Abstract: A method of reducing an artifact by using structural similarity. The method includes at least: obtaining a plurality of input Computed Tomography (CT) images including a first CT image and a second CT image, generating an artifact map in which anatomical information is removed and artifacts information is remained, by subtracting the second. CT image from the first CT image, generating, by the computer, a structural similarity map between each CT image and the artifact map, and generating, by the computer, a final reconstructed image by comparing particular parts on images of a plurality of structural similarity maps with each other and selecting data of an input CT image which has been used to generate a particular part of a structural similarity map having a lowest degree of structural similarity, as data of a particular part on the final reconstructed image.

Abstract: A method for monitoring a fetal heart rate may include the steps of: acquiring fetal heart rate monitoring data; determining a fetal heart rate value by dividing the acquired fetal heart rate monitoring data by a predetermined time interval; and determining a fetal state by applying, to the determined fetal heartbeat value, a learned artificial intelligence algorithm using a learning database including the fetal heartbeat monitoring data pre-acquired in association with a plurality of fetuses.

Abstract: A method for predicting brain disease state change is disclosed. The method includes acquiring test images obtained by capturing a portion of a human brain at a time interval, performing a pre-processing procedure of converting the test images into test voxels configured to be processed for image analysis, wherein a respective test voxel of the test voxels is composed of three-dimensional voxel units, mapping first and second test voxels selected from the test voxels acquired from a patient, with each other on a three-dimensional voxel unit, wherein the first test voxel is acquired at a first time-point and the second test voxel is acquired at a second time-point, generating a voxel-based data-set based on the mapped first and second test voxels, extracting a change in the test voxels using a deep neural network, and generating a state change probability model based on the change in the test voxels.

Abstract: A method for predicting a pulmonary disease includes acquiring a three-dimensional computed tomography (CT) image from two-dimensional CT images, each of which captures a respective body position of a first patient, dividing the three-dimensional CT image into a plurality of regions to obtain region-based three-dimensional CT images configured to be used for fractal analysis, calculating a region-based fractal dimension value indicating a fractal complexity of a respective region-based three-dimensional CT image among the generated region-based three-dimensional computed tomography images, adding additional information to the region-based fractal dimension value to generate high-dimensional data, and generating status information of the first patient based on the complexity of the generated high-dimensional data.

Abstract: The present invention relates to a method for lysing pathogen lysis and a method for extracting nucleic acid using zinc oxide nanostar, and the method for extracting nucleic acid using zinc oxide nanostar according to the present invention can extract nucleic acids by lysing cells of a pathogen without using a lysis buffer and can extract nucleic acid of high-purity and high-concentration by preventing nucleic acid degradation and fragmentation through various substances including salts contained in the lysis buffer at high concentration. In addition, the zinc oxide nanostar of the present invention (200 to 900 nm) has superior cell lysis capacity compared to the conventional zinc oxide nanoparticles (20 to 50 nm), thereby increasing the nucleic acid extraction efficiency and can extract at room temperature without a heating step to use as a field diagnostic method.

Abstract: Disclosed are a radiotherapy assistant apparatus for modulating a build-up region of a photon beam for a radiotherapy, a radiotherapy system including the radiotherapy assistant apparatus, and method for the radiotherapy system. The radiotherapy assistant apparatus for modulating a build-up region of a photon beam for a radiotherapy, including at least: a magnetic field generator that generates a magnetic field that has a direction perpendicular to a movement direction of the photon beam, the magnetic field generator is disposed on a movement route along which the photon beam moves toward a target portion of the radiotherapy; and a magnetic field intensity adjuster that adjusts an intensity of the magnetic field generated by the magnetic field generator. The magnetic field generator disperses secondary electrons that have particular energy levels equal to or lower than a preset value.

Abstract: The present invention relates to a method for determining sensitivity to a simultaneous inhibitor against poly ADP ribose polymerase (PARP) and Tankyrase. According to the present invention, a colorectal treatment effect can be maximized by sorting patients having sensitivity to the simultaneous inhibitor against PARP and Tankyrase.

Abstract: A method for diagnosing follicular thyroid carcinoma is described. The method measures protein expression levels of an aminoacyl-tRNA synthetase (ARS) or an aminoacyl-tRNA synthetase complex-interacting multifunctional protein (AIMP) in a sample, such as a thyroid tissue sample, from a subject suspected of having follicular thyroid carcinoma. The protein expression levels of ARS or AIMP are compared to the measured protein expression levels in a control.

Abstract: The present invention relates to a method for providing an ultrasonic image analysis and, more particularly, a method for providing information, which is helpful in diagnosing a disease of a fetus, by extracting a placenta part from an ultrasonic image and analyzing, by using a deep learning engine, a correlation among microscopic images for a placenta.

Abstract: Disclosed is a composition and method for preventing, ameliorating or treating an EGFR-mutant non-small cell lung cancer including a c-Jun N-terminal kinase (JNK) activator as an active ingredient. The composition significantly reduces the level of EGFR in EGFR-mutant non-small cell lung cancer cells, inducing apoptosis. Therefore, the composition is suitable for preventing, ameliorating or treating non-small cell lung cancers in subjects in need thereof. Particularly, the composition is effective in treating and preventing non-small cell lung cancers, which are difficult to effectively treat and prevent with gefitinib or erlotinib. Also disclosed is a composition and method for inhibiting the resistance of a non-small cell lung cancer to an EGFR tyrosine kinase inhibitor including a c-Jun N-terminal kinase (JNK) activator as an active ingredient. The inhibitory composition effectively overcomes resistance to EGFR tyrosine kinase inhibitors.

Abstract: A hybrid stent includes multiple main cells aligned in a spiral shape and including multiple first link units which are aligned diagonally and spaced at a predetermined distance from each other and multiple second link units which connect adjacent first link units among the multiple first link units and are spaced at a predetermined distance from each other, and one or more open cells adjacent to the multiple main cells in a longitudinal direction and aligned in a spiral shape.

Abstract: There is disclosed a multi-wavelength endoscopic system for imaging an observation site labeled with a plurality of fluorescent materials having different colors. The system includes an imaging unit configured to acquire image data by polarizing incident light reflected from the observation site in a first direction and a second direction perpendicular to the first direction, dividing a spectrum region of the incident light polarized in the first direction and the second direction into a plurality of spectrum channels and measuring the intensity of light for each of the spectrum channel. The system further includes a computing unit configured to store a single fluorescence spectrum extracted from sample image data obtained by single-treating the observation site with each of the fluorescent materials and configured to separate and output the image data obtained in the imaging unit using the single fluorescence spectrum so that each of the fluorescent materials is displayed separately.

Abstract: The present disclosure relates to a method, an apparatus and a computer program for noninvasively determining a cause of a blood pressure change. The method includes at least: obtaining maximum amplitudes of heart sounds; monitoring changes in the maximum amplitudes; estimating change amounts of indexes on a myocardial contractile force and on vascular resistance, based on increasing or decreasing of a blood pressure of the patient, and the changes in the maximum amplitudes; and determining the cause of the blood pressure change of the patient as an effect of at least one of alpha action, alpha blockage, beta action and beta blockage, based on results of the estimation of the first change amount of the first index, the second change amount of the second index and the third change amount of the third index.

Abstract: A stent for anastomosis of different kinds of organs includes a main body, and at least one fixing unit provided in the main body. At least a portion of the main body is inserted into one of different kinds of organs to be anastomosed with each other, and the rest of the main body is inserted into the other of the different kinds of organs. A distance between the different kinds of organs under the anastomosis is maintained by the fixing units.

Abstract: The present disclosure relates to an apparatus for closed reduction of a bone fracture. The apparatus includes at least: a pulling adaptor including: a handle configured to be gripped by an operator; an insertion rod that is extended from the handle in a longitudinal direction of the handle, and configured to be inserted into the bone fracture which is depressed in at least one area thereof; and a pulling lug that is bent and extended from an end of the insertion rod such that a longitudinal direction of the pulling lug is perpendicular to a longitudinal direction of the insertion rod or such that the pulling lug is inclined with respect to the insertion rod, the pulling lug being configured to be inserted into the at least one depressed area of the bone fracture, in order to pull the bone fracture.

Abstract: Disclosed is a tumor surface dose enhancing radiotherapy apparatus using a magnetic field, including a radiation beam generating unit that irradiates a radiation beam towards a tumor of a patient, a magnetic field generating unit that forms a magnetic field that is parallel to the radiation beam between the radiation beam generating unit and the tumor of the patient, and a control unit that controls a surface dose of the tumor by adjusting an intensity and an effective area of the magnetic field of the magnetic field generating unit.

Abstract: A method for preparing a radiopharmaceutical and, specifically, a method for preparing an organic fluoride-aliphatic compound usable as a radiopharmaceutical, a method for purifying the prepared organic fluoride-aliphatic compound, and a method for preparing a radiopharmaceutical by using a cassette comprising a backdraft preventing reaction container. A method for preparing an organic fluorinated aliphatic compound includes allowing a fluorine salt to react with a leaving group-containing aliphatic compound by using a multifunctional solvent represented by the following Chemical Formula 1 to obtain an aliphatic compound labeled with [18F] fluoride substituting for the leaving group. The organic fluoride-aliphatic compound can be prepared and purified through even a simple process at high yield, high efficiency, and high purity, and the radiopharmaceutical can be safely prepared without damage to a synthetic apparatus.

Abstract: The inventive concept relates to an endoscopic procedure simulator module and an endoscopic procedure simulator using the same. The endoscopic procedure simulator module according to the inventive concept includes a lesion indicating part having a discharge hole formed therein, through which a fluid is discharged to present a bleeding state, a module body to which the lesion indicating part is coupled, the module body having a fluid channel and a spacing space formed therein, in which the fluid to be discharged through the discharge hole flows through the fluid channel and the spacing space is separated from the fluid channel, and a diaphragm provided in the spacing space of the module body so as to be expandable, in which the diaphragm is expanded by a separate fluid injected into the spacing space and closes the discharge hole of the lesion indicating part.

Abstract: The present disclosure relates to a catheter delivery device having an improved mechanism for inserting a catheter into a blood vessel of a patient. The catheter delivery device includes at least: a body including a delivery path of a catheter; a pair of feeders having grippers located on the delivery path of the body and are configured to grip and release the catheter; and a rotator configured to rotate the catheter gripped by the feeders. The feeders move from a grip position where the grippers grip the catheter to a forward position where the grippers advance in a state of gripping the catheter, from the forward position to a grip release position where the grippers release the catheter, from the grip release position to a backward position where the grippers retract in a state of releasing a grip on the catheter, and from the backward position to the grip position.

Abstract: The present disclosure relates to a catheter and a surgical medical device. The catheter includes at least: a first elastic member positioned at an end portion of the catheter, a second elastic member connected with the first elastic member, the second elastic member being curved with a first radius of curvature to protrude toward a first direction; a first wire connected with a first surface of the first elastic member, and configured to pull the catheter to bend the catheter in the first direction; a second wire connected with a second surface of the first elastic member, which is opposite to the first surface, and configured to pull the catheter to bend the catheter in a second direction; and a tube containing the first elastic member, the second elastic member, the first wire, and the second wire.