Patents Assigned to The Board of Trustees Operating Michigan State University
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Patent number: 7406859Abstract: An improved nanomanipulation system is provided for performing nanomanipulation operations in relation to a sample surface. The system includes: an atomic force microscope having a probe for performing nanomanipulation operations on the sample surface, where the probe includes a cantilever having a layer of piezoelectric material; a position detector configured to ascertain deformation of the cantilever during a nanomanipulation operation; and an adaptable end effector controller adapted to receive data indicative of the deformation from the position detector and implements a control scheme based on the deformation data. The control scheme produces a control signal that is applied to the piezoelectric material of the cantilever, thereby maintaining the straight shape of the cantilever during the nanomanipulation operation.Type: GrantFiled: April 6, 2006Date of Patent: August 5, 2008Assignee: Board of Trustees operating Michigan State UniversityInventors: Ning Xi, Guangyong Li, Jiangbo Zhang
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Patent number: 7407696Abstract: Phase-change compounds, and optical storage recording media, for recording and/or storage of data, comprising such compounds, according to the formula XSbySz; wherein X is selected from the group consisting of K, Rb, Tl, Na, Li, Cs and mixtures thereof; and wherein y is about 1 or about 5, and z is about 1 or about B. Preferably, X is K, y is 5 and z is B. Also provided are optical recording media comprising a layer of the phase-change material and methods of creating a reversible phasechange by irradiating the material with a laser radiation.Type: GrantFiled: January 22, 2004Date of Patent: August 5, 2008Assignee: Board of Trustees operating Michigan State UniversityInventor: Mercouri G. Kanatzidis
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Patent number: 7381625Abstract: A method is provided for constructing a nanodevice. The method includes: fabricating an electrode on a substrate; forming a nanogap across the electrode; dispersing a plurality of nanoobjects onto the substrate using electrophoresis; and pushing one of the nanoobjects onto the electrode using a tip of an atomic force microscope, such that the nanoobject lies across the nanogap formed in the electrode. In addition, remaining nanoobjects may also be pushed away from the electrode using the atomic force microscope, thereby completing construction of a nanodevice.Type: GrantFiled: October 11, 2006Date of Patent: June 3, 2008Assignee: Board of Trustees operating Michigan State UniversityInventors: Ning Xi, Guangyong Li, Jiangbo Zhang, Hoyin Chan
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Patent number: 7378086Abstract: Vectors and methods are provided for introducing genetic material into cells of a chicken or other avian species. More particularly, vectors and methods are provided for transferring a transgene to an embryonic chicken cell, so as to create a transgenic hen wherein the transgene is expressed in the hen's oviduct and the transgene product is secreted in the hen's eggs and/or those of her offspring. In a preferred embodiment, the transgene product is secreted in the egg white.Type: GrantFiled: September 8, 2004Date of Patent: May 27, 2008Assignee: Board of Trustees Operating Michigan State UniversityInventor: William C. MacArthur
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Patent number: 7367242Abstract: An active micro-force sensor is provided for use on a micromanipulation device. The active micro-force sensor includes a cantilever structure having an actuator layer of piezoelectric material and a sensing layer of piezoelectric material bonded together. When an external force is exerted on the sensor, the sensor deforms and an applied force signal is recorded by the sensing layer. The applied force signal is then fed back to the actuating layer of the sensor via a servoed transfer function or servo controller, so that a counteracting deformation can be generated by the bending moment from the servoed actuating layer to quickly balance the deformation caused by the external micro-force.Type: GrantFiled: February 27, 2006Date of Patent: May 6, 2008Assignee: Board of Trustees operating Michigan State UniversityInventors: Ning Xi, Yantao Shen
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Patent number: 7347114Abstract: A design template includes a torso section being one of a group of a 95th percentile male, 50th percentile male and 5th female having each being one of a group of an ERECT posture, a NEUTRAL posture and a SLUMPED posture.Type: GrantFiled: March 21, 2005Date of Patent: March 25, 2008Assignee: The Board of Trustees Operating Michigan State UniversityInventors: Herbert M Reynolds, Robert Kerr, Raymond Brodeur, Khaldoun Rayes, Douglas Neal, Yuntao Cui
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Patent number: 7344888Abstract: A nucleic acid sequence of the blueberry red ringspot virus is disclosed. Also disclosed are putative promoter regions of the sequence and promoter regions capable of directing transgene expression in plants, including tissue-specific expression. Also disclosed are expression vectors, transformed plant cells and plants containing a blueberry red ringspot virus promoter and an encoded product for expression. Methods for diagnosis of blueberry red ringspot virus infection are also provided.Type: GrantFiled: March 4, 2004Date of Patent: March 18, 2008Assignee: Board of Trustees operating Michigan State UniversityInventors: Richard F Allison, Jerri Gillett, Christy Mecey
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Publication number: 20080051454Abstract: The present inventions relate to therapeutic compositions comprising, and methods utilizing, arachidonic acid derivatives and analogs for treatment of patients demonstrating symptoms of pathological conditions. Specifically, the inventions relate to therapeutic compositions for activating transient receptor potential vanilloid-1 channels (TRPV1). Additionally, therapeutic compositions are provided for increasing TRPV1-type responses. These pathological conditions include, but are limited to, hypertension, in particular salt induced hypertension, and cardiovascular complications, including myocardial infarction, kidney dysfunction, diabetes, and inflammation. Further, the inventions relate to drug screening methods for providing additional therapeutic compounds.Type: ApplicationFiled: April 23, 2007Publication date: February 28, 2008Applicant: The Board of Trustees Operating Michigan State UniversityInventor: Donna Wang
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Publication number: 20080034449Abstract: The present inventions relate to compositions and methods for providing stress tolerant transgenic plants comprising a RING domain zinc-finger motif transcription factor protein. More particularly, the invention relates to compositions and methods comprising a RING-H2 domain transcription factor protein for providing drought and salt tolerant plants, in particular comprising a recombinant XERICO gene and protein.Type: ApplicationFiled: July 12, 2006Publication date: February 7, 2008Applicant: The Board of Trustees Operating Michigan State UniversityInventors: Kyung-Hwan Han, Jae-Heung Ko
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Publication number: 20080003687Abstract: The invention relates to compositions, kits and methods used in hydroxyl radical detection. In some embodiments, the invention relates to compositions comprising a dye preferably methylene blue immobilized on a substrate. In additional embodiments, the invention relates methods of correlating color changes of a dye to the presence or absence of hydroxyl radicals. In some embodiments, the invention relates to a methylene blue dye containing test strip and its use in a method for detecting the presence of hydroxyl radicals.Type: ApplicationFiled: June 28, 2006Publication date: January 3, 2008Applicant: The Board of Trustees Operating Michigan State UniversityInventors: Andrea Yuki Satoh, Susan J. Masten, James Trosko
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Publication number: 20070292407Abstract: The present invention relates to compositions and methods relating to prophylactic treatment and treatment of meconium aspiration syndrome comprising administering to a subject in need of treatment a therapeutically effective amount of acetylcysteine (N-acetyl-L-cysteine). One aspect of the invention relates to pharmaceutical compositions and methods of treatment comprising acetylcysteine and/or DNAse and/or a compound of the antiprotease family of drugs, administered singly or in combination, as medicament for treatment of meconium aspiration syndrome admixed with a pharmaceutically acceptable diluent, carrier, or excipient.Type: ApplicationFiled: December 12, 2006Publication date: December 20, 2007Applicant: The Board of Trustees Operating Michigan State UniversityInventor: Vadim Ivanov
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Patent number: 7297946Abstract: An automated nanomanipulation system is provided for manufacturing a nanoscale structure. The system includes: a design model for the nanoscale structure; image data of a sample surface upon which the nanoscale structure is to be manufactured; a movable member configured to perform a nanomanipulation operation on the sample surface; and a path planning subsystem adapted to receive the design model and the image data. The path planning subsystem generates path data indicative of a path for traversing the movable member along the sample surface such that the movable member manipulates one or more randomly distributed nanoobjects in accordance with the design model.Type: GrantFiled: August 16, 2005Date of Patent: November 20, 2007Assignee: Board of Trustees operating Michigan State UniversityInventors: Ning Xi, Guangyong Li, Heping Chen
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Patent number: 7256325Abstract: Methods for the transformation of plants are provided. The methods of the present invention comprise the steps of a) contacting the meristematic tissue of a plant and an area of the plant below the contacted meristematic tissue to a power source, wherein the area below the meristematic tissue is contacted to a positive lead and the meristematic tissue is contacted with a DNA-containing medium which in turn is contacted with a negative lead, and b) applying low amperage current, thus causing the DNA to migrate from the DNA-containing medium into the cells of the meristematic tissue. The transformed plants may be grown to maturity. The mature plants may then self-pollinate and the seed from the plant harvested. Both the parent plant, seed from the parent plant, progeny plants and progeny seeds contain the introduced DNA.Type: GrantFiled: December 8, 1998Date of Patent: August 14, 2007Assignee: Board of Trustees operating Michigan State UniversityInventors: Richard F. Allison, Jeanne Ohrnberger, Rafaz Hoque, Mark Desrosiers
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Patent number: 7255986Abstract: The present invention relates to the use of novel nucleotide sequences for the M and N region peptide of the ferret coronavirus and derivative products for the diagnosis and treatment of epizootic catarrhal enteritis (ECE) in ferrets.Type: GrantFiled: January 30, 2003Date of Patent: August 14, 2007Assignee: The Board of Trustees Operating Michigan State UniversityInventors: Roger K. Maes, Annabel G. Wise, Matti Kiupel
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Patent number: 7241935Abstract: The present invention relates to compositions and methods for the production of Betaine lipids. The methods of the present invention comprise the expression of recombinant enzymes (e.g. from Rhodobacter sphaeroides) in host cells (e.g. bacteria, yeast, and plants) to produce Betaine lipid compounds including, but not limited to, Diacylglyceryl-O-4?-(N,N,N,-trimethyl) homoserine (DGTS). The methods and compositions of the present invention may be utilized such that the amount of phosphate containing fertilizer required for the growth of a particular plant is decreased.Type: GrantFiled: July 16, 2003Date of Patent: July 10, 2007Assignee: The Board of Trustees Operating Michigan State UniversityInventors: Christoph Benning, Wayne Riekhof
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Publication number: 20070136890Abstract: A system for expression of a heterologous polypeptide in a transgenic host cell is disclosed. The system is based upon a transgene comprising a eukaryotic promoter operably linked to a DNA sequence comprising, in the 5? to 3? direction, a DNA sequence complementary to a sequence encoding a heterologous polypeptide, a DNA sequence complementary to an internal ri-bosome entry site, and a DNA sequence corresponding to a 3? untranslated region of a positive strand single-stranded RNA virus. Following introduction of stimulus, the host cell synthesizes an RNA molecule complementary to a recombinant RNA encoded by the transgene. The stimulus can be a positive strand single-stranded RNA virus or a nucleic acid thereof. Because the complement of the recombinant RNA comprises an internal ribosome entry site and a sequence encoding a heterologous polypeptide, the host cell can synthesize the heterologous polypeptide.Type: ApplicationFiled: July 2, 2004Publication date: June 14, 2007Applicant: Board of Trustees Operating Michigan State UniversityInventor: Richard Allison
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Publication number: 20070128613Abstract: The present invention relates to molecular diagnostics. In particular, the present invention relates to PCR based diagnostics for the typing of Group B streptococci.Type: ApplicationFiled: December 6, 2005Publication date: June 7, 2007Applicant: The Board of Trustees Operating Michigan State UniversityInventors: Dele Davies, David Lacher, Thomas Whittam, Shannon Manning
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Patent number: 7226764Abstract: The present invention is directed to compositions and methods related to the synthesis and modification of uridine-5?-diphospho-sulfoquinovose (UDP-SQ). In particular, the methods of the present invention comprise the utilization of recombinant enzymes from Arabidopsis thaliana, UDP-glucose, and a sulfur donor to synthesize UDP-SQ, and the subsequent modification of UDP-SQ to form compounds including, but not limited to, 6-sulfo-?-D-quinovosyl diaclyglycerol (SQDG) and alkyl sulfoquinovoside. The compositions and methods of the invention provide a more simple, rapid means of synthesizing UDP-SQ, and the subsequent modification of UDP-SQ to compounds including, but not limited to, SQDG.Type: GrantFiled: November 8, 2000Date of Patent: June 5, 2007Assignee: The Board of Trustees Operating Michigan State UniversityInventors: Christoph Benning, Sherrie Lea Sanda, Bin Yu
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Publication number: 20070092532Abstract: Vaccine compositions for preventing the onset or induction of arthritis in a subject susceptible to developing arthritis, comprising an arthritic protective peptide comprising the amino acid sequence of SEQ ID NO: 1. In various embodiments, the anti-arthritic peptide is admixed with an adjuvant in a pharmaceutically acceptable carrier. Methods include preventing arthritis in a human or other mammal subject comprising administering the arthritic protective peptide to the subject.Type: ApplicationFiled: October 25, 2006Publication date: April 26, 2007Applicant: Board of Trustees Operating Michigan State UniversityInventor: Robert Root-Bernstein
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Patent number: RE39640Abstract: A family of isostructural compounds have been prepared having the general formula AnPbmBinO2n+m. These compounds possess a NaCl lattice type structure as well as low thermal conductivity and controlled electrical conductivity. Furthermore, the electrical properties can be controlled by varying the values for n and m. These isostructural compounds can be used for semiconductor applications such as detectors, lasers and photovoltaic cells. These compounds also have enhanced thermoelectric properties making them excellent semiconductor materials for fabrication of thermoelectric devices.Type: GrantFiled: November 6, 2003Date of Patent: May 22, 2007Assignee: Board of Trustees operating Michigan State UniversityInventors: Mercouri G. Kanatzidis, Duck-Young Chung, Stephane DeNardi, Sandrine Sportouch