Patents Assigned to The Board of Trustees of Leland Stanford Junior University
  • INHIBITION OF PROSTAGLANDIN DEGRADING ENZYME 15-PGDH TO IMPROVE JOINT STRUCTURE AND FUNCTION
    Publication number: 20240100027
    Abstract: The present disclosure provides methods of improving the structure and/or function of a joint tissue of a subject by administering to the subject an amount of a 15-PGDH inhibitor effective to inhibit 15-PGDH activity and/or reduce 15-PGDH levels in the subject. The methods described herein are useful for treating joint dysfunction and/or degeneration associated with aging, injury, disease, disorder, and/or condition.
    Type: Application
    Filed: December 9, 2021
    Publication date: March 28, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Helen M. BLAU, Nidhi BHUTANI, Mamta SINGLA, Adelaida Rosa PALLA
  • Methods of Treatment With an Iboga Alkaloid
    Publication number: 20240100062
    Abstract: Methods for treating a neuropsychiatric disorder by administering an iboga alkaloid and a cardioprotective agent in conjunction with analysis of brain image data is described. Also described are methods to improve brain health and to slow or reverse brain aging by disorder by administering an iboga alkaloid and a cardioprotective agent, where analysis of brain image data is used to monitor and/or evaluate treatment effectiveness.
    Type: Application
    Filed: September 14, 2023
    Publication date: March 28, 2024
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Soneira Inc., P.B.C.
    Inventors: Nolan R. Williams, John Philip Coetzee, Andrew Dedinas Geoly, AnnaMarie Daniels, Gregory Bird
  • Systems and methods for using mobile and wearable video capture and feedback plat-forms for therapy of mental disorders
    Patent number: 11937929
    Abstract: Behavioral and mental health therapy systems in accordance with several embodiments of the invention include a wearable camera and/or a variety of sensors (accelerometer, microphone, among various other) connected to a computing system including a display, audio output, holographic output, and/or vibrotactile output to automatically recognize social cues from images captured by at least one camera and provide this information to the wearer via one or more outputs such as (but not limited to) displaying an image, displaying a holographic overlay, generating an audible signal, and/or generating a vibration.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: March 26, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Catalin Voss, Nicholas Joseph Haber, Dennis Paul Wall, Aaron Scott Kline, Terry Allen Winograd
  • Compounding and non-rigid image registration for ultrasound speckle reduction
    Patent number: 11937977
    Abstract: This disclosure relates to ultrasound imaging with reduced speckle. Ultrasound imaging with frequency compounding and angle compounding is disclosed. Techniques are disclosed to make ultrasound imaging with frequency and angle compounding more robust. One such technique is non-rigid image registration to align ultrasound images for angle compounding. Another disclosed technique includes selecting a subset of ultrasound images for non-rigid ultrasound image registration.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: March 26, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Noah Yuzo Toyonaga, Yilei Li, Steven Chu
  • Rewiring aberrant cancer signaling to a therapeutic effector response with a synthetic two-component system
    Patent number: 11939609
    Abstract: Compositions and methods for targeted treatment of cancer are disclosed. In particular, the invention relates to methods of targeting anti-cancer therapy to cells exhibiting aberrant signaling associated with cancer pathogenesis by administering synthetic signaling proteins that couple detection of an oncogenic signal to release of therapeutic agents into cancerous cells.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: March 26, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hokyung Chung, Michael Z. Lin
  • Nanotextured metal powders for 3D printing of metals
    Patent number: 11938536
    Abstract: Metal powder particles for use in additive manufacturing are made by removing material from the surface of the particles using wet chemical etching to create a nanoscale texturing of the surface, increasing absorptivity by the metal powder particles of incident laser light and maintaining flowability. The nanoscale texturing has sub-wavelength features at laser wavelengths in the range 800-1100 nm. The particles are substantially spherical and have mean diameters in the range 10-70 ?m.
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: March 26, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ottman A. Tertuliano, Philip J. DePond, Andrew Curtis Lee, Xun Gu, Wei Cai, Adrian J. Lew
  • Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling
    Patent number: 11938153
    Abstract: The present invention relates to T cell compositions and methods of using the same in the context of therapy and treatment. In particular, the invention provides chimeric antigen receptor (CAR) T cells that are modified to maintain functionality under conditions in which unmodified CAR T cells display exhaustion. Compositions and methods disclosed herein find use in inhibiting or reversing CAR T cell exhaustion (e.g., by modulating CAR surface expression) thereby enhancing CAR T cell function. Compositions and methods of the invention fmd use in both clinical and research settings, for example, within the fields of biology, immunology, medicine, and oncology.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: March 26, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Rachel Lynn, Crystal Mackall, Tom J. Wandless, Evan Weber
  • Omega and theta—a method to measure magnetic field at AC frequencies without using current spinning
    Patent number: 11940505
    Abstract: We use the AC Hall effect to characterize a magnetic field at an unknown frequency (or frequencies). The current to the Hall sensor is driven at a known frequency f. The output Hall voltage is characterized in a frequency range from f1 to f2 (with f<f1<f2 and f2?f1<2f). This provides a measurement of the magnetic field in a frequency range from f1?f to f2?f. The resulting measurement of magnetic field spectral components is phase-independent and requires no prior knowledge of exact magnetic field frequency.
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: March 26, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Anand Vikas Lalwani, Ananth Saran Yalamarthy, Maximillian Holliday, Hannah Alpert, Carla Nicole Pinzon, Debbie G. Senesky
  • BLOCKCHAIN SYSTEM FOR CONFIDENTIAL AND ANONYMOUS SMART CONTRACTS
    Publication number: 20240095728
    Abstract: Blockchain-based, smart contract platforms have great promise to remove trust and add transparency to distributed applications. However, this benefit often comes at the cost of greatly reduced privacy. Techniques for implementing a privacy-preserving smart contract is described. The system can keep accounts private while not losing functionality and with only a limited performance overhead. This is achieved by building a confidential and anonymous token on top of a cryptocurrency. Multiple complex applications can also be built using the smart contract system.
    Type: Application
    Filed: November 20, 2023
    Publication date: March 21, 2024
    Applicants: VISA INTERNATIONAL SERVICE ASSOCIATIN, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Shashank Agrawal, Karl Benedikt Bünz, Mahdi Zamani, Dan Boneh
  • GENE CORRECTION FOR SCID-X1 IN LONG-TERM HEMATOPOIETIC STEM CELLS
    Publication number: 20240093242
    Abstract: The present disclosure provides methods and compositions for treating SCID-X1 in subjects, comprising genetically modifying cells from the subjects ex vivo by integrating a full-length, codon-optimized IL2RG cDNA at the endogenous IL2RG locus.
    Type: Application
    Filed: August 3, 2021
    Publication date: March 21, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mara Pavel-Dinu, Matthew H. Porteus
  • Electrochemical catalysts with enhanced catalytic activity
    Patent number: 11936051
    Abstract: A catalyst structure includes: (1) a substrate; (2) a catalyst layer on the substrate; and (3) an adhesion layer disposed between the substrate and the catalyst layer. In some implementations, an average thickness of the adhesion layer is about 1 nm or less. In some implementations, a material of the catalyst layer at least partially extends into a region of the adhesion layer. In some implementations, the catalyst layer is characterized by a lattice strain imparted by the adhesion layer.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: March 19, 2024
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Volkswagen Aktiengesellschaf
    Inventors: Friedrich B. Prinz, Shicheng Xu, Yongmin Kim, Thomas Jaramillo, Drew C. Higgins, Maha Yusuf, Zhaoxuan Wang, Kyung Min Lee, Marat Orazov, Dong Un Lee, Tanja Graf, Thomas Schladt, Gerold Huebner, Hanna-Lena Wittern, Jonathan Edward Mueller
  • Contrast dose reduction for medical imaging using deep learning
    Patent number: 11935231
    Abstract: A method for diagnostic imaging with reduced contrast agent dose uses a deep learning network (DLN) [114] that has been trained using zero-contrast [100] and low-contrast [102] images as input to the DLN and full-contrast images [104] as reference ground truth images. Prior to training, the images are pre-processed [106, 110, 118] to co-register and normalize them. The trained DLN [114] is then used to predict a synthesized full-dose contrast agent image [116] from acquired zero-dose and low-dose images.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: March 19, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Greg Zaharchuk, Enhao Gong, John M. Pauly
  • Immolative cell-penetrating complexes for nucleic acid delivery to the lung
    Patent number: 11931416
    Abstract: There are provided herein, inter alia, cationic amphipathic polymers, complexes, and compositions comprising same, and methods for their use including for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acids, into a cell. The complexes, compositions and methods may facilitate delivery and targeted release of the therapeutic, diagnostic and imaging agents to particular cell types and tissues.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: March 19, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tim R. Blake, Paul Wender, Robert M. Waymouth, Ronald Levy, Ole Audun Werner Haabeth, Rebecca McClellan, Adrienne Sallets
  • Systems and Methods for Targeted Neuromodulation
    Publication number: 20240081920
    Abstract: Systems and methods for neuronavigation in accordance with embodiments of the invention are illustrated. Targeting systems and methods as described herein can generate personalized stimulation targets for the treatment of mental conditions. In many embodiments, direct stimulation of a personalized the stimulation target indirectly impacts a brain structure that is more difficult to reach via the stimulation modality. In various embodiments, the mental condition is major depressive disorder. In a number of embodiments, the mental condition is suicidal ideation.
    Type: Application
    Filed: November 21, 2023
    Publication date: March 14, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nolan R. Williams, Adi Maron-Katz
  • CHIMERIC PROTEINS AND METHODS OF REGULATING GENE EXPRESSION
    Publication number: 20240084335
    Abstract: The present disclosure provides systems, compositions and methods for regulating expression of a target polynucleotide in a cell. The systems, compositions and methods comprise a chimeric receptor polypeptide comprising a G-protein coupled receptor (GPCR) or a fragment thereof, a chimeric adaptor polypeptide, at least one actuator moiety and a cleavage moiety.
    Type: Application
    Filed: September 29, 2023
    Publication date: March 14, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lei S. Qi, P.C. Dave P. Dingal
  • Systems and Methods for Generating Knowledge Graphs and Text Summaries from Document Databases
    Publication number: 20240086444
    Abstract: Systems and methods for generating knowledge graphs and text summaries from document databases are provided. In one embodiment, a system for generating knowledge graphs and text summaries includes: a device, including: a processor; and a memory containing a knowledge graph and text summary generating application, where the knowledge graph and text summary generating application directs the processor to: query a global network of biomedical relationships; construct a knowledge graph and a citation graph; apply processes to learn local context-based weights and compute summarizations; and provide results via a display.
    Type: Application
    Filed: October 9, 2020
    Publication date: March 14, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Stefano Emanuele Rensi
  • On-slide staining by primer extension
    Patent number: 11926865
    Abstract: A method for analyzing planar sample is provided. In some cases the method comprises: (a) incubating the planar sample with a capture agent that is linked to an oligonucleotide, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the oligonucleotide, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided.
    Type: Grant
    Filed: February 15, 2022
    Date of Patent: March 12, 2024
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Nikolay Samusik, Garry P. Nolan, Yury Goltsev
  • Electrochemical redox refrigeration
    Patent number: 11926783
    Abstract: A method of electrochemical redox refrigeration includes inducing a flow of an electrochemical refrigerant that is in contact with a first electrode to a second electrode; applying an electrical potential difference between the first electrode and the second electrode, wherein the electrochemical refrigerant is oxidized at one of the first electrode and second electrode and reduced at another of the first electrode and second electrode; wherein the first electrode is at least partially thermally isolated from Joule heating in the electrochemical refrigerant and from activation losses in the second electrode by an action of the flow of the electrochemical refrigerant.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: March 12, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Arunava Majumdar, Ian S. McKay
  • Oxidized surface layer on transition metal nitrides: active catalysts for the oxygen reduction reaction
    Patent number: 11929512
    Abstract: An electrode catalyst for an Oxygen Reduction Reaction (ORR) is provided that includes a transition metal nitride layer on a substrate, an ORR surface oxide layer deposited on the transition metal nitride layer, where the ORR surface oxide layer includes from sub-monolayer to 20 surface oxide monolayers.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: March 12, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Melissa E. Kreider, Michaela Burke Stevens, Alessandro Gallo, Hadi Abroshan, Seoin Back, Samira Siahrostami, Jens K. Nørskov, Laurie A. King, Thomas Francisco Jaramillo
  • Spectrally selective textile for passive radiative outdoor personal cooling
    Patent number: 11925226
    Abstract: A textile includes: (1) a matrix; and (2) particulate fillers dispersed within the matrix. The textile has a transmittance of infrared radiation at a wavelength of 9.5 ?m of at least about 40%, and the textile has a weighted average reflectivity of radiation over a wavelength range of 0.3 ?m to 2 ?m of at least about 40%.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: March 12, 2024
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Yi Cui, Shanhui Fan, Lili Cai, Alex Y. Song, Wei Li, Po-Chun Hsu