Abstract: A visible light-curable chitosan derivative, a hydrogel thereof, and a preparation method therefor are disclosed. The visible light-curable glycol chitosan derivative is curable by light in the visible light range and has a wound healing activity. A hydrogel obtained by cross-linkage of the visible light-curable glycol chitosan derivative using visible light has a wound healing effect per se, and further, a hydrogel obtained by cross-linkage in a combination of one or more growth factors has an excellent wound healing effect. In addition, a glycol chitosan hydrogel that can prevent the denaturation of contained drugs and growth factors due to the cross-linkage by visible light and is optimized for application to a wet dressing dosage form can be prepared.

Abstract: The present invention is related to a medium additive composition comprising peroxidasin for serum-free cell culture, and a method of performing serum-free culture of cells by using the same.

Abstract: The present invention relates to a biomarker and uses thereof for liver cancer diagnosis or prognosis prediction. The biomarker according to the present invention may be used as a marker for liver cancer diagnosis and prognosis prediction with improved specificity and sensitivity. Thus, the biomarker may be used not only to diagnose or prognose liver cancer with high accuracy and reliability, but also to effectively screen a liver cancer treatment agent.

Abstract: A visible light-curable chitosan derivative, a hydrogel thereof, and a preparation method therefor are disclosed. The visible light-curable glycol chitosan derivative is curable by light in the visible light range and has a wound healing activity. A hydrogel obtained by cross-linkage of the visible light-curable glycol chitosan derivative using visible light has a wound healing effect per se, and further, a hydrogel obtained by cross-linkage in a combination of one or more growth factors has an excellent wound healing effect. In addition, a glycol chitosan hydrogel that can prevent the denaturation of contained drugs and growth factors due to the cross-linkage by visible light and is optimized for application to a wet dressing dosage form can be prepared.

Abstract: The present invention relates to a thermoplastic mask monitoring system using a pressure sensor. Specifically, a thermoplastic mask according to the present invention may include: a mask having a shape determined according to a shape of a first region which is at least a part of a patient's body by using thermoplasticity, fixing the first region in close contact with the first region, and receiving radiation; and a pressure sensor provided between the mask and the first region and sensing pressure induced by a space generated between the mask and the first region.

Abstract: Disclosed herein is a snare (transparent cap) for removing a polyp which includes a stalk and a head connected to the stalk, wherein the snare includes: a body having a hollow tubular shape and an interior of which is partitioned into a plurality of chambers; a ring mounted to at least part of the body using elasticity; a first snare discharged outside the body through a first chamber among the plurality of chambers and hooks the stalk; and a second snare which is discharged outside the body through a second chamber among the plurality of chambers, wherein when the stalk is spread according to pulling the first snare that hooks the stalk, and the second snare pulls a first portion in a lower end of the stalk as spread including the head, the ring is discharged from the body and shrinks through the elasticity and then fixes the first portion.

Abstract: Provided is a technique for deriving a mathematical function for defining arterial and venous blood flow in the body by using a four-dimensional medical image. A method of analyzing blood flow by using a medical image according to an embodiment of the present disclosure includes: determining a position of a blood vessel from four-dimensional medical image data that is obtained by combining data of three-dimensional medical images of a patient's body captured at a preset period; deriving a primary function for an arterial input function and a venous output function by using a vascular signal in a head region and a vascular signal in a heart region from among vascular signals included in three-dimensional medical image data for the position of the blood vessel determined in the determining; and deriving a secondary function that is a final function for the arterial input function and the venous output function by using the primary function and a vascular signal in a neck region.

Abstract: The present invention relates to an endoscope. The present invention may include an endoscope main body; and a guide cap that is mounted to be fixed to a front end of the endoscope main body when inserting the endoscope main body into a human body and slides to protrude toward the front of the endoscope main body when withdrawing the endoscope main body inserted into the human body. An object of the present invention is to facilitate insertion of the endoscope by freely varying a length of the cap from the front end of the endoscope, and to enhance the detection rate of polyp.

Abstract: The present invention relates to various compounds capable of temporarily hardening soft tissue for surgical suturing of the soft tissue. The compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, thereby improving the suturing efficiency during suturing of the soft tissue, thereby preventing aftereffects or the like from occurring due to insufficient anastomosis. In addition, the compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, particularly pancreas, thereby increasing the suturing efficiency during pancreaticoduodenectomy and effectively preventing pancreatic leakage.

Abstract: The present invention relates to a biguanide derivative compound capable of effectively preventing and treating immune diseases. The biguanide-based derivative compound according to the present invention inhibits the generation of IL-17 and TNF-?, which are inflammatory cytokines, increases the activity of regulatory T cells having an immunomodulatory function, and exhibits excellent therapeutic effects in animal models of immune diseases. Accordingly, the biguanide-based derivative compound can be usefully used as an immunosuppressant or a pharmaceutical composition capable of preventing or treating various immune diseases, such as autoimmune diseases, inflammatory diseases, and transplant rejection, caused by the dysregulation of immune responses.

Abstract: Provided is a composition containing Bifidobacterium for alleviating, preventing or treating rheumatoid arthritis. The Bifidobacterium bifidum ATT newly isolated according to the present invention is useful as a rheumatoid arthritis medicine or a probiotic material for alleviating rheumatoid arthritis owing to potent efficacy in treating rheumatoid arthritis.

Abstract: The present invention relates to a surgical apparatus for dissecting a part of cornea during lamellar keratoplasty, which provides a surgical apparatus comprising: an injector unit including a hollow injection needle having a bevel structure at one end; a laser unit for emitting a laser for OCT imaging; an OCT detection unit for photographing a tomographic image of the cornea using the laser; a laser light sensor located on an inner surface of the bevel structure of the injection needle and connected to the laser unit and the OCT detection unit through an optical fiber; and a depth adjusting unit for adjusting a depth of the injection needle in the cornea according to an operation of a user.

Abstract: There is provided a therapeutic apparatus for photodynamic therapy that includes a hollow tube inserted into a living body; an unfolding part that is coupled to one end of the tube and is unfolded; a light irradiation part that is disposed in the unfolding part to irradiate light; and an operating part that is coupled to the other end of the tube to unfold the unfolding part, wherein the light irradiation part irradiates light when the unfolding part is unfolded. The therapeutic apparatus for photodynamic therapy according to the present disclosure allows irradiation of light by unfolding tissues of the curved portion in the living body, using an unfolding part capable of being unfolded depending on the user's selection and the light irradiation part coupled to the unfolding part, there is an effect of allowing the use of the photodynamic therapy even in a portion that cannot be conventionally treated using the photodynamic therapy.

Abstract: The present invention relates to a method for inducing differentiation, into chondrocytes, of cord blood mononuclear cell-derived induced pluripotent stem cells. In a case where a chondrogenic pellet produced by the method of the present invention is transplanted into a cartilage damage area in vivo, regeneration of cartilage can be effectively exhibited by differentiated chondrocytes. In such a case, an effective cartilage regeneration capacity can be exhibited as compared with a case where chondrocytes produced by differentiation induction with the addition of a recombinant growth factor are transplanted. Thus, the present invention can be usefully used for tissue engineering therapies.

Abstract: The present invention provides a composition for diagnosing Sjögren's syndrome in dry eye syndrome by using ATG5 or LC3B-II as a biomarker, a method of diagnosing the same, and a screening method. ATG5 or LC3B-II are used as a biomarker to effectively diagnose only Sjögren's syndrome except for non-Sjögren's syndrome in dry eye syndrome, and thus it can be useful for related fields.

Abstract: Provided are a cell line stably expressing voltage-gated sodium channel (Nav1.5), wherein a SCN5A gene (NCBI accession no. NM_198056) encoding Nav1.5 and a puromycin selection marker are inserted into a chromosome of a host cell, and a method of measuring cardiotoxicity of a test substance comprising: (1) contacting a test substance to the cell line of claim 1; and (2) measuring magnitude of voltage-gated sodium channel (Nav1.5) in the cell line in contact with the test substance.

Abstract: The present invention relates to a biguanide derivative compound capable of effectively preventing and treating immune diseases. The biguanide-based derivative compound according to the present invention inhibits the generation of IL-17 and TNF-?, which are inflammatory cytokines, increases the activity of regulatory T cells having an immunomodulatory function, and exhibits excellent therapeutic effects in animal models of immune diseases. Accordingly, the biguanide-based derivative compound can be usefully used as an immunosuppressant or a pharmaceutical composition capable of preventing or treating various immune diseases, such as autoimmune diseases, inflammatory diseases, and transplant rejection, caused by the dysregulation of immune responses.

Abstract: An aspect of the present invention provides a rectal phantom unit and a phantom device including the same, including: a holder having a penetration portion formed in a longitudinal direction thereof; a rectal simulant which is inserted to the penetration portion of the holder, includes a plurality of unit plates laminated thereon, and simulates a rectum of a body; and a film which is disposed between the rectal simulant and the holder and measures an absorbed dose of radiation irradiated to the rectal simulant.

Abstract: The present invention relates to a method for converting mesenchymal stem cells into endothelial cells by using specific transcription factors and, more specifically, a method for converting mesenchymal stem cells into endothelial cells by using Oct4, Nanog, Tal1, and LMO2, which are specific transcription factors. According to the present invention, the method for converting adult cells or mesenchymal stem cells, which are adult stem cells, into endothelial cells was developed by selecting two types of genes, which are less directly related to cancer induction, among cell reprogramming factors and two types of transcription factors, which are not expressed or expressed at a low level in mesenchymal stem cells, among transcription factors related to vascular development, and combining all four transcription factors. The method can be applied in the production of endothelial cells for forming regenerative tissue in tissue engineering and ischemic disease therapy.

Abstract: An oral or nasal endotracheal tube includes a tube part, a first balloon and a second balloon. The tube part extends along a direction with a tube shape and an end portion of the tube part is intubated into trachea. The first balloon extends with passing through the tube part, and expands or contracts a block cuff. The second balloon extends with passing through the tube part, and expands or contracts a guide cuff. The block cuff uniformly expands around the tube part and blocks the trachea after the tube part is intubated into the trachea. The guide cuff ununiformly expands around the tube part and guides the tube part to be intubated into the trachea.