Patents Assigned to Tepha, Inc.
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Patent number: 11779455Abstract: Breast fixation devices for use in breast reconstruction and breast augmentation limit the rotation or movement of breast implants after implantation that results in an unnatural appearance of the breast. The breast fixation devices can include a thin-walled enclosure in the shape of a pouch. A breast implant is secured inside the pouch to limit movement by applying compression to the breast implants, or using a mating or interlocking mechanism between the pouch and breast implant. The pouches containing the breast implants are implanted in the breast. Tissue in-growth into the pouch limits movement of the pouch-breast implant assembly and thereby limits rotation, migration, and displacement of the breast implant. The pouches preferably comprise poly-4-hydroxybutyrate or copolymer thereof.Type: GrantFiled: September 30, 2019Date of Patent: October 10, 2023Assignee: Tepha, Inc.Inventors: Skander Limem, Kristin Crescenzi, Said Rizk, Simon F. Williams
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Patent number: 11766321Abstract: Described herein are breast implant fixation devices for use in breast reconstruction and breast augmentation. Novel wraps are designed to avert lateral displacement and bottoming out of breast implants, reduce capsular contraction and implant extrusion, eliminate skin indentations and ripples caused by breast implants, and reduce or eliminate palpability. The wraps are adapted to securely fold around the breast implants, limiting relative movement between the wrap and breast implant and reducing wrinkles. Tissue in-growth into the wraps limits movement of the wrap-breast implant assembly and thereby limits movement of the breast implant.Type: GrantFiled: November 17, 2020Date of Patent: September 26, 2023Assignee: Tepha, Inc.Inventors: Skander Limem, German Oswaldo Hohl Lopez, Simon F. Williams
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Patent number: 11744696Abstract: A mastopexy implant for maintaining the breast in an elevated and aesthetically pleasing position includes a lower pole support comprising end portions which may be affixed to the chest wall or to a previously installed upper suspension strut. The implant is loaded in an insertion device. The insertion device is inserted through a small incision and into a subcutaneous pocket created in an inferior half of the breast. The lower pole support may have various constructs and in one embodiment includes a unitary conformable mesh having a plurality of arm or band members which are attached across the breast parenchyma and to the chest wall.Type: GrantFiled: August 1, 2020Date of Patent: September 5, 2023Assignee: Tepha, Inc.Inventors: Arikha Moses, Emily Stires, Anthony Natale
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Publication number: 20230226749Abstract: Methods to fabricate objects by 3D printing of poly-4-hydroxybutyrate (P4HB) and copolymers thereof have been developed. In one method, these objects are produced by continuous fused filament fabrication using an apparatus and conditions that overcome the problems of poor feeding of the filament resulting from the low softening temperature of the filament and heat creep along the fed filament. Methods using an apparatus including a heat sink, a melt tube, a heating block and nozzle, and a transition zone between the heat sink and heating block, with the melt tube extending through the heat sink, transition zone, and heat block to the nozzle are disclosed. 3D objects are also printed by fused pellet deposition (FPD), melt extrusion deposition (MED), selective laser melting (SLM), printing of slurries and solutions using a coagulation bath, and printing using a binding solution and polymer granules.Type: ApplicationFiled: March 21, 2023Publication date: July 20, 2023Applicant: Tepha, Inc.Inventors: Skander Limem, Reshad Bin Harun, Matthew Dubois, David P. Martin, Said Rizk
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Publication number: 20230201610Abstract: Nonwoven resorbable pouches that at least partially enclose implantable medical devices and improved methods for producing the implantable medical device pouches are described. The nonwoven pouches may comprise one or more drugs. Implantable medical devices that are placed in the pouches prior to implantation are prevented from migrating from the site of implantation by tissue ingrowth into the pouch. Antibiotics may be incorporated into the pouches to prevent post-operative infections. The pouches may be formed in fewer steps than conventional pouches, and without polymer coatings. Nonwoven pouches can be formed in one step by dry spinning instead of using multiple processing steps. In embodiments, the nonwoven pouches are smoother on the inside than the outside to tightly fit the implantable medical devices internally while encouraging external tissue ingrowth.Type: ApplicationFiled: February 27, 2023Publication date: June 29, 2023Applicant: Tepha, Inc.Inventors: Skander Limem, David Martin, Said Rizk, Simon F. Williams
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Publication number: 20230165673Abstract: Expandable absorbable implants have been developed that are suitable for breast reconstruction following mastectomy. The implants can be implanted in the vicinity of a tissue expander, for example, by suturing to the detached edge of the pectoralis major muscle to function as a pectoralis extender, and used to form a sling for a tissue expander. The implants, which permit tissue-ingrowth and slowly degrade, can be expanded in the breast using a tissue expander in order to form a pocket for a permanent breast implant. After expansion, the tissue expander can be removed and replaced with a permanent breast implant. The expandable implants help reduce patient discomfort resulting from tissue expansion, and avoid the need to use allografts or xenografts to create the pocket for the tissue expander. The expandable absorbable implant preferably comprises poly-4-hydroxybutyrate or copolymer thereof.Type: ApplicationFiled: December 5, 2022Publication date: June 1, 2023Applicant: Tepha, Inc.Inventors: Skander Limem, Bhavin Shah, Said Rizk, Matthew Dubois, Simon F. Williams
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Publication number: 20230149117Abstract: Implantable fiducial marker devices with a predefined shape can deform when stress is applied in vivo, and recover their shape when stress is removed reduce patient discomfort and palpability. The devices can be used to mold irregular tumor resection cavities into a more ideal shape for radiation therapy allowing more accurate treatment. After treatment, the devices resorb eliminating unnecessary testing that occurs when clinicians are unaware of implanted fiducial marker devices. Tissue ingrowth into the devices can also result in improved cosmetic outcomes when the devices are implanted in the breast after a lumpectomy. The devices preferably comprise poly-4-hydroxybutyrate or poly(butylene succinate) or copolymers thereof.Type: ApplicationFiled: March 29, 2021Publication date: May 18, 2023Applicant: Tepha, Inc.Inventors: Kemal Sariibrahimoglu, Skander Limem, Said Rizk, Simon F. Williams
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Patent number: 11639024Abstract: Methods to fabricate objects by 3D printing of poly-4-hydroxybutyrate (P4HB) and copolymers thereof have been developed. In one method, these objects are produced by continuous fused filament fabrication using an apparatus and conditions that overcome the problems of poor feeding of the filament resulting from the low softening temperature of the filament and heat creep along the fed filament. Methods using an apparatus including a heat sink, a melt tube, a heating block and nozzle, and a transition zone between the heat sink and heating block, with the melt tube extending through the heat sink, transition zone, and heat block to the nozzle are disclosed. 3D objects are also printed by fused pellet deposition (FPD), melt extrusion deposition (MED), selective laser melting (SLM), printing of slurries and solutions using a coagulation bath, and printing using a binding solution and polymer granules.Type: GrantFiled: June 28, 2022Date of Patent: May 2, 2023Assignee: Tepha, Inc.Inventors: Skander Limem, Reshad Bin Harun, Matthew Dubois, David P. Martin, Said Rizk
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Patent number: 11612754Abstract: Nonwoven resorbable pouches that at least partially enclose implantable medical devices and improved methods for producing the implantable medical device pouches are described. The nonwoven pouches may comprise one or more drugs. Implantable medical devices that are placed in the pouches prior to implantation are prevented from migrating from the site of implantation by tissue ingrowth into the pouch. Antibiotics may be incorporated into the pouches to prevent post-operative infections. The pouches may be formed in fewer steps than conventional pouches, and without polymer coatings. Nonwoven pouches can be formed in one step by dry spinning instead of using multiple processing steps. In embodiments, the nonwoven pouches are smoother on the inside than the outside to tightly fit the implantable medical devices internally while encouraging external tissue ingrowth.Type: GrantFiled: August 28, 2019Date of Patent: March 28, 2023Assignee: Tepha, Inc.Inventors: Skander Limem, David Martin, Said Rizk, Simon F. Williams
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Patent number: 11554007Abstract: Expandable absorbable implants have been developed that are suitable for breast reconstruction following mastectomy. The implants can be implanted in the vicinity of a tissue expander, for example, by suturing to the detached edge of the pectoralis major muscle to function as a pectoralis extender, and used to form a sling for a tissue expander. The implants, which permit tissue-ingrowth and slowly degrade, can be expanded in the breast using a tissue expander in order to form a pocket for a permanent breast implant. After expansion, the tissue expander can be removed and replaced with a permanent breast implant. The expandable implants help reduce patient discomfort resulting from tissue expansion, and avoid the need to use allografts or xenografts to create the pocket for the tissue expander. The expandable absorbable implant preferably comprises poly-4-hydroxybutyrate or copolymer thereof.Type: GrantFiled: February 19, 2019Date of Patent: January 17, 2023Assignee: Tepha, Inc.Inventors: Skander Limem, Bhavin Shah, Said Rizk, Matthew Dubois, Simon F. Williams
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Publication number: 20220387171Abstract: Implants with fillable reservoirs have been developed that are suitable for rhinoplasty, breast reconstruction, ear reconstruction, and replacement, reconstruction or repair of other soft tissues. The implants can be filled with graft material prior to implantation. The implants are preferably made from resorbable polymers, can be tailored to provide different geometries, mechanical properties and resorption rates in order to provide more consistent surgical outcomes. The implants preferably have an interconnected network of unit cells with rnicroporous outer layers and optionally some or all of the unit cells having at least one macropore in their outer layers. The implants can be loaded by injection with microfat, collagen, DCF, cells, bioactive agents, and other augmentation materials, prior to implantation.Type: ApplicationFiled: February 24, 2022Publication date: December 8, 2022Applicant: Tepha, Inc.Inventors: Skander Limem, Fabio Felix, Said Rizk, David P. Martin, Simon F. Williams
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Publication number: 20220362001Abstract: Absorbable implants for breast surgery that conform to the breast parenchyma and surrounding chest wall have been developed. These implants support newly lifted breast parenchyma, and/or a breast implant. The implants have mechanical properties sufficient to support a reconstructed breast, and allow the in-growth of tissue into the implant as it degrades. The implants have a strength retention profile allowing the support of the breast to be transitioned from the implant to regenerated host tissue, without significant loss of support. Three-dimensional implants for use in minimally invasive mastopexy/breast reconstruction procedures are also described, that confer shape to a patient's breast. These implants are self-reinforced, can be temporarily deformed, implanted in a suitably dissected tissue plane, and resume their preformed three-dimensional shape. The implants are preferably made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof.Type: ApplicationFiled: July 22, 2022Publication date: November 17, 2022Applicant: Tepha, Inc.Inventors: Fabio Felix, Antonio Fosco, David P. Martin, Arikha Moses, Bruce Van Natta, Said Rizk, Simon F. Williams
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Publication number: 20220354988Abstract: Absorbable monofilament fibers and self-retaining sutures with high tensile strengths have been developed. The straight pull tensile strengths of the absorbable self-retaining sutures closely approximate, equal or exceed the average minimum knot-pull tensile standards set by the United States Pharmacopeia (USP). These higher strength absorbable self-retaining sutures can therefore be used either without needing to oversize the suture for a given procedure, or by oversizing the self-retaining suture by no more than 0.1 mm in diameter. In one embodiment, the absorbable self-retaining sutures are made from poly-4-hydroxybutyrate or copolymers thereof.Type: ApplicationFiled: July 21, 2022Publication date: November 10, 2022Applicant: Tepha, Inc.Inventors: Said Rizk, Simon F. Williams
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Publication number: 20220324162Abstract: Methods to fabricate objects by 3D printing of poly-4-hydroxybutyrate (P4HB) and copolymers thereof have been developed. In one method, these objects are produced by continuous fused filament fabrication using an apparatus and conditions that overcome the problems of poor feeding of the filament resulting from the low softening temperature of the filament and heat creep along the fed filament. Methods using an apparatus including a heat sink, a melt tube, a heating block and nozzle, and a transition zone between the heat sink and heating block, with the melt tube extending through the heat sink, transition zone, and heat block to the nozzle are disclosed. 3D objects are also printed by fused pellet deposition (FPD), melt extrusion deposition (MED), selective laser melting (SLM), printing of slurries and solutions using a coagulation bath, and printing using a binding solution and polymer granules.Type: ApplicationFiled: June 28, 2022Publication date: October 13, 2022Applicant: Tepha, Inc.Inventors: Skander Limem, Reshad Bin Harun, Matthew Dubois, David P. Martin, Said Rizk
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Publication number: 20220287820Abstract: Absorbable implants can be used to create volume and shape in the breast of a patient with regenerated tissue. The implants comprise scaffolds formed from layers of parallel filaments. The layers of filaments can be stacked and bonded together to form scaffolds with porous crisscross arrangements of filaments. The implant's scaffolds may be coated or filled with cells and tissues, including autologous fat graft, and/or a vascular pedicle may be inserted into the implant. The implants are particularly suitable for use in plastic surgery procedures, for example, to regenerate or augment breast tissue following mastectomy or in mastopexy procedures, and can provide an alternative to the use of permanent breast implants in these procedures.Type: ApplicationFiled: March 8, 2022Publication date: September 15, 2022Applicant: Tepha, Inc.Inventors: Skander Limem, Kemal Sariibrahimoglu, Timothy J. Butler, German Oswaldo Hohl Lopez, Simon F. Williams
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Patent number: 11439490Abstract: Absorbable implants for breast surgery that conform to the breast parenchyma and surrounding chest wall have been developed. These implants support newly lifted breast parenchyma, and/or a breast implant. The implants have mechanical properties sufficient to support a reconstructed breast, and allow the in-growth of tissue into the implant as it degrades. The implants have a strength retention profile allowing the support of the breast to be transitioned from the implant to regenerated host tissue, without significant loss of support. Three-dimensional implants for use in minimally invasive mastopexy/breast reconstruction procedures are also described, that confer shape to a patient's breast. These implants are self-reinforced, can be temporarily deformed, implanted in a suitably dissected tissue plane, and resume their preformed three-dimensional shape. The implants are preferably made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof.Type: GrantFiled: February 21, 2020Date of Patent: September 13, 2022Assignee: Tepha, Inc.Inventors: Fabio Felix, Antonio Fosco, David P. Martin, Arikha Moses, Bruce Van Natta, Said Rizk, Simon F. Williams
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Patent number: 11426484Abstract: Absorbable monofilament fibers and self-retaining sutures with high tensile strengths have been developed. The straight pull tensile strengths of the absorbable self-retaining sutures closely approximate, equal or exceed the average minimum knot-pull tensile standards set by the United States Pharmacopeia (USP). These higher strength absorbable self-retaining sutures can therefore be used either without needing to oversize the suture for a given procedure, or by oversizing the self-retaining suture by no more than 0.1 mm in diameter. In one embodiment, the absorbable self-retaining sutures are made from poly-4-hydroxybutyrate or copolymers thereof. Methods for producing absorbable self-retaining sutures that have high tensile strengths and pronounced sheath-core structures wherein the sheath is harder than the core are also provided.Type: GrantFiled: December 9, 2019Date of Patent: August 30, 2022Assignee: Tepha, Inc.Inventors: Said Rizk, Simon F. Williams
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Patent number: D977102Type: GrantFiled: July 10, 2021Date of Patent: January 31, 2023Assignee: Tepha, Inc.Inventors: Skander Limem, Said Rizk, Simon F. Williams
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Patent number: D976407Type: GrantFiled: May 22, 2020Date of Patent: January 24, 2023Assignee: Tepha, Inc.Inventors: Skander Limem, Said Rizk, Simon F. Williams
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Patent number: D985773Type: GrantFiled: July 10, 2021Date of Patent: May 9, 2023Assignee: Tepha, Inc.Inventors: Skander Limem, Emily Stires, Rebecca Marciante, Said Rizk, Arikha Moses, Fabio Felix, Bruce Van Natta