Patents Assigned to The Board of the Regents the University of Texas
  • Noninvasive therapies in the presence of exogenous particulate agents
    Patent number: 9931516
    Abstract: Methods are disclosed for treating cell components, cells, organelles, organs, and/or tissues with acoustic energy, electromagnetic energy, static or alternating electric fields, and/or static or alternating magnetic fields in the presence or absence of exogenous particulate agents for therapeutic applications.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: April 3, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventor: Rinat O. Esenaliev
  • Monoclonal antibodies for use in diagnosis and therapy of cancers and autoimmune disease
    Patent number: 9926380
    Abstract: The specification describes the sequences for antibodies that recognize the HLA-A2-restricted peptide PR-1 in the context of HLA presentation on the surface of cancer cells. Use of these antibodies in the diagnosis and treatment of cancer and immune-related diseases are also provided.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: March 27, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jeffrey Molldrem, Anna Sergeeva
  • Methods for engineering sugar transporter preferences
    Patent number: 9926347
    Abstract: Provided herein are compositions and methods useful for transporting xylose, arabinose and other monosaccharides, into a yeast cell.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: March 27, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: Hal Alper, Eric Young
  • Compounds and anti-tumor NQO1 substrates
    Patent number: 9925180
    Abstract: Compositions comprising Formula (I) can be selectively lethal toward a variety of different cancer cell types. The compositions are useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: March 27, 2018
    Assignees: The Board of Trustees of the University of Illinois, The Board of Regents of the University of Texas System
    Inventors: Paul J. Hergenrother, David A. Boothman, Joseph S. Bair, Rahul Palchaudhuri, Elizabeth I. Parkinson
  • NAD analogs and methods of using said NAD analogs in determining ribosylation of proteins with PARP mutants
    Patent number: 9926340
    Abstract: The present disclosure provides NAD analogs of the formula: wherein R1, n, and X1 are defined herein, useful for the identification of PARP target proteins and the amino acid sequence wherein the ribose group is attached to the target protein. Also, provided herein are methods of identifying target protein and amino acid sequences. Additionally, the present disclosure provides methods of identifying DNA sequences associated with specific chromatin proteins.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: March 27, 2018
    Assignees: The Board of Regents of the University of Texas System, Biolog Life Science Institute Forshungslabor und Biochemica-Vertrieb GmbH, Cornell University
    Inventors: W. Lee Kraus, Bryan A. Gibson, Frank Schwede, Hening Lin
  • RAPID PERTUSSIS DIAGNOSIS ON A POINT-OF-CARE HYBRID MICROFLUIDIC BIOCHIP
    Publication number: 20180080067
    Abstract: Certain embodiments are directed to a point-of-care (POC) microfluidic biochip for rapid, highly sensitive and specific pertussis diagnosis. The POC biochip can be used in various venues such as physician's office, schools, hospitals, and low-resource settings so that rapid prevention and treatment of pertussis can be achieved. The POC biochip based pertussis diagnosis is low-cost and does not rely on any specialized instrument, but offers comparable sensitivity to real-time PCR.
    Type: Application
    Filed: September 12, 2017
    Publication date: March 22, 2018
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: XiuJun Li, Maowei Dou, Delfina C. Dominguez
  • Method and Apparatus for Monitoring an Organ of a Patient
    Publication number: 20180078169
    Abstract: An apparatus for determining tissue versus fluid components of an organ include a detector that generates a detector signal based on electrical signals derived from tissue and fluid. The apparatus includes a signal processor in communication with the detector which subtracts in real time a tissue component from the detector signal and produces a fluid volume signal. A method for monitoring a patient's fluid volume of a patient's organ. An apparatus for monitoring a patient's organ. A method for monitoring a patient's organ. A method to piggyback an admittance system onto a AICD/Bi-ventricular Pacemaker for a heart of a patient, in particular a weakened heart having features consistent with congestive heart failure. An apparatus for monitoring an organ, such as a heart, lungs, brain, skeletal muscle, and bladder of a patient which includes a detector which detects the admittance of the organ.
    Type: Application
    Filed: November 17, 2017
    Publication date: March 22, 2018
    Applicant: Board of Regents, The University of Texas System
    Inventors: Marc D. Feldman, John Porterfield, Karthik Raghavan, Jonathan W. Valvano, John A. Pearce
  • SYSTEMS, APPARATUSES AND METHODS FOR IMPROVED ROTATING DETONATION ENGINES
    Publication number: 20180080412
    Abstract: Rotating detonation engines are provided with various improvements pertaining to performance and reliability. Improvements pertain to, for example, a fluidic valve/premixing chamber, injection/swirl, flow control and turning, ignition, and cooling.
    Type: Application
    Filed: September 20, 2017
    Publication date: March 22, 2018
    Applicant: Board of Regents, The University of Texas System
    Inventors: Andrew R. Mizener, Frank K. Lu
  • Analysis of genomic DNA, RNA, and proteins in exosomes for diagnosis and theranosis
    Patent number: 9921223
    Abstract: The present invention provides that exosomes from human body fluid samples contain double stranded genomic DNA that spans all chromosomes and may be used to determine the mutation status of genes of interest in diseases, such as cancer. Furthermore, the present invention provides the use of exosomes to produce therapeutic proteins and for their use in therapy as well as the detection of cancer cell-derived exosomes to diagnose cancer and monitor therapeutic response.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: March 20, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: Raghu Kalluri, Sónia Melo
  • TLR-independent small molecule adjuvants
    Patent number: 9918959
    Abstract: A TLR-independent adjuvant compound that corresponds in structure to Formula I, below, or its pharmaceutically acceptable salt is disclosed in which X, Y, Z, n, R1, R2, R3, R4 and W are defined within. Also disclosed are a method of its preparation and use, as well as a pharmaceutical composition containing the same.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: March 20, 2018
    Assignees: The Board of Regents of the University of Texas System, The Scripps Research Institute
    Inventors: Dale Boger, Bruce Beutler
  • Systems and methods for physiological signal enhancement and biometric extraction using non-invasive optical sensors
    Patent number: 9918666
    Abstract: A system and method for signal processing to remove unwanted noise components including: (i) wavelength-independent motion artifacts such as tissue, bone and skin effects, and (ii) wavelength-dependent motion artifact/noise components such as venous blood pulsation and movement due to various sources including muscle pump, respiratory pump and physical perturbation. Disclosed are methods, analytics, and their uses for reliable perfusion monitoring, arterial oxygen saturation monitoring, heart rate monitoring during daily activities and in hospital settings and for extraction of physiological parameters such as respiration information, hemodynamic parameters, venous capacity, and fluid responsiveness. The system and methods disclosed are extendable to include monitoring platforms for perfusion, hypoxia, arrhythmia detection, airway obstruction detection and sleep disorders including apnea.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: March 20, 2018
    Assignee: The Board of Regents, The University of Texas System
    Inventors: Rasoul Yousefi, Mehrdad Nourani
  • Rapamycin analogs targeting proteasome function in the treatment of cancer
    Patent number: 9918968
    Abstract: The invention provides for treatment of cancers using a rapamycin analog, optionally including bortezomib. In particular, the invention addresses the treatment of bortezomib-resistant cancers using seco-rapamycin and optionally a second proteasome inhibitor. This invention relates to oncology and medicine, and more particularly to treatment of cancer. In particular, rapamycin analogs such as seco-rapamycin may be used advantageously to target the proteasome in cancer cells, optionally in conjunction with proteasome inhibitors such as bortezomib.
    Type: Grant
    Filed: December 24, 2013
    Date of Patent: March 20, 2018
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Maria E. Gaczynska, Pawel A. Osmulski
  • Memristor-based adders using memristors-as-drivers (MAD) gates
    Patent number: 9921808
    Abstract: Memristor-based adders using memristors-as-drivers (MAD) gates. As a result of employing MAD gates in memristor-based adders, such as ripple carry adders, carry select adders, conditional sum adders and carry lookahead adders, the number of delay steps may be less than half than the number of delay steps required in traditional CMOS implementations of adders. Furthermore, by using MAD gates, memristor-based adders can be implemented with less complexity (e.g., fewer memristors and drivers). As a result, by the memristor-based adders using MAD gates, the speed and complexity of a wide variety of arithmetic operations is improved.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: March 20, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: Earl Swartzlander, Lauren Guckert
  • Method of improving hydraulic fracturing by decreasing formation temperature
    Patent number: 9920608
    Abstract: A method for producing fractures in a formation to release hydrocarbons (such as a hydrocarbon gas or liquid) from the formation is disclosed. The method comprises reducing the in-situ temperature at a location in a formation having a first temperature by contacting the location with a first fluid and contacting the location with a fracturing fluid to produce fractures in the formation while the location is at a second temperature below the first temperature to release hydrocarbons from the formation. The method can include using an endothermic process to reduce the temperature at the location in the formation.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: March 20, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: Eric van Oort, Tadeusz W. Patzek, Saeid Enayatpour
  • Method and Apparatus for Determining Cardiac Performance in a Patient With a Conductance Catheter
    Publication number: 20180070851
    Abstract: An apparatus for determining cardiac performance in the patient includes a plurality of electrodes adapted to be placed in the patient and in communication with a heart chamber of the patient for measuring conductance and blood volume in the heart chamber of the patient; and a processor for determining instantaneous volume of the ventricle based on measurement of complex admittance at a plurality of frequencies to identify mechanical strength of the chamber, the processor in communication with the electrodes. A method for determining cardiac performance in a patient.
    Type: Application
    Filed: November 17, 2017
    Publication date: March 15, 2018
    Applicant: Board of Regents, The University of Texas System
    Inventors: Marc D. Feldman, Jonathan W. Valvano, John A. Pearce, Chia-Ling Wei
  • COMPOSITIONS AND METHODS FOR PROLONGED CELL STORAGE
    Publication number: 20180070581
    Abstract: Provided in some aspects are methods and compositions for preserving platelets or other cells. In some embodiments, a platelet storage media or cell storage media may comprise a low molecular weight polyethylene glycol (e.g. PEG-400) to allow for extended storage and/or refrigeration of the platelets or cells.
    Type: Application
    Filed: April 8, 2016
    Publication date: March 15, 2018
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jeffrey TARRAND, Borje ANDERSSON
  • COILED, TWISTED NANOFIBER YARN AND POLYMER FIBER TORSIONAL ACTUATORS
    Publication number: 20180073490
    Abstract: Actuators (artificial muscles) comprising twist-spun nanofiber yarn or twist-inserted polymer fibers generate torsional actuation when powered electrically, photonically, chemically, thermally, by absorption, or by other means. These artificial muscles utilize coiled yarns/polymer fibers and can be either neat or comprising a guest. In some embodiments, the torsional fiber actuator includes a first polymer fiber (exhibiting a first polymer fiber diameter) and a torsional return spring in communication with the first polymer fiber. The first polymer fiber is configured to include a first plurality of twists in a first direction to produce a twisted polymer fiber. The first polymer fiber is further configured to include a plurality of coils in the twisted polymer fiber in a second direction each coil having a mean coil diameter.
    Type: Application
    Filed: November 16, 2017
    Publication date: March 15, 2018
    Applicant: Board of Regents, The University of Texas System
    Inventors: Na Li, Carter S. Haines, Marcio D. Lima, Monica Jung DeAndrade, Shaoli Fang, Jiyoung Oh, Mikhail E. Kozlov, Dongseok Suh, Ray H. Baughman
  • Methods for treating inflammatory disorders or cancer metastasis by administering antibodies to connexin 43 (Cx43) hemichannels
    Patent number: 9914775
    Abstract: Methods for identifying compounds that positively regulate connexin 43 hemichannels.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: March 13, 2018
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jean X. Jiang, Manuel A. Riquelme, Sumin Gu
  • Antimicrobial compositions comprising glyceryl nitrates
    Patent number: 9913820
    Abstract: Provided are antimicrobial solutions comprising a glyceryl nitrate (e.g., glyeryl trinitrate) in combination with a chelator (e.g., citrate), a peroxide, a fatty acid, and/or an alcohol (e.g., ethanol). In various aspects these components may synergistically act to kill or reduce the growth of microbes, such as bacteria or fungi, present in a biofilm.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: March 13, 2018
    Assignee: Board of Regents, The University of Texas Systems
    Inventors: Issam Raad, Joel Rosenblatt
  • MOLECULAR MARKERS AND METHODS FOR SAMPLE ANALYSIS VIA MASS SPECTROMETRY
    Publication number: 20180067097
    Abstract: Methods for detecting cancer cells, or aggressive cancers, by measuring levels of cardiolipin molecules are provided.
    Type: Application
    Filed: July 12, 2017
    Publication date: March 8, 2018
    Applicant: Board of Regents, The University of Texas System
    Inventors: Livia S. EBERLIN, Jialing ZHANG