Abstract: A system and associated methods for decentralized attribution of GAN models is disclosed. Given a group of models derived from the same dataset and published by different users, attributability is achieved when a public verification service associated with each model (a linear classifier) returns positive only for outputs of that model. Each model is parameterized by keys distributed by a registry. The keys are computed from first-order sufficient conditions for decentralized attribution. The keys are orthogonal or opposite to each other and belong to a subspace dependent on the data distribution and the architecture of the generative model.

Abstract: The present disclosure provides methods of treating cancer in a patient determined to have osimertinib resistant EGFR mutations by administering a second-generation quinazolinamine derivative tyrosine kinase inhibitor.

Abstract: The present disclosure relates to nucleic acid probes and kits for determining the length of a region of tandem repeats in a subject's genome and methods of using the DNA probes for determining the length of a region of tandem repeats in a subject's genome. In some embodiments, the region of tandem repeats in telomeres.

Abstract: Provided herein are methods of predicting whether a pancreatic cancer patient will be a short-term or long-term survivor based on their intra-tumoral microbiota. Also provided are methods of treating pancreatic cancer patients using fecal microbial transfer from long-term pancreatic cancer survivors as well as pharmaceutical compositions comprising fecal microbiota obtained from long-term pancreatic cancer survivors.

Abstract: A method for controlling a first device that includes a photovoltaic array such as a satellite in Earth orbit includes receiving a laser beam that is scanned over a plurality of photovoltaic cells in the photovoltaic array. A trajectory of the laser beam along the photovoltaic array is identified based on receipt of the laser beam by the plurality of photovoltaic cells. The trajectory is compared to a plurality of pre-defined gesture strokes to identify a first gesture stroke most closely matching the trajectory. A pre-defined action associated with the first gesture stroke is performed.

Abstract: Apparatus and methods are disclosed for measuring polarization properties and phase information, for example as can be used in microscopy applications. According to one example of the disclosed technology, an apparatus includes a light source, an interferometer configured to receive light generated by the light source and split the received light into two split beam outputs. The split beam outputs including combined, interfering light beams. Two light sensors, each including a polarization-sensitive focal plane array receive a respective one of the split beam outputs from the interferometer. Thus, some examples of the disclosed technology allows for simultaneous or concurrent measurement of properties of light including intensity, wavelength, polarization, and phase.

Abstract: The present invention provides compounds (n-3 PUFA derivatives) of formula (I): that modulate conditions associated with cardiac damage, especially cardiac arrhythmias.

Abstract: A microfluidic device includes a first substrate including at least one microfluidic channel and a plurality of microwells, as well as a cooperating second substrate defining multiple split-walled cell trap structures that are registered with and disposed within the plurality of microwells. A method for performing an assay includes flowing cells and a first aqueous medium into a plurality of microwells of a microfluidic device, wherein each microwell includes a cell trap structure configured to trap at least one cell. The method further comprises flowing a nonpolar fluid with low permeability for analytes of interest through a microfluidic channel to flush a portion of the first aqueous medium from the microfluidic channel while retaining another portion of the first aqueous medium and at least one cell within each microwell. Surface tension at a non-polar/polar medium interface prevents molecule exchange between interior and exterior portions of microwells.

Abstract: A system and method for monitoring one or more physiological parameters of a subject under free-living conditions is provided. The system includes a camera configured to capture and record a video sequence including at least one image frame of at least one region of interest (ROI) of the subject's body. A computer in signal communication with the camera to receive signals transmitted by the camera representative of the video sequence includes a processor configured to process the signals associated with the video sequence recorded by the camera and a display configured to display data associated with the signals.

Abstract: The present disclosure generally relates to compositions and methods for cancer immunotherapy, as well as hematopoietic recovery following cancer treatment such as chemotherapy or irradiation.

Abstract: A cold therapy dynamic hand splint system including an electric pump, a sleeve, an inflatable bladder, a refrigeration device, and a fluid reservoir. The sleeve includes a fluid-tight cavity filled with a cold fluid pressurized by the pump, and is wrapped around the forearm of a user. The inflatable bladder has an expanded state where the bladder is charged with the fluid pressurized by the pump and chilled by the refrigeration device, and a collapsed state where the bladder is substantially empty. The bladder is small enough that a portion fits inside a palm of a contracted spastic hand while in the collapsed state, and large enough to press the spastic hand open when the bladder is in the expanded state. The fluid is maintained within a therapeutic temperature range, and is in fluidic communication with the sleeve and the bladder through the pump.

Abstract: The present disclosure describes chemically-stabilized RNA substrates that hybridize to poly-A binding protein (PABP) with high specificity in vitro, as well as their use in impairs nascent translation in a PABP-dependent mechanism in cells, thereby treating pain.

Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of HER2 or EGFR for the treatment or prevention of disease, including cancer.

Abstract: A scaffold-free microtissue is disclosed that includes one or more gold nanostructures linked to a functional moiety, wherein the functional moiety is one or more vasculogenic peptides, one or more anti-inflammatory peptides, one or more antiapoptotic peptides, one or more antinecrotic peptides, one or more antioxidant peptides, one or more oligonucleotides, one or more lipid particles, one or more phospholipid particles, one or more liposomes, one or more nanoliposomes, one or more microRNAs, or one or more siRNAs. The scaffold-free microtissue further includes a plurality of cardiac myocytes or cardiac myoblasts, which are conjugated to the one or more gold nanostructures, wherein the plurality of cardiac myocytes or cardiac myoblasts are arranged in a cluster.

Abstract: The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrofluoroalkane propellant. A portion of the one or more flocculated particles is templated by the formation of hydrofluoroalkane droplets upon atomization and the templated floc compacts upon the evaporation of the hydrofluoroalkane propellant to form a porous particle for deep lung delivery.

Abstract: Cold spray devices and systems are disclosed. They include a flowpath having an inlet adapted for receiving communication with two or more inputs and an outlet adapted to discharge the two or more inputs. A discharge nozzle may be included in the flowpath of the outlet and a confluence may be included in the flowpath at the inlet for combining the two or more inputs. A nozzle body houses the discharge nozzle separate and downstream from the confluence of the two inputs.

Abstract: The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.

Abstract: The present disclosure is directed to a system and method for surgical training with low cost, reusable materials and a highly customizable virtual environment for skill-building. According to various embodiments, a surgical training tool is usable in conjunction with a support structure configured to at least partially constrain the tool movement. Meanwhile, the tool is tracked in real-time with off-tool detectors to generate a tool path driving a virtual rendering of the surgical training tool in an operative environment. The virtual rendering may be visually observable via a display device and may include a customizable and/or selectable operative environment with one or more structures that can be operated on by the virtual surgical training tool. By tracking the virtual tool interaction with the virtual structures, a task path may be established for documenting and/or objectively assessing the performance of one or more operative tasks.

Abstract: A processor is configured with a learning framework to characterize the residuals of attribute information and its coherence with network information for improved anomaly detection.

Abstract: The disclosure relates to engineered heme sequestering peptides and their use in treating cancer and inhibiting microbial infections and colonization.