Abstract: The present disclosure provides methods for detecting heavy metals in tissues and cells while identifying cell types at the single-cell level with intracellular or cell surface heavy metal content. The cell type can be identified by contacting the cell with an antibody that binds a biomarker conjugated to a heavy metal that is different from the heavy metal detected in or on the surface of the cell. The methods include detecting heavy metals using mass cytometry.

Abstract: In certain examples, methods and semiconductor structures are directed to an apparatus including source circuitry configured to provide power to other circuitry, with the source circuitry including amplification circuitry (e.g., with a power-switching output) and a source resonator. The amplification circuitry is to provide power to the source resonator with a gain that is dependent on a coupling rate between the source circuitry and other external-receiving circuitry. The source circuitry is also to offset phase delay caused by the amplifier. In operation, the source resonator generates a magnetic field in response to the power, for highly-efficient wirelessly transfer of the power to the other circuitry.

Abstract: Systems and methods for artificial sight in accordance with embodiments of the invention are illustrated. One embodiment includes a retinal prosthesis system including an external controller, a scene imager, an eye imager, an implanted controller, and a stimulation interface in communication with the implanted controller, where the stimulation interface is positioned to stimulate a plurality of retinal ganglion cells (RGCs) of the eye, where the external controller is configured to obtain image data describing a scene from the scene imager, obtain eye position data from the eye imager, determine a field of view (FOV) in the scene based on the eye position data; where the implanted controller is configured to obtain the FOV from the external controller, continuously select stimulation pulses from a dictionary based on the FOV, and stimulate the plurality of RGCs using the stimulation interface in accordance with the selected stimulation pulses.

Abstract: A method for magnetic resonance imaging performs chemical shift encoded imaging to produce complex dual-echo images which are then applied (with imaging parameters) as input to a deep neural network to produce as output water-only and fat-only images. The deep neural network can be trained with ground truth water/fat images derived from chemical shift encoded images using a conventional water-fat separation algorithm such as projected power approach, IDEAL, or VARPRO. The chemical shift encoded imaging comprises performing an image acquisition with the MRI scanner via a spoiled-gradient echo sequence or a spin-echo sequence.

Abstract: Provided herein are, inter alia, methods for identifying subjects suffering from depression that will respond to treatment with an antidepressant.

Abstract: The present disclosure provides methods and compositions for genetically modifying hematopoietic stem and progenitor cells (HSPCs), in particular by correcting a JAK2V617F mutation in the HSPCs.

Abstract: Polyacrylamide-based copolymers act as stabilizing excipients in formulations of antibody biopharmaceutical agents without interacting directly with the antibody or altering its pharmacokinetic properties. The polyacrylamide-based copolymers confer a substantial stability benefit to high concentration compositions of a variety of antibodies by precluding adsorption of the antibody to the interfaces of the composition, preventing undesirable aggregation events and maintaining the binding activity of the antibody. Such antibody compositions are useful in methods of administering the composition to a subject.

Abstract: A device for detecting optical chirality includes a metasurface composed of a biperiodic array of nanodisks in the form of a checkerboard array [300], where the nanodisks have diameters d±?/2 such that adjacent nanodisks [302, 304] have diameters that differ by an offset ?. The nanodisks are composed of a dielectric material that is transparent and has a refractive index greater than 2 at a predetermined operational ultraviolet wavelength. The nanodisks have a width-to-height aspect ratio d/h tuned to produce spectral overlap of electric dipole and magnetic dipole modes of incident circularly polarized ultraviolet light.

Abstract: Systems, methods, and other embodiments described herein relate to specialized hardware accelerators for deep learning tasks. In one embodiment, a system includes a first waveguide and a second waveguide. The first waveguide is spaced from the second waveguide. The system includes a first phase tuning component, a second phase tuning component, and a signal mixing component. The first phase tuning component includes a first ring resonator that is coupled to the first waveguide. The second phase tuning component includes a second ring resonator that is coupled to the second waveguide. The signal mixing component includes at least a third ring resonator and a fourth ring resonator. The third ring resonator is coupled to the first waveguide and the fourth ring resonator is coupled to the second waveguide. Further, the third ring resonator and the fourth ring resonator are coupled to each other.

Abstract: Methods and apparatus for direct detection of chemical reactions are provided. Electric charge perturbations of the local environment during enzyme-catalyzed reactions are sensed by an electrode system with an immobilized target molecule. The charge perturbation caused by the polymerase reaction can uniquely identify a DNA sequence. The polymerization process generates local perturbations of charge in the solution near the electrode surface and induces a charge in a polarazible gold electrode. This event is detected as a transient current by a voltage clamp amplifier. Detection of single nucleotides in a sequence can be determined by dispensing individual dNTPs to the electrode solution and detecting the charge perturbations. Alternatively, multiple bases can be determined at the same time using a mix of all dNTPs with subsequent analysis of the resulting signal.

Abstract: A hadron therapy system that provides 3D scanning and rapid delivery of a high dose. Such systems can include a hadron source and accelerator with an RF energy modulator and an RF deflector that operate in combination to provide 3D scanning of a targeted tissue. The systems can include a permanent magnet quadrupole for magnification of the beam. The systems can include high energy hadron sources that utilize a multi-cell, multi-klystron design that achieves scanning of high energy hadron beams, for example a fixed energy of 200 MeV protons. Such systems can provide full irradiation of a liter scale tumor within one second or less.

Abstract: A stable injectable collagen-based hydrogel delivery platform and method is provided to obtain the viscosity, post-injection stability and mechanical properties needed of an injectable collagen matrix via incorporating alginate and calcium sulfate (CaSO4) into the matrix. The hydrogel (Alg/Col hydrogel) is shear-thinning, injectable through commercially available needles and stable right after injection.

Abstract: This disclosure relates to combined frequency and angle compounding for speckle reduction in ultrasound imaging. Such combined frequency and angle compounding can result in a multiplicative speckle reduction compared to using either frequency compounding or angle compounding alone. Compounding methods of this disclosure can make use of the full aperture of the ultrasound probe when acquiring individual images, hence there can be no compromise in resolution. In disclosed embodiments, ultrasound images can be obtained while an ultrasound probe is moving and the relative position and orientation of the ultrasound images can be determined from a measurement of the position and orientation of the ultrasound probe. Certain embodiments can correct for the movement and distortion of an object being imaged during the image acquisition.

Abstract: Methods of performing experimental treatments on a cohort of subjects are provided. A predictive model can be utilized to predict progression of a medical disorder or relevant imaging biomarker. The predicted medical disorder progression can be utilized as a control to determine whether an experimental treatment has an effect on the progression of the medical disorder. In some instances, the enrollment of subjects within a control group for clinical experiment is eliminated or reduced.

Abstract: A method of analyzing a population of cells is disclosed. In certain embodiments, the method includes i) obtaining an array of cells on a substrate, wherein the cells are labeled with one or more mass tags and are separated from one another, ii) measuring, using secondary ion mass spectrometry (SIMS), the abundance of the one or more mass tags at a plurality of locations occupied by the cells, thereby generating, for each individual cell measured, a set of data, and iii) outputting the set of data for each of the cells analyzed. Also provided herein are systems that find use in performing the subject method. In some embodiments, the system is an automated system for analyzing a population of cells using SIMS.

Abstract: A dual ring resonator including a base substrate, and a silicon oxide layer positioned on the base substrate having a first waveguide, a primary ring resonator optically coupled to the first waveguide, a second waveguide, and a secondary ring resonator optically coupled to the primary ring resonator and the second waveguide. The dual ring resonator further includes at least one heater disposed partially on the primary ring resonator, and a trench within at least the silicon oxide layer and surrounding at least a portion of the first waveguide and the second waveguide.

Abstract: Methods and formulations of treatment for menstrual complications, gestational complications, and to prolong gestation are described. Treatments include administration of a compound related to regulation of gestational progress or uterine contractions.

Abstract: Systems and methods for calibration of retinal prosthetics in accordance with embodiments of the invention are illustrated. A closed loop calibration process is described whereby a multi-electrode stimulation regime can be calibrated to a given user's retina. Multi-electrode stimulation can provide increased stimulation selectivity, but significantly increases complexity. Systems and methods described herein provide computational steps that significantly reduce the amount of trials and computation required in order to achieve clinically viable selectivity, making closed-loop calibration of retinal prosthetics possible in significantly less time than open-loop calibration.

Abstract: Chronic non-healing wounds represent a major source of morbidity for patients, and a significant economic burden. Current wound care treatments are passive and are unable to adapt to changes in the wound environment in real time. By integrating multimodal sensors and adding stimulators in a bandage, physiological monitoring is possible and provides an opportunity for active intervention into the complex wound environment. Here, we develop a battery-free flexible bioelectronic system consisting of wirelessly powered, closed-loop, autonomous sensing and stimulation circuits with tissue-interfacing tough conducting hydrogel electrodes for robust signal transduction, on-demand adhesion, and detachment.

Abstract: Embodiments herein describe systems and methods to determine nucleic acid thermodynamics and uses thereof. Many embodiments utilize a sequencing chip, such as an Illumina flow cell as a high-throughput platform for performing massively parallel melt curve determination. In many embodiments, nucleic acid molecules possessing a region that forms a secondary structure are affixed to a sequencing chip and hybridized with one or more labeled oligonucleotides. As the secondary structure denatures, changes in fluorescence can be measured to determine a melt curve of specific sequences.