Abstract: Functionalized pyrano[2,3-d]pyrimidin-7-one derivatives, methods for making the derivatives, and methods of using the derivatives as protein kinase inhibitors.

Abstract: An apparatus, method and system for real-time monitoring of underwater risers, cables, and mooring lines based on a Kalman filter. In an embodiment, the system is formed with sensors configured to sense an inclination of a riser segment between riser nodes of the riser between the upper end and the lower end. A data processing system is configured to employ a Kalman filter algorithm to produce real-time estimates of a deformed shape and a stress of the riser segment using the sensed inclination between the riser nodes.

Abstract: An approximating anchor device, corresponding kits, and methods for implementing the device are described herein. In one embodiment, the approximating anchor device includes a first cylindrical fastener defining a first set of cross lumens, each of the first set of cross lumens extending substantially perpendicular to a central axis of the first cylindrical fastener, a second cylindrical fastener defining a second set of cross lumens, each of the second set of cross lumens extending substantially perpendicular to a central axis of the second cylindrical fastener, and a string running through the first set of cross lumens of the first cylindrical fastener and the second set of cross lumens of the second cylindrical fastener. Tightening of the string will draw the first cylindrical fastener and the second cylindrical fastener towards each other.

Abstract: In an embodiment, the present disclosure pertains to an oleaginous bacterium. In some embodiments, the oleaginous bacterium includes lipids and at least one exogenous and inducible gene. In some embodiments, the exogenous and inducible gene encodes at least one protein capable of inducing lysis in the oleaginous bacterium to release the lipids. In an addition embodiment, the present disclosure pertains to a method of releasing lipids into an environment. In general, the method includes one or more of the following steps of: (1) introducing at least one oleaginous bacterium of the present disclosure to the environment; and (2) inducing expression of at least one exogenous gene in the oleaginous bacterium to thereby induce the expression of at least one protein. In some embodiments, the protein facilitates the lysis of the oleaginous bacterium and release of the lipids into the environment.

Abstract: Methods and systems for reducing the concentration of selenocyanate in water. In the methods and systems, water containing selenocyanate is treated an oxidant to provide oxidant-treated water, which is then contacted with a zero-valent iron treatment system comprising (a) a reactive solid comprising zero-valent iron and one or more iron oxide minerals in contact therewith and (b) ferrous iron.

Abstract: A method of capturing and converting a gas includes supplying a first gas to an adsorption column, adsorbing a first component of the first gas into an adsorbent contained in the adsorption column responsive to the adsorbent having an increased affinity for the first component, venting a second component of the first gas out of the adsorption column, supplying a second gas to the adsorption column so as to increase a partial pressure of the second gas thereby decreasing the partial pressure of the first component within the adsorption column, desorbing the first component from the adsorbent responsive to the increased partial pressure of the second gas and decreased partial pressure of the at least one first component, and transmitting a mixture of the first component and the second gas to a reactor via a reactor line.

Abstract: An autonomous landing system for vertical landing aircraft includes a vertical landing aircraft including a powertrain and an onboard camera, a motion-stabilized visual cue including a visual indicator, wherein the visual cue is configured to maintain a fixed orientation of the visual indicator with respect to a horizon, and an autonomous control system configured to control a position of the aircraft with respect to the visual indicator of the visual cue based on image data captured by the onboard camera.

Abstract: Phase change material compositions and methods for using the compositions to prepare substrate coatings or bulk blended polymers that advantageously lower friction between interacting substrate surfaces and lower substrate surface wear.

Abstract: An amphibious vehicle for traversing land and bodies of water includes a chassis, and a cycloidal propeller coupled to the chassis and which includes a plurality of cycloidal propeller blades rotatably coupled to the chassis and each extending parallel a rotational axis of the cycloidal propeller, and an extension/retraction system configured to extend the plurality of cycloidal propeller blades away from the chassis and to retract the plurality of cycloidal propeller blades towards the chassis.

Abstract: Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.

Abstract: An apparatus for measurement of Thomson scattering signals from a plasma includes a light emitting device, configured to emit a light beam into the plasma, along an axis. In addition, the apparatus includes a collector configured to collect the Thomson scattering from the plasma at an angle less than 90 degrees from the axis of the light beam. Further, the apparatus includes a sensor assembly to detect the Thomson scattering.

Abstract: A system containing a reactor vessel including zero valent iron media, a source of a conditioning additive, a source of a reaction additive, and a process control subsystem is disclosed. A method for reducing a concentration of one or more contaminants in contaminated water including contacting zero valent iron media with a conditioning additive, contacting contaminated water with conditioned zero valent iron media, and introducing a reaction additive is also disclosed. The conditioning additive and reaction additive may each contain an aluminum salt.

Abstract: Hydrogel-based sorbents and methods for their use in collecting, concentrating, and removing environmental per- and poly-fluoroalkyl substances. In one aspect, the invention provides hydrogel-based sorbents that are effective for collecting, concentrating, and removing PFASs from an environment in which the sorbent is placed; an environment in which the sorbent is in contact with (e.g., liquid communication).

Abstract: Methods and reactors for electrochemically expanding a parent material and expanded parent materials are described. Current methods of expanding parent materials incompletely-expand parent material, requiring expensive and time-consuming separation of expanded parent material from unexpanded parent materials. This problem is addressed by the methods and reactor for electrochemically expanding a parent material described herein, which during operation maintain electrical connectivity between the parent material and an electrical power source. The resulting materials described herein have a greater proportion of expanded parent material relative to unexpanded parent material compared to those made according to others methods.

Abstract: Disclosed herein are antisense oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA at the 5?-end of UBE3A-AS, which is downstream of SNORD115-45 snoRNA. Also disclosed are pharmaceutical compositions and methods for treatment of Angelman syndrome.

Abstract: In an embodiment, the present disclosure pertains to a cavitation generation device that includes a dactyl plunger rotatable about an axis between an open position and a closed position and a propus socket having a channel. The propus socket is rigidly mounted below the dactyl plunger, and the dactyl plunger is received into the propus socket when the dactyl plunger is in the closed position. The cavitation generation device can also include a torsion spring that biases the dactyl plunger into contact with the propus socket. In another embodiment, the present disclosure pertains to a method of inducing a cavitation including biasing a dactyl plunger via a torsion spring, and rotating the dactyl plunger, by action of the torsion spring, into a propus socket. The propus socket includes a nozzle-shaped channel. The method further includes ejecting a socket cavity volume through the nozzle-shaped channel thereby inducing a cavitation event.

Abstract: A pyrolysis and gasification system produce a synthesis gas and bio-char from a biomass feedstock. The system includes a feed hopper that has a flow measurement device. The system also includes a reactor that is operable in a gasification mode or a pyrolysis mode. The reactor is configured to receive the biomass feedstock from the feed hopper. The reactor is operable to provide heat to the biomass feedstock from the feed hopper to produce the synthesis gas and bio-char. The system also includes a cyclone assembly. The produced synthesis gas including the bio-char is fed to the cyclone assembly. The cyclone assembly removes a portion of the bio-char from the synthesis gas.

Abstract: A system for evaluating an ability of a blood sample to coagulate, clot, and/or occlude includes a microfluidic device including a body and a tortuous microchannel formed in the body, wherein the tortuous microchannel includes a plurality of alternating curves and has a tortuosity index (TI) of at least 2.0, and a pump fluidically configured to fluidically connect to the tortuous microchannel of the microfluidic device and to induce a blood flow through the tortuous microchannel at at least one of a constant pressure and a constant flowrate.

Abstract: A system for reducing a microbial and/or viral load on equipment using ozone includes a container including having an open configuration to provide access to an interior of the container and a closed configuration to seal the interior from an environment external the container, and wherein the interior includes a receptive region to receive the equipment, a circulation fan positioned in the interior of the container, and one or more ozone generators positioned in the interior of the container and configured to generate ozone upon activation, wherein the circulation fan is configured to provide an airflow including ozone generated by the one or more ozone generators and directed along a flowpath extending into the receptive region of the interior of the container.

Abstract: A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.