Patents Assigned to The Chancellor, Masters and Scholars of the University of Oxford
  • Patent number: 10927055
    Abstract: The invention provides a modified zeolite, a method of preparing the modified zeolite and a method of one cycle alkylating benzene in presence of one of an unmodified and modified zeolite catalyst. The modified zeolite catalyst includes zeolite with ratio of silica to alumina ranging between 5% to 95% of silica and 95% to 5% alumina, kaolinite and a binder, wherein the zeolite is modified with one or more metal oxides of Lanthanide-series of the Periodic Table. The method of alkylating benzene is one cycle process in presence of a catalyst that includes charging benzene and ethylene gas feedstock to an alkylation zone. Heated benzene and the ethylene gas feedstock are contacted in a fixed bed reactor in the alkylation zone. The catalyst for alkylating benzene is added in a catalyst zone of the fixed bed reactor.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: February 23, 2021
    Assignees: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD, THE KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY
    Inventors: Mohammad C. Al-Kinany, Hamid A Almegren, Saud A Aldrees, Eyad Al-Ghilan, Sami Al-Dress, Abdullah Al-Ghamdi, Peter P Edwards, Tiancun Xiao
  • Publication number: 20210023208
    Abstract: Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.
    Type: Application
    Filed: October 6, 2020
    Publication date: January 28, 2021
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Servic, The Chancellor, Masters and Scholars of the University of Oxford
    Inventors: Robert Seder, Geoffrey Lynn, Leonard Seymour
  • Patent number: 10799580
    Abstract: Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: October 13, 2020
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Chancellor, Masters and Scholars of the University of Oxford
    Inventors: Robert Seder, Geoffrey Lynn, Leonard Seymour
  • Patent number: 10519219
    Abstract: The present invention provides antibodies, for use in the treatment, suppression prevention of Filovirus disease, particularly Ebola virus disease. Also provided immunogens for use in eliciting such antibodies.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: December 31, 2019
    Assignees: The Secretary of State for Health, MicroPharm Limited, The Chancellor, Masters and Scholars of the University of Oxford
    Inventors: Miles Carroll, Stuart Dowall, Roger Hewson, Ian Cameron, John Landon, Antra Zeltina, David Stuart, Thomas Bowden
  • Patent number: 10436878
    Abstract: A method of localizing portable apparatus (200) obtains: a stored experience data set comprising a set of connected nodes; captured location representation data provided by at least one sensor associated with the portable apparatus, and a current pose estimate of the portable apparatus within the environment. The pose estimate is used to select a candidate set of the nodes that contain a potential match for the captured location representation data. The pose estimate is used to obtain a set of paths from path memory data, each said path comprising a set of said nodes previously traversed in the environment under similar environmental/visual conditions. The set of paths is used to refine the candidate set. The captured location representation data and the refined candidate set of nodes is compared in order to identify a current pose of the portable apparatus within the environment.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: October 8, 2019
    Assignee: The Chancellor Masters and Scholars of The University of Oxford
    Inventors: Winston Samuel Churchill, Paul Michael Newman, Christopher James Linegar
  • Patent number: 10325381
    Abstract: A method of localizing portable apparatus (100) in an environment, the method comprising obtaining captured image data representing an image captured by an imaging device (106) associated with the portable apparatus, and obtaining mesh data representing a 3-dimensional textured mesh of at least part of the environment. The mesh data is processed to generate a plurality of synthetic images, each synthetic image being associated with a pose within the environment and being a simulation of an image that would be captured by the imaging device from that associated pose. The plurality of synthetic images is analyzed to find a said synthetic image similar to the captured image data, and an indication is provided of a pose of the portable apparatus within the environment based on the associated pose of the similar synthetic image.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: June 18, 2019
    Assignee: The Chancellor Masters and Scholars of The University of Oxford
    Inventors: William Paul Maddern, Alexander Douglas Stewart, Paul Michael Newman, Geoffrey Michael Pascoe
  • Publication number: 20180342080
    Abstract: A method of localising portable apparatus (100) in an environment, the method comprising obtaining captured image data representing an image captured by an imaging device (106) associated with the portable apparatus, and obtaining mesh data representing a 3-dimensional textured mesh of at least part of the environment. The mesh data is processed to generate a plurality of synthetic images, each synthetic image being associated with a pose within the environment and being a simulation of an image that would be captured by the imaging device from that associated pose. The plurality of synthetic images is analysed to find a said synthetic image similar to the captured image data, and an indication is provided of a pose of the portable apparatus within the environment based on the associated pose of the similar synthetic image.
    Type: Application
    Filed: July 17, 2015
    Publication date: November 29, 2018
    Applicant: The Chancellor Masters and Scholars of the University of Oxford
    Inventors: WILLIAM PAUL MADDERN, ALEXANDER DOUGLAS STEWART, PAUL MICHAEL NEWMAN, GEOFFREY MICHAEL PASCOE
  • Publication number: 20180280497
    Abstract: Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.
    Type: Application
    Filed: September 9, 2016
    Publication date: October 4, 2018
    Applicants: The Chancellor, Masters and Scholars of the University of Oxford
    Inventors: Robert SEDER, Geoffrey LYNN, Leonard SEYMOUR
  • Patent number: 10070101
    Abstract: Method and apparatus for localizing transportable apparatus (100) within an environment (120) includes obtaining (202) point cloud data (114) representing a 3D point cloud with appearance information of at least part of the environment. The method further obtains (204) first frame data (110) representing an image produced by a sensor (102) onboard transportable apparatus at a first time and location within the environment and second frame data (110) representing an image produced by the sensor at a second time and location within the environment. The method harmonizes (206) information about the first frame data, the second frame data and an overlapping subset of the point cloud data in order to determine a location within the point cloud data where at least one of the first frame and the second frame was produced, thereby localizing (208) the transportable apparatus within the environment.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: September 4, 2018
    Assignee: The Chancellor Masters and Scholars of The University of Oxford
    Inventors: Paul Michael Newman, Alexander Douglas Stewart
  • Publication number: 20180105580
    Abstract: The present invention provides antibodies, for use in the treatment, suppression prevention of Filovirus disease, particularly Ebola virus disease. Also provided immunogens for use in eliciting such antibodies.
    Type: Application
    Filed: February 10, 2016
    Publication date: April 19, 2018
    Applicants: The Secretary of State for Health, MicroPharm Limited, The Chancellor, Masters and Scholars of the University of Oxford
    Inventors: Miles Carroll, Stuart Dowall, Roger Hewson, Ian Cameron, John Landon, Antra Zeltina, David Stuart, Thomas Bowden
  • Patent number: 9943532
    Abstract: Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: April 17, 2018
    Assignees: Emergent Virology LLC, The Chancellor, Masters and Scholars of the University of Oxford
    Inventors: Urban Ramstedt, Brennan Klose, Nicole Zitzmann, Raymond A. Dwek, Terry D. Butters
  • Patent number: 9875557
    Abstract: A method and system for determining extrinsic calibration parameters for at least one pair of sensing devices mounted on transportable apparatus obtains (202) image data (110) representing images captured by an image generating sensing device (102) of the pair at a series of poses during motion through an environment (120) by transportable apparatus (100). The method obtains (202) data (112) representing a 3D point cloud based on data produced by a 2D LIDAR sensing device (104) of the pair. The method selects (204) an image captured by the image at a particular pose. The method generates (210) a laser reflectance image based on a portion of the point cloud corresponding to the pose. The method computes (212) a metric measuring alignment between the selected image and the corresponding laser reflectance image and uses (214) the metric to determine extrinsic calibration parameters for at least one of the sensing devices.
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: January 23, 2018
    Assignee: The Chancellor Masters and Scholars of the University of Oxford
    Inventors: Ashley Alan Napier, Paul Michael Newman
  • Publication number: 20170304333
    Abstract: Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.
    Type: Application
    Filed: January 5, 2017
    Publication date: October 26, 2017
    Applicants: Emergent Virology LLC, THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
    Inventors: Urban RAMSTEDT, Brennan KLOSE, Nicole Zitzmann, Raymond A. Dwek, Terry D. Butters
  • Patent number: 9744188
    Abstract: Disclosed herein are methods of inducing neuronal outgrowth of a neuron. The methods comprise contacting the neuron with an agent that binds receptor protein tyrosine phosphatase ? (RPTP?), to thereby induce neuronal outgrowth of the neuron. The agent may induces clustering of RPTP? and/or inhibit binding of chondroitin sulfate proteoglycan (CSPG) to RPTP?. Examples of suitable agents are heparan sulfate proteoglycan, heparan sulfate, heparan sulfate oligosaccharides, or heparin oligosaccharides. Additional agents are also disclosed. The neuron can be a CNS neuron or peripheral neuron. Also disclosed herein are methods of treating neuronal injury in a subject comprising, administering to the subject an agent that binds RPTP?. Administration may be to a site of neuronal injury, to thereby induce neuronal outgrowth at the site of neuronal injury.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: August 29, 2017
    Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
    Inventors: John G. Flanagan, Yingjie Shen, Edith Yvonne Jones, Alexandru Radu Aricescu, Charlotte Hannah Coles
  • Patent number: 9689687
    Abstract: Navigation data is generated by receiving (502) a new experience data set (321) relating to a new experience capture. At least one stored experience data set (320) relating to at least one previous experience capture is also received (504). An experience data set includes a set of nodes, with each node comprising a series of visual image frames taken over a series of time frames. A candidate set of said nodes is obtained (506) from the stored experience data set that potentially matches a said node in the new experience data set, and then a check (508) if performed to see if a node in the candidate set matches the node in the new experience data set. If the result of the checking is positive then data relating to the matched nodes is added (510) to a place data set useable for navigation, the place data set indicating that said nodes in different said experience data sets relate to a same place.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: June 27, 2017
    Assignee: The Chancellor Masters and Scholars of The University of Oxford
    Inventors: Paul Michael Newman, Winston Samuel Churchill
  • Patent number: 9428541
    Abstract: The present invention provides a compound which is an inhibitor of sphingolipid biosynthesis for use in the treatment of a disease which has a secondary Niemann-Pick type C disease like cellular phenotype.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: August 30, 2016
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Chancellor, Masters, and Scholars of the University of Oxford
    Inventors: Frances Mary Platt, Emyr Lloyd-Evans, Forbes Dennison Porter
  • Publication number: 20160159822
    Abstract: A supramolecular metal-organic framework material is a reaction product of a copper compound, a trialkylamine represented by Chemical Formula 1, and benzene substituted with 3 or more carboxyl groups.
    Type: Application
    Filed: December 8, 2015
    Publication date: June 9, 2016
    Applicant: THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
    Inventors: Jin-Chong TAN, Abhijeet K. CHAUDHARI
  • Patent number: 9297899
    Abstract: A method of determining extrinsic calibration parameters for at least one sensor (102, 104, 106) mounted on transportable apparatus (100). The method includes receiving (202) data representing pose history of the transportable apparatus and receiving (202) sensor data from at least one sensor mounted on transportable apparatus. The method generates (204) at least one point cloud data using the sensor data received from the at least one sensor, each point in a said point cloud having a point covariance derived from the pose history data. The method then maximizes (206) a value of a quality function for the at least one point cloud, and uses (208) the maximized quality function to determine extrinsic calibration parameters for the at least one sensor.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: March 29, 2016
    Assignee: The Chancellor Masters and Scholars of the University of Oxford
    Inventors: Paul Michael Newman, William Paul Maddern, Alastair Robin Harrison, Mark Christopher Sheehan
  • Publication number: 20160077109
    Abstract: The inventors have proposed a novel panel of human serum protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis. A 2D-PAGE based proteomics study was used to identify potential fibrosis biomarkers. Serum from patients with varying degrees of hepatic scarring induced by infection with the hepatitis C virus (HCV) was analysed. Several proteins associated with liver scarring and/or viral infection were identified. These proteins include the inter-?-trypsin inhibitor heavy chain H4 fragments, complement factor H-related protein 1, CD5L, Apo L1, and ?2GPI. Increased and decreased thiolester cleavage of a2M and Complement C3, respectively, was also detected. The concentrations of these novel biomarkers can be determined using an immunoassay where the concentrations would reflect the extent of fibrosis. A fibrosis scoring scale for each of the novel biomarkers is proposed.
    Type: Application
    Filed: April 20, 2015
    Publication date: March 17, 2016
    Applicant: The Chancellor, Masters and Scholars of The University of Oxford
    Inventors: Bevin Gangadharan, Nicole Zitzmann, Raymond A. Dwek
  • Patent number: 9222116
    Abstract: A microfluidic device and method for enzymatic processing of ultra-long macromolecules is accomplished using a microfluidic device a reaction chamber with a first manifold, a second manifold, and a plurality of reaction channels. Each reaction channel extends from the first manifold to the second manifold. First inlet and outlet channels fill the reaction channels via the manifolds with one or more macromolecule containers suspended in a first carrier fluid. The first inlet and outlet channels are configured such that a flow is guided through the reaction channels, and an enzymatic reagent is fed to the reaction chamber essentially without displacing the macromolecule containers trapped in the reaction channels. The second set of inlets and outlets are configured such that a flow established from the second inlet to the second outlet is guided through at least one of the manifolds and bypasses the reaction channels.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: December 29, 2015
    Assignees: DANMARKS TEKNISKE UNIVERSITAT—DTU, THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
    Inventors: Rodolphe Marie, Anders Kristensen, Kristian Hagsted Rasmussen, Kalim Ullah Mir