Patents Assigned to The Children's Hospital of Philadelphia
  • Publication number: 20240156801
    Abstract: This disclosure relates to the identification of a subset of mGluR network gene CNVs that are predictive of efficacy of treatment with fasoracetam, as well as the identification of an mGluR network gene CNV that is predictive of an increased likelihood of having ADHD as well as having certain symptoms associated with ADHD.
    Type: Application
    Filed: June 7, 2023
    Publication date: May 16, 2024
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Garry A. Neil, Liza Squires, Hakon Hakonarson
  • Publication number: 20240157040
    Abstract: An enema assist device is provided. The device includes a support and the support is configured to be placed on a toilet bowl such that the support front is oriented towards the front of the toilet bowl. The support is configured to support a fluid delivery tip such that the fluid delivery tip is disposed on the top surface of the support and protrudes at least partially beyond a plane defined by a top of the toilet seat.
    Type: Application
    Filed: March 22, 2022
    Publication date: May 16, 2024
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Joy Kerr, Michelle Hsia, Jason Van Batavia
  • Publication number: 20240131126
    Abstract: The invention relates to modified Factor IX coding sequence, expression cassette, vectors such as viral (e.g., lenti- or adeno-associated viral) vectors, and gene transfer methods and uses. In particular, to target Factor IX nucleic acid to cells, tissues or organs for expression (transcription) of Factor IX.
    Type: Application
    Filed: December 19, 2023
    Publication date: April 25, 2024
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Katherine A. HIGH, Xavier ANGUELA
  • Publication number: 20240100036
    Abstract: Methods and uses for diagnosing and treating anxiety disorders are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: October 30, 2023
    Publication date: March 28, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • Publication number: 20240082361
    Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analogue thereof.
    Type: Application
    Filed: February 14, 2023
    Publication date: March 14, 2024
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, The Children's Hospital of Philadelphia
    Inventors: Doris STOFFERS, Diva D. DE LEON, Charles STANLEY
  • Publication number: 20240084034
    Abstract: The present disclosure is directed to antibodies binding to Glypican 2 and methods of using such antibodies to treat cancers that express or overexpress the Glypican 2 antigen.
    Type: Application
    Filed: October 31, 2023
    Publication date: March 14, 2024
    Applicants: THE CHILDREN'S HOSPITAL OF PHILADELPHIA, THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY
    Inventors: John M. MARIS, Kristopher R. BOSSE, Dimiter DIMITROV, Zhongyu ZHU, Dontcho V. JELEV
  • Publication number: 20240081675
    Abstract: Compositions and methods for the diagnosis and treatment of Covid 19 are disclosed.
    Type: Application
    Filed: November 1, 2021
    Publication date: March 14, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Audrey Ragan ODOM JOHN, Amalia Zoraida BERNA PEREZ, Elikplim AKAHO
  • Publication number: 20240075022
    Abstract: Methods for diagnosing and treating conduct disorder are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: October 30, 2023
    Publication date: March 7, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • Patent number: 11896652
    Abstract: The invention relates to modified Factor IX coding sequence, expression cassette, vectors such as viral (e.g., lenti- or adeno-associated viral) vectors, and gene transfer methods and uses. In particular, to target Factor IX nucleic acid to cells, tissues or organs for expression (transcription) of Factor IX.
    Type: Grant
    Filed: October 28, 2022
    Date of Patent: February 13, 2024
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Katherine A. High, Xavier Anguela
  • Patent number: 11891665
    Abstract: Compositions for the identification of patients at risk for the development of latent autoimmune diabetes, and methods of use thereof, for the diagnosis and treatment of the same.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: February 6, 2024
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Struan Frederick Grant, Rajashree Mishra
  • Patent number: 11887621
    Abstract: A biometric sensor device system including a biometric sensor device, and a prediction computer. The biometric sensor device includes at least one camera, and a biometric sensor device processor configured to record a time synchronized communicative interaction between participants, by controlling at least one camera to record the participants over a time period, and transfer the recorded communicative interaction to the prediction computer. The prediction computer including a prediction computer processor configured to extract, from the recorded communicative interaction, a physical characteristic of each of the participants over the time period, compare the physical characteristic of at least one of the participants with the physical characteristic of at least another one of the participants over the time period, and classify or score at least one of the participants according to a predetermined classification or dimensional scoring scheme based on the comparison.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: January 30, 2024
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Robert Schultz, G. Keith Bartley, Evangelos Sariyanidi, Julia Parish-Morris
  • Patent number: 11878056
    Abstract: Methods for preparing highly purified AAV vector formulations are provided. The highly pure AAV formulations described herein are superior for clinical use.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: January 23, 2024
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: John Fraser Wright, Guang Qu, Bernd Hauck, Katherine A. High
  • Publication number: 20240018471
    Abstract: Provided herein are engineered red blood cells expressing rare blood antigen group profiles, and methods of making use the same, are described. Also provided are recombinant reagent red blood cells that express or lack the expression of at least one protein (e.g., a blood group antigen) on its surface and uses thereof.
    Type: Application
    Filed: June 6, 2023
    Publication date: January 18, 2024
    Applicants: THE CHILDREN'S HOSPITAL OF PHILADELPHIA, NEW YORK BLOOD CENTER, INC.
    Inventors: Stella CHOU, Connie WESTHOFF
  • Publication number: 20230414766
    Abstract: Provided are macromolecular prodrugs in which camptothecin analogs are covalently bonded to polymers via ester bonds that are labile under physiological conditions. Also provided are methods of treating cancer, especially neuroblastoma with the macromolecular prodrugs.
    Type: Application
    Filed: April 27, 2023
    Publication date: December 28, 2023
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Michael Chorny, Ivan Alferiev, Garrett M. Brodeur
  • Publication number: 20230407399
    Abstract: Compositions and methods for the detection and treatment of ADHD are provided.
    Type: Application
    Filed: March 7, 2023
    Publication date: December 21, 2023
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Joseph Glessner, Josephine Elia, Hakon Hakonarson
  • Patent number: 11833256
    Abstract: The invention relates to compositions and methods as part of a pharmacotherapeutic strategy that targets the endochondral ossification process in a pharmacologically selective and site-specific manner. A variety of orthopedic pathologies are caused by or associated with generalized or local dysregulation of endochondral ossification, for example trauma to the bone growth plate or diaphysis can cause a serious imbalance in bone growth, leading to progressive deformity that today can only be treated surgically. Dysregulated endochondral ossification is also behind heterotopic ossification, which arises in soft tissues and causes pain, decrease in mobility and other clinical problems. The invention therefore provides RARy agonist and antagonist nanoparticle compositions for treating abnormal endochondral ossification and bone growth that can deliver robust local therapeutic control over a particular long bone's growth with a long-lasting effect.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: December 5, 2023
    Assignees: University of Maryland, Baltimore, The Children's Hospital of Philadelphia
    Inventors: Masahiro Iwamoto, Michael Chorny
  • Patent number: 11814440
    Abstract: The present disclosure is directed to antibodies binding to Glypican 2 and methods of using such antibodies to treat cancers that express or overexpress the Glypican 2 antigen.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: November 14, 2023
    Assignees: The Children's Hospital of Philadelphia, The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: John M. Maris, Kristopher R. Bosse, Dimiter Dimitrov, Zhongyu Zhu, Dontcho V. Jelev
  • Publication number: 20230357849
    Abstract: Compositions and methods for the treatment and diagnosis of eosinophilic esophagitis are disclosed.
    Type: Application
    Filed: September 8, 2021
    Publication date: November 9, 2023
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Patrick Sleiman, Xiao Chang
  • Patent number: 11806341
    Abstract: Methods and uses for diagnosing and treating anxiety disorders are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Grant
    Filed: October 28, 2021
    Date of Patent: November 7, 2023
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charily Kao
  • Patent number: 11806340
    Abstract: Methods for diagnosing and treating conduct disorder are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: November 7, 2023
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao