Abstract: Disclosed is a voltage regulator for an integrated circuit. The voltage regulator can be configured to regulate a supply voltage provided to the integrated circuit. The integrated circuit can operate a near threshold value irrespective of a magnitude of the supply voltage. The voltage regulator can include a single Field Effect Transistor (FET) based circuit. The single FET based circuit can be configured to regulate the supply voltage.

Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.

Abstract: Immunogenic compositions comprising viral vectors and surfactants are provided. Methods for administration and preparation of such compositions are also provided.

Abstract: Devices and methods for removal of calculus (including for example, kidney stones) are disclosed. In an embodiment, a device for removal of kidney stones includes a substantially sealable pouch that can be inserted into the kidney for capturing a kidney stone. The pouch is also designed to permit fragmentation of the kidney stone inside the pouch, while preventing kidney stone fragments from escaping from the pouch. As a result, the likelihood of dispersing stone fragments during fragmentation of a large stone is greatly lessened.

Abstract: In one embodiment, a hybrid foil bearing includes a bearing sleeve, multiple inner foils provided within the sleeve, the foils having gas outlets from which pressurized gas can be injected into an interior of the bearing, and integrated gas flow paths that radially extend through the bearing sleeve and deliver the gas to the gas outlets.

Abstract: Disclosed are systems and methods for performing automatic, large-scale analysis mobile applications to determine and analyze application vulnerability. The disclosed systems and methods include identifying potentially vulnerable applications, identifying the application entry points that lead to vulnerable behavior, and generating smart input for text fields. Thus, a fully automated framework is implemented to run in parallel on multiple emulators, while collecting vital information.

Abstract: Certain embodiments are directed to methods of identifying a subject having a higher risk of prostate cancer recurrence. The methods can include the step of measuring levels of one or more of FLIP, transcription factor Sp1, and transcription factor Sp3 in a prostate sample from the subject, wherein elevated levels of FLIP, transcription factor Sp1, and transcription factor Sp3 identify a subject as high risk for prostate cancer recurrence.

Abstract: Certain embodiments are directed to liposome compositions comprising a synthetic lipid composition encapsulating a scent suppressing solution.

Abstract: Provided is a method of detecting the presence of an anti-Zika virus (ZIKV) antibody in a sample, including contacting a sample with a suspension having a plurality of microspheres wherein individual microspheres are conjugated to a peptide and the peptide includes a ZIKV peptide selected from the group including ZIKV NS1, ZIKV NS5, and ZIKV envelope protein, forming a first incubated suspension by incubating said sample with said suspension to permit binding of anti-ZIKV antibodies present in the sample to said microspheres, forming a second incubated suspension by contacting said first incubated suspension with an anti-ZIKV antibody detecting-reagent to permit binding of the anti-ZIKV antibody detecting reagent to said microspheres, removing from the second incubated suspension anti-ZIKV antibody detecting-reagent molecules that are not bound to said microspheres, and detecting the presence of anti-ZIKV antibody detecting-reagent molecules in the second incubated suspension.

Abstract: Embodiments of the invention are directed to a vascular structure forming implant produced by additive manufactured Ti-6Al-4V scaffolds a living implant.

Abstract: Disclosed are systems and methods for monitoring biopotential signals in biomedical devices. The disclosure provides a mixed signal background calibration that stabilizes the time-varying coupling gain between the body and an electrode due to motion artifacts. The calibration technique involves a low-level test signal in the form of a one-bit pseudorandom bit-sequence that is injected through a reference electrode to the body, detected by the sensing electrode and recorded along with the bio signals. A digital algorithm is employed in the backend to identify the acquisition channel characteristics while maintaining its normal operation of recording. Programmable gain stages in analog or digital domain(s) can be used to stabilize the overall gain of the channel. The disclosed technique is in the background and not interfering with the normal recording operation(s), and provides continuous monitoring of the ETI and continuous correction of the ensuing channel characteristic degradation due to the ETI variation.

Abstract: A wireless sensor system is described which can be used to measure temperature and/or pressure within an electromagnetically shielded environment. The sensor system includes an embedded processor which intermittently transmits data from the sensors. In electromagnetically shielded environments, the processor transmits the data when the electromagnetically shielding components are moved into a non-shielding configuration.

Abstract: Memristor-based adders using memristors-as-drivers (MAD) gates. As a result of employing MAD gates in memristor-based adders, such as ripple carry adders, carry select adders, conditional sum adders and carry lookahead adders, the number of delay steps may be less than half than the number of delay steps required in traditional CMOS implementations of adders. Furthermore, by using MAD gates, memristor-based adders can be implemented with less complexity (e.g., fewer memristors and drivers). As a result, by the memristor-based adders using MAD gates, the speed and complexity of a wide variety of arithmetic operations is improved.

Abstract: Methods for fabricating and replicating self-aligned multi-tier nanoscale structures for a variety of cross-sectional geometries. These methods can utilize a single lithography step whereby the need for alignment and overlay in the process is completely eliminated thereby enabling near-zero overlay error. Furthermore, techniques are developed to use these methods to fabricate self-aligned nanoscale multi-level/multi-height patterns with various shapes for master templates, replica templates and nanoimprint based pattern replication. Furthermore, the templates can be used to pattern multiple levels in a sacrificial polymer resist and achieve pattern transfer of the levels into a variety of substrates to form completed large area nanoelectronic and nanophotonic devices using only one patterning step.

Abstract: DNA is sequenced by (a) independently sequencing first and second strands of a dsDNA to obtain corresponding first and second sequences; and (b) combining the first and second sequences to generate a consensus sequence of the dsDNA. By independently sequencing first and second strands the error probability of the consensus sequence approximates a multiplication of those of the first and second sequences.

Abstract: Methods for fabricating and replicating self-aligned multi-tier nanoscale structures for a variety of cross-sectional geometries. These methods can utilize a single lithography step whereby the need for alignment and overlay in the process is completely eliminated thereby enabling near-zero overlay error. Furthermore, techniques are developed to use these methods to fabricate self-aligned nanoscale multi-level/multi-height patterns with various shapes for master templates, replica templates and nanoimprint based pattern replication. Furthermore, the templates can be used to pattern multiple levels in a sacrificial polymer resist and achieve pattern transfer of the levels into a variety of substrates to form completed large area nanoelectronic and nanophotonic devices using only one patterning step.

Abstract: This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.

Abstract: A method for delivering therapeutic light ion radiation to a target volume of a subject, wherein the target volume is located at a predetermined depth from the skin, includes irradiating a surface of the skin with an array of light ion minibeams comprising parallel, spatially distinct minibeams at the surface in an amount and spatially arranged and sized to maintain a tissue-sparing effect from the skin to a proximal side of the target volume, and to merge into a solid beam at a proximal side of the target volume. A gap between the parallel, spatially distinct minibeams at the surface and a species of light ions forming the minibeams are selected such that the array merges into a solid beam at a predetermined beam energy, and across all energies for Bragg-peak spreading, at a proximal side of the target volume.

Abstract: A catheter includes an elongated tube, wherein a portion of the elongated tube is positionable inside the body of a subject such that, during use, bodily fluids travel from the subject through the elongated tube. A timing device is coupled to the elongated tube, wherein, after the catheter is inserted into the body of the subject, the timing device provides an indication of the amount of time that the catheter has been disposed inside the subject.