Abstract: The disclosure provides methods for improved hematopoietic stem cell transplantations, including methods to enhance protection from graft versus host disease while maintaining effective immune responses such as graft versus tumor immune responses. The disclosure provides methods for administering, for example, hematopoietic stem and progenitor cells, regulatory T cells, and conventional T cells, wherein the conventional T cells are administered after the hematopoietic stem and progenitor cells and regulatory T cells. The disclosure also provides methods for administering, for example, hematopoietic stem and progenitor cells, regulatory T cells, and conventional T cells, wherein the regulatory T cells have not been cryopreserved prior to administration.
Type:
Grant
Filed:
February 7, 2019
Date of Patent:
April 9, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: Provided herein are methods for treating, reducing and/or ameliorating symptoms of autism spectrum disorder (ASD) in a subject, where at least one measure of social impairment, anxiety, or repetitive behaviors is treated and/or ameliorated. Aspects include intranasally administering arginine vasopressin (AVP), or an analog of vasopressin, to a subject (e.g., a child between 6 and 12 years of age and having endogenous pre-treatment levels between about 0.045 and about 4.028 pg/mL, where the mean was 1.324 pg/mL). In children having high pre-treatment blood levels of AVP (e.g., about 25% or more above the mean pre-treatment AVP blood levels of the treatment group; or having pre-treatment blood vasopressin levels greater than 1.324 pg/mL), the treatment was enhanced. Because no difference in pre-treatment blood AVP levels was observed between control and ASD subjects, it was surprising that AVP treatment was more effective in subjects having high pre-treatment AVP levels.
Type:
Grant
Filed:
July 10, 2019
Date of Patent:
April 9, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Karen J. Parker, Dean S. Carson, Antonio Y. Hardan
Abstract: Simulated motion of the papillary muscles in a heart simulator is provided that simulates natural motion of the papillary muscles. This improves heart valve simulation. This can be done with a six degree of freedom robotic actuator (e.g., a Stewart platform or the like) appropriately driven by a controller. This can also be done with a robotic actuator that provides constrained motion of its effector by including a mechanical linkage, as long as the resulting simulated papillary muscle motion includes time-varying position and orientation of the papillary muscle.
Type:
Grant
Filed:
March 1, 2021
Date of Patent:
April 2, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Y. Joseph Woo, Michael John Paulsen, Annabel M. Imbrie-Moore, Matthew Park, Rohun Kulkarni
Abstract: A method for quantitative magnetic resonance imaging (MRI) includes [800] performing an MRI scan using a conventional pulse sequence to obtain a qualitative MR image; and [802] applying the qualitative MR image as input to a deep convolutional neural network (CNN) to produce a quantitative magnetic resonance (MR) relaxation parametric map. The qualitative MR image is the only image input to the deep neural network to produce the quantitative MR relaxation parametric map. The conventional pulse sequence may be a Spoiled Gradient Echo sequence, a Fast Spin Echo sequence, a Steady-State Free Precession sequence, or other sequence that is commonly used in current clinical practice.
Type:
Grant
Filed:
December 12, 2019
Date of Patent:
April 2, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: Aspects of various embodiments are directed to sensor apparatuses and methods thereof. An example sensor apparatus includes a capacitor and sensor circuitry. The capacitor includes a first substrate having a first electrode, a second substrate having a second electrode, and a dielectric layer. The dielectric layer has a plurality of apertures arranged in a pattern, the first and second electrode being separated by the dielectric layer and arranged with an overlapping area with respect to one another. The sensor circuitry is coupled to the capacitor and configured and arranged to detect normal and shear forces applied to the sensor apparatus based on changes in capacitance derived from changes in at least one of a distance between the first and second electrodes and the overlapping area of the first and second electrodes.
Type:
Grant
Filed:
July 10, 2019
Date of Patent:
April 2, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Zhenan Bao, Mark R. Cutkosky, Jooyeun Ham
Abstract: Methods and compositions are provided for the treatment of Alzheimer's Disease (AD) by administering to a patient a therapeutically effective amount of an agent that inhibits signaling mediated by a bone morphogenetic protein type 1A receptor (BMPR-1A) or bone morphogenetic protein type 2 receptor (BMPR-2). Also provided are methods and compositions to increase the rate of neural stem cell self-renewal.
Type:
Application
Filed:
November 17, 2023
Publication date:
March 28, 2024
Applicants:
CZ Biohub SF, LLC, The Board of Trustees of the Leland Stanford Junior University
Inventors:
Elizabeth Yang Chen, Felicia Reinitz, Jane Antony, Michael F. Clarke, Robert C. Jones
Abstract: Compositions comprising an iboga alkaloid and a cardioprotective agent are provided. Use of the compositions in treating neuropsychiatric disorders are described, where the cardioprotective agent is administered before, during and/or after the iboga alkaloid.
Type:
Application
Filed:
September 14, 2023
Publication date:
March 28, 2024
Applicants:
The Board of Trustees of the Leland Stanford Junior University, Soneira Inc., P.B.C.
Inventors:
Nolan R. Williams, Ian Kratter, AnnaMarie Daniels, Gregory Bird
Abstract: Inducible promoters for the coordinated expression of at least one heterologous gene in yeast and methods of using them are disclosed. In particular, the invention relates to sets of inducible promoters derived from S. cerevisiae and related species that can be induced in the presence of nonfermentable carbon sources.
Type:
Application
Filed:
September 6, 2023
Publication date:
March 28, 2024
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Colin Harvey, Ulrich Schlecht, Maureen Elizabeth Hillenmeyer
Abstract: The present disclosure provides methods of improving the structure and/or function of a joint tissue of a subject by administering to the subject an amount of a 15-PGDH inhibitor effective to inhibit 15-PGDH activity and/or reduce 15-PGDH levels in the subject. The methods described herein are useful for treating joint dysfunction and/or degeneration associated with aging, injury, disease, disorder, and/or condition.
Type:
Application
Filed:
December 9, 2021
Publication date:
March 28, 2024
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Helen M. BLAU, Nidhi BHUTANI, Mamta SINGLA, Adelaida Rosa PALLA
Abstract: Methods for treating a neuropsychiatric disorder by administering an iboga alkaloid and a cardioprotective agent in conjunction with analysis of brain image data is described. Also described are methods to improve brain health and to slow or reverse brain aging by disorder by administering an iboga alkaloid and a cardioprotective agent, where analysis of brain image data is used to monitor and/or evaluate treatment effectiveness.
Type:
Application
Filed:
September 14, 2023
Publication date:
March 28, 2024
Applicants:
The Board of Trustees of the Leland Stanford Junior University, Soneira Inc., P.B.C.
Inventors:
Nolan R. Williams, John Philip Coetzee, Andrew Dedinas Geoly, AnnaMarie Daniels, Gregory Bird
Abstract: Processes and materials to detect cancer, transplant rejection, or fetal genetic abnormalities from a biopsy are described. In some cases, nucleic acid molecules, such as cell-free nucleic acids, can be sequenced, and the sequencing result can be utilized to detect sequences indicative of a neoplasm, transplant rejection, or fetal genetic abnormality. Detection of somatic variants occurring in phase and/or insertions and deletions (indels) can indicate the presence of cancer, transplant rejection, or fetal genetic abnormalities in a diagnostic scan, and a clinical intervention can be performed.
Type:
Application
Filed:
August 18, 2023
Publication date:
March 28, 2024
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Jacob J. Chabon, David M. Kurtz, Maximilian Diehn, Arash Ash Alizadeh
Abstract: This disclosure relates to ultrasound imaging with reduced speckle. Ultrasound imaging with frequency compounding and angle compounding is disclosed. Techniques are disclosed to make ultrasound imaging with frequency and angle compounding more robust. One such technique is non-rigid image registration to align ultrasound images for angle compounding. Another disclosed technique includes selecting a subset of ultrasound images for non-rigid ultrasound image registration.
Type:
Grant
Filed:
June 18, 2019
Date of Patent:
March 26, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Noah Yuzo Toyonaga, Yilei Li, Steven Chu
Abstract: Behavioral and mental health therapy systems in accordance with several embodiments of the invention include a wearable camera and/or a variety of sensors (accelerometer, microphone, among various other) connected to a computing system including a display, audio output, holographic output, and/or vibrotactile output to automatically recognize social cues from images captured by at least one camera and provide this information to the wearer via one or more outputs such as (but not limited to) displaying an image, displaying a holographic overlay, generating an audible signal, and/or generating a vibration.
Type:
Grant
Filed:
August 9, 2021
Date of Patent:
March 26, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Catalin Voss, Nicholas Joseph Haber, Dennis Paul Wall, Aaron Scott Kline, Terry Allen Winograd
Abstract: Compositions and methods for targeted treatment of cancer are disclosed. In particular, the invention relates to methods of targeting anti-cancer therapy to cells exhibiting aberrant signaling associated with cancer pathogenesis by administering synthetic signaling proteins that couple detection of an oncogenic signal to release of therapeutic agents into cancerous cells.
Type:
Grant
Filed:
May 1, 2019
Date of Patent:
March 26, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: Metal powder particles for use in additive manufacturing are made by removing material from the surface of the particles using wet chemical etching to create a nanoscale texturing of the surface, increasing absorptivity by the metal powder particles of incident laser light and maintaining flowability. The nanoscale texturing has sub-wavelength features at laser wavelengths in the range 800-1100 nm. The particles are substantially spherical and have mean diameters in the range 10-70 ?m.
Type:
Grant
Filed:
March 28, 2022
Date of Patent:
March 26, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Ottman A. Tertuliano, Philip J. DePond, Andrew Curtis Lee, Xun Gu, Wei Cai, Adrian J. Lew
Abstract: The present invention relates to T cell compositions and methods of using the same in the context of therapy and treatment. In particular, the invention provides chimeric antigen receptor (CAR) T cells that are modified to maintain functionality under conditions in which unmodified CAR T cells display exhaustion. Compositions and methods disclosed herein find use in inhibiting or reversing CAR T cell exhaustion (e.g., by modulating CAR surface expression) thereby enhancing CAR T cell function. Compositions and methods of the invention fmd use in both clinical and research settings, for example, within the fields of biology, immunology, medicine, and oncology.
Type:
Grant
Filed:
March 30, 2018
Date of Patent:
March 26, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Rachel Lynn, Crystal Mackall, Tom J. Wandless, Evan Weber
Abstract: We use the AC Hall effect to characterize a magnetic field at an unknown frequency (or frequencies). The current to the Hall sensor is driven at a known frequency f. The output Hall voltage is characterized in a frequency range from f1 to f2 (with f<f1<f2 and f2?f1<2f). This provides a measurement of the magnetic field in a frequency range from f1?f to f2?f. The resulting measurement of magnetic field spectral components is phase-independent and requires no prior knowledge of exact magnetic field frequency.
Type:
Grant
Filed:
May 27, 2022
Date of Patent:
March 26, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: The present disclosure provides methods and compositions for treating SCID-X1 in subjects, comprising genetically modifying cells from the subjects ex vivo by integrating a full-length, codon-optimized IL2RG cDNA at the endogenous IL2RG locus.
Type:
Application
Filed:
August 3, 2021
Publication date:
March 21, 2024
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Abstract: Blockchain-based, smart contract platforms have great promise to remove trust and add transparency to distributed applications. However, this benefit often comes at the cost of greatly reduced privacy. Techniques for implementing a privacy-preserving smart contract is described. The system can keep accounts private while not losing functionality and with only a limited performance overhead. This is achieved by building a confidential and anonymous token on top of a cryptocurrency. Multiple complex applications can also be built using the smart contract system.
Type:
Application
Filed:
November 20, 2023
Publication date:
March 21, 2024
Applicants:
VISA INTERNATIONAL SERVICE ASSOCIATIN, The Board of Trustees of the Leland Stanford Junior University
Inventors:
Shashank Agrawal, Karl Benedikt Bünz, Mahdi Zamani, Dan Boneh
Abstract: A catalyst structure includes: (1) a substrate; (2) a catalyst layer on the substrate; and (3) an adhesion layer disposed between the substrate and the catalyst layer. In some implementations, an average thickness of the adhesion layer is about 1 nm or less. In some implementations, a material of the catalyst layer at least partially extends into a region of the adhesion layer. In some implementations, the catalyst layer is characterized by a lattice strain imparted by the adhesion layer.
Type:
Grant
Filed:
December 13, 2019
Date of Patent:
March 19, 2024
Assignees:
The Board of Trustees of the Leland Stanford Junior University, Volkswagen Aktiengesellschaf
Inventors:
Friedrich B. Prinz, Shicheng Xu, Yongmin Kim, Thomas Jaramillo, Drew C. Higgins, Maha Yusuf, Zhaoxuan Wang, Kyung Min Lee, Marat Orazov, Dong Un Lee, Tanja Graf, Thomas Schladt, Gerold Huebner, Hanna-Lena Wittern, Jonathan Edward Mueller