Abstract: There is disclosed a method for treating pulmonary inflammatory disease comprising administering an effective amount of resiniferatoxin (RTX) by an epidural, peri-ganglionic or intra-ganglionic administration. In some embodiments, the dose of RTX for an adult human is from about 0.1 ?g to about 100 ?g.
Type:
Application
Filed:
March 12, 2021
Publication date:
May 11, 2023
Applicant:
Board of Regents of the University of Nebraska
Inventors:
Alexis Nahama, Henry Hongjun Ji, Irving H. Zucker, Hanjun Wang
Abstract: A filament or printing material placed in a syringe for 3D printing comprising polymers, proteins, and/or functional particles and materials is provided. Methods of treating a bone defect in a subject in need thereof comprising using a handheld 3D printer to apply a filament or the printing material placed in a syringe to the bone defect of the subject are also provided. Methods of fixing or gluing natural or synthetic bone grafts using a handheld 3D printer to apply a filament or the printing material placed in a syringe over and around the defect or at the interface of a flap and the bone. Methods of printing a graft cage for retaining bone grafts and/or bone graft substitute in its desired location during healing for treatment of critical-sized segmental defects in long bones are provided.
Type:
Grant
Filed:
December 29, 2021
Date of Patent:
April 18, 2023
Assignees:
KING ABDULAZIZ UNIVERSITY, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
Inventors:
Adnan Memic, Tuerdimaimaiti Abudula, Ali Tamayol, Azadeh Mostafavi, Carina Russell, Tyrell Williams, Numan Abdullah Salah, Ahmed Salem AlShahrie, Ammar AbdulGhani Melaibari, Asija Memic, Mohammed Shaaban Abdelwahab, Mehdi Kazemzadeh Narbat
Abstract: The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Certain embodiments include various modular medical devices for in vivo medical procedures.
Type:
Grant
Filed:
July 6, 2021
Date of Patent:
April 4, 2023
Assignee:
Board of Regents of the University of Nebraska
Inventors:
Shane Farritor, Erik Mumm, Philip Chu, Nishant Kumar, Jason Dumpert, Yutaka Tsutano
Abstract: An apparatus for assessing user frailty is disclosed. In embodiments, the apparatus includes a housing that defines (or is defined by) a body and a handle coupled to the body. The apparatus includes a force sensor at least partially disposed within the handle. The apparatus further includes an inertial sensor at least partially disposed within the housing. The apparatus may further include a user interface device disposed within a cavity of the body. The user interface device may be coupled to the force sensor and the inertial sensor via one or more signal paths. In embodiments, the user interface device includes a controller with a touchscreen coupled to the controller.
Type:
Grant
Filed:
December 21, 2018
Date of Patent:
March 14, 2023
Assignee:
Board of Regents of the University
of Nebraska
Abstract: In various embodiments methods of distinguishing Crohn's disease from ulcerative colitis are provided. In certain embodiments the methods comprise determining, or causing to be determined, the level of IgG antibodies that bind a malondialdehyde-acetaldehyde adduct (MAA adduct) in a biological sample from a mammal, where an elevated level of said antibodies as compared to the average level found in a mammal with Crohn's disease is an indicator that the mammal has ulcerative colitis rather than Crohn's disease.
Type:
Application
Filed:
January 15, 2021
Publication date:
March 9, 2023
Applicant:
Board of Regents of the University of Nebraska
Inventors:
Geoffrey M. Thiele, Amar Singh, Michael J. Duryee, Rizwan Ahmad
Abstract: Various medical devices and related systems, including robotic and/or in vivo medical devices, and various robotic surgical devices for in vivo medical procedures. Included herein, for example, is a robotic surgical system having a support beam positionable through an incision, and a robotic device having a device body, first and second rotating shoulder components coupled to the device body, and first and second robotic arms coupled to the first and second shoulder components, respectively.
Type:
Grant
Filed:
June 7, 2021
Date of Patent:
February 28, 2023
Assignee:
Board of Regents of the University of Nebraska
Inventors:
Shane Farritor, Tyler Wortman, Kyle Strabala, Ryan McCormick, Amy Lehman, Dmitry Oleynikov, Eric Markvicka
Abstract: Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.
Type:
Grant
Filed:
March 1, 2021
Date of Patent:
February 21, 2023
Assignee:
Board of Regents of the University of Nebraska
Inventors:
Dong Wang, Fang Yuan, Zhenshan Jia, Xiaobei Wang
Abstract: A number of improvements are provided relating to computer aided surgery. The improvement relates to both the methods used during computer aided surgery and the devices used during such procedures. Some of the improvement relate to controlling the selection of which data to display during a procedure and/or how the data is displayed to aid the surgeon. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled automatically to improve the efficiency of the procedure. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure.
Type:
Grant
Filed:
August 11, 2021
Date of Patent:
January 31, 2023
Assignee:
Board of Regents of the University
of Nebraska
Abstract: A healthcare provider user interface for treatment option and authorization is disclosed herein. In embodiments, a healthcare provider interface includes a display coupled to one or more processors. The display includes a graphical user interface comprising one or more input interface display pages and one or more output interface display pages. The one or more input interface display pages may include one or more fields configured to receive information including patient demographic and physiological information, insurance information, past treatments, and one or more medical diagnoses. The one or more output interface display pages may include a treatment list generated based on the received information and a prior authorization output.
Type:
Grant
Filed:
March 31, 2022
Date of Patent:
January 17, 2023
Assignee:
Board of Regents of the University
of Nebraska
Abstract: Disclosed are compositions, methods, and kits for modifying DNA within cells as well as compositions and methods for modifying gene expression in a cell. In particular, the invention generally relates to compositions, methods, and kits for DNA editing using single-stranded DNA. Compositions and methods for modifying gene expression using artificial microRNAs (amiRNA) are also contemplated.
Type:
Grant
Filed:
February 7, 2018
Date of Patent:
January 17, 2023
Assignees:
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, TOKAI UNIERSITY EDUCATIONAL SYSTEM
Inventors:
Channabasavaiah B. Gurumurthy, Hiromi Miura, Masato Ohtsuka
Abstract: Disclosed are compositions, methods, and kits for modifying DNA within cells as well as compositions and methods for modifying gene expression in a cell. In particular, the invention generally relates to compositions, methods, and kits for DNA editing using single-stranded DNA. Compositions and methods for modifying gene expression using artificial microRNAs (amiRNA) are also contemplated.
Type:
Grant
Filed:
December 1, 2017
Date of Patent:
January 10, 2023
Assignees:
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, TOKAI UNIVERSITY EDUCATIONAL SYSTEM
Inventors:
Channabasavaiah B. Gurumurthy, Hiromi Miura, Masato Ohtsuka
Abstract: In various embodiments methods are provided for identifying a mammal having an elevated risk for an adverse cardiac event (e.g. an MI) and/or determining the prognosis for the mammal. In certain embodiments the methods comprise determining, or causing to be determined, the presence and/or level of antibodies that bind a malondialdehyde acetaldehyde adduct (MAA adduct) in a biological sample from the mammal, where an elevated level of anti-MAA adduct antibodies, as compared to the level found in a normal healthy mammal is an indicator that that said mammal has one or more atherosclerotic lesions and/or is at elevated risk for a myocardial infarction.
Type:
Grant
Filed:
February 4, 2020
Date of Patent:
January 3, 2023
Assignee:
Board of Regents of The University Of Nebraska
Inventors:
Geoffrey M. Thiele, Daniel R. Anderson, Michael J. Duryee
Abstract: A number of improvements are provided relating to computer aided surgery utilizing an on tool tracking system. The various improvements relate generally to both the methods used during computer aided surgery and the devices used during such procedures. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled using the OTT device. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure including the rate of and type of data processed depending upon a CAS mode.
Type:
Application
Filed:
September 4, 2022
Publication date:
December 29, 2022
Applicant:
Board of Regents of the University of Nebraska
Inventors:
Hani HAIDER, Ibrahim AL-SHAWI, Osvaldo Andres BARRERA
Abstract: Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly.
Type:
Grant
Filed:
March 5, 2019
Date of Patent:
December 20, 2022
Assignee:
Board of Regents of the University of Nebraska
Inventors:
Jack Mondry, Shane Farritor, Eric Markvicka, Thomas Frederick, Joe Bartels
Abstract: An antimicrobial composition containing a synergistic combination of an imidazole antifungal agent and activated creatinine is provided, wherein the imidazole antifungal agent represents in the range of about 0.5 mol % to about 30 mol % of the combination of the antifungal agent and the activated creatinine in the composition. Methods for treating bacterial infections, fungal infections, viral infections, and wounds are also provided, as are other methods of use, including methods for disinfecting inert surfaces, methods for preserving food products, and methods for treating plants. In addition, the invention provides a method for enhancing the antifungal effect of an imidazole antifungal agent as well as a method for enhancing the antibacterial effect of activated creatinine. Compositions and methods involving use of activated 2-amino-imidazol-4-one analogs other than activated creatinine are also provided.
Type:
Application
Filed:
June 6, 2022
Publication date:
December 8, 2022
Applicant:
Board of Regents of the University of Nebraska
Abstract: Disclosed herein are various robotic surgical devices and systems that include first and second elongate bodies, first and second driveshafts disposed through the second elongate body, and an in-line shoulder joint with a robotic arm coupled thereto. In certain implementations, the in-line shoulder joint has a differential yoke and a dual shaft disposed within the yoke lumen.
Type:
Grant
Filed:
April 21, 2021
Date of Patent:
November 22, 2022
Assignee:
Board of Regents of the University of Nebraska
Abstract: The various robotic medical devices include robotic devices that are disposed within a body cavity and positioned using a support component disposed through an orifice or opening in the body cavity. Additional embodiments relate to devices having arms coupled to a device body wherein the device has a minimal profile such that the device can be easily inserted through smaller incisions in comparison to other devices without such a small profile. Further embodiments relate to methods of operating the above devices.
Type:
Grant
Filed:
October 8, 2019
Date of Patent:
November 1, 2022
Assignee:
Board of Regents of the University of Nebraska
Inventors:
Eric Markvicka, Tom Frederick, Jack Mondry, Joe Bartels, Shane Farritor
Abstract: A number of improvements are provided relating to computer aided surgery utilizing an on tool tracking system. The various improvements relate generally to both the methods used during computer aided surgery and the devices used during such procedures. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled using the OTT device. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure including the rate of and type of data processed depending upon a CAS mode.
Type:
Grant
Filed:
September 24, 2018
Date of Patent:
October 11, 2022
Assignee:
Board of Regents of the University of Nebraska
Inventors:
Hani Haider, Ibrahim Al-Shawi, Osvaldo Andres Barrera