Patents Assigned to Terumo BCT, Inc.
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Patent number: 8399245Abstract: A system and method for rotating a cell growth chamber of a cell expansion system includes a rotatable member for engaging a chamber coupling attached to the cell growth chamber. The rotatable member includes an independently operable mechanism for engaging a rotatable fitting associated with the chamber coupling. In at least one embodiment, the chamber coupling is selectively rotatable by turning the rotatable member, thereby rotating the cell growth chamber around a first axis. The cell growth chamber is also selectively rotatable around a second axis by turning the rotatable fitting associated with the chamber coupling. Other novel aspects include a way of attaching the cell growth chamber to the shaft assembly, and a new tube routing clip.Type: GrantFiled: February 9, 2010Date of Patent: March 19, 2013Assignee: Terumo BCT, Inc.Inventors: Paul M. Leuthaeuser, Jon A. Dodd, Thomas G. DiLorenzo
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Publication number: 20130040797Abstract: A method is provided in a centrifugal blood processing system for adding replacement fluid without a dedicated peristaltic pump to blood components being returned to the donor. A disposable blood processing set for use in the method comprises a hermetically sealed set of blood bags, connecting tubes, needles or connectors, and supporting structures with a replacement fluid line coupled directly to a return reservoir without contact with an intervening pump.Type: ApplicationFiled: August 8, 2012Publication date: February 14, 2013Applicant: Terumo BCT, Inc.Inventors: John R. LINDNER, William SWEAT
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Patent number: 8366086Abstract: A hand held opener for opening a frangible closer comprising a handle adapted to be gripped by an operator, a motion actuator operatively connected to the handle, a first shaft connected to the motion actuator, a second shaft connected to the motion actuator, a first gripper portion on the first shaft adapted to grip the frangible closer in a first location, and a second gripper portion on the second shaft adapted to grip the frangible closer in a second location wherein the motion actuator provides reciprocal movement to the shafts to rotate the frangible closer in one direction and to rotate the frangible closer in a direction opposite the first direction.Type: GrantFiled: November 24, 2009Date of Patent: February 5, 2013Assignee: Terumo BCT, Inc.Inventors: Joseph D. Bucciaglia, Victor D. Dolecek, Darryl Hudock
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Patent number: 8337380Abstract: An apparatus for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising a valve design that facilitates loading and unloading of blood bags and associated tubing and bag sets. The valves comprise a rotating head, mounted on a shaft, which assumes a “load” position. The head pivots to an “open” position, which secures the tube in its designated location, but which maintains an open lumen through the tube. When the head is in a “closed” position, blood components cannot flow through the tube. The valve apparatus comprises means for maintaining a constant pressure on the tube and contact with the tube as the tube is melted and sealed.Type: GrantFiled: November 8, 2010Date of Patent: December 25, 2012Assignee: Terumo BCT, Inc.Inventors: Bruce Ellingboe, Hong Duc Nguyen
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Patent number: 8337379Abstract: A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of “spoiling” the image, “diffusing” the image, “edge detection”, “edge linking”, “region-based confirmation”, and “interface calculation”. “Spoiling” reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. “Diffusing” smoothes out small oscillations in the interface boundary, making the location of the interface more distinct. “Edge detection” computes the rate of change in pixel intensity, or. “Edge linking” connects adjacent maxima. “Region-based confirmation” creates a pseudo image of the regions that qualify as distinct. “Final edge calculation” uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.Type: GrantFiled: July 2, 2007Date of Patent: December 25, 2012Assignee: Terumo BCT, Inc.Inventors: Christopher Fletcher, William Sweat, Jeremy Kolenbrander, Aditya Dalvi, John R. Linder
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Publication number: 20120316049Abstract: A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, a primary outlet and a side tap outlet adjacent the inlet. A valve that is responsive to centrifugal force (a “gravity” valve) selects between the outlet and the side tap outlet. The gravity valve is mounted on the rotor. When the rotor spins at high speed, the gravity valve may open the primary outlet and close the side tap outlet. When the rotor spins at a lower speed, the gravity valve may open the side tap outlet and close the primary outlet.Type: ApplicationFiled: June 12, 2012Publication date: December 13, 2012Applicant: TERUMO BCT, INC.Inventors: Brian M. HOLMES, James R. LADTKOW
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Publication number: 20120316051Abstract: A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, and outlet and a side tap outlet adjacent the inlet. The inlet may protrude into the cell separation chamber forming a circumferential well surrounding the protruding inlet. The side tap outlet may connect to the well. The set and system comprise means for selectively drawing fluid from either the outlet or the side tap outlet.Type: ApplicationFiled: May 23, 2012Publication date: December 13, 2012Applicant: TERUMO BCT, INC.Inventor: Brian M. HOLMES
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Patent number: 8321145Abstract: This invention relates to a cell expansion system and to a method of determining when to harvest cells from the cell expansion system.Type: GrantFiled: August 6, 2009Date of Patent: November 27, 2012Assignee: Terumo BCT, Inc.Inventor: Glen Delbert Antwiler
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Publication number: 20120295352Abstract: Embodiments described herein generally relate to systems and methods for promoting the expansion of high density non-adherent cells through the use of a cell growth chamber, a mass transfer device, and a fluid circulation loop. Improved cell growth is achieved in the cell growth chamber by using a chamber having a particular orientation and shape, e.g., conical, to create a media-rich reservoir for growing cells. By placing the chamber in a vertical position, the force of media flow along the chamber walls is substantially equal and opposite to the gravitational force on the cells. The interaction of these forces maintains the non-adherent cells in suspension. The use of the cell growth chamber in conjunction with the mass transfer device and fluid circulation loop(s) creates efficiencies by relying on the cumulative and combined features of the devices.Type: ApplicationFiled: May 16, 2012Publication date: November 22, 2012Applicant: TERUMO BCT, INC.Inventor: Glen Delbert ANTWILER
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Patent number: 8309347Abstract: Cell expansion systems and methods of use are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second circulation loops (intracapillary loops and extracapillary loops) associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. Detachable flow circuits and methods of expanding cells are also provided.Type: GrantFiled: March 5, 2008Date of Patent: November 13, 2012Assignee: Terumo BCT, Inc.Inventor: Glen Delbert Antwiler
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Patent number: 8287742Abstract: Method for separating a volume of whole blood into at least a plasma component and a red blood cell component comprising centrifuging a separation bag containing a volume of whole blood so as to separate therein at least a first component comprising plasma and a second component comprising red blood cells; transferring the first component into a plasma component bag during centrifugation of the separation bag; transferring into the separation bag a volume of wash solution from a wash solution bag during centrifugation of the separation bag; mixing the volume of wash solution with the second component; centrifuging the separation bag so as to separate therein a washed red blood cell component and a supernatant component; and transferring the supernatant component into a waste bag during centrifugation of the separation bag.Type: GrantFiled: December 5, 2007Date of Patent: October 16, 2012Assignee: Terumo BCT, Inc.Inventor: Brian M. Holmes
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Patent number: 8277406Abstract: A method for separating a volume of whole blood contained in a separation bag into at least three components comprising centrifuging the separation bag so as to separate therein a first inner layer comprising plasma, a second intermediate layer comprising platelets, a third intermediate layer comprising lymphocytes, monocytes and granulocytes and a fourth outer layer comprising red blood cells, transferring, into a plasma component bag connected to the separation bag, a plasma component and transferring into a mononuclear cell component bag a mononuclear cell components.Type: GrantFiled: December 8, 2009Date of Patent: October 2, 2012Assignee: Terumo BCT, Inc.Inventors: Thomas Felt, Brian M. Holmes, Bruce Gibbs
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Publication number: 20120205041Abstract: The present invention relates to a method of assemblying a cell growth module, and preventing the formation of cytotoxic chemicals in the cell growth module which may interfere with the growth of the cells in the cell growth module. Electromagnetic radiation such as gamma irradiation may be used to treat the membrane surface prior to the membrane being inserted into the housing. The cell growth module includes at least a membrane and a housing.Type: ApplicationFiled: October 4, 2010Publication date: August 16, 2012Applicant: TERUMO BCT, INC.Inventor: Fredrik Dalborg
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Patent number: 8241196Abstract: The invention relates to apparatus for controlling the processing of blood into blood components, particularly components for stroboscopic LED light sources for centrifuges. A digital control circuit controls a high amperage linear voltage regulator. The voltage regulator charges a capacitor bank, which in turn powers LED light sources. The digital control circuit comprises an N-channel switched mode FET. The switched mode FET receives a pulsed digital signal from the microprocessor controlling the blood processing apparatus. A by-pass resistor in parallel with the FET allows most of the current to flow past the FET, thus minimizes heating of the FET. The performance of the FET, therefore, remains stable despite extended use of the apparatus.Type: GrantFiled: December 4, 2009Date of Patent: August 14, 2012Assignee: Terumo BCT, Inc.Inventor: Joseph A. Scibona
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Patent number: 8236184Abstract: A method related to using a squeezing or transfer fluid to transfer fluid or components between bags in a centrifuge wherein the squeezing fluid can be reversed to reduce squeezing and such fluid an also be used to build up a over-pressure for rapid movement.Type: GrantFiled: October 31, 2007Date of Patent: August 7, 2012Assignee: Terumo BCT, Inc.Inventors: Brian M. Holmes, Peter Pihlstedt
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Patent number: 8226537Abstract: A disposable blood separation set of a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber a baffle within a separation area. The baffle may have a plurality of vanes with openings therein. A protruding inlet may have a frustro-conical inner surface that slants radially outwardly from an inlet to a mouth of the protruding inlet. A circumferential well may surround the protruding inlet.Type: GrantFiled: May 19, 2011Date of Patent: July 24, 2012Assignee: Terumo BCT, Inc.Inventors: John Pittinger, Robert Langley, Mary Langley, legal representative, Logan Fender
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Patent number: 8173027Abstract: Method for separating a volume of composite liquid into at least a first component and a second component including centrifuging a separation bag containing a volume of composite liquid and a volume of gas so as to sediment at least a first component and a second component separation bag; displacing a volume of hydraulic fluid against the separation bag to cause a transfer of at least one fraction of the content of the separation bag into at least one component bag connected to the separation bag; determining the volume of hydraulic fluid displaced and determining the volume of the composite liquid or the transferred components from the determined volume of displaced hydraulic fluid.Type: GrantFiled: August 28, 2007Date of Patent: May 8, 2012Assignee: Terumo BCT, Inc.Inventors: Niclas Högberg, Brian M. Holmes, Briden Ray Stanton, Lars Persson, Lars Strandberg, Peter Pihlstedt
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Patent number: 8163555Abstract: A disposable apparatus for cell expansion, having at least one bioreactor. The bioreactor has a cellular growth area and a supply area, the cellular growth area being separated from said supply area by a membrane. A fluid recirculation path in fluid communication with the cellular growth area allows for hermetically removing a sample containing cellular matter. This may comprise an elongated tube, or a plurality of parallel tube segments. The parallel tube segments have inflow ends and outflow ends, and the inflow ends are joined at a first common juncture and the outflow ends are joined at a second common juncture. The common junctures may comprise valves.Type: GrantFiled: February 16, 2010Date of Patent: April 24, 2012Assignee: Terumo BCT, Inc.Inventor: Glen Delbert Antwiler