Patents Assigned to The Charles Stark Draper Laboratory, Inc.
  • Patent number: 10926254
    Abstract: The invention provides microfluidic devices, methods for imaging cells, and methods for preparing such microfluidic devices. The microfluidic devices are contemplated to provide advantages for use in imaging of cells and subcellular compartments in an environment that mimics in vivo conditions. The microfluidic devices can used with a microscope equipped with an oil emersion objective lens.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: February 23, 2021
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Jeffrey T. Borenstein, Joseph L. Charest, Joseph Cuiffi, Alla Epshteyn, Angela B. Holton, James Ching-Ming Hsiao
  • Patent number: 10913987
    Abstract: The system described herein for bacterial identification can be used as a point-of-care or lab-based diagnostic system. In some implementations, the system can be used to detect other foreign agents within blood or other samples. The system can include disposable microfluidic cartridges that are removable from the system. The microfluidic cartridges can receive a sample, such as a blood sample, that is suspected of containing bacterial cells and separate the bacterial cells from the blood sample. Once the bacterial cells are separated from the blood, the system can introduce the recombinant detector bacteriophages into the system that can infect the bacterial cells. The system can then detect the expression of reporter genes from the recombinant detector bacteriophages.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: February 9, 2021
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Jason W. Holder, Jason O. Fiering
  • Patent number: 10913925
    Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: February 9, 2021
    Assignees: The Charles Stark Draper Laboratory, Inc., The Massachusetts Institute of Technology
    Inventors: Joseph Cuiffi, Jeffrey T. Borenstein, Anilkumar Harapanahalli Achyuta, Mark J. Mescher, Linda Griffith, Samuel Walker Inman
  • Patent number: 10914723
    Abstract: A method for separating particles in a biofluid includes pretreating the biofluid by introducing an additive, flowing the pretreated biofluid through a microfluidic separation channel, and applying acoustic energy to the microfluidic separation channel. A system for microfluidic separation, capable of separating target particles from non-target particles in a biofluid includes at least one microfluidic separation channel, a source of biofluid, a source of additive, and at least one acoustic transducer coupled to the microfluidic separation channel. A kit for microfluidic particle separation includes a microfluidic separation channel connected to an acoustic transducer, a source of an additive, and instructions for use.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: February 9, 2021
    Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventors: Jason O. Fiering, Kenneth T. Kotz
  • Patent number: 10908372
    Abstract: Embodiments described herein improve the performance of active sensing systems, such as LiDAR systems, and enable detection of objects closer to the system's sensor. Illustrative embodiments enable spatial separation of the excitation and return signal on a photonic integrated chip (“PIC”) such that separate waveguides can be used for the excitation and return signals, enabling isolation of the system's detectors from the excitation source without the use of a splitter or circulator. For example, preferred embodiments avoid loss due to the use of splitters and the need for gating the detector, and are desirably compatible with chip-scale systems. Moreover, illustrative embodiments enable keeping the excitation and detection paths on the same PIC (e.g. in an interleaved configuration), which helps keep the system more compact and avoid issues introduced by parallax.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: February 2, 2021
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Michael G. Moebius, Steven J. Spector
  • Patent number: 10902165
    Abstract: In an embodiment, a method for testing a highly-automated driving (HAD) vehicle includes simulating a testing environment. The testing environment includes objects, terrain(s), roadways, or conditions. The method further converts the objects to either a converted hardware object signal having synthetic analog signals, or a converted software object signal having synthetic digital signals, the synthetic signals emulating the objects of the testing environment. The method further either directs the converted hardware object signals to sensor hardware of the HAD vehicle, causing sensor hardware to perceive the objects of the testing environment emulated by the converted hardware object signals, or directs the converted software object signals to a signal processing unit of the HAD vehicle.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: January 26, 2021
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventor: Justin Delva
  • Patent number: 10901190
    Abstract: A digital camera optically couples a monocentric lens to image sensor arrays, without optical fibers, yet shields the image sensor arrays from stray light. In some digital cameras, baffles are disposed between an outer surface of a monocentric lens and each image sensor array to shield the image sensor arrays from stray light. In other such digital cameras, an opaque mask defines a set of apertures, one aperture per image sensor array, to limit the amount of stray light. Some digital cameras include both masks and baffles.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: January 26, 2021
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Erik L. Waldron, Gregory P. Blasche, Paul Bohn, Robin Mark Adrian Dawson, Walter Foley, Samuel Harrison, Matthew T. Jamula, Juha-Pekka J. Laine, Benjamin F. Lane, Sean McClain, Francis J. Rogomentich, Stephen P. Smith, John James Boyle
  • Patent number: 10900025
    Abstract: The present disclosure provides compositions including recombinant B11 bacteriophages, methods for making the same, and uses thereof. The recombinant B11 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: January 26, 2021
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Connor McBrine, Georgiana Kourepenos, Parker Dow, Jason Holder
  • Patent number: 10898125
    Abstract: A method of predicting progression of a cognitive state in a subject is disclosed including obtaining a neuroimage of the subject, acquiring a data sample from the neuroimage, selecting a time at which to predict progression of the cognitive state, and performing a calculation on the data sample by a transformation function to determine data associated with multiple cognitive metrics. A method of evaluating a cognitive state of a subject is also disclosed including providing a convolutional neural network, training the convolutional neural network with reference data to construct a transformation function, using the transformation function to predict multiple cognitive metrics from a subject data sample and a selected time, and determining the cognitive state of the subject from the predicted cognitive metrics. A cognitive evaluation system is also disclosed including a memory, a processor, and a cognitive state prediction component configured to program the processor with a transformation function.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: January 26, 2021
    Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventors: Lev E. Givon, Laura Jane Mariano, Abraham Schneider, John Irvine
  • Patent number: 10876840
    Abstract: A passive ring interferometer sensor includes an electromagnetic ring path configured to receive a pair of electromagnetic waves from an electromagnetic radiation source and to direct the waves to be counter-propagating within the ring path toward respective ends of the path. A combination junction receives the waves from the respective ends and combines the waves to be co-propagating within a coupling path. Polarization elements are configured to set the waves to be mutually co-polarized within the electromagnetic ring path and to be mutually cross-polarized within the coupling path. A detector is configured to receive the mutually cross-polarized waves from the coupling path and to detect second-order coherence. Embodiments can sense rotation rate as fiber-optic gyroscopes or serve as other types of sensors such as gravitational wave sensors. Embodiments may have greatly increased unambiguous range and decreased sensitivity to any centroid wavelength shift.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: December 29, 2020
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventor: Gilbert D. Feke
  • Patent number: 10866877
    Abstract: A software instruction code repair system comprising an instruction code example pool. The example pool comprises a set of good instruction code examples and a set of bad instruction code examples. The software instruction code repair system further comprises a sequence-to-sequence (seq2seq) network that is configured to generate a corrected instruction code example, based on one example of the set of bad instruction code examples. The software instruction code repair system further comprises a discriminator configured to randomly select one of the corrected instruction code example and one instruction code example of the set of good instruction code examples to produce a selected instruction code example. The discriminator is further configured to make a determination that the selected instruction code example is most likely taken either the instruction code example pool or the seq2seq network.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: December 15, 2020
    Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventors: Jacob Harer, Tomo Lazovich, Rebecca Russell, Onur Ozdemir, Louis Kim
  • Patent number: 10859620
    Abstract: Aspects are generally directed to a compact and low-noise electric field detector, methods of operation, and methods of production thereof. In one example, an electric field detector includes a proof mass, a source of concentrated charge coupled to the proof mass, and a substrate having a substrate offset space defined therein, the proof mass being suspended above the substrate offset space. The electric field detector further includes a sense electrode disposed on the substrate within the substrate offset space and proximate the proof mass, the sense electrode being configured to measure a change in capacitance relative to the proof mass from movement of the proof mass in response to a received electric field at the source of concentrated charge. The electric field detector includes a control circuit coupled to the sense electrode and configured to determine a characteristic of the electric field based on the measured change in capacitance.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: December 8, 2020
    Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventors: James A. Bickford, Stephanie Lynne Golmon, Paul A. Ward, William D. Sawyer, Marc S. Weinberg, John J. LeBlanc, Louis Kratchman, James S. Pringle, Jr., Daniel Freeman, Amy Duwel, Max Lindsay Turnquist, Ronald Steven McNabb, Jr., William A. Lenk
  • Patent number: 10857427
    Abstract: A hard-point fixture placement system places a fixture that is pre-loaded with a curable adhesive by mechanically extruding the adhesive between the fixture and a target surface to which the fixture is to be attached. The placement system includes an irradiating device to cure the adhesive. The hard-point fixture stores the adhesive in a reservoir that is protected from the curing radiation. Once the curing process is complete, the fixture is released from the placement system leaving the fixture affixed to the target surface.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: December 8, 2020
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Daniel King, Isaac Ehrenberg, Alexander Sawyer, Graham Arrick, Juliette E. Mahaffey, William McFarland, David Carter
  • Patent number: 10845432
    Abstract: A system and method for calibrating rigid and non-rigid arrays of 3-axis magnetometers. Such arrays might be used to analyze structures containing ferromagnetic material. The calibration determines scale factor and bias parameters of each magnetometer in the array, and the relative orientation and position of each magnetometer in the array. Once the parameters are determined, the actual magnetic field value at the magnetometer location can be simply related to magnetometer measurements. The method and system can be used to calibrate an array of 3-axis magnetometers in aggregate as opposed to individual magnetometers. This is critical in large arrays to increasing reproducibility of the calibration procedure and decreasing time required to complete calibration procedure.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: November 24, 2020
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Michael Sorensen, Philip Babcock, Cort Johnson, Neil Sunil Patel
  • Patent number: 10838150
    Abstract: A coupling interface arrangement is described for a photonic integrated circuit (PIC) device. The PIC includes an interface coupling surface having optical grating elements arranged to form optical output locations that produce corresponding light output beams. A coupling lens couples the light output beams into a conjugate plane at a far-field scene characterized by one or more optical aberrations that degrade optical resolution of the light outputs. The optical grating elements are configured to correct for the one or more optical aberrations.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: November 17, 2020
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Michael G. Moebius, Steven J. Byrnes, Steven J. Spector, Francis J. Rogomentich, Matthew A. Sinclair
  • Patent number: 10838427
    Abstract: A vision-aided inertial navigation system determines navigation solutions for a traveling vehicle. A navigation solution module analyzes image sensor poses and estimated inertial navigation solutions to produce a time sequence of system navigation solution outputs that represent changing locations of the traveling vehicle. A loop closure detector performs a two-threshold image classification to classify an incoming navigation image as novel, loop-closing, or neither, and the navigation solution module resets the navigation solution output to represent a previous location when the loop closure detector classifies an incoming navigation image as loop-closing.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: November 17, 2020
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Richard W. Madison, Melanie K. Stich
  • Patent number: 10837755
    Abstract: A multi-beam optical phased array on a single planar waveguide layer or a small number of planar waveguide layers enables building an optical sensor that performs much like a significantly larger telescope. Imaging systems use planar waveguides created using micro-lithographic techniques. These imagers are variants of “phased arrays,” common and familiar from microwave radar applications. However, there are significant differences when these same concepts are applied to visible and infrared light.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: November 17, 2020
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Benjamin F. Lane, Steven J. Spector, Alan X. Zhou, Julian A. Brown, Michael G. Moebius
  • Patent number: 10835757
    Abstract: An optical neurostimulation and detection system and method are disclosed. The system includes a medical device including an implantable body, and a stimulation controller that connects to the medical lead device and provides a light source. One or more light emitter modules of the lead body couple light signals of the light source into modulated light signals, and the modulated light signals are emitted through the one or more light emitter modules to stimulate neural cells and/or neural tissue of a subject. In a preferred embodiment, the light emitter modules include a surface acoustic wave (SAW) transducer that couples the light source into the modulated light signals. Such a system provides emitted light incident upon the neural tissue of a much higher resolution than current systems and methods and can provide long-term implantation with fewer side effects and less tissue damage than current systems and methods.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: November 17, 2020
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Joseph J. Register, Carlos A. Segura, Gregg E. Favalora
  • Patent number: 10823913
    Abstract: MEMS-actuated optical switches can be implemented on photonic chips. These switches are compact, essentially planar, simple to implement and include only one moving MEMS component per switch. The switches exhibit low optical loss, require low power to operate, and are simple to control and easy to integrate with other optical devices. Each switch has two optical waveguides that are optically coupled in an ON switch state and not coupled in an OFF switch state. An end or a medial section of one of the two waveguides may translate between the ON and OFF states to affect the coupling. Alternatively, a coupling frustrator may translate between the ON and OFF states to affect the coupling.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: November 3, 2020
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Michael G. Moebius, Steven J. Spector, Eugene H. Cook, Jonathan J. Bernstein
  • Patent number: 10815535
    Abstract: The present disclosure provides methods and kits for generating recombinant bacteriophage genomes.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: October 27, 2020
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Jason Holder, Connor McBrine, Sarah Gruszka, Miles Rogers, Nicole Billings