Patents Assigned to The Children's Hospital of Philadelphia
  • Systems and Methods for Computing Measurements for Mitochondrial Diseases
    Publication number: 20240233950
    Abstract: This disclosure is directed to methods of methods of computing a composite measurement comprising employing two or more sub-instruments to measure one or more clinical symptoms of mitochondrial dysfunction or mitochondrial disease. This disclosure is also directed to methods of assessing and managing a subject with mitochondrial dysfunction or mitochondrial disease using a composite measurement.
    Type: Application
    Filed: January 19, 2024
    Publication date: July 11, 2024
    Applicants: RIBONOVA, INC., The Children's Hospital of Philadelphia
    Inventors: Marni J. Falk, Nigel L. Webb, Shana E. McCormack, Eric C. Yuen, Zarazuela Zolkipli-Cunningham, Anthony W. Ford-Hutchinson
  • Compositions and methods for the treatment of brain injury
    Patent number: 12029713
    Abstract: Compositions and methods are provided for the alleviation of pathology induced by traumatic brain injury.
    Type: Grant
    Filed: February 13, 2023
    Date of Patent: July 9, 2024
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventor: Akiva S. Cohen
  • CAPSAICIN AND TRPV1 MODULATOR COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20240216304
    Abstract: Provided herein are combinations of capsaicin and TrpV1 modulators that are useful for treating capsaicin-responsive diseases or disorders.
    Type: Application
    Filed: December 15, 2021
    Publication date: July 4, 2024
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Francesca Fieni, Michael Zemel
  • APPARATUS AND METHODS FOR INFANT AND MEDICAL DEVICE SUPPORT
    Publication number: 20240206644
    Abstract: The present disclosure relates to apparatus and methods for safely and securely holding an infant and medical equipment proximal to the infant. In particular embodiments, an apparatus may comprise an infant support device configured to support an infant proximal to a user. Exemplary embodiments may also comprise a medical equipment support device configured to support medical equipment proximal to the infant.
    Type: Application
    Filed: March 9, 2021
    Publication date: June 27, 2024
    Applicant: The Children's Hospital of Philadelphia
    Inventor: Amy G. Kelly
  • ADENO-ASSOCIATED VIRAL VECTORS FOR TRANSDUCTION OF COCHLEA
    Publication number: 20240197920
    Abstract: Provided herein are compositions and methods for delivering a molecular therapeutic to the cochlea of a subject. The methods comprise administering an adeno-associated virus (AAV) to the cerebrospinal fluid of the subject. The AAVs encode a therapeutic transgene for molecular therapy. Optionally, the therapeutic transgene may be operably linked to a cochlea-specific promoter.
    Type: Application
    Filed: April 27, 2022
    Publication date: June 20, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Beverly DAVIDSON, Paul RANUM
  • COMPOSITIONS AND METHODS USEFUL FOR THE TREATMENT OF H-ABC LEUKODYSTROPHY
    Publication number: 20240200065
    Abstract: Compositions and methods for the treatment of H-ABC leukodystrophy are disclosed.
    Type: Application
    Filed: April 18, 2022
    Publication date: June 20, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Adeline VANDERVER, Sunetra SASE, Akshata ALMAD
  • Compositions and methods for treatment of mitochondrial respiratory chain dysfunction and other mitochondrial disorders
    Patent number: 12011452
    Abstract: Compositions and methods for treatment of mitochondrial respiratory chain dysfunction and other mitochondrial disorders are provided. Also disclosed are a number of screening assays having utility for the identification of agents which modulate the phenotype associated with mitochondrial respiratory chain dysfunction.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: June 18, 2024
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Marni J. Falk, Eiko Nakamaru-Ogiso
  • NONSELECTIVE METABOTROPIC GLUTAMATE RECEPTOR ACTIVATORS FOR TREATMENT OF ANOREXIA NERVOSA AND BINGE EATING DISORDER
    Publication number: 20240189295
    Abstract: This application relates to methods of diagnosing and treating anorexia nervosa (AN) and binge eating disorder (BED) with a nonselective activator of metabotropic glutamate receptors (mGluRs).
    Type: Application
    Filed: February 20, 2024
    Publication date: June 13, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • ANTIMICROBIAL ELUTING AIRWAY DEVICES
    Publication number: 20240189490
    Abstract: The present disclosure provides improved airway intervention devices that are coated with a material and contain an antimicrobial peptide. The devices are useful in controlling the microbial flora of the airway and preventing infections and conditions such as subglottic stenosis, pneumonia (VAP), laryngeal infection, post-operative dressing/packing-induced infection, upper airway infection, rhinosinusitis, choanal atresia, vocal fold injury and paralysis.
    Type: Application
    Filed: April 8, 2022
    Publication date: June 13, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Riccardo L. GOTTARDI, Matthew R. ARONSON
  • COMPOSITIONS AND METHODS FOR TREATMENT OF MITOCHONDRIAL RESPIRATORY CHAIN DYSFUNCTION AND OTHER MITOCHONDRIAL DISORDERS
    Publication number: 20240180938
    Abstract: Compositions and methods for treatment of mitochondrial respiratory chain dysfunction and other mitochondrial disorders are provided. Also disclosed are a number of screening assays having utility for the identification of agents which modulate the phenotype associated with mitochondrial respiratory chain dysfunction.
    Type: Application
    Filed: November 17, 2023
    Publication date: June 6, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Marni J. Falk, Eiko Nakamaru-Ogiso
  • ENEMA ASSIST DEVICE
    Publication number: 20240157040
    Abstract: An enema assist device is provided. The device includes a support and the support is configured to be placed on a toilet bowl such that the support front is oriented towards the front of the toilet bowl. The support is configured to support a fluid delivery tip such that the fluid delivery tip is disposed on the top surface of the support and protrudes at least partially beyond a plane defined by a top of the toilet seat.
    Type: Application
    Filed: March 22, 2022
    Publication date: May 16, 2024
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Joy Kerr, Michelle Hsia, Jason Van Batavia
  • METHODS OF DIAGNOSING AND TREATING ADHD IN BIOMARKER POSITIVE SUBJECTS
    Publication number: 20240156801
    Abstract: This disclosure relates to the identification of a subset of mGluR network gene CNVs that are predictive of efficacy of treatment with fasoracetam, as well as the identification of an mGluR network gene CNV that is predictive of an increased likelihood of having ADHD as well as having certain symptoms associated with ADHD.
    Type: Application
    Filed: June 7, 2023
    Publication date: May 16, 2024
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Garry A. Neil, Liza Squires, Hakon Hakonarson
  • MODIFIED FACTOR IX, AND COMPOSITIONS, METHODS AND USES FOR GENE TRANSFER TO CELLS, ORGANS, AND TISSUES
    Publication number: 20240131126
    Abstract: The invention relates to modified Factor IX coding sequence, expression cassette, vectors such as viral (e.g., lenti- or adeno-associated viral) vectors, and gene transfer methods and uses. In particular, to target Factor IX nucleic acid to cells, tissues or organs for expression (transcription) of Factor IX.
    Type: Application
    Filed: December 19, 2023
    Publication date: April 25, 2024
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Katherine A. HIGH, Xavier ANGUELA
  • METHODS OF DIAGNOSING AND TREATING ANXIETY DISORDER
    Publication number: 20240100036
    Abstract: Methods and uses for diagnosing and treating anxiety disorders are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: October 30, 2023
    Publication date: March 28, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • GLYPICAN 2 AS A CANCER MARKER AND THERAPEUTIC TARGET
    Publication number: 20240084034
    Abstract: The present disclosure is directed to antibodies binding to Glypican 2 and methods of using such antibodies to treat cancers that express or overexpress the Glypican 2 antigen.
    Type: Application
    Filed: October 31, 2023
    Publication date: March 14, 2024
    Applicants: THE CHILDREN'S HOSPITAL OF PHILADELPHIA, THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY
    Inventors: John M. MARIS, Kristopher R. BOSSE, Dimiter DIMITROV, Zhongyu ZHU, Dontcho V. JELEV
  • BREATH BIOMARKERS OF SARS-COV-2 IN CHILDREN AND METHODS OF USE THEREOF FOR THE DIAGNOSIS AND TREATMENT OF COVID-19
    Publication number: 20240081675
    Abstract: Compositions and methods for the diagnosis and treatment of Covid 19 are disclosed.
    Type: Application
    Filed: November 1, 2021
    Publication date: March 14, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Audrey Ragan ODOM JOHN, Amalia Zoraida BERNA PEREZ, Elikplim AKAHO
  • METHODS AND COMPOSITIONS FOR TREATING HYPOGLYCEMIC DISORDERS
    Publication number: 20240082361
    Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analogue thereof.
    Type: Application
    Filed: February 14, 2023
    Publication date: March 14, 2024
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, The Children's Hospital of Philadelphia
    Inventors: Doris STOFFERS, Diva D. DE LEON, Charles STANLEY
  • METHODS OF DIAGNOSING AND TREATING CONDUCT DISORDER
    Publication number: 20240075022
    Abstract: Methods for diagnosing and treating conduct disorder are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: October 30, 2023
    Publication date: March 7, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • Modified factor IX, and compositions, methods and uses for gene transfer to cells, organs, and tissues
    Patent number: 11896652
    Abstract: The invention relates to modified Factor IX coding sequence, expression cassette, vectors such as viral (e.g., lenti- or adeno-associated viral) vectors, and gene transfer methods and uses. In particular, to target Factor IX nucleic acid to cells, tissues or organs for expression (transcription) of Factor IX.
    Type: Grant
    Filed: October 28, 2022
    Date of Patent: February 13, 2024
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Katherine A. High, Xavier Anguela
  • Compositions for differentiating latent autoimmune diabetes in adults from childhood-onset type 1 diabetes and methods for diagnosing and treating disease
    Patent number: 11891665
    Abstract: Compositions for the identification of patients at risk for the development of latent autoimmune diabetes, and methods of use thereof, for the diagnosis and treatment of the same.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: February 6, 2024
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Struan Frederick Grant, Rajashree Mishra