Patents Assigned to The Brigham & Women's Hospital, Inc.
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Publication number: 20240192298Abstract: According to a first aspect of the present inventive concept, there is provided a method for performing a diffusion weighted magnetic resonance measurement on a sample, the method comprising: operating a magnetic resonance scanner to apply a diffusion encoding sequence to the sample; and operating the magnetic resonance scanner to acquire from the sample one or more echo signals; wherein the diffusion encoding sequence comprises a diffusion encoding time-dependent magnetic field gradient g(t) with non-zero components gl(t) along at least two orthogonal directions y and z, and a b-tensor having at least two non-zero eigenvalues, the magnetic field gradient comprising a first and subsequent second encoding block, wherein an n-th order gradient moment magnitude along direction l?(y, z) is given by |Mnl(t)|=|?0tgl(t?)t?ndt?|, and the first encoding block is adapted to yield, at an end of the first encoding block: along said direction y, |Mny(t)|?Tn for each 0?n?m, where Tn is a predetermined n-th order threshType: ApplicationFiled: July 17, 2023Publication date: June 13, 2024Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Irvin Teh, Samo Lasic, Markus Nilsson, Filip Szczepankiewicz
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Patent number: 12007687Abstract: Described are systems and methods for multi-material printing. The systems and methods can utilize a stereolithographic printing device, a moving stage, and a microfluidic device. The microfluidic device can include a plurality of reservoirs, each reservoir housing a different ink for printing, and a microfluidic chip. The microfluidic chip can include a chamber that comprises a plurality of inlets, a printing region, and one or more outlets as well as an elastic membrane.Type: GrantFiled: May 26, 2023Date of Patent: June 11, 2024Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Yu Shrike Zhang, Ali Khademhosseini
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Patent number: 11998762Abstract: Some aspects of the disclosure provide a radiation therapy system. The system can include a radiation source configured to emit a radiation therapy beam, a collimator positioned to attenuate at least a periphery of the radiation therapy beam, a radiation fiducial marker configured to be coupled to a patient, and a first radiation detector and a second radiation detector configured to receive the radiation therapy beam after passing through a patient. The system also includes a computer configured to determine a position of the radiation fiducial marker using information from the first detector and the second detector.Type: GrantFiled: December 7, 2020Date of Patent: June 4, 2024Assignee: The Brigham and Women's Hospital, Inc.Inventors: Ross Berbeco, Yue-Houng Hu
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Patent number: 11999931Abstract: A microfluidic device for processing cells for the intracellular delivery of molecules or other cargo includes a plurality of microchannels disposed in a substrate or chip and fluidically coupled to an inlet configured to receive a solution containing the cells and the molecules or other cargo to be delivered intracellularly to the cells. Each of the plurality of microchannels has one or more constriction regions therein, wherein the constriction regions comprise an omniphobic, superhydrophilic, or superhydrophobic surface. In some embodiments, multiple microfluidic devices operating in parallel are used to process large numbers of cells. The device and method has particularly applicability to delivering gene-editing molecules intracellularly to cells.Type: GrantFiled: August 19, 2017Date of Patent: June 4, 2024Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Steven J. Jonas, Paul S. Weiss, Xu Hou, Joanna Aizenberg, Alireza Khademhosseini
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Patent number: 12000827Abstract: The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.Type: GrantFiled: December 27, 2022Date of Patent: June 4, 2024Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Omid Farokhzad, Morteza Mahmoudi, Claudia Corbo
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Patent number: 11994510Abstract: Methods for diagnosing, treating, and monitoring the treatment of fusariosis or scedosporiosis are described. The methods can include detecting the presence of one or more volatile organic compounds (VOCs) in the breath of subjects suspected of having fusariosis or scedosporiosis.Type: GrantFiled: October 11, 2017Date of Patent: May 28, 2024Assignee: The Brigham and Women's Hospital, Inc.Inventor: Sophia Koo
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Patent number: 11994512Abstract: Disclosed here is a generally applicable framework that utilizes massively-parallel single-cell RNA-seq to compare cell types/states found in vivo to those of in vitro models. Furthermore, Applicants leverage identified discrepancies to improve model fidelity. Applicants uncover fundamental gene expression differences in lineage-defining genes between in vivo systems and in vitro systems. Using this information, molecular interventions are identified for rationally improving the physiological fidelity of the in vitro system. Applicants demonstrated functional (antimicrobial activity, niche support) improvements in Paneth cell physiology using the methods.Type: GrantFiled: January 4, 2019Date of Patent: May 28, 2024Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Benjamin E. Mead, Jose Ordovas-Montanes, Alexander K. Shalek, Jeffrey Karp, Robert Langer
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Patent number: 11982610Abstract: A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.Type: GrantFiled: September 22, 2023Date of Patent: May 14, 2024Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Utkan Demirci, Waseem Asghar
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Patent number: 11981705Abstract: The present application relates to sequences that enhance permeation of immunotherapy agents across the blood brain barrier (BBB), compositions comprising the sequences, and methods of use thereof to treat brain cancer, e.g., glioblastoma (GBM). Further disclosed are a number of potential targeting peptide sequences identified that enhance permeation through the BBB, when inserted into the capsid of an adeno-associated virus (AAV).Type: GrantFiled: January 8, 2021Date of Patent: May 14, 2024Assignee: The Brigham and Women's Hospital, Inc.Inventors: Fengfeng Bei, E. Antonio Chiocca
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Patent number: 11971404Abstract: The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.Type: GrantFiled: December 27, 2022Date of Patent: April 30, 2024Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Omid Farokhzad, Morteza Mahmoudi, Claudia Corbo
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Patent number: 11951156Abstract: In some aspects, the invention teaches pharmaceutical compositions that include a TGF-? ligand trap, and methods of using a TGF-? ligand trap to treat, prevent, or reduce the progression rate of pulmonary hypertension (PH). The invention also provides methods of using a TGF-? ligand trap to treat, prevent, or reduce the progression rate of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, right ventricular hypertrophy, diseases associated with excessive TGF-? signaling, diseases associated with excessive GDF15 signaling, and diseases associated with excessive PAI-1 signaling. The invention further provides methods of using a TGF-? ligand trap to reduce right ventricular systolic pressure in a subject.Type: GrantFiled: April 17, 2020Date of Patent: April 9, 2024Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., ACCELERON PHARMA, INC.Inventors: Paul B. Yu, Asya Grinberg, Dianne S. Sako, Roselyne Castonguay, Rita Steeves, Ravindra Kumar
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Publication number: 20240108241Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).Type: ApplicationFiled: December 15, 2023Publication date: April 4, 2024Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., The General Hospital CorporationInventors: Robert S. Langer, Carlo Giovanni Traverso, Malvika Verma, Feyisope Eweje, Christoph Winfried Johannes Steiger, Junwei Li, Nhi Phan, Hen-Wei Huang, Jacqueline Chu, John Ashraf Fou Salama
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Patent number: 11946064Abstract: Described herein are compositions and methods for treating a disease in a subject by administering delivery vectors that express artificial microRNAs, artificial microRNA clusters, and/or a combination of microRNA clusters and associated non-coding RNAs to the subject. Also described herein are methods for preparing artificial microRNAs and artificial microRNA clusters.Type: GrantFiled: April 30, 2019Date of Patent: April 2, 2024Assignee: The Brigham and Women's Hospital, Inc.Inventors: Pierpaolo Peruzzi, Ennio Antonio Chiocca
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Patent number: 11946846Abstract: A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.Type: GrantFiled: September 13, 2023Date of Patent: April 2, 2024Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Utkan Demirci, Waseem Asghar
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Patent number: 11939616Abstract: The present disclosure provides, inter alia, compositions and methods for enforcing a pattern of cell surface fucosylated lactosaminyl glycans on a human cell. In certain embodiments, the compositions and/or methods utilize one or more members of the ?(1,3)-fucosyltransferase family. In certain embodiments, a process for custom-modifying a fucosylated lactosaminyl glycan on a human cell is disclosed.Type: GrantFiled: September 22, 2020Date of Patent: March 26, 2024Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventor: Robert Sackstein
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Publication number: 20240093156Abstract: The disclosure provides methods and compositions for reprogramming fibroblasts into limb progenitors.Type: ApplicationFiled: August 15, 2023Publication date: March 21, 2024Applicants: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.Inventors: Clifford J. Tabin, Yuji Atsuta, Alan R. Rodrigues, ChangHee Lee, Olivier Pourquie
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Patent number: 11926809Abstract: Systems and methods are provided for provided for automatic evaluation of sperm morphology. An image of a semen sample is obtained, and at least a portion of the image is provided to a convolutional neural network classifier. The convolutional neural network classifier evaluates the portion of the image to assign to the portion of the image a set of likelihoods that the portion of the image belongs to a plurality of output classes representing the morphology of sperm within the portion of the image. A metric is assigned to the semen sample based on the likelihoods assigned by the convolutional neural network.Type: GrantFiled: September 3, 2019Date of Patent: March 12, 2024Assignee: BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Hadi Shafiee, Manoj Kumar Kanakasabapathy, Prudhvi Thirumalaraju
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Patent number: 11926062Abstract: A continuum robot having at least two independently manipulateable bendable section for advancing the robot through a passage, without contacting fragile elements within the passage, wherein the robot incorporates control algorithms that enable the continuum robot to operate and advance into the passage, as well as the systems and procedures associated with the continuum robot and said functionality.Type: GrantFiled: February 12, 2021Date of Patent: March 12, 2024Assignees: Canon U.S.A., Inc., The Brigham and Women's Hospital, Inc.Inventors: Fumitaro Masaki, Franklin King, Nobuhiko Hata, Takahisa Kato
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Publication number: 20240076736Abstract: The disclosure provides compositions and methods for characterizing the genome and transcriptome at a single cell level. In some embodiments, the method provides for the characterization of CRISPR editing outcomes and phenotypes, as well as other alterations in polynucleotide sequences, particularly in primary cells.Type: ApplicationFiled: October 25, 2023Publication date: March 7, 2024Applicant: The Brigham and Women's Hospital, Inc.Inventors: Yuriy BAGLAENKO, Soumya RAYCHAUDHURI
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Patent number: RE49978Abstract: According to an aspect of the present inventive concept there is provided a method of performing diffusion weighted magnetic resonance measurements on a sample, the method includes performing diffusion weighted magnetic resonance measurements on the sample, where the measurements include a first measurement with a first diffusion encoding sequence having a first diffusion weighting tensor representation B1 with at least two non-zero eigenvalues and a second measurement with a second diffusion encoding sequence having a second diffusion weighting tensor representation B2 with at least two non-zero eigenvalues.Type: GrantFiled: December 20, 2021Date of Patent: May 21, 2024Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Samo Lasic, Daniel Topgaard, Markus Nilsson, Hans Magnus Henrik Lundell