Abstract: Hydroxybenzamide derivative compounds having ?-cell protective activity against ER stress, and methods of their use in treating diabetes and other conditions and diseases associated with ER stress. In one non-limiting embodiment, the derivative is 3-hydroxy-N-(4-(trifluoromethyl)benzyl)benzamide.

Abstract: A probe is described. The probe includes a probe antenna, a transmitter, a receiver and circuitry including hardware. The probe antenna is constructed of a dielectric material connected to a waveguide, the probe antenna has a far field region. The transmitter is coupled to the probe antenna. The receiver is coupled to the probe antenna. The hardware is configured to communicate with the transmitter to enable the transmitter to direct a pulse of electromagnetic energy to the probe antenna and to receive a reflection signal from the receiver, the hardware is configured to determine a material property of a material within the far-field region of the probe antenna by analyzing the reflection signal.

Abstract: A surgical evacuation apparatus and method for evacuating a biological material from a body cavity. The surgical evacuation apparatus has a shaft and a scoop extending from a distal end of the shaft. The shaft has a supply inlet for connecting to a pressurized fluid source and an outlet for connecting to a vacuum source. An evacuation channel extends from the scoop to the outlet. A fluid supply channel extends in the shaft from the supply inlet towards the distal end and intersects the evacuation channel proximate the scoop. Material desired to be removed from the body cavity is collected in the scoop by a user. The biological material collected in the scoop is broken up by a fluid stream from the supply channel and is drawn into the evacuation channel by a vacuum applied by the vacuum source and is removed from the body cavity.

Abstract: A mounting system for mounting a solar panel assembly to a base assembly includes a panel support bracket, a base bracket and a clamp configured to exert a compressive force to hold the panel support bracket and the base bracket together. The clamp comprises a V-shaped clamp body that includes a pair of legs that are spring-loaded to oppose an approximation of the legs by an external compressive force. The clamp includes a pair of receiver slots, with each of the pair of receiver slots located on a corresponding one of the pair of legs. The pair of receiver slots collectively provides a clearance to admit the panel support bracket and the base bracket when the legs are compressed together.

Abstract: A liquid composite molding method includes the steps of providing a part mold that has an inlet gate and an exit gate, placing a fabric preform over the part mold, placing a membrane over the fabric preform and securing a pressure cap to the part mold. The pressure cap and part mold together form a pressure chamber with a headspace between the membrane and the pressure cap. The method further includes the step of filling the fabric preform with liquid resin under the membrane while applying pressure within the headspace over the membrane. The method may be practiced with an apparatus that has a pressure chamber, a fabric preform inside the pressure chamber, a membrane over the fabric preform, a resin injection assembly, and a resin extraction assembly. The pressure chamber includes a part mold and a pressure cap. A headspace is formed above the membrane within the pressure chamber.

Abstract: Antibodies and antigen-binding fragments thereof that specifically bind to human DCLK1 protein, hybridomas or other cell lines which express such antibodies and antigen-binding fragments thereof, nucleic acids, vectors, and host cells comprising nucleic acids which encode such antibodies and antigen-binding fragments thereof, and methods of use thereof are disclosed. In at least certain non-limiting embodiments, the antibodies or antigen-binding fragments thereof specifically bind to an epitope within isoform 2 or 4 of DCLK1 protein.

Abstract: Cyclic depsipeptide-class molecules, referred to herein as persephacins (including analogs thereof), having similarities to aureobasidin A, are described. The persephacins have antimicrobial activity, such as antifungal activity against a diverse range of clinically-relevant fungal pathogens, antiprotozoan parasite activity, and antibacterial activity, and can be used for example in treatments of difficult-to-treat ocular fungal infections at lower concentrations than natamycin. The active compounds may be combined with a secondary compound in a composition.

Abstract: A method and system of nanoscale photoacoustic tomography (nPAT) for non-invasive three-dimensional mapping and characterization of fine cellular structures (such as but not limited to organelles, vesicles, and macromolecules) of biological samples is disclosed.

Abstract: A method comprises performing data pre-processing of initial signals to obtain pre-processed initial signals; building a first machine learning model based on the pre-processed initial signals; generating output signals using the first machine learning model; computing ranks of the output signals; computing classifications of the output signals; and building a set of stacked machine learning models based on the ranks and the classifications. The set of stacked machine learning models may be used to generate subsurface well log data, NMR data, or other data.

Abstract: A method of producing dendritic gold nanoparticles by combining a gold precursor solution, a reducing agent, and a bifunctional peptide having an amine-rich amino acid sequence into a buffered aqueous solution in a single container, and agitating the mixture causing the formation of the dendritic gold nanoparticles having a surface with a positive charge and a second end portion of the bifunctional peptide exposed on the surface of the dendritic gold nanoparticles. The dendritic gold nanoparticles may be used to deliver therapeutic, diagnostic, and/or immunogenic amino acid sequences as portions of the bifunctional peptide.

Abstract: A gas sensor comprising: a substrate; a grating array disposed on top of the substrate and comprising grates; and voids defined by the grates and configured to confine gas molecules for absorption of light and analysis. A method of gas sensing comprising: generating first light; converting the first light into second light using grates of a grating array; resonating the second light within the grating array; confining gas molecules in voids defined by the grates; and causing the gas molecules to absorb the second light within the voids.

Abstract: Tracking patient compliance with treatment protocols is an important aspect of delivering high quality healthcare. A system for tracking compliance with protocols that include the periodic consumption of oral medication includes a mobile computing device and a pill tracking dispenser. The mobile computing device includes an application program configured to record the periodic consumption of oral medication by the patient. The pill tracking dispenser can be connected to the mobile computing device through a wireless network. The pill tracking dispenser is configured to report to the mobile computing device the number of times the oral medication is consumed by the patient.

Abstract: A double skin façade (DSF) for a building is disclosed. The DSF has a first façade, a second façade, and a gap extending therebetween. Movement of air is driven in an upward direction toward an upper end of the DSF, causing movement of air contaminants from a lower end of the DSF to the upper end of the DSF, and thereby enhancing the air quality of the street canyon by removing air contaminants from a street level adjacent the building. Also disclosed is a building having a DSF, and a method of enhancing air quality in a street canyon by constructing a DSF on a building.

Abstract: High photoluminescence, high stability, inorganic perovskite compounds comprising an alkali metal selected from potassium (K), rubidium (Rb), and cesium (Cs); copper (Cu); and at least one halogen selected from chlorine (Cl), bromine (Br), and iodine (I). The perovskites may be free of lead (Pb). The inorganic perovskite compound may be used in an optoelectronic device. The optoelectronic device optionally contains a phosphor such as a blue-emitting phosphor. The inorganic perovskite compound may be used as an anti-counterfeiting nanotaggant applied on or within an object that susceptible to counterfeiting to enable confirmation of an authentic object.

Abstract: A charging cable apparatus having a connector, an electrically-conductive cable extending from the connector, the cable configured to be connectable to a charging station for receiving a charging current from the charging station, and having a heat pipe with a phase change section having a wicking structure, the wicking structure having a working fluid therein during operation for receiving heat generated during current flow within the cable. The charging cable apparatus may further have an external condensing surface in fluid communication with the phase change section of the heat pipe for accelerating condensation of evaporated working fluid. The charging cable apparatus may be connected to a charging station for charging an electric battery such as a battery of an electric vehicle.

Abstract: A PV device comprises a first mirror comprising a reflectance of higher than 50%; a second mirror interface; and an optical cavity positioned between the first mirror and the second mirror interface and comprising at least one IC stage. Each of the at least one IC stage comprises a conduction band; a valence band; a hole barrier comprising a first band gap; an absorption region coupled to the hole barrier, comprising a second band gap that is less than the first band gap, and configured to absorb photons; and an electron barrier coupled to the absorption region so that the absorption region is positioned between the hole barrier and the electron barrier. The electron barrier comprises a third band gap that is greater than the second band gap. The PV device is configured to operate at a forward bias voltage with a net photon absorption for generating an electric output.

Abstract: A mounting system for mounting a solar panel assembly to a base assembly includes a panel support bracket, a base bracket and a clamp configured to exert a compressive force to hold the panel support bracket and the base bracket together. The clamp comprises a V-shaped clamp body that includes a pair of legs that are spring-loaded to oppose an approximation of the legs by an external compressive force. The clamp includes a pair of receiver slots, with each of the pair of receiver slots located on a corresponding one of the pair of legs. The pair of receiver slots collectively provides a clearance to admit the panel support bracket and the base bracket when the legs are compressed together.

Abstract: A pile for use in a ground pile system has a tubular body and one or more sensor modules attached to the tubular body. Each of the one of more sensor modules includes a sensor guard that has a perimeter and a sensor nested within the sensor guard. The sensor is recessed within the perimeter of the sensor guard to protect the sensor during installation of the pile. A data acquisition unit can be used to receive data from the one or more sensor modules. The data acquisition unit includes a solar panel array, a battery charged by the solar panel array, a modem powered by the battery, and a computer powered by the battery. The computer is configured to receive signals from the sensors and transmit the signals to a remote operation center through the modem.

Abstract: Microparticulate drug compositions comprising nanocrystals of poorly soluble drugs combined with a carrier are disclosed. Also disclosed are pharmaceutical compositions that include the microparticulate drug compositions. Further disclosed are methods of preparing and using the microparticulate drug compositions/pharmaceutical compositions.