Abstract: Provided is an optical modulator including a substrate, and a plurality of unit structures periodically on the substrate, one of the plurality of unit structures including a heater layer on a first surface of the substrate, an antenna on a first surface of the heater layer, the antenna including a phase change material, a passivation layer on the substrate, the heater layer, and the antenna, and a reflector on a second surface of the substrate opposite to the first surface of the substrate.

Abstract: A method for 3D object detection is described. The method includes predicting, using a trained monocular depth network, an estimated monocular input depth map of a monocular image of a video stream and an estimated depth uncertainty map associated with the estimated monocular input depth map. The method also includes feeding back a depth uncertainty regression loss associated with the estimated monocular input depth map during training of the trained monocular depth network to update the estimated monocular input depth map. The method further includes detecting 3D objects from a 3D point cloud computed from the estimated monocular input depth map based on seed positions selected from the 3D point cloud and the estimated depth uncertainty map. The method also includes selecting 3D bounding boxes of the 3D objects detected from the 3D point cloud based on the seed positions and an aggregated depth uncertainty.

Abstract: Systems and methods for computing variation in physiological parameters and covariate relationships are provided. Sensor data derived can be transformed into physiological interval data. A point-process model with global optimization can be fit to the physiological interval data. Variation of the physiological interval data can be computed using the fitted model. Covariate data can also be collected. A state-space model with global optimization can be fit to the physiological interval data and covariate data.

Abstract: Haptic-robot control based on local autonomy and a dual-proxy model is provided. The dual proxy guarantees generation of safe and consistent commands for two local controllers, which ensure the compliance and stability of the systems on both sides. A Force-Space Particle Filter enables an autonomous modeling and rendering of the task contact geometry from the robot state and sensory data. The method suppresses the instability issues caused by the transfer of power variables through a network with communication delays in conventional haptic-robot controllers. The results demonstrated the transparency and high fidelity of the method, and robustness to communication delays. While the conventional method failed for communication delays higher that milliseconds, the dual proxy method maintained high performance for delays up to one and a half seconds. The local autonomy-based haptic control of robots with the dual-proxy model enables applications in areas such as medical, underwater and space robotics.

Abstract: A system for creating an endoluminal valve from a blood vessel wall, includes: a tubular assembly having a longitudinal axis, a proximal end, a distal portion with a distal end, and a first lumen extending from the proximal end to a distal port located proximate the distal portion, the distal port located along the longitudinal axis, the distal portion having a supporting surface on a same side of the tubular assembly as the distal port, the supporting surface extending in a longitudinal direction and offset from a surface of the tubular assembly proximal the distal port and configured to contact the blood vessel wall; and a tissue dissection probe disposed within the first lumen, the tissue dissection probe having a fluid delivery lumen extending to a fluid delivery port located at a distal end of the tissue dissection probe, the tissue dissection probe configured to be inserted into the blood vessel wall.

Abstract: A fault-tolerant quantum computing scheme implements quantum computing based on three-dimensional cluster states using just a small number of physical components. The technique may be implemented using a single actively controlled qubit [100], e.g., a quantum emitter, and a pair of delay line loops [106, 108], which can be physically realized using existing technologies in quantum photonic and phononic systems. A three-dimensional cluster state is prepared by using the actively con-trolled qubit to generate data qubits that propagate through the two delay line loops, interact with the actively controlled qubit, and then are measured by a detector [110].

Abstract: A dilation device is provided for modeling mitral regurgitation in a mitral valve that includes an annular housing surrounding an aperture; a first anterior blade mounted to the housing and defining a substantially straight inner edge adjacent the aperture; and a plurality of posterior blades mounted to the housing and defining a curved inner edge adjacent the aperture, the posterior blades movable to dilate a valve mounted to the blades. An annulus of a valve may be sutured to the blades such that valve is disposed adjacent the aperture, and the dilation device may be actuated to cause the posterior blades to dilate a posterior region of the valve.

Abstract: A method of producing a conductive nanoporous support, comprises: (i) producing an inorganic template by mixing and subjecting to high-energy ball milling an inorganic material and a powder selected from a carbonaceous material, a polymer, or a metal oxide; and (ii) coating the inorganic template with metal nanoparticles to obtain the nanoporous support. The invention further relates to a conductive nanoporous support, an electrolytic electrode, or gas diffusion electrode and an electrolytic cell or fuel cell.

Abstract: Systems and methods for treatment verification and re-treatment with iboga alkaloids in accordance with embodiments of the invention are illustrated. One embodiment includes obtaining a first arterial spin labeling (ASL) scan of a patient's brain pre-treatment with an iboga-alkaloid for a neuropsychiatric condition, obtaining a second ASL scan of the patient's brain post-treatment, measuring changes in regional cerebral blood flow (rCBF) in a left orbitofrontal cortex, left insula, right cingulate cortex, and left putamen of the patient's brain based on the first ASL scan and the second ASL scan, determining that the treatment succeeded when either (i) rCBF increased by at least 0.1 in the left orbitofrontal cortex, or (ii) rCBF increased by any amount in the left orbitofrontal cortex and in at least two of the left insula, right cingulate cortex, and left putamen, and determining that the treatment failed when it is not determined that the treatment succeeded.

Abstract: A photo-curable composition includes a fluorinated monomer including cross-linkable functional groups, and a photoinitiator. Manufacturing methods using the photo-curable composition are provided.

Abstract: The present disclosure provides light-responsive polypeptides, and nucleic acids comprising nucleotide sequences encoding the light-responsive polypeptides. The present disclosure provides methods, devices, and systems for controlling the activity of a cell expressing a light-responsive polypeptide of the present disclosure.

Abstract: A method for magnetic resonance imaging (MRI) tag tracking includes: synthetically generating tagged data from natural images combined with programmed tag motion and a full Bloch simulation; training a convolutional neural network (CNN) with the synthetically generated tagged data to generate grid tag motion paths; acquiring MRI images using a tagged imaging method; inputting the acquired images into the CNN to estimate motion paths of tracked points; and determining from the estimated motion paths a path of tag lines through the cardiac cycle from a set of tagged MRI images. The method can calculate strain curves from the estimated motion paths using Ecc derivation.

Abstract: The present invention provides a metal mold and the method of making the metal mold for casting directional gecko-inspired adhesives that require deep, slanted features and an undercut wedge structure. The durable metal mold can be used for high quantities. In one example, compression molding is used to mass produce the adhesives. What normally takes 24 hours to produce now with compressing molding takes 5 minutes. Compression molding allows us to increase daily production from 1 adhesive patch to thousands per day.

Abstract: A molecular design principle utilizes a steric hindrance effect to tune the solvation structures of Li+ ions. By substituting the methoxy groups on DME with larger-sized ethoxy groups, the resulting 1,2-diethoxyethane (DEE) has weaker solvation ability and consequently more anion-rich inner solvation shells, both of which enhance interfacial stability at cathode and anode. According to certain additional aspects, the present embodiments relate to a family of fluorinated-1,2-diethyoxyethane (fluorinated-DEE) molecules that are readily synthesized in large scales to use as the electrolyte solvents. Selected positions on 1,2-diethyoxyethane (DEE, distinct from the diethyl ether are functionalized with various numbers of fluorine atoms through iterative tuning, to reach a balance between CE, oxidative stability, and ionic conduction. Paired with 1.2 M lithium bis(fluorosulfonyl)imide (LiFSI), these fluorinated-DEE-based, single-salt single-solvent electrolytes are thoroughly characterized.

Abstract: The disclosure is directed to methods and compositions for screening a library of aptamers for aptamers having a binding affinity to a target molecule. The methods and compositions described herein utilize a throughput approach that is able to simultaneously measure binding affinity and link the binding affinity to the identity (e.g., sequence) of the aptamer.

Abstract: A conformal graphene-encapsulated battery electrode material is formed by: (1) coating a battery electrode material with a metal catalyst to form a metal catalyst-coated battery electrode material; (2) growing graphene on the metal catalyst-coated battery electrode material to form a graphene cage encapsulating the metal catalyst-coated battery electrode material; and (3) at least partially removing the metal catalyst to form a void inside the graphene cage.

Abstract: Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.

Abstract: Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.

Abstract: Provided herein are compositions, methods, and kits for proliferating muscle cells by exposing the muscle cells to a prostaglandin E2 (PGE2) compound or compound that activates PGE2 signaling. Also provided are methods for regenerating muscle in a subject suffering from muscular atrophy, dystrophy, and/or injury by administering a PGE2 compound alone or in combination with isolated muscle cells. The PGE2 compound in combination with the isolated muscle cells can be administered prophylactically to prevent a muscle disease or condition.

Abstract: Systems and methods for multi-view cooperative contrastive self-supervised learning, may include receiving a plurality of video sequences, the video sequences comprising a plurality of image frames; applying selected images of a first and second video sequence of the plurality of video sequences to a plurality of different encoders to derive a plurality of embeddings for different views of the selected images of the first and second video sequences; determining distances of the derived plurality of embeddings for the selected images of the first and second video sequences; detecting inconsistencies in the determined distances; and predicting semantics of a future image based on the determined distances.