Patents Assigned to The Childrens Hospital, Inc.
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Patent number: 7901692Abstract: The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. The invention also relates to a novel 110 kDa NTHi outer membrane protein and the polynucleotide that encodes this outer membrane protein. Methods of screening for NTHi infection, and treating and preventing NTHi related disorders are also contemplated.Type: GrantFiled: April 15, 2010Date of Patent: March 8, 2011Assignee: Nationalwide Children's Hospital, Inc.Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr.
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Patent number: 7893237Abstract: The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.Type: GrantFiled: January 7, 2008Date of Patent: February 22, 2011Assignee: Nationwide Children's Hospital, Inc.Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr.
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Publication number: 20100310569Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.Type: ApplicationFiled: August 20, 2010Publication date: December 9, 2010Applicants: NATIONWIDE CHILDREN'S HOSPITAL INC., THE BOARD OF REGENTS OF UNIVERSITY OF OKLAHOMAInventors: Lauren O. Bakaletz, Robert S. Munson, JR., David W. Dyer
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Publication number: 20100310601Abstract: The present invention provides adeno-associated virus (AAV) materials and methods which are useful for DNA delivery to cells. More particularly, the invention provides recombinant AAV (rAAV) genomes, methods for packaging rAAV genomes, stable host cell lines producing rAAV and methods for delivering genes of interest to cells utilizing the rAAV. Particularly disclosed are rAAV useful in generating immunity to human immunodeficiency virus-1 and in therapeutic gene delivery for treatment of neurological disorders.Type: ApplicationFiled: January 19, 2010Publication date: December 9, 2010Applicant: NATIONWIDE CHILDREN'S HOSPITAL INC.Inventor: Philip R. Johnson
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Patent number: 7816086Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.Type: GrantFiled: December 23, 2009Date of Patent: October 19, 2010Assignees: Nationwide Children's Hospital, Inc., The Board of Regents of University of OklahomaInventors: Lauren O. Bakaletz, Robert S. Munson, Jr., David W. Dyer
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Publication number: 20100261155Abstract: Provided herein are isolated paramyxovirus pre-triggered fusion proteins, or functional fragments thereof, which contain one or more CRAC domains in a location that is away from the transmembrane domain. Also provided herein is a computer model of the structure of the pre-triggered F protein. Compositions that directly or indirectly bind and interfere with the normal activity or binding of the pre-triggered F proteins, or the CRAC domains, are useful as antiviral agents in the treatment of paramyxovirus infections. Thus, disclosed herein are methods of screening for antiviral agents, using the isolated pre-triggered F protein, or functional fragments thereof.Type: ApplicationFiled: June 6, 2008Publication date: October 14, 2010Applicant: NATIONWIDE CHILDREN'S HOSPITAL, INC.Inventors: Mark E. Peeples, Matthew Kennedy, William Ray
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Publication number: 20100260800Abstract: The invention relates to Adeno-associated virus vectors. In particular, it relates to Adeno-associated virus vectors with modified capsid proteins and materials and methods for their preparation and use.Type: ApplicationFiled: June 21, 2010Publication date: October 14, 2010Applicant: Nationwide Children's Hospital Inc.Inventors: Jeffrey S. Bartlett, Matthew Stachler
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Patent number: 7811591Abstract: The invention described herein relates to a chimeric protein comprising the NTHi twitching pilus major subunit protein (PilA) presenting a portion of the NTHi OMP P5 protein. The invention provides for vaccine compositions comprising the recombinant chimeric protein and methods of eliciting an immune response using the recombinant chimeric proteins of the invention.Type: GrantFiled: July 5, 2006Date of Patent: October 12, 2010Assignee: Nationwide Children's Hospital, Inc.Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr.
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Publication number: 20100196382Abstract: The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. The invention also relates to a novel 110 kDa NTHi outer membrane protein and the polynucleotide that encodes this outer membrane protein. Methods of screening for NTHi infection, and treating and preventing NTHi related disorders are also contemplated.Type: ApplicationFiled: April 15, 2010Publication date: August 5, 2010Applicant: NATIONWIDE CHILDREN'S HOSPITAL, INC.Inventors: Lauren O. Bakaletz, Robert S. Munson, JR.
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Patent number: 7749492Abstract: The invention relates to Adeno-associated virus vectors. In particular, it relates to Adeno-associated virus vectors with modified capsid proteins and materials and methods for their preparation and use.Type: GrantFiled: June 3, 2005Date of Patent: July 6, 2010Assignee: Nationwide Children's Hospital, Inc.Inventors: Jeffrey S. Bartlett, Matthew Stachler
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Patent number: 7723504Abstract: The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. The invention also relates to a novel 110 kDa NTHi outer membrane protein and the polynucleotide that encodes this outer membrane protein. Methods of screening for NTHi infection, and treating and preventing NTHi related disorders are also contemplated.Type: GrantFiled: November 28, 2007Date of Patent: May 25, 2010Assignee: Nationwide Children's Hospital, Inc.Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr.
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Patent number: 7662627Abstract: The present invention provides adeno-associated virus (AAV) materials and methods which are useful for DNA delivery to cells. More particularly, the invention provides recombinant AAV (rAAV) genomes, methods for packaging rAAV genomes, stable host cell lines producing rAAV and methods for delivering genes of interest to cells utilizing the rAAV. Particularly disclosed are rAAV useful in generating immunity to human immunodeficiency virus-1 and in therapeutic gene delivery for treatment of neurological disorders.Type: GrantFiled: May 9, 2006Date of Patent: February 16, 2010Assignee: Nationwide Children's Hospital, Inc.Inventor: Philip R. Johnson, Jr.
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Publication number: 20100035973Abstract: The invention provides for methods of modulating an immune response against a therapeutic polypeptide or an antigenic polypeptide delivered via rAAV comprising administering a modulator of programmed death-1 (PD-1) signaling.Type: ApplicationFiled: July 13, 2007Publication date: February 11, 2010Applicant: Nationwide Children's Hospital, Inc.Inventor: Christopher Walker
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Patent number: 7638282Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.Type: GrantFiled: June 28, 2007Date of Patent: December 29, 2009Assignees: Nationwide Children's Hospital, Inc., The Board of Regents of University of OklahomaInventors: Lauren O. Bakaletz, Robert S. Munson, Jr., David W. Dyer
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Publication number: 20090105188Abstract: The present invention relates to a method for treating or preventing necrotizing enterocolitis (NEC) in a human neonate in need thereof, comprising administering to the neonate a pharmaceutically effective amount of a composition comprising a poly(ADP-ribose) synthetase/polymerase (PARP) inhibitor. Also contemplated herein is an infant food or treatment composition comprising a PARP inhibitor in an amount that is 5 to 500 times greater than a daily recommended intake dosage for the PARP inhibitor.Type: ApplicationFiled: October 17, 2008Publication date: April 23, 2009Applicant: Nationwide Children's Hospital, Inc.Inventors: Peter J. Giannone, John a. Bauer
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Patent number: 7501131Abstract: The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.Type: GrantFiled: December 21, 2004Date of Patent: March 10, 2009Assignee: Nationwide Children's Hospital, Inc.Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr.
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Publication number: 20090041774Abstract: The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.Type: ApplicationFiled: January 7, 2008Publication date: February 12, 2009Applicant: CHILDREN'S HOSPITAL INC.Inventors: Lauren O. Bakaletz, Robert S. Munson, JR.
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Publication number: 20080311110Abstract: The invention described herein relates to a chimeric protein comprising the NTHi twitching pilus major subunit protein (PilA) presenting a portion of the NTHi OMP P5 protein. The invention provides for vaccine compositions comprising the recombinant chimeric protein and methods of eliciting an immune response using the recombinant chimeric proteins of the invention.Type: ApplicationFiled: July 5, 2006Publication date: December 18, 2008Applicant: Nationwide Children's Hospital, Inc.Inventors: Lauren O. Bakaletz, Robert S. Munson, JR.
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Patent number: 7306805Abstract: The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. The invention also relates to a novel 110 kDa NTHi outer membrane protein and the polynucleotide that encodes this outer membrane protein. Methods of screening for NTHi infection, and treating and preventing NTHi related disorders are also contemplated.Type: GrantFiled: March 24, 2004Date of Patent: December 11, 2007Assignee: Children's Hospital, Inc.Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr.
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Publication number: 20070264256Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.Type: ApplicationFiled: June 28, 2007Publication date: November 15, 2007Applicants: CHILDREN'S HOSPITAL INC., The Board of Regents of University of OklahomaInventors: Lauren Bakaletz, Robert Munson, David Dyer