Patents Assigned to The Board of Regents of the University of Oklahoma
  • Patent number: 11021521
    Abstract: Mutants of Gram-negative bacteria having outer membranes comprising modified OrbA nanopores absent an N-terminal plug domain are disclosed. The modified OrbA nanopores confer the outer membrane of the bacteria with enhanced permeability. The mutants of Gram-negative bacteria optionally comprise efflux-deficient efflux pumps. The mutants may be used, for example, in a screening method for identifying a compound having an anti-bacterial activity.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: June 1, 2021
    Assignee: THE BOARD OR REGENTS OF THE UNIVERSITY OF OKLAHOMA
    Inventors: Helen Zgurskaya, Jon W. Weeks
  • Publication number: 20210139346
    Abstract: A method for desalinating a brine includes the use of a cooled intermediate-cold-liquid (ICL), which combines with the brine in a crystallization or freezing tank to produce a slurry of ice, brine, and ICL. The method includes steps for separating the ICL, ice and brine, and returning the separated ICL to the source of cooled ICL tank. The method concludes with the steps of passing the separated brine to the crystallization tank, and melting the separated ice to form desalinated water. The method is significant in that it produces desalinated liquid water and solid salts. The combination of superior heat transfer with high quality purified water and competitive desalination economy makes the disclosed freeze desalination technology an attractive solution for desalination of highly concentrated brines produced in a variety of industries, including but not limited to the oil and gas industry and reject brine management.
    Type: Application
    Filed: November 11, 2020
    Publication date: May 13, 2021
    Applicant: The Board of Regents of the University of Oklahoma
    Inventors: Hamidreza Shabgard, Ramkumar N. Parthasarathy, Jie Cai
  • Patent number: 10979932
    Abstract: A method comprises operating in an idle user state; determining to exit the idle user state and enter an active user state; obtaining cell loads of cells; calculating association functions based on the cell loads; determining, from among the association functions, a first association function with a maximum value; selecting a first cell associated with the first association function as a target cell; and entering the active user state by connecting to the first cell.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: April 13, 2021
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Ali Imran, Ahmad Asghar, Hasan Farooq
  • Patent number: 10976069
    Abstract: Flow device systems for use in an HVAC system (“HVAC”) are described. The system may include a controller receiving sensor signals including differential pressure, valve commands, fan/pump speed, and fan/pump motor power signal from the HVAC. The controller transmits override valve commands for multiple valve positions of the valve and multiple speeds of the fan and pump. A characteristic curve may be determined from the signals provided from the HVAC and the measured flow rate at each valve position or fan/pump speed during transmission of the plurality of override valve commands for the valve positions of the valve and fan/pump speed for fan/pump operation frequencies. Virtual flow rate through the valve, fan or pump is determined using the characteristic curve. In addition, valve dynamic behavior is determined using valve stiction and valve stiction plus deadband. Valve commands are updated based on valve dynamic behavior and a valve characteristic curve.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: April 13, 2021
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Li Song, Gang Wang
  • Patent number: 10975124
    Abstract: The disclosure is directed in non-limiting embodiments to compounds, compositions, and methods of treating conditions and diseases associated with activation of the gonadotropin GnRH receptor (GnRHR), particularly those involving GnRHR activating autoantibodies (GnRHR AAbs). In one non-limiting embodiment, the disease is Polycystic Ovary Syndrome (PCOS). The therapeutic compounds in at least certain embodiments include peptides which at least partially comprise D-amino acids, such as retro-inverso D-amino acid (RID) peptides, which are able to bind with high affinity to GnRHR AAbs.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: April 13, 2021
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: David Charles Kem, Xichun Yu, Hongliang Li, LaTasha B. Craig
  • Patent number: 10969365
    Abstract: In one aspect, methods of biomolecular analysis are described herein. Briefly, a method comprises providing a composition comprising glycosaminoglycans and contacting the composition with a membrane comprising at least one nanopore. An electric field is applied across the nanopore, and data of glycosaminoglycan translocation events through the nanopore are recorded. A molecular weight distribution of the glycosaminoglycans is derived from the data.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: April 6, 2021
    Assignees: WAKE FOREST UNIVERSITY HEALTH SCIENCES, THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
    Inventors: Adam R. Hall, Elaheh Rahbar, Paul DeAngelis
  • Patent number: 10953113
    Abstract: An imaging agent and a method of its use for imaging a necrosis in a tissue of a subject. The imaging method may be positron emission tomography (PET). In at least one embodiment the imaging agent comprises 2-deoxy-2-[18F]fluoroglucaric acid (18F-FGA), or a pharmaceutically-acceptable salt thereof. The imaging agent may be disposed in a pharmaceutically-acceptable excipient, carrier, diluent, or vehicle. The imaging agent may be contained within a kit. The disclosure includes in at least one embodiment a method of preparing a radiopharmaceutical such as 18F-FGA for use in imaging.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: March 23, 2021
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
    Inventors: Vibhudutta Awasthi, Hailey Houson, Gregory Nkepang
  • Patent number: 10953040
    Abstract: The present disclosure describes compositions comprising ?-lactam antibiotics and branched polyethylenimines (BPEI), having efficacy against various Gram-positive bacteria, for example Gram-positive bacteria having resistance against ?-lactam antibiotics, one non-limiting example of which is Methicillin-resistant Staphylococcus aureus (MRSA). The compositions result in the resensitization of such resistant bacterial strains to traditional antibiotic therapies such as ?-lactam antibiotics.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: March 23, 2021
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Charles V. Rice
  • Patent number: 10946371
    Abstract: Disclosed is a method of treating spent equilibrium catalyst (ECAT) for reuse, in which a quantity of spent ECAT comprising hydrophilic particles with differing levels of metal contamination is disposed into a reactor and treated to form carbon nanotubes on the particles having metal contamination, thereby rendering at least a portion of the spent ECAT particles hydrophobic; the hydrophobic particles can then be separated from the hydrophilic particles. Also disclosed is a method of remediating an oil spill using a carbon nanotube sponge material.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: March 16, 2021
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Steven P. Crossley, Nicholas M. Briggs, Daniel E. Resasco
  • Patent number: 10948209
    Abstract: A system and method for controlling HVAC equipment in a residential setting. The system may include an outdoor temperature sensor positioned to measure outdoor temperatures, an indoor air temperature sensor to measure indoor space air temperatures, a supply duct air temperature sensor positioned to measure supply duct air temperatures, a return duct air temperature sensor positioned to measure return duct air temperatures, an air blower current sensor positioned to measure air blower currents, and/or an air compressor current sensor positioned to measure air compressor currents, and a controller operable to receive the measures of outdoor temperature, indoor space air temperature, supply duct air temperature, return duct air temperature, air blower current, air compressor current, and measures of solar irradiation intensity and wind speed. The controller may be programmed with instructions to input the measures into a thermal model for outputting signals for implementing changes in the system.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: March 16, 2021
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Li Song, Choon Yik Tang
  • Patent number: 10933126
    Abstract: An immunogenic composition containing a Clostridium difficile (C. difficile) surface polysaccharide II (PSII) or an immunogenic portion thereof; and an ?-galactosylceramide (?-GC) or analog or derivative thereof, which is able to bind to a CD1d glycoprotein, optionally containing a C. difficile TcdB C-terminal domain (CTD), or an immunogenic portion thereof, and/or an adjuvant. A method of treating, ameliorating, or inhibiting a C. difficile infection or a C. difficile-associated diarrhea in a subject by administering the immunogenic composition, particularly in subjects at risk for a C. difficile infection. A method of protecting a subject's gut microflora by administering the immunogenic composition or a composition containing ?-GC and an alum adjuvant.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: March 2, 2021
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Mark L. Lang, Jimmy D. Ballard
  • Patent number: 10899822
    Abstract: Compositions are disclosed that include D-amino acid peptides and that are capable of specifically binding to at least one autoantibody against a G-protein coupled receptor. The autoantibody is produced in a patient having or being predisposed to a disease, condition, or disorder, and the autoantibody is capable of binding to a specific epitope of the G-protein coupled receptor. Methods of production and use of said compositions are also disclosed.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: January 26, 2021
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: David C. Kem
  • Patent number: 10900035
    Abstract: Three-way junction (3WJ) RNA scaffolds derived from phi29, M2, SF5, and GA1 pRNAs and which have high stability are described. The pRNA 3WJ scaffolds can be used to form compounds, conjugates, compositions, and nanoparticles for delivery of active agents for therapeutic and/or diagnostic functions.
    Type: Grant
    Filed: February 26, 2017
    Date of Patent: January 26, 2021
    Assignees: The Board of Regents of the University of Oklahoma
    Inventors: Alyssa C. Hill, Susan J. Schroeder
  • Publication number: 20210001575
    Abstract: A liquid composite molding method includes the steps of providing a part mold that has an inlet gate and an exit gate, placing a fabric preform over the part mold, placing a membrane over the fabric preform and securing a pressure cap to the part mold. The pressure cap and part mold together form a pressure chamber with a headspace between the membrane and the pressure cap. The method further includes the step of filling the fabric preform with liquid resin under the membrane while applying pressure within the headspace over the membrane. The method may be practiced with an apparatus that has a pressure chamber, a fabric preform inside the pressure chamber, a membrane over the fabric preform, a resin injection assembly, and a resin extraction assembly. The pressure chamber includes a part mold and a pressure cap. A headspace is formed above the membrane within the pressure chamber.
    Type: Application
    Filed: July 3, 2020
    Publication date: January 7, 2021
    Applicant: The Board of Regents of the University of Oklahoma
    Inventors: M Cengiz Altan, Mehmet Akif Yalcinkaya
  • Publication number: 20200408622
    Abstract: A toe dynamometer is configured to accurately and precisely measure toe extensor strength. The toe dynamometer includes a platform configured to accommodate a patient's foot, and a sensor assembly comprising a force sensor and a toe cap connected to the force sensor. The force sensor is configured to measure forces applied to the force sensor by toe flexion on the force sensor and from toe extension away on the force sensor through the toe cap.
    Type: Application
    Filed: June 29, 2020
    Publication date: December 31, 2020
    Applicant: The Board of Regents of the University of Oklahoma
    Inventors: Hongwu Wang, Elizabeth Hile, Mustafa Ghazi, Lewis Baumgardner, Sarah Brown, Raghuveer Chandrashekhar
  • Patent number: 10876116
    Abstract: Antisense compounds for suppressing expression of ARTD3a are disclosed, as well as pharmaceutical compositions containing same and methods of producing and using same. The antisense compounds can be used to treat inflammatory disorders and conditions related to interferon-alpha production.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: December 29, 2020
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Carol F. Webb, Julie Ward, Michelle Ratliff
  • Patent number: 10879608
    Abstract: A radio frequency (RF) scanner system provided with a multi-axis articulated robot and a sensor suite positioned on a first end of the multi-axis articulated robot. The sensor suite is provided with a shield, an antenna array probe, and a surface sensor. The shield has a first side and a second side opposite the first side. The first side is configured for positioning towards an active phased array antenna. The surface sensor is configured to determine X, Y, and Z positions of the active phased array antenna.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: December 29, 2020
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Jorge L. Salazar-Cerreno, Damon Andrew Schmidt, Caleb Fulton, Robert D. Palmer, Rodrigo Manuel Lebron Garcia, Alessio Mancini, Simon Thierry Pierre Duthoit, Matthew Stephen McCord, John Brent Meier, Redmond Clay Kelley
  • Patent number: 10874631
    Abstract: Certain embodiments are directed to methods for treating Ewing family tumors (EFT) comprising administering an effective amount of altertoxin II to a subject having EFT.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: December 29, 2020
    Assignees: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
    Inventors: Susan L Mooberry, Andrew J Robles, April L Risinger, Robert H Cichewicz, Saikat Haldar, Peter Houghton
  • Patent number: 10857219
    Abstract: Compositions that include one isolated, class I HLA-E trimolecular complex that includes a peptide ligand unique to M. tuberculosis-infected cells are disclosed. Isolated compositions that include the three components of the trimolecular complex and/or a polynucleotide encoding one or more of the three components are also disclosed.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: December 8, 2020
    Assignees: The Board of Regents of the University of Oklahoma, Oregon Health & Science University, The United States Government as Represented by the Department of Veterans Affairs
    Inventors: William H. Hildebrand, Curtis McMurtrey, David Lewinsohn, Deborah Lewinsohn, Melanie Harriff
  • Publication number: 20200370264
    Abstract: A pile for use in a ground pile system has a tubular body and one or more sensor modules attached to the tubular body. Each of the one of more sensor modules includes a sensor guard that has a perimeter and a sensor nested within the sensor guard. The sensor is recessed within the perimeter of the sensor guard to protect the sensor during installation of the pile. A data acquisition unit can be used to receive data from the one or more sensor modules. The data acquisition unit includes a solar panel array, a battery charged by the solar panel array, a modem powered by the battery, and a computer powered by the battery. The computer is configured to receive signals from the sensors and transmit the signals to a remote operation center through the modem.
    Type: Application
    Filed: May 18, 2020
    Publication date: November 26, 2020
    Applicant: The Board of Regents of the University of Oklahoma
    Inventor: Amy Cerato