Patents Assigned to The Catholic University of America
  • Patent number: 11401530
    Abstract: Described is an “artificial virus” (AV) programmed with biomolecules that can enter human cells and carry out precise human genome modification. The AVs comprise: at least one viral vector, such as bacteriophage T4; at least one therapeutic molecule, such as DNA, RNA, protein and their complex; and a lipid coating. Also described is a method of human genome modification, using such an AV, and a method of program such an AV.
    Type: Grant
    Filed: June 28, 2021
    Date of Patent: August 2, 2022
    Assignee: The Catholic University of America
    Inventors: Venigalla B. Rao, Jingen Zhu
  • Patent number: 11219686
    Abstract: Bivalent immunogenic compositions against anthrax and plague are disclosed herein. One bivalent immunogenic composition comprises a triple fusion protein containing three antigens, F1 and V from Yersinia pestis and PA antigen from Bacillus anthracis fused in-frame and retaining structural and functional integrity of all three antigens. Another bivalent immunogenic composition comprises bacteriophage nanoparticles arrayed with these three antigens on the capsid surface of the bacteriophage nanoparticles. These bivalent immunogenic compositions are able to elicit robust immune response in a subject administered said the bivalent immunogenic compositions and provide protection to the subject against sequential or simultaneous challenge with both anthrax and plague pathogens.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: January 11, 2022
    Assignee: The Catholic University of America
    Inventor: Venigalla B. Rao
  • Patent number: 11155835
    Abstract: Described is hybrid viral vector comprising: a first virus such as bacteriophage T4; one or more second virus such as adeno-associated virus (AAV) attached to the first virus through cross-bridges, such as avidin-biotin cross-bridges; one or more DNA molecules packaged in the first virus; one or more nucleic acid molecules packaged in the second virus; and one or more proteins displayed on the surface of the first virus. Also described are methods of making and using such a hybrid viral vector.
    Type: Grant
    Filed: August 11, 2020
    Date of Patent: October 26, 2021
    Assignee: The Catholic University of America
    Inventors: Venigalla B. Rao, Jingen Zhu
  • Patent number: 10981828
    Abstract: An embodiment includes a Class C fly ash (CFA) cementitious composition with a controllable setting time comprising at least one Class C fly ash; at least one alkali hydroxide; at least one source of phosphate; and water. Alternate embodiments include a Class C fly ash (CFA) cementitious composition with a solid activator comprising at least one Class C fly ash; at least one alkali carbonate; at least one source of phosphate; and water.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: April 20, 2021
    Assignee: The Catholic University of America
    Inventors: Weiliang Gong, Hui Xu, Werner Lutze, Ian L. Pegg
  • Patent number: 10656306
    Abstract: A computer system and method for improving the accuracy of predictions of the amount of renewable energy, such as solar energy and wind energy, available to an electric utility, and/or refine such predictions, by providing improved integration of meteorological forecasts. Coefficient values are calculated for a renewable energy generation model by performing a regression analysis with the forecasted level of renewable energy posted by the utility, forecasted weather conditions and measures of seasonality as explanatory variables. Accuracy is further enhanced through the inclusion of a large number of time series variables that reflect the systematic nature of the energy/weather system. The model also uses the original forecast posted by the system operator as well as variables to control for season.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: May 19, 2020
    Assignee: The Catholic University of America
    Inventors: Kevin F. Forbes, Ernest M. Zampelli
  • Patent number: 10556002
    Abstract: Bivalent immunogenic compositions against anthrax and plague are disclosed herein. One bivalent immunogenic composition comprises a triple fusion protein containing three antigens, F1 and V from Yersinia pestis and PA antigen from Bacillus anthracia fused in-frame and retaining structural and functional integrity of all three antigens. Another bivalent immunogenic composition comprises bacteriophage nanoparticles arrayed with these three antigens on the capsid surface of the bacteriophage nanoparticles. These bivalent immunogenic compositions are able to elicit robust immune response in a subject administered said the bivalent immunogenic compositions and provide protection to the subject against sequential or simultaneous challenge with both anthrax and plague pathogens.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: February 11, 2020
    Assignee: The Catholic University of America
    Inventor: Venigalla B. Rao
  • Patent number: 10441940
    Abstract: Complexing or chelating agents that offer strong, selective bonding with uranium as well as a broad pH range of effectiveness, specifically including the pH range around 8.2, together with the acrylic double bonds required for radiation-induced grafting on polymers to remove uranium from a solution such as seawater. The novel adsorbing species are phosphorus-containing molecules, in particular organic phosphates, phosphonates and phosphoric acids. Organic phosphorus compounds, for example, organic phosphates, phosphonates, and phosphoric acids, are attached to polymer fibers to form fibers, fiber fabrics or membranes that are effective, or show activity, in uranium adsorption.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: October 15, 2019
    Assignees: UNIVERSITY OF MARYLAND, College Park, CATHOLIC UNIVERSITY OF AMERICA
    Inventors: Chanel Tissot, Aaron Barkatt, Mohamad I. Al-Sheikhly
  • Patent number: 10407470
    Abstract: Provided herein are HIV vaccines that encompasses recombinant trimers that mimic native HIV-1 envelope trimers. Also provided are methods of administering to a subject in need thereof an HIV vaccine provided herein to elicit antibodies against a recombinant trimer in the subject. A recombinant trimer is formed by a recombinant protein comprising a recombinant HIV-1 gp140 fused to a tag through a linker at C-terminus of the recombinant HIV-1 gp140, wherein the linker is sufficiently long so that the tag is accessible for binding by a binding molecule bound on a solid matrix during purification of the recombinant trimer.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: September 10, 2019
    Assignee: The Catholic University of America
    Inventors: Venigalla B. Rao, Wadad Alsalmi
  • Patent number: 10127568
    Abstract: Systems and methods improve the forecast of electricity consumption, and/or refining such predictions. Predictions may be refined by accounting for factors such as preliminary predictions, pricing and cost information associated with future supply of energy, the extent of anticipated changes in the predictions, the time of day and/or anticipated daylight for the period of time. Coefficient values are calculated for a forecast error model that takes into account factors related to electricity consumption using existing historical electrical grid data. Using the calculated values, the forecast error model may be applied to current electricity demand forecasts.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: November 13, 2018
    Assignee: THE CATHOLIC UNIVERSITY OF AMERICA
    Inventors: Kevin F. Forbes, Ernest M. Zampelli, O. Chris S. St. Cyr
  • Patent number: 10005819
    Abstract: An approach of producing recombinant trimers that mimic native HIV-1 envelope trimers is developed. A recombinant protein forming the recombinant trimers encompasses a recombinant HIV-1 gp140 fused to a tag through a linker at C-terminus of the recombinant HIV-1 gp140. The linker is sufficiently long so that the tag is accessible for binding by a binding molecule bound on a solid matrix. After expressed in a cell, the recombinant protein is secreted into the culture medium and assembles into recombinant trimers therein. The recombinant trimers may be directly purified from the culture medium. Cleaved and uncleaved trimers from different clade viruses are produced.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: June 26, 2018
    Assignee: The Catholic University of America
    Inventors: Venigalla B. Rao, Wadad Alsalmi
  • Patent number: 9975924
    Abstract: An approach of producing recombinant trimers that mimic native HIV-1 envelope trimers is developed. A recombinant protein forming the recombinant trimers encompasses a recombinant HIV-1 gp140 fused to a tag through a linker at C-terminus of the recombinant HIV-1 gp140. The linker is sufficiently long so that the tag is accessible for binding by a binding molecule bound on a solid matrix. After expressed in a cell, the recombinant protein is secreted into the culture medium and assembles into recombinant trimers therein. The recombinant trimers may be directly purified from the culture medium. Cleaved and uncleaved trimers from different clade viruses are produced.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: May 22, 2018
    Assignee: The Catholic University of America
    Inventors: Venigalla B. Rao, Wadad Alsalmi
  • Patent number: 9944679
    Abstract: Provided herein are HIV vaccines that encompasses recombinant trimers that mimic native HIV-1 envelope trimers. Also provided are methods of administering to a subject in need thereof an HIV vaccine provided herein to elicit antibodies against a recombinant trimer in the subject. A recombinant trimer is formed by a recombinant protein comprising a recombinant HIV-1 gp140 fused to a tag through a linker at C-terminus of the recombinant HIV-1 gp140, wherein the linker is sufficiently long so that the tag is accessible for binding by a binding molecule bound on a solid matrix during purification of the recombinant trimer.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: April 17, 2018
    Assignee: The Catholic University of America
    Inventors: Venigalla B. Rao, Wadad Alsalmi
  • Patent number: 9919974
    Abstract: A composite binder comprises: one or more Class F fly ash materials, one or more gelation enhancers, and one or more hardening enhancers, wherein each of the one or more Class F fly ash materials comprises 15 wt. % or less calcium oxide, and wherein the composite binder is a Portland cement-free binder for concrete. Also provided are Geopolymer Composite Cellular Concretes (GCCCs) including the composite binder and methods of making these GCCCs.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: March 20, 2018
    Assignee: The Catholic University of America
    Inventors: Weiliang Gong, Werner Lutze, Ian L. Pegg
  • Patent number: 9850288
    Abstract: An approach of producing recombinant trimers that mimic native HIV-1 envelope trimers is developed. A recombinant protein forming the recombinant trimers encompasses a recombinant HIV-1 gp140 fused to a tag through a linker at C-terminus of the recombinant HIV-1 gp140. The linker is sufficiently long so that the tag is accessible for binding by a binding molecule bound on a solid matrix. After expressed in a cell, the recombinant protein is secreted into the culture medium and assembles into recombinant trimers therein. The recombinant trimers may be directly purified from the culture medium. Cleaved and uncleaved trimers from different clade viruses are produced.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: December 26, 2017
    Assignee: The Catholic University of America
    Inventors: Venigalla B. Rao, Wadad Alsalmi
  • Patent number: 9834583
    Abstract: An approach of producing recombinant trimers that mimic native HIV-1 envelope trimers is developed. A recombinant protein forming the recombinant trimers encompasses a recombinant HIV-1 gp140 fused to a tag through a linker at C-terminus of the recombinant HIV-1 gp140. The linker is sufficiently long so that the tag is accessible for binding by a binding molecule bound on a solid matrix. After expressed in a cell, the recombinant protein is secreted into the culture medium and assembles into recombinant trimers therein. The recombinant trimers may be directly purified from the culture medium. Cleaved and uncleaved trimers from different clade viruses are produced.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: December 5, 2017
    Assignee: The Catholic University of America
    Inventors: Venigalla B. Rao, Wadad Alsalmi
  • Patent number: 9834479
    Abstract: A geopolymer composite binder is provided herein, the composite binder including (i) at least one fly ash material having less than or equal to 15 wt % of calcium oxide; (ii) at least one gelation enhancer; and (iii) at least one hardening enhancer having a different composition from a composition of the at least one fly ash material.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: December 5, 2017
    Assignee: The Catholic University of America
    Inventors: Weiliang Gong, Werner Lutze, Ian Pegg
  • Patent number: 9827457
    Abstract: The present invention provides compositions and methods for converting hazardous waste glass into safe and usable material. In particular, the present invention provides compositions and methods for producing ceramic products from toxic-metal-containing waste glass, thereby safely encapsulating the metals and other hazardous components within the ceramic products.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: November 28, 2017
    Assignee: The Catholic University of America
    Inventors: Hao Gan, Malabika Chaudhuri, Biprodas Dutta, Ian L. Pegg
  • Patent number: 9701722
    Abstract: Described herein is a soluble HIV-1 retrovirus transmembrane glycoprotein gp41 trimer (Soc-gp41M-Fd) containing a partial ectodomain and the cytoplasmic domain, that is fused to the small outer capsid (Soc) protein of bacteriophage T4 and the Foldon domain of the bacteriophage T4 fibritin (Fd). The gp41 trimer that has a prehairpin structure could be utilized to understand the mechanism of viral entry and as a candidate for development of HIV-1 vaccines, diagnostics and therapeutics. Other secondary embodiments of the gp41 proteins containing different modifications are also disclosed. According to one embodiment, the gp41 trimer is further attached to a cell penetration peptide (CPP). Methods of producing gp41 trimers are also disclosed.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: July 11, 2017
    Assignee: The Catholic University of America
    Inventors: Venigalla B. Rao, Guofen Gao
  • Patent number: 9580477
    Abstract: An approach of producing recombinant trimers that mimic native HIV-1 envelope trimers is developed. A recombinant protein forming the recombinant trimers encompasses a recombinant HIV-1 gp140 fused to a tag through a linker at C-terminus of the recombinant HIV-1 gp140. The linker is sufficiently long so that the tag is accessible for binding by a binding molecule bound on a solid matrix. After expressed in a cell, the recombinant protein is secreted into the culture medium and assembles into recombinant trimers therein. The recombinant trimers may be directly purified from the culture medium. Cleaved and uncleaved trimers from different clade viruses are produced.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: February 28, 2017
    Assignee: The Catholic University of America
    Inventors: Venigalla B. Rao, Wadad Alsalmi
  • Patent number: 9523101
    Abstract: Complex viruses are assembled from simple protein subunits by sequential and irreversible assembly. During genome packaging in bacteriophages, a powerful molecular motor assembles at the special portal vertex of an empty prohead to initiate packaging. An aspect of the invention relates to the phage T4 packaging machine being highly promiscuous, translocating DNA into finished phage heads as well as into proheads. Single motors can force exogenous DNA into phage heads at the same rate as into proheads and phage heads undergo repeated initiations, packaging multiple DNA molecules into the same head. This shows that the phage DNA packaging machine has unusual conformational plasticity, powering DNA into an apparently passive capsid receptacle, including the highly stable virus shell, until it is full. These features allow for the design of a novel class of nanocapsid delivery vehicles.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: December 20, 2016
    Assignee: The Catholic University of America
    Inventor: Venigalla B. Rao