Abstract: The present invention provides compositions comprising new strains of Pseudomonas fluorescens and Burkholderia cenocepacia. Secreted fraction compositions produced by these bacterial strains, and the methods for producing these compositions are also provided. Herein, the inventors demonstrate that these bacterial strains and compositions may be used to inhibit the growth of a broad spectrum of plant pathogens.

Abstract: Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.

Abstract: A battery storage system is configured to store batteries in a safe manner that reduces the threat of thermal runaway. Batteries held by the system are electrically connected to at least one load that is powered by energy from the batteries, thereby depleting the charge level of the batteries. In some embodiments, the load is a temperature control device that is configured to cool the batteries to help prevent a thermal runaway condition during storage. That is, discharging of the battery helps not only to reduce the charge levels in the batteries, thereby decreasing the likelihood of an occurrence of thermal runaway, but also cool the batteries further decreasing the likelihood of such an occurrence. Thus, over time, the battery storage system efficiently controls the charge levels and temperatures of the batteries so that a thermal runaway condition is unlikely.

Abstract: Disclosed are methods of preparing hematopoietic stem cells and progenitor cells (HSPCs) for transplant into a subject and to methods of using the treated cells. More particularly, methods of the invention comprise treating HSPCs ex vivo with an effective amount of a GABBR1 agonist and administering the treated HSPCs to the subject.

Abstract: A microfluidic system includes a flexible substrate having a skin-facing surface and a back-facing surface; a microfluidic network at least partially embedded in or supported by the flexible substrate; a sensor fluidically connected to the microfluidic network, wherein the microfluidic network is configured to transport a biofluid from a skin surface to the sensor; and a capping layer, having a capping layer skin-facing surface and a back-facing surface, wherein the back-facing surface of the capping layer is attached to the skin-facing surface of the substrate. The flexible substrate is at least partially formed of a thermoplastic elastomer or a polymer configured to provide a high barrier to vapor or liquid water transmission.

Abstract: The present disclosure provides prime editors, editor systems and methods of uses thereof. Specifically, the disclosure provides methods of use of split prime editors for editing genomic DNA.

Abstract: A method of spontaneously patterning a polymer during frontal polymerization includes activating an initiation region of a monomer solution to reaction to initiate a polymerization reaction. A polymerization front is generated and propagates through the monomer solution in a radial or longitudinal direction away from the initiation region. The monomer solution is spontaneously heated downstream of the polymerization front by thermal transport away from the polymerization reaction. Once a localized region of the monomer solution reaches a temperature sufficient for spontaneous initiation of another polymerization reaction, a new polymerization front is generated and propagates through the monomer solution in a circumferential or transverse direction.

Abstract: A unique class of perfluorocarbon-free Dextran-based oxygen nanobubbles (DONBs) and formulations thereof. The critical components in the formulation are chosen among the U.S. Food, and Drug Administration's (FDA) approved compounds, which provide a biocompatible environment for incorporating pharmaceutical agents. Moreover, the nanobubbles are fabricated with simple sonication and homogenization method that easily fulfills the current good manufacturing practices (cGMP) requirements, which will promote scaleup production for commercial manufacturing. The formulated DONBs release oxygen over an extended period to keep the partial pressure of oxygen within the inner retina high and thus preserve retinal tissue from ischemia.

Abstract: A multiple mechanically actuated regenerative output system having a rack gear that moves linearly between a first position and a second position to a shaft of an alternator.

Abstract: Microfabricated particulate matter (PM) monitors and fractionators within the PM monitors are provided. A primary channel of a vertical or out-of-plane fractionator receives air samples, comprising particles of varying sizes, from the external environment. The air samples then pass through a plurality of microfluidic channels, wherein inertial forces are applied within the microfluidic channels to separate the particles by size. The fractionator comprises a horizontal air outlet for particles having a size below a threshold size and a vertical air outlet for particles having a size above a threshold size. Thus, the proportion of PM in the air sample is reduced prior to deposition on a PM monitor. A virtual cyclone may also be provided that comprises a bend positioned at a flow path through a primary channel of the vertical microfabricated fractionator.

Abstract: A microheater comprises an optical fiber including a rare earth-doped glass core surrounded by a glass cladding. The rare earth-doped glass core comprises a rare earth dopant at a concentration sufficient for luminescence quenching such that, when the rare earth dopant is pumped with light at an absorption band wavelength, at least about 90% of absorbed pump light is converted into heat.

Abstract: Provided are actuation devices, virtual reality devices formed from the actuation devices, and related virtual reality methods. The devices may comprise a plurality of spatially distributed actuators, each actuator configured for interacting with a biological skin surface; a wireless controller configured to receive operative command signals to control each of the actuators; and a wireless power system to power the actuators. Also provided are unique layouts of multiple interconnected devices to achieve large area coverage.

Abstract: As anode having an anode material, a current collector, a graphene-based material, and the graphene-based material covers the anode material.

Abstract: An apparatus for fabricating a hybrid tube includes a rotatable mandrel and a first housing configured to translate alongside the rotatable mandrel while dispensing a first strip to be helically wound about the mandrel. The first housing includes an angle adjustment mechanism to control a dispensation angle of the first strip. The apparatus also includes least one energy or adhesive source for bonding overlapping strip portions on the rotatable mandrel and forming the hybrid tube. The at least one energy or adhesive source is configured for translation alongside the rotatable mandrel.

Abstract: A redundant meter measurement system includes a first water sensor configured to measure a first set of water use data and a second water sensor configured to measure a second set of water use data. The system also includes a controller communicatively coupled to the first water sensor and the second water sensor. The controller is configured to receive the first set of water use data from the first water sensor and receive the second set of water use data from the second water sensor. The controller is also configured to store the first set of water use data and the second set of water use data as a collection of water use data. The controller is also configured to enable transmission of the collection of water use data to a remote device.

Abstract: Described herein is a method and system for controlling an interior-mounted permanent magnet (IPM) alternating-current (AC) electrical machine utilizing a space vector pulse-width modulated (SVPWM) converter operably connected between an electrical power source and the IPM AC electrical machine comprising three neural networks (NNs), including a controller NN operably connected to the SVPWM converter, a parameter estimator NN, and a flux-weakening and MTPA NN.

Abstract: A multi-modal heart diagnostic system is provided. The diagnostic system can monitor heart activity and assists a user or operator in performing echocardiography. The system can include a positioning device that is placed on a patient's chest. The positioning device can incorporate several multi-modal sensors. The multi-modal sensors can measure different parameters associated with an assessment of heart activity. The multi-modal sensors can also be used to provide information that can assist an operator in positioning the probe within the positioning device to capture an echocardiogram.

Abstract: This invention relates to methods of expanding T regulatory cells through OX40L and Jagged-1 induced signaling. The methods can be used for treating autoimmune diseases.

Abstract: A biosensor having a core/shell nanocomposite of TiO2/rGO formed by hydrothermally coating reduced graphene oxide (rGO) flakes on titanate nanowires.

Abstract: Provided herein are compositions and methods for the fermentative production of 2,3-butanediol (2,3-BDO), compositions and methods for making methyl ethyl ketone (MEK), and methods of inducing drought tolerance in plants.