Patents Assigned to Texas A & M University
  • PHOSPHINE-UREA LIGANDS FOR TRANSITION METAL CATALYZED CROSS-COUPLING REACTIONS
    Publication number: 20240218002
    Abstract: Carbon-carbon bond forming reactions are the cornerstone of organic chemistry. A new class of ligands was developed for transition metal catalyzed cross-coupling reactions. These phosphine-urea ligands incorporate a urea subunit into the backbone of the ligand, which is designed to bind to the organometallic coupling partner and simultaneously facilitate and direct transmetalation of the nucleophile. Synthetic routes were designed and executed to synthesize phosphine-urea ligands. These ligands catalyze a wide variety of cross-coupling reactions including Suzuki, Negishi, and Buchwald-Hartwig cross-couplings. Aryl-aryl, alkyl-aryl, and alkyl-alkyl C—C cross-couplings are performed successfully with these ligands. In addition, specific chiral phosphine-urea ligands catalyze Negishi cross-couplings enantioselectively from a racemic alkylzinc nucleophile.
    Type: Application
    Filed: December 11, 2023
    Publication date: July 4, 2024
    Applicant: The Texas A&M University System
    Inventors: Levi T. Litwiller, Andy A. Thomas, Lupita Sarahi Aguirre, Hai T. Ly
  • INTRACELLULAR TARGETED NANOCARRIERS: TOWARDS CONTROLLED DRUG DELIVERY FOR NONINVASIVE NEUROREGENERATION TREATMENT
    Publication number: 20240216285
    Abstract: In an embodiment, the present disclosure pertains to a nanocarrier having a shell and a core disposed within the shell. In some embodiments, the shell includes a functionalized surface. In an additional embodiment, the present disclosure pertains to a method of drug delivery. In general, the method includes administering a nanocarrier to a subject, targeting, by the nanocarrier, an area in the subject, and releasing a composition having the drug to the area. In some embodiments, the nanocarrier has a shell and a core disposed within the shell. In some embodiments, the shell includes a functionalized surface.
    Type: Application
    Filed: April 26, 2022
    Publication date: July 4, 2024
    Applicant: The Texas A&M University System
    Inventor: Ya Wang
  • MANUFACTURING OF HIGH-PERFORMANCE INTUMESCENT FLAME-RETARDANT POLYMERS
    Publication number: 20240199958
    Abstract: In an embodiment, the present disclosure pertains to a flame-retardant composite composed of a polymer, an intumescent flame retardant (IFR), and a metal-organic framework (MOF). In some embodiments, the MOF is a zeolitic imidazolate framework (ZIF). In some embodiments, the MOF is a bimetallic MOF. In some embodiments, the bimetallic MOF is a bimetal ZIF. In an additional embodiment, the present disclosure pertains to a flame-retardant composite composed of a polymer that can include, without limitation, polypropylene, polyethylene, high-density polyethylene, low-density polyethylene, polystyrene, polyvinyl chloride, poly(methyl methacrylate), a polyolefin, and combinations thereof, an IFR, and a ZIF.
    Type: Application
    Filed: April 28, 2022
    Publication date: June 20, 2024
    Applicant: The Texas A&M University System
    Inventors: Qingsheng Wang, Ruiqing Shen, Yufeng Quan
  • SYSTEMS AND METHODS FOR PROVIDING TACTILE FEEDBACK TO A USER
    Publication number: 20240201783
    Abstract: A system for providing tactile feedback to a user includes a device comprising a touch surface to be touched by the user, one or more thermal elements distributed across the touch surface of the device and configured to heat the touch surface and thereby modulate the friction between the user's skin and the touch surface, and a controller connected to the one or more thermal elements and configured to control the operation of the one or more thermal elements to provide a plurality of predefined temperature distributions across the touch surface.
    Type: Application
    Filed: April 13, 2022
    Publication date: June 20, 2024
    Applicant: The Texas A&M University System
    Inventors: Changhyun Choi, Mary Cynthia Hipwell, Yuan Ma, Jonathan R. Felts
  • Engineering the production of a conformational variant of occidiofungin that has enhanced inhibitory activity against fungal species
    Patent number: 12004514
    Abstract: Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: June 11, 2024
    Assignees: The Texas A&M University System, Mississippi State University
    Inventors: James Leif Smith, Akshaya Ravichandran, Shien Lu, Ganyu Gu
  • Methods for treating selenocyanate in wastewater
    Patent number: 11987512
    Abstract: Methods and systems for reducing the concentration of selenocyanate in water. In the methods and systems, water containing selenocyanate is treated an oxidant to provide oxidant-treated water, which is then contacted with a zero-valent iron treatment system comprising (a) a reactive solid comprising zero-valent iron and one or more iron oxide minerals in contact therewith and (b) ferrous iron.
    Type: Grant
    Filed: January 27, 2022
    Date of Patent: May 21, 2024
    Assignee: The Texas A&M University System
    Inventor: Yongheng Huang
  • Controlled release vaccines and methods of treating diseases and disorders
    Patent number: 11975060
    Abstract: Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to vaccines. In additional embodiments, the invention relates to formulations capable of releasing said vaccines at a controlled rate of release in vivo. In further embodiments, the invention relates to modified strains of the bacteria Brucella melitensis and Brucella abortus. In still further embodiments, the invention relates to compositions that do not induce clinical symptoms or splenomegaly in a subject receiving said compositions.
    Type: Grant
    Filed: January 18, 2021
    Date of Patent: May 7, 2024
    Assignee: The Texas A&M University System
    Inventors: Thomas A. Ficht, Allison Ficht, Renee Tsolis, Leslie Garry Adams, Angela M. Arenas-Gamboa
  • FREE-FORM FABRICATION OF CONTINUOUS CARBON FIBER COMPOSITES USING ELECTRIC FIELDS
    Publication number: 20240140020
    Abstract: An out-of-oven system for free-form fabrication of continuous carbon fiber composites includes a dielectric barrier discharge (DBD) applicator configured to create an electric field proximal to the continuous carbon fiber composite. The DBD applicator includes a first electrode disposed within a dielectric barrier, and a second electrode spaced apart from the first electrode. The first and second electrodes are configured to allow the continuous carbon fiber composite to pass therebetween to cure the continuous carbon fiber composite. The system uses Joule heating to cure the continuous carbon fiber composite.
    Type: Application
    Filed: October 27, 2023
    Publication date: May 2, 2024
    Applicants: The Texas A&M University System, Essentium Inc.
    Inventors: Smita Shivraj Dasari, Anubhav Sarmah, Aniela Wright, Micah J. Green, Nirup Nagabandi, Daniel Carey
  • COMPOSITE STRUCTURES FOR ELECTRIC MOTORS
    Publication number: 20240120789
    Abstract: A composite rotor for an electric motor includes an annular composite support plate extending radially relative a central axis of the composite rotor between an inner diameter defining a central opening of the composite support plate and an outer diameter, wherein the composite support plate includes a quasi-isotropic composite material, and an annular magnet assembly extending around the central axis of the composite rotor and coupled to a surface of the composite support plate.
    Type: Application
    Filed: October 6, 2023
    Publication date: April 11, 2024
    Applicant: The Texas A&M University System
    Inventors: Moble Benedict, Chase B. Wiley, Bansi Jayesh Patel, Karanveer Shyamdhar Dubey
  • Amphibious vehicles comprising cycloidal propellers
    Patent number: 11938768
    Abstract: An amphibious vehicle for traversing land and bodies of water includes a chassis, and a cycloidal propeller coupled to the chassis and which includes a plurality of cycloidal propeller blades rotatably coupled to the chassis and each extending parallel a rotational axis of the cycloidal propeller, and an extension/retraction system configured to extend the plurality of cycloidal propeller blades away from the chassis and to retract the plurality of cycloidal propeller blades towards the chassis.
    Type: Grant
    Filed: May 14, 2021
    Date of Patent: March 26, 2024
    Assignees: The Texas A&M University System, The Regents of the University of Michigan
    Inventors: Moble Benedict, Sean M. McHugh, Chase B. Wiley, Ramsay A. Ramsey, Adam Kellen, Yin Lu Young
  • Rotary-wing, hover-capable aircraft and methods
    Patent number: 11932428
    Abstract: A projectile-launched aircraft system includes a projectile launcher including a triggering mechanism, a rotary-wing, hover-capable aircraft including a rotor assembly that includes at least one rotor blade, wherein the rotor blade includes a stowed configuration and a deployed configuration that is circumferentially spaced from the stowed configuration about a pivot axis, wherein, upon actuation of the triggering mechanism, the projectile launcher is configured to launch the aircraft along a flightpath.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: March 19, 2024
    Assignee: The Texas A&M University System
    Inventors: Moble Benedict, Hunter J. Denton, Hao Kang, Vikram Hrishikeshavan
  • Functionalized exfoliated nanoclay and non-polar polymer nanocomposite compositions
    Patent number: 11932718
    Abstract: Exfoliated nanoplatelets functionalized with a non-polar moiety, such as an ethylene or propylene derived polymer, are useful for forming composites, films, and polymer blends.
    Type: Grant
    Filed: March 16, 2021
    Date of Patent: March 19, 2024
    Assignees: The Texas A&M University System, Formosa Plastics Corporation
    Inventors: Hung-Jue Sue, Joseph Baker, Mingzhen Zhao, Hong-Mao Wu, Wen-Hao Kang, Jen-Long Wu
  • Recovery of rare earth metals and other metals from natural liquid sources by electrodialysis metathesis
    Patent number: 11920250
    Abstract: Provided herein is an electrodialysis metathesis system that has at least one stack or quad of compartments arranged so each compartment is in fluid communication with its adjacent compartment via alternating cation- and anion-exchange membranes. The compartments in a stack are a feed compartment, a substitution salt solution compartment, a first concentrated compartment and a second concentrated compartment. Also provided are processes and methods for separating or recovering a metal, for example, a rare earth element, or a salt or a combination thereof from a salt-containing water. Simultaneous metathesis reactions and electrodialysis across the stack recovers one or more metal or salts from the salt-containing water which desalinates the salt-containing water.
    Type: Grant
    Filed: July 19, 2022
    Date of Patent: March 5, 2024
    Assignee: The Texas A&M University System
    Inventors: Lucy Mar Camacho Chico, Mohammad U. Shafiq
  • Systems and methods for Thomson scattering background interference suppression
    Patent number: 11924956
    Abstract: An apparatus for measurement of Thomson scattering signals from a plasma includes a light emitting device, configured to emit a light beam into the plasma, along an axis. In addition, the apparatus includes a collector configured to collect the Thomson scattering from the plasma at an angle less than 90 degrees from the axis of the light beam. Further, the apparatus includes a sensor assembly to detect the Thomson scattering.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: March 5, 2024
    Assignee: The Texas A&M University System
    Inventors: Richard B. Miles, Christopher Limbach, Alexandros Gerakis
  • Method of fabricating a two dimensional membrane with periodic nanopores
    Patent number: 11912577
    Abstract: Provided herein are methods for creating or fabricating nanopore(s) on a membrane. The membrane is bombarded by ions, for example, C60 ions through at least one nanotunnel through a mask that is positioned on the membrane. Also provided is a two dimensional membrane with at least one nanopore thereon fabricated via these methods.
    Type: Grant
    Filed: November 13, 2021
    Date of Patent: February 27, 2024
    Assignee: The Texas A&M University System
    Inventor: Lin Shao
  • Chemical modulators of store-operated calcium channels and their therapeutic applications
    Patent number: 11905244
    Abstract: Methods of identification of inhibitors of calcium release-activated calcium (CRAC) channel and small molecule inhibitors of CRAC channel, including methods of their synthesis and pharmaceutical use, are disclosed.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: February 20, 2024
    Assignee: The Texas A&M University System
    Inventors: Yubin Zhou, Lian He
  • Compositions and methods of enhancing immune responses to or limiting infection
    Patent number: 11904005
    Abstract: Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: February 20, 2024
    Assignees: The Board of Trustees of the University of Arkansas, The Texas A&M University System
    Inventors: John R. Barta, Luc Berghman, Srichaitanya Shivaramaiah, Olivia B. Faulkner, Lisa Bielke, Billy Hargis
  • Lignin Fractionation and Fabrication for Quality Carbon Fiber
    Publication number: 20240052530
    Abstract: A method of producing carbon fibers by forming, via a one pot acidic precipitation, a precipitated lignin from a precipitation solution by contacting a lignin solution and an acid solution, wherein the precipitation solution comprises the lignin solution and the acid solution, wherein the lignin solution comprises lignin dissolved in a basic aqueous solution, and wherein the acidic solution has a pH of less than or equal to about 6, 5, 4, 3, or 2; forming precursor fibers from the precipitated lignin; and subjecting the precursor fibers to thermostabilization, carbonization, or both to produce the carbon fibers.
    Type: Application
    Filed: October 16, 2023
    Publication date: February 15, 2024
    Applicant: The Texas A&M University System
    Inventors: Joshua Shuhua Yuan, Qiang Li
  • SYSTEMS AND METHODS FOR PRODUCING TRAVELING WAVES ALONG SURFACES EXPOSED TO SUPERSONIC FLUID FLOWS
    Publication number: 20240043112
    Abstract: A supersonic flow system in which a supersonic flow is encountered includes a surface configured to be exposed to a supersonic fluid flow, wherein the surface includes an upstream end and a downstream end opposite the upstream end, a wave generator coupled to the surface and including one or more actuators configured to selectably induce strain in the surface, and a wave controller in signal communication with the wave generator and configured to activate the one or more actuators to induce one or more travelling waves configured to travel along the surface between the upstream end and the downstream end of the surface.
    Type: Application
    Filed: April 19, 2023
    Publication date: February 8, 2024
    Applicant: The Texas A&M University System
    Inventor: Iman Borazjani
  • Hybrid St. Augustinegrass named ‘DALSA 1618’
    Patent number: PP35807
    Abstract: ‘DALSA 1618’ is an interploid hybrid variety of St. Augustinegrass. ‘DALSA 1618’ possesses a unique combination of drought and shade tolerance that allows its use across the southcentral and southeastern United States.
    Type: Grant
    Filed: August 22, 2022
    Date of Patent: May 14, 2024
    Assignee: The Texas A&M University System
    Inventors: Ambika Chandra, Anthony D. Genovesi