Abstract: A microelectronic device and method of making the same including a substrate and at least one expansion layer that adds stress to the substrate when said substrate expands.

Abstract: The neural network includes layers, and the layers each include a plurality of units, the plurality of units each have a weight coefficient associated with each input to a unit, and an importance parameter indicating importance of the weight coefficient. The method includes: in learning of a task, adjusting a first weight coefficient based on the importance parameter of the first weight coefficient and a first gradient of the first weight coefficient determined using a training set; and after the learning has been completed, determining, based on the training set, respective second gradients of a plurality of second weight coefficients included in a first layer including the first weight coefficient, and calculating the importance parameter of the first weight coefficient to be used in learning of a next task based on the respective second gradients.

Abstract: Compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other cancer therapies that achieve the same or similar therapeutic effect.

Abstract: A saliva-based testing method that bypasses the need for RNA isolation/purification is described herein. In experiments with inactivated SARS-CoV-2 virus spiked into saliva, this method has a limit of detection of 500-1000 viral particles per mL, rivalling the standard NP swab method. Initial studies showed excellent performance with 100 clinical samples. This saliva-based process is operationally simple, utilizes readily available materials, and can be easily implemented by existing testing sites thus allowing for high-throughput, rapid, and repeat testing of large populations.

Abstract: A system and method remotely allocate bandwidth among content consumers on a computing network based on optimizing an aggregate objective pertaining to a plurality of flows of content. The system and method create a profile for each flow of the plurality of flows from a content provider to a content consumer on the computing network. Information is stored in each profile based on at least a metric associated with the corresponding flow. A target bandwidth for each profile is computed remotely, based on optimizing an aggregate objective pertaining to the plurality of flows of content. The optimizing is also based on the information stored in their respective profiles. The system and method distribute the bandwidth to each flow of the plurality of flows based on the target bandwidth remotely computed for each profile.

Abstract: A triboelectric generator can include respective contact members including a first contact member and second contact member. The respective contact members can be movable with respect to each other such that the respective contact members separate from each other in a first configuration and contact each other in a second configuration. The first contact member can include a first conductive layer and a contact layer. The second contact member can be spaced apart from the first contact member in the first configuration and can include an insulating contact layer and a second conductive layer. The insulating contact layer can be configured to come into contact with the contact layer of the first contact member and the transition of the respective contact members from the first configuration to the second configuration can create triboelectric charges. In some examples, the first contact member can include a non-contact insulating layer.

Abstract: Magnetic resonance imaging systems and methods are provided for time-efficiently producing a plurality of image contrasts, the plurality of image contrasts including a first contrast being coupled with a second contrast and acquired over a plurality of key parameters that govern the second contrast to which the first contrast is coupled. In addition, the plurality of image contrasts is used to simultaneously map the first contrast, the second contrast, and additional contrasts.

Abstract: The invention relates to FcRn polypeptides, to antibodies and related fragments thereof containing the FcRn polypeptides, to production of said antibodies and fragments and to use of said antibodies and fragments for therapy of various conditions.

Abstract: A method of making a carbon-metal oxide composite electrode for a supercapacitor includes continuously injecting a carbon material solution into a coagulation solution, where the carbon material solution comprises a carbon source and a liquid, and the coagulation solution comprises a metal nitrate or chloride and an organic solvent. An extruded structure comprising the metal nitrate or chloride interspersed with carbon is formed from the continuous injection. The extruded structure is annealed under conditions sufficient to convert the metal nitrate or chloride to metal oxide. Thus, a composite structure comprising the metal oxide and the carbon is formed, where the metal oxide is uniformly dispersed within the composite structure.

Abstract: A method of decomposing a cured aromatic epoxy resin uses a molten salt bath at less than about 350° C. The molten salt bath includes a plurality of alkali metal hydroxides. The cured aromatic epoxy resin can be in intimate physical contact with a metal or alloy. The cured aromatic epoxy resin can be patterned by a lithographic method. The lithographic method can be multibeam interference lithography to form a three-dimensional photonic crystal template on a conductive substrate for electrodeposition of metal. Contacting the three-dimensional photonic crystal template with the electrodeposited metal with the molten salt bath can form a metal matrix device displaying a periodic pattern that is the inverse of the periodic pattern of the decomposed three-dimensional photonic crystal template.

Abstract: A method to control the density of a three-dimensional photonic crystal template involves changing the irradiation time from at least four laser beams to yield a periodic percolating matrix of mass and voids free of condensed matter from a photoresist composition. The photoresist composition includes a photoinitiator at a concentration where the dose or irradiation is controlled by the irradiation time and is less than the irradiation time that would convert all photoinitiator to initiating species such that the density of the three-dimensional photonic crystal template differs for different irradiation times. A deposition of reflecting or absorbing particles can be patterned on the surface of the photoresist composition to form a template with varying densities above different areas of the substrate.

Abstract: Disclosed herein a self-healing, flexible, conductive compositions. The conductive compositions include conductive polymers and acidic polyacrylamides. The compositions are useful in a wide range of applications, including wearable electronics and sensors. The compositions may be prepared using environmentally friendly procedures.

Abstract: Disclosed are compositions derived from 2,2?bisimidazoles building blocks and methods of making the same. The disclosed compositions are capable of withstanding temperatures up to 600° C. and substantially flame resistant.

Abstract: The current disclosure relates to the design of an apparatus for enhancing the operation and reliability of high-power multi-chip modules, which are used in the design and implementation of power electronics converters. This apparatus is especially useful for modules containing recently commercialized, high-performance wide band-gap semiconductors such as Silicon Carbide (SiC), which commonly emit undesirable high-frequency ringing and oscillation in the “Near-RF” spectral band between 1-30 MHz. The disclosed apparatus provides near-complete elimination of this high frequency spectral content, while leaving the desired frequency range (1-100 kHz) of the module unaffected. In addition to the suppression of this undesirable high-frequency content, the disclosed apparatus also provides for accurate, galvanically-isolated, high-bandwidth, real-time current measurement, which is essential for some types of power electronics converters.

Abstract: Aspects of the subject disclosure may include, for example, obtaining video data from a single monocular camera, wherein the video data comprises a plurality of frames, wherein the camera is attached to a mobile robot that is travelling along a lane defined by a row of crops, wherein the row of crops comprises a first plant stem, and wherein the plurality of frames include a depiction of the first plant stem; obtaining robot velocity data from encoder(s), wherein the encoder(s) are attached to the robot; performing foreground extraction on each of the plurality of frames of the video data, wherein the foreground extraction results in a plurality of foreground images; and determining, based upon the plurality of foreground images and based upon the robot velocity data, an estimated width of the first plant stem. Additional embodiments are disclosed.

Abstract: Embodiments of compositions and methods for the treatment of blood disorders and malignancies in a subject are described herein. In one embodiment, a composition for the treatment of a blood disorder or a malignancy in a subject comprises decitabine, tetrahydrouridine, and an excipient. In another embodiment, a method for the treatment of a blood disorder or a malignancy in a subject comprises the oral administration of a composition comprising decitabine and tetrahydrouridine. In some examples, the composition may be administered 1-3 times weekly.

Abstract: Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.

Abstract: A method of making a deformable electronic device comprises forming a multilayer device structure comprising functional layers on a flexible substrate. At least one, some or all of the functional layers comprises a stack of 2D monolayers, and a number or proportion of misaligned interfaces within each stack of 2D monolayers is controlled to obtain a predetermined bending stiffness. Each of the misaligned interfaces comprises a twist angle and/or lattice mismatch between adjacent 2D monolayers. The functional layers may include electronically active layers and other layers having a dielectric, insulating, and/or protective function.

Abstract: Systems and methods are provided to implement a moving target defense for a server computer. The server computer can be provided both a permanent IP address and a temporary IP address. The temporary IP address can be used when communicating with client computers connected to the server computer. The temporary IP address can be dynamically changed at a predetermined interval that can be varied based on conditions at the server computer. An intrusion detection system can be used with the moving target defense systems and methods to identify attacks on the server computer based on the temporary IP address(es) provided by the server computer. When an attack is identified, the corresponding client computer is determined based on the temporary IP address and the client computer is placed on a blacklist that is not provided with new temporary IP addresses when the server computer changes temporary IP address.

Abstract: Methods of RNA-guided DNA endonuclease-mediated genome editing in Bacteria and Archaea are provided.