Abstract: Disclosed is a tumor surface dose enhancing radiotherapy apparatus using a magnetic field, including a radiation beam generating unit that irradiates a radiation beam towards a tumor of a patient, a magnetic field generating unit that forms a magnetic field that is parallel to the radiation beam between the radiation beam generating unit and the tumor of the patient, and a control unit that controls a surface dose of the tumor by adjusting an intensity and an effective area of the magnetic field of the magnetic field generating unit.

Abstract: Disclosed are a radiotherapy assistant apparatus for modulating a build-up region of a photon beam for a radiotherapy, a radiotherapy system including the radiotherapy assistant apparatus, and method for the radiotherapy system. The radiotherapy assistant apparatus for modulating a build-up region of a photon beam for a radiotherapy, including at least: a magnetic field generator that generates a magnetic field that has a direction perpendicular to a movement direction of the photon beam, the magnetic field generator is disposed on a movement route along which the photon beam moves toward a target portion of the radiotherapy; and a magnetic field intensity adjuster that adjusts an intensity of the magnetic field generated by the magnetic field generator. The magnetic field generator disperses secondary electrons that have particular energy levels equal to or lower than a preset value.

Abstract: Provided is a catheter to be inserted into an object. The catheter includes a main body having a tubular shape and an expansion layer formed on an outer circumferential surface of the main body, and the expansion layer contains an expandable material which is expanded by contact with a liquid.

Abstract: The present disclosure relates to a method for generating an insertion trajectory of a surgical needle from an entry point to a target, including the steps of: preparing a medical image including the target and an anatomical structure; and extracting an insertion trajectory in consideration of at least one of a degree of invasion into the anatomical structure through the insertion trajectory and a distance of the insertion trajectory. Further, the present disclosure relates to a method for generating an insertion trajectory of a medical device, and a robot for interventional procedures including needle insertion.

Abstract: A mucosal dose control radiotherapy apparatus using magnetic fields includes: a radiation generator irradiating radiation toward a tumor region of a patient; a magnetic field generator forming a magnetic field in a body of the patient; and a controller controlling a radiation dose transmitted from the radiation generator to the tumor region of the patient by adjusting a direction and a strength of the magnetic field of the magnetic field generator.

Abstract: Provided is a non-invasive system for estimating an atrial signal, including a plurality of sensors to sense a surface electrocardiogram signal, a reference atrial signal generation unit to generate an estimated ventricular signal with respect to a R wave in an electrocardiogram signal from one sensor among the plurality of sensors, and to generate a reference atrial signal by subtracting the estimated ventricular signal from the electrocardiogram signal from the one sensor, and an atrial signal estimation unit to generate an estimated atrial signal by applying a constrained independent component analysis algorithm based on the reference atrial signal to the received surface electrocardiogram signal, and to estimate one of the estimated atrial signals as an actual atrial signal, and a method using the same.

Abstract: The present invention relates to a breast cancer diagnosis device. More particularly, the present invention relates to a breast cancer diagnosis device for early detection of the presence or absence of breast cancer lesions inside the breast of a diagnosis subject. The breast cancer diagnosis device includes: an X-ray diagnosis unit generating an X-ray image of a diagnosis subject; an optical diagnosis unit generating an optical transmission image of the diagnosis subject; and a transfer unit which is coupled to the X-ray diagnosis unit and the optical diagnosis unit to transfer all or part of the X-ray diagnosis unit and the optical diagnosis unit, and sequentially transfer all or part of the X-ray diagnosis unit or the optical diagnosis unit toward the diagnosis subject.

Abstract: Disclosed herein is a marker composition that includes sphingosine 1-phosphate (S1P) lipid and that may be used to predict the risk of fracture or osteoporosis; a kit that includes an antibody that specifically binds to the S1P lipid and that can be used to predict the risk of fracture or osteoporosis; and a method that can be used to obtain information that allows prediction of the risk of fracture or osteoporosis and includes measurements of S1P lipid concentrations by measuring the binding of a S1P-specific antibody to SIP lipid. The S1P lipid disclosed herein is highly expressed in individuals with fracture, regardless of their bone mineral density. Accordingly, it may be useful as a biomarker of the risk of fracture or osteoporosis.

Abstract: A method of quantifying a medical image is disclosed herein. The method of quantifying a medical image includes acquiring regions of interest based on a medical image; filtering the sizes of the acquired regions of interest using length scale analysis; classifying the regions of interest whose sizes have been filtered, according to the sizes of the regions of interest; and visualizing the regions of interest whose sizes have been filtered, so that the regions of interest whose sizes have been filtered are distinguished from each other in the medical image according to the sizes of the regions of interest.

Abstract: A method for distinguishing between pulmonary arteries and pulmonary veins and a method for quantifying blood vessels are disclosed. The method for distinguishing between pulmonary arteries and pulmonary veins includes: forming a set of pulmonary vessels for points corresponding to pulmonary vessels, wherein each of the points of the set of pulmonary vessels has weight information; forming a tree from the points of the set of pulmonary vessels by using the weight information; and distinguishing between the pulmonary arteries and the pulmonary veins by separating the tree into a plurality of regions. The method for quantifying blood vessels includes: extracting blood vessels as a three-dimensional set of voxels based on medical images of an organ; finding the voxels of blood vessels included in a region of interest of the organ; and quantifying length information of the blood vessels by using the found voxels.

Abstract: The present disclosure relates to a brain disease diagnosis service apparatus including at least: a receiving unit for receiving an image of a subject to be diagnosed; a preprocessing unit for estimating a transformation matrix in order to align a predetermined standard image with the image received by the receiving unit, and for applying the estimated transformation matrix to a predetermined standard brain region map, thereby generating an individual brain region map for the subject to be diagnosed; a feature point extracting unit for calculating a ratio occupied by brain lesions for each brain region in the individual brain region map, generated by the preprocessing unit, of the subject to be diagnosed, thereby extracting feature points; and a disability type determining unit for determining a disability type on the basis of the ratio of the brain lesions, calculated by the feature point extracting unit, for each brain region.

Abstract: Disclosed herein is a method for acquiring and processing a medical image, comprising obtaining the first to n-th sectional images of the first to n-th regions through non-sequential sectional-image acquisition starting from one of the first to n-th regions and sequentially arranging the obtained first to n-th sectional images.

Abstract: The present invention relates to a pyrrolopyridazine derivative represented by Formula 1 of the detailed description, or a pharmaceutically acceptable salt thereof. The compound according to the present invention and a pharmaceutically acceptable salt thereof can inhibit the activity of protein kinase(s), and thus are useful for preventing or treating diseases related thereto.

Abstract: A pharmaceutical composition for preventing or treating a fracture or osteoporosis, includes, as an active ingredient, a gene selected from a group consisting of slit1, slit2, slit3, robo1, robo2 and vilse, or an expressed protein of the gene. A marker composition for predicting the risk of the occurrence of a fracture or osteoporosis includes the protein. A kit for predicting the risk of the occurrence of a fracture or osteoporosis includes an antibody that specifically binds to the protein. An information provision method for predicting the risk of the occurrence of a fracture or osteoporosis includes measuring the level of expression of the slit protein through an antigen-antibody binding reaction using an antibody that specifically binds to the protein. The slit3 may increase bone formation and decrease bone reabsorption in a cellular and animal model, and has a negative correlation with the incidence rate of osteoporosis.

Abstract: The present invention relates to a composition for treatment or metastasis suppression of cancers which includes a p34 expression inhibitor or activity inhibitor as an active ingredient. According to the present invention, the p34 protein knock-down causes monoubiquitination of PTEN and accordingly nuclear localization of PTEN is induced, as a result, an Akt pathway which is related to survival, proliferation, invasive properties and metastatic properties of tumors is inhibited, and thus there is an effect of significantly reducing clonogenic potential and tumor forming potential of various cancer cells which simultaneously express PTEN and NEDD4-1. Consequently, the p34 gene expression inhibitor or p34 protein activity inhibitor according to the present invention can be effectively used as a treatment agent or a metastasis suppression agent for cancers.

Abstract: Provided is a semiconductor-based ion-responsive urine sensor (IRUS) capable of detecting an analyte in urine by a non-invasive method. When a urine sensor according to an aspect is used, it is possible to diagnose a patient accurately in a comfortable condition and to use the urine sensor for point-of-care (POC) diagnosis.

Abstract: The present invention relates to A system for monitoring the cardiovascular system using a heart sound, which comprises a heart sound receiving means(100) for receiving a heart sound(HS); DSP (Digital Signal Processor) module(200) for converting the heart sound(HS) received from said heart-sound receiving means(100) to a digital signal; and an arithmetic section(300) for calculating phonocardiogram(PCG) from the digital signal converted in the DSP module (200) and calculating information related to a preload or information related to a cardiac contractile force or information related to a respiratory change.

Abstract: The present disclosure relates to a brain disease diagnosis service apparatus including at least: a receiving unit for receiving an image of a subject to be diagnosed; a preprocessing unit for estimating a transformation matrix in order to align a predetermined standard image with the image received by the receiving unit, and for applying the estimated transformation matrix to a predetermined standard brain region map, thereby generating an individual brain region map for the subject to be diagnosed; a feature point extracting unit for calculating a ratio occupied by brain lesions for each brain region in the individual brain region map, generated by the preprocessing unit, of the subject to be diagnosed, thereby extracting feature points; and a disability type determining unit for determining a disability type on the basis of the ratio of the brain lesions, calculated by the feature point extracting unit, for each brain region.

Abstract: There is provided a composition for prophylaxis or treatment of vascular or valvular calcification including a dipeptidylpeptidase-4 (DPP-4) inhibitor. The DPP-4 according to one exemplary embodiment of the present disclosure is expressed at an increased level when blood vessels and valves are calcified, and the calcification decreases remarkably upon administration of the DPP-4 inhibitor. Therefore, the DPP-4 inhibitor can be useful in treatment or prophylaxis of blood vessels or valves.

Abstract: Provided is a non-invasive system for estimating an atrial signal, including a plurality of sensors to sense a surface electrocardiogram signal, a reference atrial signal generation unit to generate an estimated ventricular signal with respect to a R wave in an electrocardiogram signal from one sensor among the plurality of sensors, and to generate a reference atrial signal by subtracting the estimated ventricular signal from the electrocardiogram signal from the one sensor, and an atrial signal estimation unit to generate an estimated atrial signal by applying a constrained independent component analysis algorithm based on the reference atrial signal to the received surface electrocardiogram signal, and to estimate one of the estimated atrial signals as an actual atrial signal, and a method using the same.