Patents Assigned to The Boots Company
  • Nail lacquers
    Patent number: 5330750
    Abstract: A nail lacquer composition which comprises 0.05 to 10% by weight of crystalline inorganic fibers having an aspect ratio of at least 2:1 is described. Preferred inorganic fibers are calcium salts such as calcium metasilicate and calcium sulphate. The use of such fibers has been found to give nail lacquer compositions with excellent wear and adhesion properties.
    Type: Grant
    Filed: March 18, 1993
    Date of Patent: July 19, 1994
    Assignee: The Boots Company Plc.
    Inventors: Christine Sheard, Julia E. Fisher
  • Mouthwash
    Patent number: 5328682
    Abstract: Abrasive mouthwash compositions suitable for a "rinse and brush" type product are described and are broadly defined as a pourable suspension containing the following essential components:a) 0.1-50% abrasive e.g. silica;b) 0.01-5% suspending agent e.g. montmorillonite clay;c) 0.1-5% surfactant e.g. sodium lauryl sulphate andd) liquid carrier e.g. water and humectant.Optional further components include flavourings, colourings, anti-plaque agents, anti-tartar agents, agents for sensitive teeth, fluoride ion sources and sweeteners.
    Type: Grant
    Filed: April 21, 1993
    Date of Patent: July 12, 1994
    Assignee: Boots Company plc
    Inventors: John H. Pullen, Rabinder Singh, Kathryn A. Phillips
  • Biphenyl-substituted guanidine derivatives useful as hypoglycaemic agents
    Patent number: 5302720
    Abstract: Compounds of formula I ##STR1## and their salts in which R.sub.1 is optionally substituted phenyl, R.sub.2 is alkyl, cycloalkyl or optionally substituted amino, or R.sub.2 and R.sub.3 together with the nitrogen and carbon atoms to which they are attached form an optionally substituted heterocyclic ring or R.sub.3 and R.sub.4 together with the nitrogen atom to which they are attached form an optionally substituted heterocyclic ring and R.sub.5 is H, halo, alkyl, alkoxy, trifluoromethyl or a group of formula S(O).sub.m R.sub.8 in which m is 0, 1 or 2 and R.sub.8 is alkyl have utility in the treatment of diabetes particularly in the treatment of hyperglycaemia.
    Type: Grant
    Filed: June 17, 1992
    Date of Patent: April 12, 1994
    Assignee: The Boots Company
    Inventor: Balasubramanian Gopalan
  • Sunscreen compositions
    Patent number: 5250289
    Abstract: A sunscreening composition which comprises a water-in-oil emulsion which comprises a) 0.5 to 30% by weight of titanium dioxide having a mean primary particle size of less than 100 nm, b) 5 to 20% by weight of an oil phase, c) 1 to 15% by weight of an emulsifier, and d) at least 40% by weight of an aqueous phase. The titanium dioxide may be coated with aluminium stearate. Further sunscreening agents may be included. The oil phase may be a hydrocarbon oil, a wax, a natural oil, a silicone oil or a mixture. Preferred emulsifiers are sesquioleates such as polyglyceryl-2-sesquioleate or sorbitan sesquioleate, polyethoxylated esters of derivatives of natural oils such as polyethoxylated esters of hydrogenated castor oil or silicone emulsifiers such as silicone polyols.
    Type: Grant
    Filed: January 11, 1990
    Date of Patent: October 5, 1993
    Assignee: The Boots Company PLC
    Inventors: Stephen Boothroyd, Edward Galley, Arija M. Stammers
  • Therapeutic agents
    Patent number: 5240712
    Abstract: A high content of 2-(4-isobutylphenyl)propionic acid is achieved in a pharmaceutical composition by solidifying molten 2-(4-isobutylphenyl)propionic acid to provide a unit dose composition. The composition may be prepared by heating the 2-(4-isobutylphenyl)-propionic acid until molten, optionally mixing with pharmaceutically acceptable excipients, forming into a unit dosage presentation and allowing the composition to solidify. Preferably the composition contains greater than 80% ibuprofen or S(+)-ibuprofen and is filled into a hard gelatin capsule.
    Type: Grant
    Filed: March 24, 1992
    Date of Patent: August 31, 1993
    Assignee: The Boots Company PLC
    Inventors: Alan Smith, John F. Lampard
  • Phenylamidine and phenylguanidine derivatives and their use as antidiabetic agents
    Patent number: 5223498
    Abstract: Compounds of formula I ##STR1## and their salts in which n=0 or 1, R.sub.1 and R.sub.2 are each aliphatic or cycloalkyl or NR.sub.1 R.sub.2 is an optionally substituted heterocyclic ring, R.sub.3 is alkyl, cycloalkyl or optionally substituted amino, R.sub.5 is an aliphatic group, R.sub.6 is H, an optionally substituted aliphatic group or a cycloalkyl group, or R.sub.3 and R.sub.5 together with the nitrogen and carbon atoms to which they are attached form an optionally substituted heterocyclic ring or R.sub.5 and R.sub.6 together with the nitrogen to which they are attached form a heterocyclic ring optionally substituted by alkyl and R.sub.7 is optionally substituted alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkoxycarbonyl, trifluoromethyl or cyano have utility as hypoglycemic agents.
    Type: Grant
    Filed: December 28, 1989
    Date of Patent: June 29, 1993
    Assignee: The Boots Company plc
    Inventor: Balasubramanian Gopalan
  • Process for the manufacture of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate
    Patent number: 5068440
    Abstract: A process for the preparation of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate, a non-hygroscopic material which can be used as a pharmaceutical in the treatment of depression.
    Type: Grant
    Filed: January 19, 1990
    Date of Patent: November 26, 1991
    Assignee: Boots Company, PLC
    Inventors: James E. Jeffery, Derek Whybrow
  • Arylcyclobutylmethylamine therapeutic agents
    Patent number: 5047432
    Abstract: Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof; in which R.sub.1 and R.sub.2, which are the same or different, are H or an optionally substituted hydrocarbon group or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form an optionally substituted heterocyclic ring;R.sub.3 is an optionally substituted aromatic hydrocarbon group; andR.sub.4 is a hydrocarbon group containing at least one substituent selected from the group consisting of hydroxy and acylated derivatives thereof, optionally substituted alkoxy groups, optionally substituted cycloalkyloxy groups, optionally substituted alkylenedioxy groups, oxo and groups of formula S(O).sub.p R.sub.5 in which p is 0, 1 or 2 and R.sub.5 is an alkyl group, said hydrocarbon group being optionally substituted by additional substituents,are useful in the treatment of depression.
    Type: Grant
    Filed: June 20, 1990
    Date of Patent: September 10, 1991
    Assignee: The Boots Company Plc
    Inventors: John R. Housley, James E. Jeffery, David N. Johnston, Bruce J. Sargent
  • Process for the preparation of 1-methyl-3-methylthio-4-quinolone and the sulfinyl, and sulfonyl analogs thereof
    Patent number: 5011931
    Abstract: A process to prepare compounds of formula I ##STR1## in which n=0, 1 or 2 comprising the cyclisation of compounds of formula II ##STR2## in which n=0, 1 or 2. The cyclisation may be effected in the presence of an organic or inorganic base or thermally at a temperature in the range 40.degree.-160.degree. C.Compounds of formula II and certain analogues thereof are disclosed as cardiovascular agents.
    Type: Grant
    Filed: June 23, 1989
    Date of Patent: April 30, 1991
    Assignee: The Boots Company PLC
    Inventors: Lachlan MacLean, David L. Roberts, Kenneth Barron, Kenneth J. Nichol, Albert E. Harrison
  • Quinolone sulphonates having antihypertensive activity
    Patent number: 4997840
    Abstract: Quinolone sulphonates of formula I ##STR1## in which R.sub.1 is lower alkyl; R.sub.2 is lower alkyl; and R.sub.3, R.sub.4 and R.sub.5, which may be the same or different, are hydrogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulphinyl, lower alkylsulphonyl, halo, halogenated lower alkyl, halogenated lower alkoxy, cyano, phenyl or phenyl substituted by 1 or 2 groups independently selected from lower alkyl, lower alkoxy and halo, have antihypertensive activity.Processes for preparing compounds of formula I and pharmaceutical compositions containing them are described.Compounds of formula I are also indicated for use in the treatment of heart failure and ischaemic heart disease.
    Type: Grant
    Filed: September 1, 1989
    Date of Patent: March 5, 1991
    Assignee: The Boots Company, PLC
    Inventors: Roy V. Davies, Michael D. Brown, Nicholas J. Holman
  • Depilatory compositions
    Patent number: 4981682
    Abstract: A depilatory composition comprising a depilatory compound, in particular potassium thioglycolate, and a tertiary amine of general formula INR.sub.1 R.sub.2 R.sub.3 Iwherein R.sub.1 represents a long chain fatty moiety having 8 to 36 carbon atoms and R.sub.2 and R.sub.3 each independently represent a fatty moiety having 1 to 36 carbon atoms. The composition has pH of between 11.5 and 12.7. The softening effect of the tertiary amine avoids the growth of stiff stubble and does not reduce the efficacy of the depilatory compound.
    Type: Grant
    Filed: March 9, 1990
    Date of Patent: January 1, 1991
    Assignee: The Boots Company PLC
    Inventors: Stephen Boothroyd, Christine Sheard
  • Therapeutic compound
    Patent number: 4929629
    Abstract: N,N-Dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate is a non-hygroscopic material which can be used as a pharmaceutical in the treatment of depression.
    Type: Grant
    Filed: April 19, 1989
    Date of Patent: May 29, 1990
    Assignee: Boots Company, PLC
    Inventor: James E. Jeffery
  • Arylcyclobutylmethylamines
    Patent number: 4925879
    Abstract: Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof; in which R.sub.1 and R.sub.2, which are the same or different, are H or an optionally substituted hydrocarbon group or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form an optionally substituted heterocyclic ring;R.sub.3 is an optionally substituted aromatic hydrocarbon group; andR.sub.4 is a hydrocarbon group containing at least one substituent selected from the group consisting of hydroxy and acylated derivatives thereof, optionally substituted alkoxy groups, optionally substituted cycloalkyloxy groups, optionally substituted alkylenedioxy groups, oxo and groups of formula S(O).sub.p R.sub.5 in which p is 0, 1 or 2 and R.sub.5 is an alkyl group, said hydrocarbon group being optionally substituted by additional substituents,are useful in the treatment of depression.
    Type: Grant
    Filed: August 1, 1988
    Date of Patent: May 15, 1990
    Assignee: Boots Company, PLC
    Inventors: John R. Housley, James E. Jeffery, David N. Johnston, Bruce J. Sargent
  • Thieno[3,2-b]pyridine-6-carboxamide compounds useful in treating hypertension
    Patent number: 4877793
    Abstract: Novel 7(4H)-thieno[3,2-b]pyridinones of the formula I, ##STR1## wherein R is lower alkyl, and R.sub.1 is hydrogen, lower alkyl, lower alkoxy, halo, trifluoromethyl, or phenyl optionally substituted with one or two substituents selected from halo, lower alkyl, lower alkoxy and trifluoromethyl.The compounds are useful in the treatment of cardiovascular diseases. Pharmaceutical compositions containing the novel compounds and processes for preparing the novel compounds are also described.
    Type: Grant
    Filed: November 19, 1987
    Date of Patent: October 31, 1989
    Assignee: The Boots Company, PLC
    Inventor: Roy V. Davies
  • Medical treatment
    Patent number: 4871774
    Abstract: Compounds of formula I ##STR1## in which Ar is optionally substituted phenyl, R.sub.1 is an optionally substituted aliphatic group and R.sub.2 and R.sub.3 are H or optionally substituted alkyl groups or R.sub.2 and R.sub.3 together with the nitrogen atom to which they are attached complete a heterocyclic ring, are used in the treatment of Parkinson's disease. The compounds of formula I may be administered with a dopamine precursor such as levodopa and/or a dopa decarboxylase inhibitor such as carbiodopa or benserazide. A preferred compound of formula I is N,N-dimethyl-1[1-(4-chlorophenyl)-cyclobutyl]-3-methylbutylamine hydrochloride monohydrate.
    Type: Grant
    Filed: August 18, 1988
    Date of Patent: October 3, 1989
    Assignee: The Boots Company PLC
    Inventor: John A. Rees
  • 1,4dihydroquinoline-3-carboxamides
    Patent number: 4855291
    Abstract: Quinolones of the formula I ##STR1## in which the dotted line between positions 2 and 3 of the quinolone ring represents an optional bond; R is hydrogen or lower alkyl; R.sub.1 is lower alkyl; and R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, are hydrogen, halo, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulphinyl, lower alkylsulphonyl, trifluoromethyl, cyano, fluorinated lower alkoxy, phenyl optionally substituted by one or two substituents selected from lower alkyl, lower alkoxy, lower alkylthio, halo and trifluoromethyl, the group --OAr or the group --S(O).sub.n Ar in which Ar is phenyl optionally substituted by one or two substituents selected from lower alkyl, lower alkoxy, lower alkylthio, halo and trifluoromethyl and n is 0, 1 or 2, or the group --NR.sub.5 R.sub.6 or the N-oxide thereof in which R.sub.5 and R.sub.
    Type: Grant
    Filed: June 25, 1987
    Date of Patent: August 8, 1989
    Assignee: The Boots Company plc
    Inventor: Roy V. Davies
  • Therapeutic agents
    Patent number: 4839176
    Abstract: A solid storage stable composition comprising ibuprofen or a pharmaceutically acceptable salt thereof and codeine or a pharmaceutically acceptable salt thereof together with a sufficient amount of a pharmaceutically acceptable insoluble salt of carboxymethylcellulose to prevent discoloration of the composition.
    Type: Grant
    Filed: December 8, 1987
    Date of Patent: June 13, 1989
    Assignee: Boots Company PLC
    Inventors: Mahendra G. Pankhania, Michael C. Meyer
  • Pharmaceutical tablet
    Patent number: D302337
    Type: Grant
    Filed: September 1, 1987
    Date of Patent: July 18, 1989
    Assignee: Boots Company plc
    Inventors: Paul Bresloff, Alan Crunkhorn, Karrar A. Khan
  • Blocker sole with tap insert
    Patent number: D306232
    Type: Grant
    Filed: May 31, 1989
    Date of Patent: February 27, 1990
    Assignee: Acme Boot Company, Inc.
    Inventor: Craig C. Cummings
  • Dry shaver
    Patent number: D322691
    Type: Grant
    Filed: May 24, 1989
    Date of Patent: December 24, 1991
    Assignee: The Boots Company, PLC
    Inventor: John S. Davies