Patents Assigned to The Children's Hospital of Philadelphia
  • MODIFIED FACTOR IX, AND COMPOSITIONS, METHODS AND USES FOR GENE TRANSFER TO CELLS, ORGANS, AND TISSUES
    Publication number: 20230142320
    Abstract: The invention relates to modified Factor IX coding sequence, expression cassette, vectors such as viral (e.g., lenti- or adeno-associated viral) vectors, and gene transfer methods and uses. In particular, to target Factor IX nucleic acid to cells, tissues or organs for expression (transcription) of Factor IX.
    Type: Application
    Filed: October 28, 2022
    Publication date: May 11, 2023
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Katherine A. HIGH, Xavier ANGUELA
  • Polymer-based macromolecular prodrugs
    Patent number: 11642414
    Abstract: Provided are macromolecular prodrugs in which camptothecin analogs are covalently bonded to polymers via ester bonds that are labile under physiological conditions. Also provided are methods of treating cancer, especially neuroblastoma with the macromolecular prodrugs.
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: May 9, 2023
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Michael Chorny, Ivan Alferiev, Garrett M. Brodeur
  • Cleavable esters for nanocarrier-based cancer therapy
    Patent number: 11633485
    Abstract: A co-drug according to Formula (I) or Formula (II) is provided, R—X—NH—CO—CO—OR1??(I) R—X—CO—O—CH2—CO—OR1??(II) wherein R is a tocol moiety, a tocol analog moiety, or a capsaicinoid moiety; X is a direct bond or a linking group; and OR1 is the residue of an anticancer or antirestenotic agent bearing at least one hydroxyl group by which the CO—OR1 ester linkage is formed. Nanoparticles that include the abovementioned co-drug are also provided, as well as a method of treating a cancer patient that includes administering an effective amount of the co-drug or nanoparticles.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: April 25, 2023
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Ivan Alferiev, Michael Chorny, Garrett M. Brodeur
  • FASORACETAM CRYSTALLINE FORMS
    Publication number: 20230088814
    Abstract: The disclosure is directed to crystalline forms and mixtures thereof of R-fasoracetam. Such crystalline forms include Form II monohydrate R-fasoracetam and the anhydrate form of R-fasoracetam. The disclosure further includes mixtures of the anhydrate form of R-fasoracetam together with one or more of Form I monohydrate R-fasoracetam and Form II monohydrate R-fasoracetam.
    Type: Application
    Filed: November 30, 2022
    Publication date: March 23, 2023
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Tom Leyssens, Bram Harmsen
  • Solid forms of fasoracetam
    Patent number: 11608324
    Abstract: The disclosure is directed to cocrystals of fasoracetam, including R-fasoracetam, and various coformers. Crystalline materials comprising fasoracetam, including R-fasoracetam, are also provided. The disclosure further includes pharmaceutical compositions and methods of treatment of the cocrystals and crystalline materials of the disclosure.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: March 21, 2023
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Tom Leyssens, Richard Alan Couch, Michael Paul Rene Guillot, Bram Harmsen, Thomas R. Bailey, Martin Appelmans
  • Association of genetic variations to diagnose and treat attention-deficit hyperactivity disorder (ADHD)
    Patent number: 11591656
    Abstract: Compositions and methods for the detection and treatment of ADHD are provided.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: February 28, 2023
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Berta Almoguera, Lyam Vazquez, Patrick Sleiman
  • NOVEL DRUGGABLE TARGETS FOR THE TREATMENT OF INFLAMMATORY DISEASES SUCH AS SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) AND METHODS FOR DIAGNOSIS AND TREATMENT USING THE SAME
    Publication number: 20230054595
    Abstract: Compositions and methods for the management and treatment of inflammatory disorders including SLE are disclosed.
    Type: Application
    Filed: December 18, 2020
    Publication date: February 23, 2023
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Struan Grant, Andrew Wells, Chun Su
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF LYMPHATIC SYSTEM DISORDERS
    Publication number: 20230048706
    Abstract: Compositions and methods for the diagnosis and treatment of lymphatic anomaly are disclosed.
    Type: Application
    Filed: July 28, 2022
    Publication date: February 16, 2023
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Dong Li, Lifeng Tian, Kenny Nguyen, Patrick Sleiman
  • Compositions and methods for the treatment of brain injury
    Patent number: 11576885
    Abstract: Compositions and methods are provided for the alleviation of pathology induced by traumatic brain injury.
    Type: Grant
    Filed: October 6, 2020
    Date of Patent: February 14, 2023
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventor: Akiva S. Cohen
  • Automatic detection of airway device, endotracheal intubation, and tube misplacement in children during the anesthesia procedure
    Patent number: 11577037
    Abstract: Algorithms for detecting endotracheal intubation and/or misplacement of endotracheal tubes in child patients during anesthesia for use with anesthesia machines, mechanical ventilators, and/or respiratory function monitors. An algorithm uses end-tidal carbon dioxide (EtCO2), and tidal volume (TV) or peak inspiratory pressure (PIP) to detect exact intubation time. Another algorithm uses respiratory parameters to identify and/or confirm the type of airway device used during mechanical ventilation, and to detect if and when an issue has arisen with use of a specific airway device to provide real-time decision support to attending medical care professionals.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: February 14, 2023
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Mohamed Rehman, Ali Jalali
  • OLEIC ACID DERIVATIVES AS TREATMENTS FOR FRIEDREICH ATAXIA AND INHIBITORS OF FERROPTOSIS
    Publication number: 20230023267
    Abstract: The invention relates to compounds of Formula I or Formula II: to compositions comprising such compounds, and to methods of use thereof for treating neurodegenerative disorders, such as Friedreich ataxia.
    Type: Application
    Filed: November 12, 2020
    Publication date: January 26, 2023
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, The Children's Hospital of Philadelphia
    Inventors: Amos SMITH, Robert B. WILSON, Donna M Huryn, Maria Grazia Cotticelli, Shujuan XIA, Taehee LEE, Roberto FORESTIERI
  • Compositions and methods for detection and modulation of T cell mediated immune responses against viral vectors utilized for gene therapy
    Patent number: 11559589
    Abstract: Compositions and methods are provided for inhibiting T cell mediated destruction of virally transduced, trangene containing cells.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: January 24, 2023
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Katherine A. High, Marcela V. Maus, Federico Mingozzi, Daniel J. Hui
  • Fasoracetam crystalline forms
    Patent number: 11535604
    Abstract: The disclosure is directed to crystalline forms and mixtures thereof of R-fasoracetam. Such crystalline forms include Form II monohydrate R-fasoracetam and the anhydrate form of R-fasoracetam. The disclosure further includes mixtures of the anhydrate form of R-fasoracetam together with one or more of Form I monohydrate R-fasoracetam and Form II monohydrate R-fasoracetam.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: December 27, 2022
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Tom Leyssens, Bram Harmsen
  • SYSTEMS AND METHODS FOR EARLY DETECTION AND MANAGEMENT OF CLINICAL CRITICAL EVENTS
    Publication number: 20220406421
    Abstract: The present disclosure relates to systems and methods for early detection and management of clinical critical events.
    Type: Application
    Filed: November 13, 2020
    Publication date: December 22, 2022
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Victor M. RUIZ, Lingyun SHI, Fan MI, Fuchiang TSUI
  • TEMPERATURE MONITORING AND INDICATOR SYSTEM FOR A CAST SAW
    Publication number: 20220402049
    Abstract: A power tool, such as a cast saw is disclosed. The cast saw is equipped with at least one thermocouple and and/or at least one infrared detector that measure the temperature of the cutting blade on the cast saw or the area in the cast immediately surrounding the cutting blade. The cast saw is also equipped with at least one LED that can alert a user of the cast saw when blade or the area in the cast immediately surrounding the blade is approaching or has reached a temperature that may burn a patient. Also disclosed is a shroud for the cutting blade of the cast saw. The shroud not only surrounds at least part of the blade but also houses the thermocouple or infrared detector and the LEDs(s). A method of operating the cast saw to cut a cast off of a patient is also disclosed.
    Type: Application
    Filed: September 25, 2020
    Publication date: December 22, 2022
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Bernard David HORN, John Todd Rutter LAWRENCE
  • DEVICES AND METHODS FOR GUIDEWIRE MANAGEMENT
    Publication number: 20220362525
    Abstract: Devices and methods for management of a guidewire during catheter insertion. Particular embodiments include unidirectional valves to allow movement of a guidewire in one direction only.
    Type: Application
    Filed: July 9, 2020
    Publication date: November 17, 2022
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventor: Mark WEBER
  • Compositions and methods for treating fragile X syndrome and related syndromes
    Patent number: 11497816
    Abstract: Compositions and methods are provided for the inhibition, treatment and/or prevention of fragile X syndrome and related disorders.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: November 15, 2022
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Beverly L. Davidson, Carolyn M. Yrigollen, Alejandro Monteys, Bryan Simpson
  • CXR4 as a susceptibility locus in juvenile idiopathic arthritis (JIA) and methods of use thereof for the treatment and diagnosis of the same
    Patent number: 11499194
    Abstract: Compositions and methods useful for the diagnosis and treatment of juvenile idiopathic arthritis are disclosed.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: November 15, 2022
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Terri H. Finkel, Haitao Zhang, Hakon Hakonarson
  • Modified factor IX, and compositions, methods and uses for gene transfer to cells, organs, and tissues
    Patent number: 11491213
    Abstract: The invention relates to modified Factor IX coding sequence, expression cassette, vectors such as viral (e.g., lenti- or adeno-associated viral) vectors, and gene transfer methods and uses. In particular, to target Factor IX nucleic acid to cells, tissues or organs for expression (transcription) of Factor IX.
    Type: Grant
    Filed: July 12, 2021
    Date of Patent: November 8, 2022
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Katherine A. High, Xavier Anguela
  • NOVEL GENETIC MARKERS FOR POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (POTS) AND METHODS OF USE THEREOF FOR DIAGNOSIS AND TREATMENT OF THE SAME
    Publication number: 20220349008
    Abstract: Compositions and methods for the diagnosis and treatment of POTS are disclosed. In one aspect, a method for identifying a human subject having a predisposition for, or having, postural orthostatic tachycardia syndrome (POTS) is provided. An exemplary embodiment comprises obtaining a nucleic acid sample from said subject; detecting a nucleic acid having one or more single nucleotide polymorphisms (SNPs) in the locus encoding PPP1R12B selected from rs12741415 and/or GSA-rs116062217, or a SNP in linkage disequilibrium with one or more of the SNPs, by contacting the nucleic acid sample with a probe or primer of sufficient length and composition to detect the SNP; and identifying the subject as having a predisposition for POTS if one or more SNPs are identified.
    Type: Application
    Filed: September 9, 2020
    Publication date: November 3, 2022
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Huiqi Qu