Patents Assigned to The Board of Trustees of Leland Stanford Junior University
  • Publication number: 20220304992
    Abstract: The present disclosure provides compositions and methods based on the identification of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as a therapeutic target in aging, dystrophic muscle to improve muscle atrophy, increase muscle mass, function and strength. Further provided herein are compositions and methods for the rejuvenation of aged tissue. In particular, 15-PGDH inhibitors, such as SW033291, are used to elevate the levels of prostaglandin E2 (PGE2) in the muscle or tissue.
    Type: Application
    Filed: June 11, 2020
    Publication date: September 29, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Helen M. Blau, Adelaida Rosa Palla, Andrew Tri Van Ho
  • Patent number: 11456148
    Abstract: Improved aberration correction in multipass electron microscopy is provided by having Fourier images of the sample (instead of real images) at the reflection planes of the resonator. The resulting ?1 magnification of the sample reimaging can be compensated by appropriate sample placement or by adding compensating elements to the resonator. This enables simultaneous correction of lowest order chromatic and spherical aberration from the electron objective lenses. If real images of the sample are at the reflection planes of the resonator instead, only the lowest order chromatic aberration can be corrected.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: September 27, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mark A. Kasevich, Stewart A. Koppell, Brannon Klopfer, Thomas Juffmann, Marian Mankos
  • Patent number: 11452774
    Abstract: Mixed allergen compositions of two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an animal allergen; and at least one of: a non-nut plant allergen; a biotic agent; and a vitamin. Also provided are methods of administering the mixed allergen compositions to a subject. The mixed allergen compositions find use in a variety of applications, including health maintenance, immune balance, gut balance, immune support, health improvement and therapeutic applications.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: September 27, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Kari C. Nadeau
  • Patent number: 11452440
    Abstract: A visual function evaluation is performed using a sequence of interactions with a mobile device. A patient user may perform a variety of visual tests using the mobile device. The mobile device transmits the test results to a remote server implementing analysis of the visual function results using network service. The network service receives the test results, processes the results, and provides the processed results to a healthcare provider. The processed results may include trends of the user's visual function test performance. The healthcare provider, such as a physician, may optimize and administer treatment based on the data. Early detection of changes in visual function can enable the healthcare provider to individualize treatment, helping to prevent vision loss while minimizing visits to the office, discomfort, and expense.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: September 27, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daniel Palanker, Mark Blumenkranz
  • Patent number: 11450889
    Abstract: An electrochemical device includes: (1) a compartment; (2) a container including a liquid reactant; and (3) a conveyance mechanism fluidly connected to the container and the compartment and configured to convey the liquid reactant from the container into the compartment, wherein the liquid reactant is a eutectic mixture of two or more different redox-active substances.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: September 20, 2022
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Antonio Baclig, William C. Chueh, Andrey Poletayev, Victoria Ng, Devi Ganapathi, Emily Penn
  • Patent number: 11448918
    Abstract: Provided are a grating device, a screen including the grating device, a method of manufacturing the screen, and a display apparatus including the screen. The grating device includes a transparent substrate and a diffraction grating arranged on the transparent substrate, the diffraction grating includes a plurality of meta-diffraction patterns, and each meta-diffraction pattern has a curved shape with a center of curvature provided in a direction parallel to the substrate. The screen includes a first polarizer, a second polarizer arranged next to the first polarizer, and a diffraction grating that is transparent to polarized light that has passed through the second polarizer and reflects polarized light having a polarization direction perpendicular to the polarized light, wherein the diffraction grating includes a plurality of meta-diffraction patterns, each meta-diffraction pattern having a curved shape with a center of curvature positioned in a travelling direction of incident light.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: September 20, 2022
    Assignees: SAMSUNG ELECTRONICS CO., LTD., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sunghoon Lee, Mark L. Brongersma, Brandon Born
  • Patent number: 11446356
    Abstract: Engineered peptides that bind with high affinity (low equilibrium dissociation constant (Kd)) to the cell surface receptors of fibronectin (?5?1) or vitronectin (?v?3 and ?v?5 integrins) are disclosed as useful as imaging tissue. These peptides are based on a molecular scaffold into which a subsequence containing the RGD integrin-binding motif has been inserted. The subsequence (RGD mimic) comprises about 9-13 amino acids, and the RGD contained within the subsequence can be flanked by a variety of amino acids, the sequence of which was determined by sequential rounds of selection (in vitro evolution). The molecular scaffold is preferably based on a knottin, e.g., EETI (Trypsin inhibitor 2 (Trypsin inhibitor II) (EETI-II) [Ecballium elaterium (Jumping cucumber)], AgRP (Agouti-related protein), and Agatoxin IVB, which peptides have a rigidly defined three-dimensional conformation. It is demonstrated that EETI tolerates mutations in other loops and that the present peptides may be used as imaging agents.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: September 20, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jennifer R. Cochran, Richard H. Kimura, Aron M. Levin
  • Patent number: 11446897
    Abstract: Disclosed is a sub-laminate module for use in forming a composite laminate structure. The sub-laminate module comprises: a first ply set containing a first ply layer oriented at a first angle and a second ply layer oriented at a second angle, the second angle being equal and opposite the first angle; a second ply set containing a third ply layer oriented at a third angle and a fourth ply layer oriented at a fourth angle, the fourth angle being equal and opposite the third angle; and an acute angle defined by a difference between the first angle and the third angle, wherein the second ply layer is positioned adjacent the third ply layer and the second and third ply layers are both positioned intermediate the first and fourth ply layers, so as to define a double-double helix arrangement. Associated composite laminate structures and methods are also disclosed.
    Type: Grant
    Filed: March 31, 2018
    Date of Patent: September 20, 2022
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Stephen W. Tsai, Robert Rainsberger
  • Patent number: 11447747
    Abstract: The disclosure provides methods for improved hematopoietic stem cell transplantations, including methods to enhance protection from graft versus host disease while maintaining effective immune responses such as graft versus tumor immune responses. The disclosure provides methods for administering, for example, hematopoietic stem and progenitor cells, regulatory T cells, and conventional T cells, wherein the conventional T cells are administered after the hematopoietic stem and progenitor cells and regulatory T cells. The disclosure also provides methods for administering, for example, hematopoietic stem and progenitor cells, regulatory T cells, and conventional T cells, wherein the regulatory T cells have not been cryopreserved prior to administration.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: September 20, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Everett Hurteau Meyer, Robert S. Negrin
  • Patent number: 11447774
    Abstract: Fusion constructs encoding RNase-H-like domain containing compositions are disclosed. Disclosed are also compositions and methods utilizing RNase-H-like domain containing compositions for the treatment of cancer. Also disclosed are the methods of making and using the RNase-H-like domain containing compositions in treating various diseases, conditions, and cancer.
    Type: Grant
    Filed: March 4, 2020
    Date of Patent: September 20, 2022
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Intima Bioscience, Inc.
    Inventors: Lei S. Qi, Modassir S. Choudhry, Xueqiu Lin, Xiaoshu Xu
  • Patent number: 11447833
    Abstract: Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: September 20, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: David M. Kurtz, Maximilian Diehn, Arash Ash Alizadeh
  • Patent number: 11451265
    Abstract: Described herein are methods of making and using and apparatus for wirelessly communicating data and providing power, particularly from a location exterior to a body and to an implantable device disposed within a body with tissue. The described embodiments provide apparatus and methods for efficiently transfer data and power between an external transceiver and an (implanted) biomedical device. The method is to modulate power carrier, which wirelessly powers the device, using an asynchronous modulation scheme, such as amplitude shift keying (ASK) modulation, with minimal modulation depth in order to not disrupt the power flow. The digital data is encoded in the pulse width, eliminating the need for synchronization to the power carrier signal and further minimizing the power consumption necessary for data transfer. Additionally, a reverse backscatter method for obtaining data from the implant is described that has flexible, low power operation.
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: September 20, 2022
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Anatoly Anatolievich Yakovlev, Daniel Pivonka, Ada Shuk Yan Poon, Teresa H. Meng
  • Publication number: 20220288010
    Abstract: The present disclosure provides methods and compositions for inhibiting monoacylglycerol lipase (MAGL) in order to attenuate the rewarding effects of and delay tolerance to the analgesic properties of opioids such as morphine without reducing their analgesic effects.
    Type: Application
    Filed: March 23, 2022
    Publication date: September 15, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Francis Lee, Anjali M. Rajadhyaksha, Arlene Martinez-Rivera
  • Publication number: 20220288013
    Abstract: Apparatuses, devices, compositions, and methods to ameliorate undesired side effects or outcomes, such as fibrosis due to surgical implants, wounds, or other bodily injury. In particular, described are apparatuses, devices, and compositions containing inhibitors of Wnt11 as well as methods of making and using them. These apparatuses, devices, compositions, and methods may be especially useful for preventing, reducing or treating unwanted fibrosis, such as that resulting from a biomedical implant implanted in an individual.
    Type: Application
    Filed: July 16, 2020
    Publication date: September 15, 2022
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Britta A. KUEHLMANN, Geoffrey C. GURTNER, Clark Andrew BONHAM
  • Publication number: 20220290103
    Abstract: The present disclosure provides compositions and methods for producing and using modified auxotrophic host cells for improved therapy involving administration of an auxotrophic factor.
    Type: Application
    Filed: May 8, 2020
    Publication date: September 15, 2022
    Applicants: AUXOLYTIC LTD, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: James Patterson, Matthew Porteus, Volker Wiebking
  • Publication number: 20220293859
    Abstract: A method of making flexible and stretchable semiconductor devices with reduced footprints can include coating a gate electrode layer having a first composition over an elastomer layer, solidifying a portion of the gate electrode layer by irradiation to form a gate electrode, coating a dielectric layer having a second composition over the gate electrode layer, solidifying a portion of the dielectric layer by the irradiation to form a gate dielectric, coating a semiconductor layer having a third composition over the dielectric layer, solidifying a portion of the semiconductor layer by the irradiation to form a device core, coating a terminal layer having the first composition over the dielectric layer, and solidifying a portion of the terminal layer by the irradiation to form a source electrode and a drain electrode contacting the semiconductor layer.
    Type: Application
    Filed: March 14, 2022
    Publication date: September 15, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Yuxin Liu, Yuqing Zheng, Zhenan Bao
  • Patent number: 11439664
    Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: September 13, 2022
    Assignees: The Board of Trustees of the Leland Stanford Junior University, UNIVERSITY OF WASHINGTON
    Inventors: Kenan Christopher Garcia, Jonathan Sockolosky, David Baker, Chris King
  • Patent number: 11439662
    Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: September 13, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Samuel Strober, Robert Lowsky
  • Patent number: 11440887
    Abstract: Noncovalent small-molecule inhibitors of the enzyme OGG1, methods of their manufacture, and applications for their administration are provided. Small molecule inhibitors were shown to be selective for inhibiting OGG1 over multiple repair enzymes, including other base excision repair enzymes, and it displayed no toxicity in two human cell lines. The inhibitors provide a tool for the study of the role of OGG1 in multiple disease-related pathways, and a therapeutic target for the treatment thereof.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: September 13, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eric T. Kool, Yuki Tahara
  • Publication number: 20220283144
    Abstract: Provided herein are compositions and methods for identifying and using stem cell regulation factors. For example, in some embodiments, provided herein are compositions and methods for identifying stem cell regulation factors using marker gene expression libraries. Also provided herein are compositions and methods for generating differentiated cells lines and uses of such cell lines.
    Type: Application
    Filed: October 7, 2021
    Publication date: September 8, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lei S. Qi, Yanxia Liu