Patents Assigned to Terumo BCT, Inc.
  • Publication number: 20140051167
    Abstract: One or more embodiments are described directed to a method and system for concentrating components of a fluid circulated through a cell growth chamber such as a cell growth chamber. Accordingly, embodiments include methods and systems that utilize a tangential flow filter to concentrate components of a fluid that in embodiments includes expanded cells. In embodiments, a concentrated fluid component and a concentrated cell component are generated by flowing the fluid with expanded cells across a tangential flow filter. The concentrated cell component may be recirculated to the tangential flow filter to reach some desired concentration of cells. The concentrated fluid component may be collected to utilize cellular-produced constituents in the concentrated fluid component.
    Type: Application
    Filed: August 20, 2013
    Publication date: February 20, 2014
    Applicant: Terumo BCT, Inc.
    Inventors: Brian J. NANKERVIS, Thomas G. DiLorenzo, Michael E. Kinzie, Mark E. Jones
  • Publication number: 20140005023
    Abstract: A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.
    Type: Application
    Filed: August 29, 2013
    Publication date: January 2, 2014
    Applicant: Terumo BCT, Inc.
    Inventors: Jeremy P. KOLENBRANDER, Brian M. HOLMES, Thomas J. FELT, James R. LADTKOW
  • Publication number: 20130264288
    Abstract: Method and apparatus for separating plasma from blood in a separation vessel, separating the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the separation vessel to receive the separated plasma, and adding photosensitizer to the desired plasma proteins for viral inactivation treatment of such proteins.
    Type: Application
    Filed: April 5, 2013
    Publication date: October 10, 2013
    Applicant: Terumo BCT, Inc.
    Inventors: Dennis J. HLAVINKA, Thomas J. FELT, Gabriela MALDONADO-CODINA
  • Patent number: 8540614
    Abstract: An apparatus for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising a valve design that facilitates loading and unloading of blood bags and associated tubing and bag sets. The valves comprise a rotating head, mounted on a shaft, which assumes a “load” position. The head pivots to an “open” position, which secures the tube in its designated location, but which maintains an open lumen through the tube. When the head is in a “closed” position, blood components cannot flow through the tube. The valve apparatus comprises means for maintaining a constant pressure on the tube and contact with the tube as the tube is melted and sealed.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: September 24, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: Bruce Ellingboe, Hong Duc Nguyen
  • Patent number: 8535210
    Abstract: A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: September 17, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: Jeremy P. Kolenbrander, Brian M. Holmes, Thomas J. Felt, James R. Ladtkow
  • Patent number: 8523750
    Abstract: A centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and a method for controlling the blood processing apparatus comprising separating a blood component in a separation chamber; flowing the blood component out of the separation chamber and into a concentration chamber; concentrating the blood component in the concentration chamber; and flushing the blood component out of the concentration chamber. The method further comprising simultaneously flowing a solution, such as a wash solution or PAS, into the concentration chamber between the separation chamber and the concentration chamber.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: September 3, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: John Pittinger, Logan Fender
  • Patent number: 8501015
    Abstract: A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of “spoiling” the image, “diffusing” the image, “edge detection”, “edge linking”, “region-based confirmation”, and “interface calculation”. “Spoiling” reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. “Diffusing” smoothes out small oscillations in the interface boundary, making the location of the interface more distinct. “Edge detection” computes the rate of change in pixel intensity. “Edge linking” connects adjacent maxima. “Region-based confirmation” creates a pseudo image of the regions that qualify as distinct. “Final edge calculation” uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: August 6, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: Christopher Fletcher, William Sweat, Jeremy Kolenbrander, Aditya Dalvi, John R. Linder
  • Publication number: 20130157366
    Abstract: A system and method for rotating a cell growth chamber of a cell expansion system includes a rotatable member for engaging a chamber coupling attached to the cell growth chamber. The rotatable member includes an independently operable mechanism for engaging a rotatable fitting associated with the chamber coupling. In at least one embodiment, the chamber coupling is selectively rotatable by turning the rotatable member, thereby rotating the cell growth chamber around a first axis. The cell growth chamber is also selectively rotatable around a second axis by turning the rotatable fitting associated with the chamber coupling. Other novel aspects include a way of attaching the cell growth chamber to the shaft assembly, and a new tube routing clip.
    Type: Application
    Filed: February 13, 2013
    Publication date: June 20, 2013
    Applicant: Terumo BCT, Inc.
    Inventor: Terumo BCT, Inc.
  • Publication number: 20130153047
    Abstract: The invention pertains to a method of connecting at least two containers for enabling a transfer of liquid from one container to the other container, comprising the steps of: a) Depositing a first cassette including at least a first container on a first tray. The first container has a plurality of connecting means. b) Depositing a second cassette including a second container on a second tray. The cassettes or the containers include a data storage means. c) The data are read by respective data reading means. d) The data are processed and it is verified whether they match each other. e1) In case of a negative result, the second cassette is removed and the steps from step b) onwards are repeated. e2) In case of a positive verification result, the containers are connected. f) Removing the second cassette. g) Repeating steps b) to f) a plurality of times.
    Type: Application
    Filed: June 21, 2011
    Publication date: June 20, 2013
    Applicant: TERUMO BCT, INC.
    Inventors: Roland Biset, Francois Bidet, Wilfried Mertens
  • Publication number: 20130153482
    Abstract: Described are embodiments of a filter that may include an outer housing, an inlet tube, an outlet tube, filter media and an attachment element attaching the filter media to one of the inlet and outlet tubes. Other embodiments describe methods of manufacturing a filter.
    Type: Application
    Filed: December 14, 2012
    Publication date: June 20, 2013
    Applicant: TERUMO BCT, INC.
    Inventor: Terumo BCT, Inc.
  • Publication number: 20130149692
    Abstract: A method for determining platelet pre-count in centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and having an inlet line, and an outlet line. The apparatus tests flow conditions using a red light-green light sensor to determine a donor platelet pre-count.
    Type: Application
    Filed: December 7, 2012
    Publication date: June 13, 2013
    Applicant: Terumo BCT, Inc.
    Inventor: Terumo BCT, Inc.
  • Patent number: 8449439
    Abstract: A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of “spoiling” the image, “diffusing” the image, “edge detection”, “edge linking”, “region-based confirmation”, and “interface calculation”. “Spoiling” reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. “Diffusing” smoothes out small oscillations in the interface boundary, making to the location of the interface more distinct. “Edge detection” computes the rate of change in pixel intensity. “Edge linking” connects adjacent maxima. “Region-based confirmation” creates a pseudo image of the regions that qualify as distinct. “Final edge calculation” uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: May 28, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: Christopher Fletcher, William Sweat, Jeremy P. Kolenbrander, Aditya Dalvi, John R. Lindner
  • Publication number: 20130107043
    Abstract: A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of “spoiling” the image, “diffusing” the image, “edge detection”, “edge linking”, “region-based confirmation”, and “interface calculation”. “Spoiling” reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. “Diffusing” smoothes out small oscillations in the interface boundary, making the location of the interface more distinct. “Edge detection” computes the rate of change in pixel intensity. “Edge linking” connects adjacent maxima. “Region-based confirmation” creates a pseudo image of the regions that qualify as distinct. “Final edge calculation” uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.
    Type: Application
    Filed: November 16, 2012
    Publication date: May 2, 2013
    Applicant: TERUMO BCT, INC.
    Inventor: TERUMO BCT, INC.
  • Publication number: 20130105571
    Abstract: The invention pertains to a cassette (1) provided as a cover of an accommodation section of a container (3) which can be filled with a liquid separable into individual components by means of a centrifuge, having: a plurality of containers (3, 5, 7) where a central container (3) is fixedly arranged at the cassette (1) and said central container (3) is connected to at least one outer container (5, 7) through interruptible connection means (15, 17, 11), and a data storage device (19) arranged on the cassette (1) or on the central container (3). Furthermore, the invention pertains to a workstation for marking containers (5, 7) containing a liquid and a corresponding method.
    Type: Application
    Filed: June 21, 2011
    Publication date: May 2, 2013
    Applicant: TERUMO BCT, INC.
    Inventors: Roland Biset, Francois Bidet
  • Publication number: 20130102070
    Abstract: Cell expansion systems and methods of use are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second circulation loops (intracapillary loops and extracapillary loops) associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. Detachable flow circuits and methods of expanding cells are also provided.
    Type: Application
    Filed: October 16, 2012
    Publication date: April 25, 2013
    Applicant: TERUMO BCT, INC.
    Inventor: Terumo BCT, Inc.
  • Patent number: 8425448
    Abstract: This invention is directed to a method of collecting and separating whole blood into components. The method includes the steps of adding an anticoagulant having an acidic pH to a bag for collecting and/or separating whole blood, collecting whole blood in the bag, loading the bag containing anticoagulated whole blood on a rotor, spinning the bag on the rotor to separate the whole blood into at least one component; and squeezing the bag on the rotor to push the component from the separation bag into at least one satellite bag.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: April 23, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: Thomas Felt, Peter Pihlstedt, Bruce Gibbs
  • Publication number: 20130085054
    Abstract: An apparatus for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising a valve design that facilitates loading and unloading of blood bags and associated tubing and bag sets. The valves comprise a rotating head, mounted on a shaft, which assumes a “load” position. The head pivots to an “open” position, which secures the tube in its designated location, but which maintains an open lumen through the tube. When the head is in a “closed” position, blood components cannot flow through the tube. The valve apparatus comprises means for maintaining a constant pressure on the tube and contact with the tube as the tube is melted and sealed.
    Type: Application
    Filed: November 20, 2012
    Publication date: April 4, 2013
    Applicant: TERUMO BCT, INC.
    Inventor: Terumo BCT, Inc.
  • Publication number: 20130072367
    Abstract: A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of “spoiling” the image, “diffusing” the image, “edge detection”, “edge linking”, “region-based confirmation”, and “interface calculation”. “Spoiling” reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. “Diffusing” smoothes out small oscillations in the interface boundary, making to the location of the interface more distinct. “Edge detection” computes the rate of change in pixel intensity. “Edge linking” connects adjacent maxima. “Region-based confirmation” creates a pseudo image of the regions that qualify as distinct. “Final edge calculation” uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.
    Type: Application
    Filed: November 16, 2012
    Publication date: March 21, 2013
    Applicant: TERUMO BCT, INC.
    Inventor: Terumo BCT, Inc.
  • Patent number: 8399245
    Abstract: A system and method for rotating a cell growth chamber of a cell expansion system includes a rotatable member for engaging a chamber coupling attached to the cell growth chamber. The rotatable member includes an independently operable mechanism for engaging a rotatable fitting associated with the chamber coupling. In at least one embodiment, the chamber coupling is selectively rotatable by turning the rotatable member, thereby rotating the cell growth chamber around a first axis. The cell growth chamber is also selectively rotatable around a second axis by turning the rotatable fitting associated with the chamber coupling. Other novel aspects include a way of attaching the cell growth chamber to the shaft assembly, and a new tube routing clip.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: March 19, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: Paul M. Leuthaeuser, Jon A. Dodd, Thomas G. DiLorenzo
  • Publication number: 20130040797
    Abstract: A method is provided in a centrifugal blood processing system for adding replacement fluid without a dedicated peristaltic pump to blood components being returned to the donor. A disposable blood processing set for use in the method comprises a hermetically sealed set of blood bags, connecting tubes, needles or connectors, and supporting structures with a replacement fluid line coupled directly to a return reservoir without contact with an intervening pump.
    Type: Application
    Filed: August 8, 2012
    Publication date: February 14, 2013
    Applicant: Terumo BCT, Inc.
    Inventors: John R. LINDNER, William SWEAT