Patents Assigned to The Charles Stark Draper Laboratory, Inc.
  • Patent number: 11921238
    Abstract: A method of lidar imaging pulses a scene with laser pulse sequences from a laser light source. Reflected light from the scene is measured for each laser pulse to form a sequence of time resolved light signals. Adjoining time bins in the time resolved light signals are combined to form super time bins. A three dimensional image of the scene is created from distances determined based on maximum intensity super time bins. One or more objects are located within the image. For each object, the time resolved light signals are combined to form a single object time resolved light signal from which to determine distance to the object.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: March 5, 2024
    Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventors: Joseph Hollmann, Zachary R. Hoffman
  • Patent number: 11890620
    Abstract: Miniaturized DNA microarrays are described to be used in conjunction with microfluidic channels or microcentrifuge tubes and microcentrifuge filters to reduce sample size, incubation time and to increase overall binding efficiency.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: February 6, 2024
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Kirsty A. McFarland, Charles A. Lissandrello, Andrew P. Magyar, Erin Rosenberger
  • Publication number: 20240036031
    Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.
    Type: Application
    Filed: October 16, 2023
    Publication date: February 1, 2024
    Applicant: The Charles Stark Draper Laboratory, Inc.
    Inventors: Ashley Lynne Beckwith, Jeffrey Borenstein, Nathan Moore, Daniel Doty, Luis Velasquez-Garcia
  • Patent number: 11878300
    Abstract: A device, system and process involve conducting electroporation of microvesicles or exosomes or other target structures in a microfluidic arrangement at pressures that exceed atmospheric pressure. Single as well as multiple flow configurations can be employed. In some cases, the system and its operation are computer-controlled for partial or complete automation.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: January 23, 2024
    Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventors: Jonathan R. Coppeta, Timothy J. Biliouris, Daniel F. King, Vishal Tandon
  • Patent number: 11872702
    Abstract: Embodiments provide functionality to prevent collisions between robots and objects. An example embodiment detects a type and a location of an object based on a camera image of the object, where the image has a reference frame. Motion of the object is then predicted based on at least one of: the detected type of the object, the detected location of the object, and a model of object motion. To continue, a motion plan for the robot is generated that avoids having the robot collide with the object based on the predicted motion of the object and a transformation between the reference frame of the image and a reference frame of the robot. The robot can be controlled to move in accordance with the motion plan or a signal can be generated that controls the robot to operate in accordance with the motion plan.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: January 16, 2024
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: David M. S. Johnson, Syler Wagner, Steven Lines, Mitchell Hebert, Connor Lawson
  • Patent number: 11874379
    Abstract: A system and method of LIDAR imaging to overcome scattering effects pulses a scene with light pulse sequences from a light source. Reflected light from the scene is measured for each light pulse to form a sequence of time-resolved signals. Time-resolved contrast is calculated for each location in a scene. A three-dimensional map or image of the scene is created from the time-resolved contrasts. The three-dimensional map is then utilized to affect operation of a vehicle.
    Type: Grant
    Filed: October 25, 2022
    Date of Patent: January 16, 2024
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventor: Joseph Hollmann
  • Publication number: 20240002919
    Abstract: A removable cartridge to be used in a system for extracting and detecting nucleic acids from heterogeneous samples includes a plurality of reservoirs defining at least a first wash buffer reservoir for holding a first wash buffer and a microfluidic assembly configured to attach to the plurality of reservoirs. The microfluidic assembly includes at least one sample reservoir and a nucleic acid extraction matrix in fluid communication to an automated sample preparation (ASP) reservoir through a first flow channel defined by the microfluidic assembly. An assay chamber is in fluid communication with a third flow channel and with the waste reservoir through a fourth flow channel such that a labeled nucleic acid-containing sample flows through the assay chamber and then to the waste reservoir, wherein vibration-driven mixing agitates fluids while present in the assay chamber. Finally, a nucleic acid-detecting microarray module is positioned in the assay chamber.
    Type: Application
    Filed: May 1, 2023
    Publication date: January 4, 2024
    Applicant: The Charles Stark Draper Laboratory, Inc.
    Inventors: Charles A. LISSANDRELLO, Aditi R. NAIK, Diana J. LEWIS, Erin ROSENBERGER, Joseph Neil URBAN, Jason FIERING, Caleb R. Bell, Cait Ni Chleirigh, Ernest Kim
  • Patent number: 11859162
    Abstract: Transfer of genetic and other materials to cells is conducted in a hands-free, automated, high throughput, continuous process. A system using a microfluidic hydrodynamic sheath flow configuration includes arrangements for pushing cells from side streams containing a cell culture medium to a central stream containing an electroporation buffer. Electroporation can be conducted in an assembly in which two or more microfluidic channels are provided in a parallel configuration and in which various layers can be stacked together to form a laminate type structure.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: January 2, 2024
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Vishal Tandon, Charles A. Lissandrello, Jenna L. Balestrini, Jonathan R. Coppeta, Patricia A. Swierk
  • Patent number: 11863086
    Abstract: An electrostatic motor includes a cylindrical rotor and a stator. Electrodes are disposed on an inside cylindrical surface of the stator. Electrets and/or electrically conductive electrodes are disposed on the cylindrical rotor and a dielectric fluid fills space between the rotor and the stator to prevent discharge of the electrets. A mask is used to charge portions of an electret cylinder or other curved surface.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: January 2, 2024
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Louis Beryl Kratchman, James A. Bickford
  • Patent number: 11852626
    Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: December 26, 2023
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Ashley Lynne Beckwith, Jeffrey Borenstein, Nathan Moore, Daniel Doty, Luis Velasquez-Garcia
  • Patent number: 11835513
    Abstract: A method for separating particles in a biofluid includes pretreating the biofluid by introducing an additive, flowing the pretreated biofluid through a microfluidic separation channel, and applying acoustic energy to the microfluidic separation channel. A system for microfluidic separation, capable of separating target particles from non-target particles in a biofluid includes at least one microfluidic separation channel, a source of biofluid, a source of additive, and at least one acoustic transducer coupled to the microfluidic separation channel. A kit for microfluidic particle separation includes a microfluidic separation channel connected to an acoustic transducer, a source of an additive, and instructions for use.
    Type: Grant
    Filed: February 9, 2021
    Date of Patent: December 5, 2023
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Jason O. Fiering, Kenneth T. Kotz
  • Publication number: 20230383286
    Abstract: The present disclosure provides methods of generating recombinant bacteriophage genomes. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a linear bacteriophage DNA genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.
    Type: Application
    Filed: November 14, 2022
    Publication date: November 30, 2023
    Applicant: The Charles Stark Draper Laboratory, Inc.
    Inventors: Connor McBrine, Jason Holder
  • Patent number: 11815668
    Abstract: A method of fabricating a visible spectrum optical component includes: providing a substrate; forming a resist layer over a surface of the substrate; patterning the resist layer to form a patterned resist layer defining openings exposing portions of the surface of the substrate; performing deposition to form a dielectric film over the patterned resist layer and over the exposed portions of the surface of the substrate, wherein a top surface of the dielectric film is above a top surface of the patterned resist layer; removing a top portion of the dielectric film to expose the top surface of the patterned resist layer and top surfaces of dielectric units within the openings of the patterned resist layer; and removing the patterned resist layer to retain the dielectric units over the substrate.
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: November 14, 2023
    Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventors: Robert C. Devlin, Mohammadreza Khorasaninejad, Federico Capasso, Hongkun Park, Alexander Arthur High
  • Patent number: 11802306
    Abstract: Methods of detecting unknown genetic modifications in a DNA sample from an organism are disclosed.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: October 31, 2023
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Kirsty A. McFarland, Andrew P. Magyar, Ting Pang, Michael Springer
  • Patent number: 11782714
    Abstract: A method comprises receiving a current instruction for metadata processing performed in a metadata processing domain that is isolated from a code execution domain including the current instruction. The method further comprises determining, by the metadata processing domain in connection with metadata for the current instruction, whether to allow execution of the current instruction in accordance with a set of one or more policies. The one or more policies may include a set of rules that enforces execution of a complete sequence of instructions in a specified order from a first instruction of the complete sequence to a last instruction of the complete sequence. The metadata processing may be implemented by a metadata processing hierarchy comprising a control module, a masking module, a hash module, a rule cache lookup module, and/or an output tag module.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: October 10, 2023
    Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventor: Andreā€² DeHon
  • Patent number: 11773133
    Abstract: Compositions and methods for optically-verified, sequence-controlled polymer synthesis are described.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: October 3, 2023
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Andrew P. Magyar, Melissa M. Sprachman
  • Patent number: 11771876
    Abstract: A system for the delivery of therapeutic substances to cavities of a patient. The system can include a handpiece tool coupled with a pump. The handpiece tool can include a shaft including a first portion of a channel coupled to a multi-input tubing. The handpiece tool can include an angled portion coupled with the shaft. The handpiece tool can include a second portion of the channel, wherein the angled portion positions a tip portion within a cavity, wherein the tip portion projects from the angled portion and includes an outlet and a third portion of the channel. The handpiece tool can include a collar a distance from the outlet, the collar configured to control a distance the tip portion projects. The handpiece tool can include a mixing chamber configured to receive the components of the drug and output the mixed drug via the third portion of the channel.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: October 3, 2023
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Marcello Peppi, Ernest Soonho Kim
  • Patent number: 11774602
    Abstract: A distributed navigation system includes navigation platforms, each having a universal navigation processor, relative navigation systems to provide source information to the navigation platforms, navigation filters provided on one or more of the universal navigation processors, and an anchor navigation node disposed on one or more of the navigation platforms to form one or more anchor navigation platforms. Each anchor navigation node includes an inertial navigation system, a clock, and absolute navigation systems, which are used, in combination with source information, to determine navigation information. The anchor navigation platforms provide the navigation information to other navigation platforms.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: October 3, 2023
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Juha-Pekka J. Laine, Benjamin F. Lane, William W. Whitacre, Robin Mark Adrian Dawson, Joseph M. Kinast, Cort Nolan Johnson, Gregory P. Blasche, Michael A. Aucoin, Jeffrey D. Jungemann, Peter A. Lewis, Stephen P. Smith
  • Patent number: 11762062
    Abstract: A LiDAR system emits single mode light from a photonic integrated circuit (PIC) and is capable of receiving a different mode light, or multiple modes of light, into the PIC. Objects in the LiDAR's field of view may reflect light with a mode different from the mode of the light that illuminated the objects. Thus, in some embodiments, a single-mode optical waveguide, a single-mode-multi-mode optical junction, a multi-mode optical waveguide and an array of optical emitters on the PIC are configured to emit into free space light of a single mode from each optical emitter of the array of optical emitters. The multi-mode optical waveguide and the array of optical emitters are configured to receive from the free space light of a mode different from the single mode, or multiple modes, and to couple the light of the different mode or multiple modes into the multi-mode optical waveguide.
    Type: Grant
    Filed: May 5, 2021
    Date of Patent: September 19, 2023
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Steven J. Byrnes, Michael G. Moebius, Steven J. Spector
  • Patent number: 11760967
    Abstract: This disclosure provides systems and methods for seeding cell cultures in a microfluidic device. The systems and methods of this disclosure can enable flow of a cell solution from one side of a scaffold, such as a porous substrate or membrane, to the other side of the scaffold. Flow of the liquid can pass through the scaffold while the cells themselves do not, resulting in the cells driven to the surface of the scaffold for consequent attachment. A microfluidic device can include a microfluidic feature structured to create a seal between a cell seeding tool and an inlet to a microchannel of the microfluidic device. This can enable a pressure-driven flow to push fluid down the channel and through pores of the membrane. In contrast, traditional gravity fed seeding of cells may not create enough pressure to drive fluid through the pores of the scaffold.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: September 19, 2023
    Assignee: Charles Stark Draper Laboratory, Inc.
    Inventors: Hesham Azizgolshani, Brian Cain, Joseph Charest, Jonathan Robert Coppeta, Brett Isenberg, Timothy Petrie