Abstract: Prediction of allograft rejection is provided based on the quantification of transplant-derived circulating cell-free DNA (dd-cfDNA levels) in the absence of a donor genotype. The technology provided herein alleviates some of the barriers to the implementation of Genome Transplant Dynamics (GTD), which will further widen its clinical application.

Abstract: Nanoparticles comprising a platinum group metal and a base metal, catalytic compositions comprising such nanoparticles and a support material, and methods of making such nanoparticles and catalytic compositions are disclosed. Catalytic articles and exhaust gas treatment systems, as well as methods of treating an exhaust gas stream comprising a pollutant using these catalytic articles and exhaust gas treatment systems, are also disclosed.

Abstract: A dispersion-engineered 2D optical phased array device includes optical slow light waveguides [202, 208, 218] arranged parallel to each other; waveguide bends [206, 216] optically coupling ends of adjacent waveguides of the optical slow light waveguides to form a serpentine optical configuration; wherein the optical slow light waveguides comprise first waveguides of a first waveguide type and second waveguides of a second waveguide type, wherein the first waveguides and the second waveguides are arranged adjacent to each other and alternate with each other; wherein the optical slow light waveguides comprise phased array sections forming a phased array [214], wherein first waveguides and second waveguides have dispersion slopes of opposite sign and the same group index; wherein the optical slow light waveguides comprise slow light delay waveguide sections [210] that provide a delay between adjacent waveguides.

Abstract: One or more embodiments relate to an electrically conductive polymer with a crosslinkable additive. The electrically conductive polymer is a directly photopatternable Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) PEDOT:PSS film with cross-linked network made of a plurality of monomers. The directly photopatternable PEDOT:PSS film PEDOT as such has a better conductivity and stretchability compared to its other counterparts. The directly photopatternable PEDOT:PSS film can further be supplemented with poly(ethylene glycol) diacrylate (PEGDA) which can help with the removal of PSS. Advantageously, the PEGDA supplemented PEDOT:PSS film can exhibit a larger charge storage capacity.

Abstract: An optical modulator with a wide aperture, high acceptance angle, low required drive voltages and high operating frequency is provided. The modulator relies on the photoelastic effect and makes use of mechanical resonance in order to improve efficiency. The acoustic excitation and optical propagation path are nominally co-aligned, so the required symmetry breaking is provided by having the modulator material be optically and/or mechanically anisotropic. Such a modulator can be used to enable efficient and low-cost per-pixel optical ranging and speed sensing.

Abstract: A coupled storage qubit nanomechanical resonator in a processing qubit superconducting circuit is provided that includes a phononic crystal resonator (PCR) film disposed on a substrate, where the PCR film includes a defect mode in a bandgap of the PCR film where a storage qubit is encoded, a pair of electrodes generate voltages within the PCR film, where the defect is dimensioned to support a unique electrical potential generated by a local mechanical phonon mode of the PCR film, where a unique resonance frequency that is dependent on the defect dimensions is output from the PCR film, a coupling capacitor that is coupled to the PCR film, where the coupling capacitor is disposed to receive the output unique resonance frequency, and a processing qubit, where the processing qubit is capacitively coupled to the PCR film by the coupling capacitor, where the storage qubits are connected to the processing qubits.

Abstract: Host cells that are engineered to produce benzylisoquinoline alkaloid (BIAS) precursors, such as norcoclaurine (NC) and norlaudanosoline (NL), are provided. The host cells may have one or more engineered modifications selected from: a feedback inhibition alleviating mutation in a enzyme gene; a transcriptional modulation modification of a biosynthetic enzyme gene; an inactivating mutation in an enzyme; and a heterologous coding sequence. Also provided are methods of producing a BIA of interest or a precursor thereof using the host cells and compositions, e.g., kits, systems etc., that find use in methods of the invention.

Abstract: Provided herein are compounds, pharmaceutical formulations, and methods for treatment of cancer, particularly including chronic myeloid leukemias, and neurodegenerative disorders in a subject.

Abstract: Disclosed herein are Fenton filters comprising a porous substrate and a catalyst coating the porous substrate, wherein the catalyst includes a matrix and single metal atoms incorporated in the matrix. Also disclosed herein are methods of generating radicals from an oxidant, electrolyzers, methods of generating hydrogen peroxide, and water treatment systems.

Abstract: Devices, systems, and methods for shock absorption are provided herein. Collapsible shock absorption devices have an inner wall having at least one orifice, an outer wall, and a fluid sealed within the outer wall can mitigate sharp increases in force during loading and can better distribute loading forces. In some cases, collapsible shock absorption devices disclosed herein are used for prevention of injury to a biological tissue of a subject or damage to an inanimate object.

Abstract: This disclosure provides data showing that LEFTY inhibits differentiation-promoting pathways such as BMP7/pSMAD5 in breast cancer cell lines, over and above its known role of inhibiting Nodal/pSMAD2. LEFTY competes with BMP7 to bind to its cell surface receptor BMPR2, leading to inhibition of pSMAD5. The LEFTY-BMPR2 interaction is dominant over BMP-BMPR2 in tumorigenic cells, resulting in diminished pSMAD status, whereas in non-tumorigenic cells, there is minimal LEFTY-BMPR2 interaction, increased BMP7-BMPR2 association, and elevated pSMAD. Compositions and methods for inducing or inhibiting expression and/or the activity of LEFTY and BMP proteins are described, which can be used in diagnosis and therapy of cancer and other conditions, and to promote proliferation of stem cells.

Abstract: Systems and methods for synthetic image generation include a method of generating synthetic histological slide images that includes translating each of several RNA-Seq records into a latent space, training a first diffusion model to produce a first synthetic histological slide image at a lower resolution using the translated RNA-Seq records and associated histological slides, training a second diffusion model to upscale lower resolution synthetic histological slide images produced by the first diffusion model to higher resolution synthetic histological slide images, obtaining a given RNA-Seq record, translating the given RNA-Seq record into the latent space, providing the latent representation of the given RNA-Seq record to the trained first diffusion model to generate a given lower resolution synthetic histological slide image, and providing the given lower resolution synthetic histological slide image to the trained second diffusion model to generate a given higher resolution synthetic histological slide im

Abstract: Novel human interleukin-2 (IL-2) muteins or variants thereof, and nucleic acid molecules and variants thereof are provided. Methods for producing these muteins as well as methods for stimulating the immune system of an animal are also disclosed. In addition, the invention provides recombinant expression vectors comprising the nucleic acid molecules of this invention and host cells into which expression vectors have been introduced. Pharmaceutical compositions are included comprising a therapeutically effective amount of a human IL-2 mutein of the invention and a pharmaceutically acceptable carrier. The IL-2 muteins can be used in pharmaceutical compositions for use in treatment of cancer and in stimulating the immune response.

Abstract: Described are various dual-tapered composite laminate structures. These structures may comprise a plurality of finite sub-laminate cards, each one of the plurality of cards having the same shape and size as the other ones of the plurality of cards and having opposing surfaces oriented in a card plane, opposing primary edges of the planar surfaces, and opposing secondary edges of the planar surfaces, the opposing secondary edges being perpendicular to the opposing primary edges. The finite sub-laminate cards are stacked relative to one another in a successively offset manner. Also described are methods of stacking and sliding (for offset) the finite sub-laminate cards. Tapered fuselage skin and fuel tank covers are also considered.

Abstract: In an integrated optical device, squeezed light is used internally to effectively increase an optical modulation effect. One exemplary device operates by squeezing the light at the input, then sending it through an electro-optic stage where its phase picks up the signal of interest, and finally anti-squeezing it to obtain a displaced coherent state. Thus the displacement is amplified by the level of squeezing that is achieved inside the device and it is thereby less sensitive to loss. Since this device behaves simply as an electro-optic modulator, albeit one with an exponentially enhanced sensitivity, no extra considerations are needed to integrate the modulator into a system. Such devices can be operated as modulators or as sensors, and can make use of optical phase shift effects other than the electro-optic effect.

Abstract: Polyacrylamide-based copolymers act as stabilizing excipients in formulations of antibody biopharmaceutical agents without interacting directly with the antibody or altering its pharmacokinetic properties. The polyacrylamide-based copolymers confer a substantial stability benefit to high concentration compositions of a variety of antibodies by precluding adsorption of the antibody to the interfaces of the composition, preventing undesirable aggregation events and maintaining the binding activity of the antibody. Such antibody compositions are useful in methods of administering the composition to a subject.

Abstract: An airway visualization system is described herein having an elongate delivery sheath and defining at least one lumen therethrough, wherein the length is positionable within an airway of a subject. An isolation component positioned near or at a distal end of the elongate delivery sheath is expandable to at least partially obstruct the airway and a controller is in communication with the delivery sheath. The controller is also configured to manipulate a fluid flow through the at least one lumen whereby a pressure change within the airway of the subject is imparted sufficiently to at least partially expand or collapse the airway to alter the density of the airway.

Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.

Abstract: In some embodiments, there is provided an apparatus including a common bus and a plurality of oscillatrode circuits coupled to the common bus, the plurality of oscillatrode circuits including a first oscillatrode circuit outputting a first frequency tone when a first input voltage is detected by the first oscillatrode circuit and a second oscillatrode circuit outputting a second frequency tone when a second input voltage is detected by the second oscillatrode circuit, wherein common bus carries the first frequency tone and the second frequency tone at different frequencies in a frequency division multiplex signal. Related systems, methods, and articles of manufacture are also disclosed.

Abstract: Systems and methods for decoding indented speech from neuronal activity in accordance with embodiments of the invention are illustrated.