Patents Assigned to THE ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY
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Patent number: 10472670Abstract: Methods modifying conventional SIP so that isotopic incorporation into the genomes of individual microbial taxa can be quantified are described. Further, methods to quantify the baseline densities of the DNA of individual microbial taxa without exposure to isotope tracers and then to quantify the change in DNA density of each taxon caused by isotope incorporation are described. The distribution of DNA of each taxon along a density gradient reflects the influence of isotope incorporation only, without reflecting the guanine-plus-cytosine content.Type: GrantFiled: June 30, 2017Date of Patent: November 12, 2019Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITYInventors: Bruce Hungate, Egbert Schwartz, Rebecca Mau, Jane Marks
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Patent number: 10469273Abstract: The present disclosure relates to implementations of physically unclonable functions (PUFs) for cryptographic and authentication purposes. Specifically, the disclosure describes implementations of machine learning engines (MLEs) in conjunction with PUFs generating outputs having multiple states.Type: GrantFiled: May 17, 2019Date of Patent: November 5, 2019Assignee: Arizona Board of Regents on Behalf of Northern Arizona UniversityInventors: Fatemeh Afghah, Bertrand Francis Cambou
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Patent number: 10454691Abstract: Systems and methods for providing variable access authentication respond to the need of a hierarchical level of security, which may include the use of multiple physically unclonable functions (PUFs) and/or the distribution of a set of authentication keys with “don't care” states. Each of the multiple PUFs can drive a separate level of access control, while “don't care” states can be included in the authentication keys when the security risk levels are lower. These two methods can be implemented independently, or in a combination for higher levels of security. At one end of the embodiment the IT manager can have backdoor capabilities if a user forgot a password, on the other end access control to an Internet device needs to be extremely stringent when the user operates in unsafe territory.Type: GrantFiled: May 24, 2017Date of Patent: October 22, 2019Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITYInventor: Bertrand Francis Cambou
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Patent number: 10439828Abstract: The present invention provides a method for authenticating distributed peripherals on a computer network using an array of physically unclonable functions (PUF). As each PUF is unique, each PUF is able to generate a plurality of challenge response pairs that are unique to that PUF. The integrated circuits of the PUF comprise a plurality of cells, where a parameter (such as a voltage) of each cell may be measured (possibly averaged over many readings). The plurality of cells in the PUF may be arranged in a one, two or more dimensional matrix. A protocol based on an addressable PUF generator (APG) allows the protection of a network having distributed peripherals such as Internet of things (IoT), smart phones, lap top and desk top computers, or ID cards. This protection does not require the storage of a database of passwords, or secret keys, and thereby is immune to traditional database hacking attacks.Type: GrantFiled: July 16, 2018Date of Patent: October 8, 2019Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITYInventor: Bertrand Cambou
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Patent number: 10432410Abstract: The present invention provides a method for authenticating distributed peripherals on a computer network using an array of physically unclonable functions (PUF). As each PUF is unique, each PUF is able to generate a plurality of challenge response pairs that are unique to that PUF. The integrated circuits of the PUF comprise a plurality of cells, where a parameter (such as a voltage) of each cell may be measured (possibly averaged over many readings). The plurality of cells in the PUF may be arranged in a one, two or more dimensional matrix. A protocol based on an addressable PUF generator (APG) allows the protection of a network having distributed peripherals such as Internet of things (IoT), smart phones, lap top and desk top computers, or ID cards. This protection does not require the storage of a database of passwords, or secret keys, and thereby is immune to traditional database hacking attacks.Type: GrantFiled: July 16, 2018Date of Patent: October 1, 2019Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITYInventor: Bertrand Cambou
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Patent number: 10320573Abstract: The present invention provides a method for authenticating distributed peripherals on a computer network using an array of physically unclonable functions (PUF). As each PUF is unique, each PUF is able to generate a plurality of challenge response pairs that are unique to that PUF. The integrated circuits of the PUF comprise a plurality of cells, where a parameter (such as a voltage) of each cell may be measured (possibly averaged over many readings). The plurality of cells in the PUF may be arranged in a one, two or more dimensional matrix. A protocol based on an addressable PUF generator (APG) allows the protection of a network having distributed peripherals such as Internet of things (IoT), smart phones, lap top and desk top computers, or ID cards. This protection does not require the storage of a database of passwords, or secret keys, and thereby is immune to traditional database hacking attacks.Type: GrantFiled: November 9, 2016Date of Patent: June 11, 2019Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITYInventor: Bertrand Francis Cambou
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Patent number: 10293080Abstract: Compositions for enhancing wound healing are disclosed herein. Also disclosed are methods of making the compositions and methods of using the compositions for the prevention of biofilm formation and for the inhibition of pathogen growth and proliferation.Type: GrantFiled: October 4, 2017Date of Patent: May 21, 2019Assignees: The Arizona Board of Regents on Behalf of Northern Arizona University, Dixie State UniversityInventors: Robert Kellar, Nathan Christopher Nieto, Andrew Koppisch, Rico Del Sesto
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Patent number: 10214782Abstract: Embodiments of the invention provide a method of detecting one or more strains of Klebsiella pneumoniae. The method may include forming a plurality of mixtures for nucleic amplification. The method can include amplification of specific sequences within the K. pneumonia genome that can provide definitive information to distinguish between one or more types or strains of K. pneumonia.Type: GrantFiled: July 20, 2016Date of Patent: February 26, 2019Assignees: The Translational Genomics Research Institute, Arizona Board of Regents on Behalf of Northern Arizona UniversityInventors: Jolene Bowers, Elizabeth Driebe, David Engelthaler, Paul Keim
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Patent number: 10213478Abstract: The present invention comprises methods of treating an infection using a pharmaceutical composition comprising an active ingredient selected from Table 1. In some aspects, the infection can be caused by one or more pathogens, including fungal pathogens. For example, the infection may be Valley Fever.Type: GrantFiled: November 24, 2015Date of Patent: February 26, 2019Assignees: The Translational Genomics Research Institute, Arizona Board of Regents on behalf of Northern Arizona UniversityInventors: David Engelthaler, Elizabeth Driebe, Hongwei “Holly” Yin, Michael Valentine, Donald Chow, Jolene Bowers, Paul Keim
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Patent number: 10185820Abstract: The present invention provides a method for authenticating distributed peripherals on a computer network using an array of physically unclonable functions (PUF). As each PUF is unique, each PUF is able to generate a plurality of challenge response pairs that are unique to that PUF. The integrated circuits of the PUF comprise a plurality of cells, where a parameter (such as a voltage) of each cell may be measured (possibly averaged over many readings). The plurality of cells in the PUF may be arranged in a one, two or more dimensional matrix. A protocol based on an addressable PUF generator (APG) allows the protection of a network having distributed peripherals such as Internet of things (IoT), smart phones, lap top and desk top computers, or ID cards. This protection does not require the storage of a database of passwords, or secret keys, and thereby is immune to traditional database hacking attacks.Type: GrantFiled: November 9, 2016Date of Patent: January 22, 2019Assignee: Arizona Board of Regents on behalf of Northern Arizona UniversityInventor: Bertrand Francis Cambou
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Patent number: 10100368Abstract: The present invention provides multiplex assays, methods and kits that may be used to detect and confirm the presence of MRSA in a sample. The methods include real-time PCR assays, and the kits and compositions include oligonucleotides used as primers and probes. The present invention further comprises assays useful to identify and differentiate MRSA, MSSA, MRSE, MSSE, MRCNS and MSCNS in a sample.Type: GrantFiled: March 18, 2011Date of Patent: October 16, 2018Assignees: The Translational Genomics Research Institute, Arizona Board of Regents on behalf of Northern Arizona UniversityInventors: Elizabeth Driebe, David Engelthaler, Jolene Bowers, Paul Keim
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Publication number: 20180274011Abstract: Embodiments of the invention provide a method of genotyping a C. gattii sample, which can include forming a plurality of mixtures for nucleic amplification. The method can include amplification of specific sequences within the C. gattii genome that can provide definitive genotype information to distinguish between one or more types or subtypes of C. gattii.Type: ApplicationFiled: June 11, 2018Publication date: September 27, 2018Applicants: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE, ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITYInventors: David Engelthaler, Elizabeth Driebe, Erin Kelley, Paul Keim
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Patent number: 10050796Abstract: The present invention provides a method for authenticating distributed peripherals on a computer network using an array of physically unclonable functions (PUF). As each PUF is unique, each PUF is able to generate a plurality of challenge response pairs that are unique to that PUF. The integrated circuits of the PUF comprise a plurality of cells, where a parameter (such as a voltage) of each cell may be measured (possibly averaged over many readings). The plurality of cells in the PUF may be arranged in a one, two or more dimensional matrix. A protocol based on an addressable PUF generator (APG) allows the protection of a network having distributed peripherals such as Internet of things (IoT), smart phones, lap top and desk top computers, or ID cards. This protection does not require the storage of a database of passwords, or secret keys, and thereby is immune to traditional database hacking attacks.Type: GrantFiled: November 9, 2016Date of Patent: August 14, 2018Assignee: Arizona Board of Regents on behalf of Northern Arizona UniversityInventor: Bertrand Francis Cambou
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Patent number: 9994917Abstract: Embodiments of the invention provide a method of genotyping a C. gattii sample, which can include forming a plurality of mixtures for nucleic amplification. The method can include amplification of specific sequences within the C. gattii genome that can provide definitive genotype information to distinguish between one or more types or subtypes of C. gattii.Type: GrantFiled: August 6, 2015Date of Patent: June 12, 2018Assignees: The Translational Genomics Research Institute, Arizona Board of Regents on Behalf of Northern Arizona UniversityInventors: David Engelthaler, Elizabeth Driebe, Erin Kelley, Paul Keim
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Patent number: 9944994Abstract: Described herein are DNA primer sequences designed for the determination of gene or transcript information from Anuran species, and which may be used in studies for developmental and/or toxicity testing and for environmental toxicology or ecological assessment. Also described herein is a rapid, sensitive, high-throughput assay useful for supporting potential risk assessment across vertebrate clades, and that is also useful for evaluation of complex contaminant mixtures.Type: GrantFiled: August 11, 2016Date of Patent: April 17, 2018Assignee: Arizona Board of Regents on Behalf of Northern Arizona UniversityInventors: Catherine R. Propper, Stephen M. Beckstrom-Sternberg, Caren C. Helbing, Nicholas J. Veldhoen
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Patent number: 9914978Abstract: The present invention provides a method, a kit and composition for determining MRSA and other Staphylococcus strain resistance to one or more antibiotic agents through detecting the presence of the respective antibiotic resistance gene. The methods include real-time PCR assays, and the kits and compositions include oligonucleotides used as primers and probes.Type: GrantFiled: March 18, 2011Date of Patent: March 13, 2018Assignees: The Translational Genomics Research Institute, Arizona Board of Regents on Behalf of Northern Arizona UniversityInventors: Elizabeth Driebe, David Engelthaler, Jolene Bowers, Paul Keim
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Publication number: 20170022543Abstract: Embodiments of the invention provide a method of detecting one or more strains of Klebsiella pneumoniae. The method may include forming a plurality of mixtures for nucleic amplification. The method can include amplification of specific sequences within the K. pneumonia genome that can provide definitive information to distinguish between one or more types or strains of K. pneumonia.Type: ApplicationFiled: July 20, 2016Publication date: January 26, 2017Applicants: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE, ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITYInventors: Jolene Bowers, Elizabeth Driebe, David Engelthaler, Paul Keim
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Publication number: 20160326603Abstract: The present technology provides methods and kits that may be used to detect and quantify the presence of Coccidioides species. The methods include quantification real-time PCR assays, and the kits and compositions include oligonucleotides used as primers and probes.Type: ApplicationFiled: July 29, 2016Publication date: November 10, 2016Applicants: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE, ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITYInventors: Bridget Barker, Elizabeth Driebe, David Engelthaler, Paul Keim, Jolene Bowers
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Patent number: 9459685Abstract: A system for optimizing energy efficiency of an embedded system. A hardware abstraction layer (HAL) is coupled to hardware of an embedded system. An energy hardware abstraction layer (eHAL) couples to the hardware and to the HAL. A hypervisor couples to the HAL and to the eHAL. One or more applications couple to the hypervisor, the HAL and the eHAL. The eHAL measures energy use of the embedded system, constructs a model of energy use of the embedded system and, using the model, determines how to one of reduce and minimize energy use of the embedded system. The hypervisor is configured to alter one or more hardware parameters to one of reduce and minimize energy use of the embedded system as the embedded system performs one or more tasks. In implementations a real time operating system (RTOS) is coupled to the one or more applications and to the hypervisor.Type: GrantFiled: December 10, 2013Date of Patent: October 4, 2016Assignee: Arizona Board of Regents on behalf of Northern Arizona UniversityInventor: Paul G. Flikkema
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Patent number: 9448227Abstract: Described herein are DNA primer sequences designed for the determination of gene or transcript information from Anuran species, and which may be used in studies for developmental and/or toxicity testing and for environmental toxicology or ecological assessment. Also described herein is a rapid, sensitive, high-throughput assay useful for supporting potential risk assessment across vertebrate clades, and that is also useful for evaluation of complex contaminant mixtures.Type: GrantFiled: October 7, 2014Date of Patent: September 20, 2016Assignee: The Arizona Board of Regents on Behalf of Northern Arizona UniversityInventors: Catherine R. Propper, Stephen M. Beckstrom-Sternberg, Caren C. Helbing, Nicholas J. Veldhoen