Patents Assigned to The Childrens Hospital, Inc.
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Patent number: 9533033Abstract: The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.Type: GrantFiled: March 7, 2016Date of Patent: January 3, 2017Assignee: NATIONWIDE CHILDREN'S HOSPITAL, INC.Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr.
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Patent number: 9469851Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.Type: GrantFiled: July 24, 2012Date of Patent: October 18, 2016Assignee: NATIONWIDE CHILDREN'S HOSPITAL, INC.Inventors: Scott Quenton Harper, Jian Liu, Sara Garwick Coppens, Lindsay Wallace
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Patent number: 9434928Abstract: The present invention relates to recombinant adeno-associated virus (rAAV) delivery of an alpha-sarcoglycan gene. The invention provides rAAV products and methods of using the rAAV in the treatment of limb girdle muscular dystrophies such as LGMD2D.Type: GrantFiled: November 21, 2012Date of Patent: September 6, 2016Assignee: NATIONWIDE CHILDREN'S HOSPITAL, INC.Inventors: Jerry R. Mendell, Louis Chicoine, Louise Rodino-Klapac, Kelly Reed Clark, Thomas J. Preston
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Patent number: 9309294Abstract: The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.Type: GrantFiled: January 9, 2015Date of Patent: April 12, 2016Assignee: NATIONWIDE CHILDREN'S HOSPITAL, INC.Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr.
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Patent number: 9133482Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the myotilin gene. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of myotilin. The methods have application in the treatment of muscular dystrophies such as Limb Girdle Muscular Dystrophy Type 1A.Type: GrantFiled: October 21, 2013Date of Patent: September 15, 2015Assignee: NATIONWIDE CHILDREN'S HOSPITAL, INC.Inventors: Scott Quenton Harper, Jian Liu
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Patent number: 9108213Abstract: A fluid container spray device having a trigger lock mechanism with trigger tabs extending outwardly from the trigger and cleats extending inwardly from a moveable shroud. The cleats obstruct the tabs when the shroud is in a trigger lock position. A lever extending from beneath the shroud can be depressed, thereby moving the shroud from the trigger lock position to a trigger release position. The movement of the shroud to the trigger release position moves the connected cleats from their obstructive position to a position out of the trigger tabs' path of movement, thereby permitting use of the trigger to pump fluid from the container. The shroud is biased toward the trigger lock position. Thus, release of the container by the user restores the locked configuration, thereby preventing use by children.Type: GrantFiled: June 13, 2014Date of Patent: August 18, 2015Assignees: Nationwide Children's Hospital, Inc., The Ohio State UniversityInventors: Carolina Gill, Blaine Lilly, Thornton K. Lothrop, Scott Shim, Lara B. McKenzie, Kristin J. Roberts, Nicolas G. Nelson
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Patent number: 9060977Abstract: The invention is related to methods of protecting, preventing and reducing intestinal injury in a human subject suffering from or at risk for shock, hemorrhagic shock or hemorrhagic shock and resuscitation (HS/R) comprising administering heparin binding epidermal growth factor (HB-EGF). The invention is also related to methods of inhibiting deterioration of intestinal blood flow and methods of preserving and increasing intestinal blood flow by administering HB-EGF to a human subject. In addition, the methods of the invention should improve the clinical outcome of human subject suffering from or at risk for shock, hemorrhagic shock or hemorrhagic shock and resuscitation.Type: GrantFiled: January 9, 2012Date of Patent: June 23, 2015Assignee: NATIONWIDE CHILDREN'S HOSPITAL, INC.Inventors: Gail E. Besner, Osama N. El-Assal
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Publication number: 20150044170Abstract: The present invention relates generally to the use of recombinant adeno-associated viruses (rAAV) for gene delivery and more specifically to the use of rAAV to deliver genes encoding human immunodeficiency virus entry inhibitors to target cells in mammals.Type: ApplicationFiled: April 9, 2014Publication date: February 12, 2015Applicant: NATIONWIDE CHILDREN'S HOSPITAL, INC.Inventors: Philip R. Johnson, JR., Kelly Reed Clark
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Publication number: 20150038443Abstract: The present invention provides small molecules useful to affect cancer cells, along with related methods. The present compounds, formulations, kits and methods are useful for a variety of research, diagnostic and therapeutic purposes. STAT3 inhibitors, particularly LLL12, are disclosed. The STAT3 inhibitors are useful to treat breast cancer in general and breast cancer initiating cells in particular.Type: ApplicationFiled: October 16, 2014Publication date: February 5, 2015Applicants: NATIONWIDE CHILDREN'S HOSPITAL, INC., THE OHIO STATE UNIVERSITYInventors: Pui-Kai Li, Chenglong Li, Jiayuh Lin
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Patent number: 8883749Abstract: The present invention provides small molecules useful to affect cancer cells, along with related methods. The present compounds, formulations, kits and methods are useful for a variety of research, diagnostic and therapeutic purposes. STAT3 inhibitors, particularly LLL12, are disclosed. The STAT3 inhibitors are useful to treat breast cancer in general and breast cancer initiating cells in particular.Type: GrantFiled: November 24, 2010Date of Patent: November 11, 2014Assignees: The Ohio State University, Nationwide Children's Hospital, Inc.Inventors: Pui-Kai Li, Chenglong Li, Jiayuh Lin
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Patent number: 8882718Abstract: The present invention is a protective sleeve for containing medical lines, comprising: (a) a foldable sleeve comprising first and second side panels, and adapted to be opened and closed along its longitudinal axis so as to form a conduit for medical lines, at least one of the panels being transparent, the foldable sleeve adapted to be reversibly opened along its longitudinal axis, and having releasable closures to maintain the foldable sleeve in a folded closed position; and (b) a plurality of rigid members incorporated into the sleeve and along the longitudinal axis.Type: GrantFiled: December 2, 2013Date of Patent: November 11, 2014Assignee: Nationwide Children's Hospital, Inc.Inventors: Joyce Mullet, Nancy Ryan-Wenger, Micah Skeens
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Publication number: 20140322169Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.Type: ApplicationFiled: July 24, 2012Publication date: October 30, 2014Applicant: NATIONWIDE CHILDREN'S HOSPITAL, INC.Inventors: Scott Quenton Harper, Jian Liu, Sara Garwick, Lindsay Wallace
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Patent number: 8757447Abstract: A fluid container spray device having a trigger lock mechanism with trigger tabs extending outwardly from the trigger and cleats extending inwardly from a moveable shroud. The cleats obstruct the tabs when the shroud is in a trigger lock position. A lever extending from beneath the shroud can be depressed, thereby moving the shroud from the trigger lock position to a trigger release position. The movement of the shroud to the trigger release position moves the connected cleats from their obstructive position to a position out of the trigger tabs' path of movement, thereby permitting use of the trigger to pump fluid from the container. The shroud is biased toward the trigger lock position. Thus, release of the container by the user restores the locked configuration, thereby preventing use by children.Type: GrantFiled: November 2, 2011Date of Patent: June 24, 2014Assignees: Nationwide Children's Hospital, Inc., The Ohio State UniversityInventors: Carolina Gill, Blain Lilly, Thornton K. Lothrop, Scott Shim, Lara B. McKenzie, Kristin J. Roberts, Nicolas G. Nelson
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Patent number: 8729041Abstract: The present invention provides compositions and methods featuring miR-26 microRNA polynucleotides for the diagnosis, treatment or prevention of hepatic neoplasia.Type: GrantFiled: December 2, 2009Date of Patent: May 20, 2014Assignees: The Johns Hopkins University, Nationwide Children's Hospital, Inc.Inventors: Joshua T. Mendell, Kathryn A. Mendell, Raghu R. Chivukula, Erik A. Wentzel, Jerry R. Mendell, K. Reed Clark, Janaiah Kota
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Publication number: 20140127221Abstract: The invention relates to the polynucleotide sequence of a nontypeable strain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.Type: ApplicationFiled: January 9, 2014Publication date: May 8, 2014Applicant: NATIONWIDE CHILDREN'S HOSPITAL, INC.Inventors: Lauren O. Bakaletz, Robert S. Munson, JR., David W. Dyer
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Publication number: 20140120107Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.Type: ApplicationFiled: December 23, 2013Publication date: May 1, 2014Applicants: The Board of Regents of University of Oklahoma, Nationwide Children's Hospital, Inc.Inventors: Lauren O. Bakaletz, Robert S. Munson, JR., David W. Dyer
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Publication number: 20140088511Abstract: The present invention is a protective sleeve for containing medical lines, comprising: (a) a foldable sleeve comprising first and second side panels, and adapted to be opened and closed along its longitudinal axis so as to form a conduit for medical lines, at least one of the panels being transparent, the foldable sleeve adapted to be reversibly opened along its longitudinal axis, and having releasable closures to maintain the foldable sleeve in a folded closed position; and (b) a plurality of rigid members incorporated into the sleeve and along the longitudinal axis.Type: ApplicationFiled: December 2, 2013Publication date: March 27, 2014Applicant: NATIONWIDE CHILDREN'S HOSPITAL, INC.Inventors: Joyce Mullet, Nancy Ryan-Wenger, Micah Skeens
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Patent number: 8652773Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.Type: GrantFiled: September 12, 2012Date of Patent: February 18, 2014Assignee: Nationwide Children's Hospital, Inc.Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr., David W. Dyer
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Publication number: 20140045925Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the myotilin gene. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of myotilin. The methods have application in the treatment of muscular dystrophies such as Limb Girdle Muscular Dystrophy Type 1A.Type: ApplicationFiled: October 21, 2013Publication date: February 13, 2014Applicant: Nationwide Children's Hospital, Inc.Inventors: Scott Quenton HARPER, Jian Liu
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Patent number: 8628917Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.Type: GrantFiled: July 19, 2012Date of Patent: January 14, 2014Assignees: Nationwide Children's Hospital, Inc., The Board of Regents of the University of Oklahoma, Children's Hosptial Inc.Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr., David W. Dyer