth System of Higher Education
    Inventors: Rongjla Tao, Xlaojun Xu, Ke Huang
  • Heteroaryl sulfones and sulfonamides and therapeutic uses thereof
    Patent number: 8143428
    Abstract: Compounds of Formula I: wherein R1, R2, M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents.
    Type: Grant
    Filed: June 8, 2005
    Date of Patent: March 27, 2012
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • SYSTEMS AND METHODS FOR DETECTING CONCEALED NUCLEAR MATERIAL
    Publication number: 20120024044
    Abstract: Methods and systems for detecting nuclear material concealed within an enclosure are provided. An ionized air density is measured at one or more locations outside of the enclosure. The presence of the concealed nuclear material is detected, for each of the one or more locations, based on a characteristic of the measured ionized air density indicative of concealed nuclear materials.
    Type: Application
    Filed: February 5, 2010
    Publication date: February 2, 2012
    Applicants: U.S. Naval Research Laboratory, Temple University of the Commonwealth System of Higher Education
    Inventors: Rongjia Tao, Dong Ho Wu
  • Composition and methods for the treatment of proliferative diseases
    Patent number: 8106033
    Abstract: Methods and compositions are provided for treating proliferative disorders, wherein the composition comprises at least one compound according to Formula I: wherein R1 is selected from the group consisting of —OH, —NH2, —NH—CH2—CO2H, —NH—CH(CH3)—CO2H, and —NH—C(CH3)2—CO2H, or a pharmaceutically acceptable salt of such a compound; and an anthracycline, e.g. doxorubicin, or a pharmaceutically acceptable salt thereof, or a platin, e.g. oxaliplatin, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: January 31, 2012
    Assignees: Temple University - Of The Commonwealth System of Higher Education, Mount Sinai School of Medicine
    Inventors: E. Premkumar Reddy, James F. Holland
  • ORTHOTIC SHOE AND INSOLE ASSEMBLIES
    Publication number: 20120017467
    Abstract: An orthotic shoe sole assembly and an orthotic insole are disclosed herein. The orthotic shoe assembly includes a shoe sole having an exposed surface and at least one exposed cavity accessible via the exposed surface. The at least one exposed cavity includes a central region and a plurality of channels extending from the central region. A resilient member is removably positioned within the central region of the exposed cavity. The resilient member is configured to resiliently expand into at least one of the plurality of channels of the exposed cavity. The orthotic insole is removably positioned to selectively conceal the exposed cavity of the shoe sole and the resilient member. The orthotic insole includes a central axis member for supporting a foot along its central axis.
    Type: Application
    Filed: October 26, 2009
    Publication date: January 26, 2012
    Applicant: Temple University of the Commonwealth System of Higher Education
    Inventors: Kendrick Whitney, James McGuire, Richard Posoff
  • METHOD FOR INHIBITING DECOMPOSITION OF METAL SULFIDE-CONTAINING MATERIAL
    Publication number: 20120021130
    Abstract: This invention provides methods of producing a crosslinked lipid coating on a metal sulfide-containing material using a chemical initiator. The crosslinked lipid coating attached to the surface of the material prevents dissolution or oxidation of the material. The methods may be useful to prevent oxidation and leaking of sulfide-containing material in the environment and may be used in the control of environmental pollution.
    Type: Application
    Filed: March 4, 2010
    Publication date: January 26, 2012
    Applicants: THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK, STONY BROOK, TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Daniel R. Strongin, Martin Schoonen, JUn Hao
  • PROCESS FOR IDENTIFYING DRUGS FOR TREATING GASTROESOPHAGEAL REFLUX
    Publication number: 20110294698
    Abstract: Methods for identifying modulators of gastroesophageal smooth muscle relaxation include isolating various types of smooth muscle fibers from the stomach or esophagus and inducing the fibers to contract. The isolated and contracted fibers are used to screen test compounds for the compound's capacity to modulate relaxation of the smooth muscle fibers. In addition, newly identified unique nicotinic acetylcholine receptors are expressed in a cell, and used to screen test compounds for the compound's capacity to modulate the biological activity of the receptors.
    Type: Application
    Filed: June 21, 2011
    Publication date: December 1, 2011
    Applicant: Temple University of the Commonwealth System of Higher Education
    Inventors: Michael R. Ruggieri, Larry S. Miller, Alan S. Braverman, Anil K. Vegesna, Mary F. Barbe
  • 3-acyl coumarins, thiochromones and quinolones and therapeutic uses thereof
    Patent number: 8067461
    Abstract: Compounds of Formula I: wherein R1, R2, M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: November 29, 2011
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: M. V. Ramana Reddy, E. Premkumar Reddy
  • ADMINISTRATION OF ANGIOCIDIN FOR THE TREATMENT OF CANCER
    Publication number: 20110288021
    Abstract: Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth arrest and/or apoptosis of tumor cells, as well as inducing differentiation of tumor cells to inhibit tumorigenicity and to confer a non-tumor or healthy phenotype.
    Type: Application
    Filed: November 20, 2009
    Publication date: November 24, 2011
    Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: George P. Tuszynski, John F. Wong, Taffy Williams
  • Secret sharing technique with low overhead information content
    Patent number: 8059816
    Abstract: An apparatus and method for sharing a secret comprising the steps of generating a first random matrix, generating a first projection matrix from the first random matrix, and determining a first remainder matrix from the first projection matrix and the first secret matrix. The first secret matrix may be determined using the remainder matrix and a plurality of distributed vector shares.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: November 15, 2011
    Assignee: Temple University of the Commonwealth System of Higher Education
    Inventor: Li Bai
  • PURIFICATION OF SINGLE WALLED CARBON NANOTUBES BY DYNAMIC ANNEALING
    Publication number: 20110274611
    Abstract: A method for removing impurities from carbon nanotubes is described. Impurities may be removed from the carbon nanotubes by exposing the carbon nanotubes to a temperature, and controlling the temperature such that the temperature is constantly increasing to remove at least a portion of the impurities from the carbon nanotubes.
    Type: Application
    Filed: November 11, 2009
    Publication date: November 10, 2011
    Applicant: Temple University - of the Commonwealth System of Higher Education
    Inventors: Nikolay N. Dementev, Eric U. Borguet
  • LOCKING ROD FUSION DEVICE
    Publication number: 20110251614
    Abstract: A locking rod fusion device and method uses internal locking rods and screws that will lock together. In particular, the device allows the insertion of multiple locking rods in combination with a plate, which requires less dissection and disruption of soft tissues and vasculature. The device also provides a more stable internal construct for fusions that prevent non-unions, hardware failure and reoccurrence of deformities, such as Charcot foot. The device combines the strength of locking technology and the utility and ease of an internal rod system to provide a single stable construct in multiple planes as apposed to using multiple plates or screws separately.
    Type: Application
    Filed: November 10, 2009
    Publication date: October 13, 2011
    Applicant: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventor: Jason A. Piraino
  • ACYLATION OF HINDERED AMINES AND FUNCTIONALIZED BIS-PEPTIDES OBTAINED THEREBY
    Publication number: 20110184171
    Abstract: Functionalized bis-peptides as well as other amide-containing compounds are obtained by acylation of hindered amines. The functionalized bis-peptides are useful as shape-programmable nanostructures that are immune to denaturation and that contain arrays of functional groups having designed catalytic, protein-binding and/or sensor capabilities.
    Type: Application
    Filed: January 14, 2011
    Publication date: July 28, 2011
    Applicants: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Christian E. Schafmeister, Zachary Z. Brown
  • PROCESS FOR TRANSIENT AND STEADY STATE DELIVERY OF BIOLOGICAL AGENTS TO THE LUNG VIA BREATHABLE LIQUIDS
    Publication number: 20110162646
    Abstract: The present invention includes a transient method of delivering a biological agent in a breathable liquid to a lung of a patient. The present invention includes a steady state method of delivering a biological agent in a breathable liquid to a lung of a patient. The steps of both the transient delivery method and the steady state delivery method can be controlled by a servo-control unit. A supplementary biological agent delivery step can be performed in both the transient method of delivering a biological agent and the steady state method of delivering a biological agent.
    Type: Application
    Filed: March 17, 2011
    Publication date: July 7, 2011
    Applicant: Temple University - Of The Commonwealth System of Higher Education
    Inventors: Thomas H. Shaffer, Marla R. Wolfson
  • Substituted phenoxy-and phenylthio-derivatives for treating proliferative disorders
    Patent number: 7932242
    Abstract: Substituted phenol derivatives of Formula (I) are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: April 26, 2011
    Assignees: Temple University - Of The Commonwealth System of Higher Education, Onconova Therapeutics Inc.
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy, Stanley C. Bell
  • METHODS AND DEVICES FOR GENERATION OF BROADBAND PULSED RADIATION
    Publication number: 20100321767
    Abstract: Methods and apparatus for non-collinear optical parametric ampliffication (NOPA) are provided. Broadband phase matching is achieved with a non-collinear geometry and a divergent signal seed to provide bandwidth gain. A chirp may be introduced into the pump pulse such that the white light seed is amplified in a broad spectral region.
    Type: Application
    Filed: February 27, 2009
    Publication date: December 23, 2010
    Applicant: Temple University of the Commonwealth System of Higher Education
    Inventors: Eric Borguet, Oleksandr Isaienko