Abstract: A sensor can selectively detect quantum signatures in charge transfer processes via a tunneling current. In one aspect, the sensor can include a metal electrode having a first surface and a second surface. The sensor can also include an insulator film having a first thickness, a first surface area and a first surface chemistry. The insulator film can be coupled to the metal electrode via the first surface. The sensor can also include a functionalization film having a second thickness, a second surface area and a second surface chemistry. The functionalization film can be coupled to the metal electrode via the second surface. The insulator film and the functionalization film are configured to separate the metal electrode from an electrochemical solution comprising the analyte.

Abstract: Systems and methods for structuring unstructured data according to a data object structure that enables fast query look-ups across a variety of space and time dimensions. Furthermore, many embodiments optimize the storage of the data objects using a set of compression techniques that configure the data types used for the data objects based on properties of the stored data. Furthermore, many embodiments provide are able to service query look-up requests without having to deserialize data within the byte stream format as stored in memory by encoding information that provide memory locations for requested data, thereby allowing for the immediate retrieval of the data as it is stored in the persistent memory.

Abstract: An electrochemical device includes an anode having sodium or lithium; a cathode having a carbonaceous material; a separator; and an electrolyte that includes a metal halide, a fluorinated electrolyte compound, and thionyl chloride; wherein the electrochemical device is a primary battery or a secondary battery.

Abstract: Systems and method for light field imaging with mirror arrays in accordance with embodiments of the invention are illustrated. One embodiment includes a light field imaging system, including a mirror array where each mirror in the mirror array is positioned to reflect light from a target object towards a lens such that a different view of the target object is visible in each mirror from the viewpoint of the lens. The system further includes a lens configured to focus the reflected light, a sensor configured to capture an image depicting a plurality of reflections of the target object, a processor, and a memory containing a light field imaging application that directs the processor to obtain the captured image, extract a light field of the target object based on the plurality of reflections of the target object, and construct a three-dimensional model of the target object based on the light field.

Abstract: This document describes techniques for radio frequency (RF) based micro-motion tracking. These techniques enable even millimeter-scale hand motions to be tracked. To do so, radar signals are used from radar systems that, with conventional techniques, would only permit resolutions of a centimeter or more.

Abstract: In some embodiments, a device for generating mid-infrared radiation is provided. The device may include a thin film quadratic nonlinear waveguide formed on a mid-infrared transparent cladding by a thin film material of a predetermined film thickness, the waveguide having a predetermined etch depth and a predetermined top width. At least one of the predetermined film thickness, the predetermined etch depth, and the predetermined top width may be tuned for the device to generate a coherent idler wave as a mid-infrared radiation from a fixed pump wave and a tunable signal wave.

Abstract: An apparatus and method for extracting nitrogen including compounds from wastewater is disclosed herein. The methods and apparatus use molecularly designed selective electrocatalysts, electrolytes, and separation reactors to enable automated, distributed ammonia manufacturing with minimal environmental impacts. In some embodiments, a method of nitrogen reduction of wastewater is provided. The method includes: providing an apparatus including: a first chamber comprising a salt solution; a second chamber comprising a wastewater source; a third chamber comprising a salt solution and a third electrode, wherein the second chamber is positioned between the first chamber and the third chamber; an anion exchange membrane positioned between the first chamber and the second chamber; and a cation exchange membrane positioned between the second chamber and the third chamber; applying a potential bias between any two of the first chamber, the second chamber, and the third chamber.

Abstract: A non-reciprocal microwave network is provided that includes an in-line ferromagnetic element with adjoining polarizing adapters to achieve directivity via a multi-mode interaction at or near the ferrite to act as new class of 4-port circulator or 2-port isolator, with standard waveguide inputs for assembly in larger networks.

Abstract: High affinity PD-1 mimic polypeptides are provided, which (i) comprise at least one amino acid change relative to a wild-type PD-1 protein; and (ii) have an increased affinity for PD-L1 relative to the wild-type protein. Compositions and methods are provided for modulating the activity of immune cells in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity PD-1 mimic polypeptide, which blocks the physiological binding interaction between PD-1 and its ligand PD-L1 and/or PD-L2.

Abstract: A method of producing para-hydroxybenzoic acid (pHBA) or a derivative thereof includes culturing the recombinant microorganism in a fermentation broth, wherein said recombinant microorganism comprising a genetically engineered pathway expressing at least one nucleic acid sequence encoding a polypeptide selected from: an exogenous chorismate pyruvate lyase of EC 5.4.4.2 or EC 4.1.3.40; an exogenous 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase of EC 4.1.2.15, or EC 2.5.1.54; an exogenous shikimate kinase of EC 2.7.1.71; or an exogenous 3-dehydroquinate dehydratase (DHQ) of EC 4.2.1.10; adding a carbon source to the fermentation broth; and isolating the pHBA from the fermentation broth.

Abstract: Systems and methods for increasing hypnotizability in accordance with embodiments of the invention are illustrated. One embodiment includes a method of treating a recipient using hypnotherapy, including applying neurostimulation to a recipient's brain such that functional connectivity between an anterior cingulate cortex (ACC) and a dorsolateral prefrontal cortex (DLPFC) of the recipient's brain is increased, and activity in the ACC is decreased, and applying hypnotherapy in order to treat a condition of the recipient. In a further embodiment, the condition is selected from the group consisting of depression, anxiety, phobia, pain, stress, disordered eating, sleep disorders, posttraumatic stress, and addiction.

Abstract: A method for treating a subject suffering from a disease is provided. The method includes diagnosing the subject as suffering from a disease; upregulating the cathelicidin gene CAMP in the subject; and administering to the subject at least one treatment for the disease.

Abstract: The present disclosure provides methods and compositions for treating X-CGD in subjects, comprising genetically modifying cells from the subjects ex vivo by integrating a functional, codon-optimized CYBB cDNA at the endogenous CYBB locus.

Abstract: Many embodiments provide the formation of active Pd sites upon steam treatment. Steam treatment of Pd catalysts can improve redox combustion reaction efficiencies. Several embodiments provide the formation of twin boundaries under steam treatment can improve catalytic activities of nanoparticle catalysts.

Abstract: Humanized or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to and neutralize human CD47, and find use in various therapeutic methods. Preferred are non-activating antibodies. Embodiments of the invention include isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the humanized or chimeric anti-CD47 monoclonal antibodies; and cell lines that produce these monoclonal antibodies. Also provided are amino acid sequences of the antibodies.

Abstract: A treatment planning prediction method to predict a Dose-Volume Histogram (DVH) or Dose Distribution (DD) for patient data using a machine-learning computer framework is provided with the key inclusion of a Planning Target Volume (PTV) only treatment plan in the framework. A dosimetric parameter is used as an additional parameter to the framework and which is obtained from a prediction of the PTV-only treatment plan. The method outputs a Dose-Volume Histogram and/or a Dose Distribution for the patient including the prediction of the PTV-only treatment plan. The method alleviates the complicated process of quantifying anatomical features and harnesses directly the inherent correlation between the PTV-only plan and the clinical plan in the dose domain. The method provides a more robust and efficient solution to the important DVHs prediction problem in treatment planning and plan quality assurance.

Abstract: Kerr and electro-optic frequency comb generation in integrated lithium niobate devices is provided. In various embodiments, a microring resonator comprising lithium niobate is disposed on a thermal oxide substrate. The microring resonator has inner and outer edges. Electrodes are positioned along the inner and outer edges of the microring resonator. The electrodes are adapted to modulate the refractive index of the microring. A pump laser is optically coupled to the microring resonator. The microring resonator is adapted to emit an electro-optical frequency comb when receiving a pump mode from the pump laser and when the electrodes are driven at a frequency equal to a free-spectral-range of the microring resonator.

Abstract: Systems, methods, and other embodiments described herein relate to improving controls in a device according to risk. In one embodiment, a method includes, in response to receiving sensor data about a surrounding environment of the device, identifying objects from the sensor data that are present in the surrounding environment. The method includes generating a control sequence for controlling the device according to a risk-sensitivity parameter to navigate toward a destination while considering risk associated with encountering the objects defined by the risk-sensitivity parameter. The method includes controlling the device according to the control sequence.

Abstract: A method for scarless genome editing is disclosed. In particular, the method provides scarless genome modification by using homology directed repair (HDR) steps to genetically modify cells and remove unwanted sequences. This method can be used for genome editing, including introducing mutations, deletions, or insertions at any position in the genome without leaving silent mutations, selection marker sequences, or other additional undesired sequences in the genome.

Abstract: Systems and methods for predicting a future cardiovascular event are provided. Electrocardiogram waveform data can be acquired and utilized in a trained computational model to predict a future cardiovascular event. Clinical interventions, clinical surveillance, and clinical treatments can be performed based on a future cardiovascular event prediction.