Abstract: The present invention comprises methods of treating an infection using a pharmaceutical composition comprising an active ingredient selected from Table 1. In some aspects, the infection can be caused by one or more pathogens, including fungal pathogens. For example, the infection may be Valley Fever.

Abstract: The present disclosure relates to implementations of computing systems. Specifically, the disclosure describes implementations of computing systems that use ternary states for implementing security systems.

Abstract: An Amplicon Sequencing Analysis Pipeline (ASAP) system (120, 600) characterizes a genetic sample. The ASAP system (120, 600) receives assay configuration data individually associating reference sequences and genetic characteristics. The ASAP system (120, 600) processes amplicon sequencing data and the reference sequences to characterize the genetic sample based on the individual associations between the reference sequences and the genetic characteristics in the assay configuration data. The ASAP (120, 600) system transfers genetic data indicating the genetic characteristics for the genetic sample and indicating interpretation metrics for amplicon sequencing read depth and quality related to the genetic characteristics.

Abstract: The present invention relates to method of detecting and characterizing one or more Borrelia species causing Lyme Disease or tick-borne relapsing fever within a sample from a subject, the method comprising: a) subjecting DNA and/or RNA from the sample to a PCR amplification reaction using primer pairs targeting at least one region of Borrelia 16S rRNA and at least one region of flaB, ospA, ospB, ospC, glpQ, 16S-23S intergenic spacer (IGS1), 5S-23S intergenic spacer (IGS2), bbk32, dbpA, dbpB, and/or p66; and b) analyzing amplification products resulting from the PCR amplification reaction to detect the one or more Borrelia species.

Abstract: Compositions for enhancing wound healing are disclosed herein. Also disclosed are methods of making the compositions and methods of using the compositions for the prevention of biofilm formation and for the inhibition of pathogen growth and proliferation.

Abstract: A system and method for the generation of composite private keys are provided. First and second bitstreams are retrieved from an addressable cryptographic table by deriving addresses in the addressable cryptographic table from an initial instruction, accessing first and second bit values stored at addresses belonging to the derived addresses in the addressable cryptographic table, and outputting the first bit values as the first bitstream and the second bit values as the second bitstream. The first bitstream is concatenated with data from the first bitstream to form a data stream having a desired length and the second bitstream is concatenated with data from the second bitstream to form a selector stream having the desired length. A first composite encryption key having a length longer than the first and second bitstreams is formed by selecting values of the data stream identified by corresponding bit values of the selector stream.

Abstract: Systems and methods for secure enrollment of physical unclonable function devices include providing a device with an enrollment controller. The enrollment controller receives an enrollment request from an enrollment system and authenticates the request. If the request is authentic, the enrollment controller generates challenges in a pseudorandom order determined by a random seed that is shared with the enrollment system. The enrollment controller issues the challenges to interrogation circuitry coupled to a PUF array and records the responses. The responses are transmitted in encrypted form, and in the pseudorandom order, to the enrollment system. The responses are encrypted using a random number shared with the enrollment system. The enrollment system and the enrollment controller can independently generate the encryption key using the shared random number and/or other securely shared information.

Abstract: The present disclosure relates to implementations of computing systems. Specifically, the disclosure describes implementations of physically unclonable functions (PUFs) that use ternary states for implementing security systems.

Abstract: Several methods may be used to exploit the natural physical variations of sensors, to generate cryptographic physically unclonable functions (PUF) that may strengthen the cybersecurity of microelectronic systems. One method comprises extracting a stream of bits from the calibration table of each sensor to generate reference patterns, called PUF challenges, which can be stored in secure servers. The authentication of the sensor is positive when the data streams that are generated on demand, called PUF responses, match the challenges. To prevent a malicious party from generating responses, instructions may be added as part of the PUF challenges to define which parts of the calibration tables are to be used for response generation. Another method is based on differential sensors, one of them having the calibration module disconnected. The response to a physical or chemical signal of such a sensor may then be used to authenticate a specific pair of sensors.

Abstract: Systems and methods of authentication and encrypted communication between a server and client using independently-generated shared encryption keys are disclosed. Clients with arrays of physical-unclonable-function devices respond to server-issued challenges. The clients derive encryption keys from responses to those challenges generated by measuring PUF devices specified by the challenges. The clients send messages encrypted with the encryption keys to the server. The server independently reproduces the client-generated encryption keys using information about the PUF devices. When the keys match, the clients are authenticated. It may be desirable to inject errors into the challenge responses generated by the clients to improve security. When errors are injected, attackers cannot determine correct challenge responses except by brute force.

Abstract: A powered exoskeleton is designed to provide assistance to a user, where the powered exoskeleton may have power-generating elements in one location and power-applying elements in another location, so that a user can easily wear the powered exoskeleton.

Abstract: Systems and methods for secure communication between devices where one device has a physical unclonable function (“PUF”) array of PUF devices and another device stores data representing characteristics of the PUF array include encryption schemes using repeated application of one-way cryptographic functions to message segments. The devices transmit or receive a processing instruction used to determined PUF devices whose measured characteristics are used to derive encryption keys. Messages are segmented and message information is securely transmitted by repeatedly application of a suitable one-way cryptographic function to each message segment where the number of applications of the function is determined by each message segment.

Abstract: Disclosed herein is a computing system with the capability to execute instructions in different positional notation values. The definition of a positional notation value is given by the general formula that represent a base 10 numeral in any positional notation in the following manner: . . . d3r3+d2r2+d1r1+d0r0, where d is a coefficient, r is the base of the positional number system (i.e. r=2 for binary, or r=3 for ternary), and the exponent is the position of the digit. The computing may provide a configuration which hybridizes the instructions of multiple positional notation values in variable ratios. The computing system may dynamically switch between the multiple hybridized instructions sets. Embodiments may be applied to provide security benefits.

Abstract: Systems and methods for securing blockchain and other cryptographically signed ledgers are disclosed. Client devices with arrays of physical-unclonable-function devices are respond to challenges from a server. Characteristics of the arrays are stored by the server during a secure enrollment process. Subsequently, the server issues challenges to the clients and receives responses generated by the clients from characteristics of portions of the arrays specified by the challenges. The challenge responses are used to authenticate the clients and are also used as cryptographic private keys for signing transaction blocks. Public keys corresponding to the private keys are generated allowing signed transaction blocks to be validated as well as allowing clients originating the transactions to be authenticated by other clients. Ternary PUF characterization schemes are used to achieve acceptable authentication error rates.

Abstract: A computing device includes an array of addressable elements. Each addressable element is a hardware element that generates a substantially consistent response when interrogated. The device includes a processor coupled to the array of addressable elements and configured to communicate using a communication network. The processor receives a public key, and processes the public key to produce at least a set of addresses. Each address in the set of addresses identifies one or more hardware elements in the array of addressable elements. The processor generates a set of responses by interrogating the one or more hardware elements in the array of addressable elements identified by the set of addresses according to a set of reading instructions, appends the responses in the set of responses to generate a private key, receives an encrypted message and decrypts the encrypted message using the private key to generate an unencrypted message.

Abstract: The present invention provides a method of detecting one or more Klebsiella species within a sample from a subject, the method comprising: subjecting DNA and/or RNA from the sample to a PCR amplification reaction using primer pairs targeting species-specific canonical single nucleotide polymorphisms (canSNPs); and analyzing amplification products resulting from the PCR amplification reaction to detect the one or more Klebsiella species. The present invention also provides a kit for detection of one or more Klebsiella species, Klebsiella clonal groups, AMR genes, and/or virulence genes, the kit comprising primer pairs targeting species-specific canSNPs, K. pneumoniae genes M1 and M2, clonal group-specific canSNPs, AMR genes, and/or virulence genes.

Abstract: The present disclosure includes a multiplexed peptide assay to generate an epitope-resolved view of antibody reactivity across all human coronaviruses (CoVs). PepSeq accurately classifies SARS-CoV-2 exposure status and reveals epitopes across the Spike and Nucleocapsid proteins. Two of these represent recurrent reactivities to conserved, functionally-important sites in the S2 subunit of Spike, regions that we show are also targeted for the endemic CoVs in pre-pandemic controls. At one of these sites, we demonstrate that the SARS-CoV-2 response strongly and recurrently cross-reacts with the endemic virus hCoV-OC43. The disclosed epitope-resolved analysis reveals new CoV targets for the development of diagnostics, vaccines and therapeutics, including a site that may have broad neutralizing potential.

Abstract: Systems and methods of encrypted communication between a server and client devices using keyless encryption schemes are disclosed. Client devices with arrays of physical-unclonable-function devices respond to challenges from a server. Characteristics of the arrays are stored by the server during a secure enrollment process. Subsequently, the server issues challenges to the clients. The clients derive a ciphertext according to a variable cipher scheme determined using responses to the challenges issued by the server using characteristics of portions of the arrays specified by the challenges. The server and clients may independently determine encryption and decryption procedures using characteristics of the arrays.

Abstract: Methods and compositions related to molecules and formulations comprising antibiofilm materials are provide, including new formulations of Deep Eutectic Solvents (DES) that are chemically related to choline geranate. Specifically, geranic acid (a component of choline geranate DES) is a molecule from the isoprenoid/terpene family of compounds. Other members of this family as DES components include isoprenoid acids and chemical derivatives thereof.

Abstract: Various embodiments of a system for linear unmixing of spectral images using a dispersion model are disclosed herein.