Patents Assigned to The Childrens Hospital, Inc.
  • Patent number: 7901692
    Abstract: The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. The invention also relates to a novel 110 kDa NTHi outer membrane protein and the polynucleotide that encodes this outer membrane protein. Methods of screening for NTHi infection, and treating and preventing NTHi related disorders are also contemplated.
    Type: Grant
    Filed: April 15, 2010
    Date of Patent: March 8, 2011
    Assignee: Nationalwide Children's Hospital, Inc.
    Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr.
  • Patent number: 7893237
    Abstract: The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.
    Type: Grant
    Filed: January 7, 2008
    Date of Patent: February 22, 2011
    Assignee: Nationwide Children's Hospital, Inc.
    Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr.
  • Publication number: 20100310569
    Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.
    Type: Application
    Filed: August 20, 2010
    Publication date: December 9, 2010
    Applicants: NATIONWIDE CHILDREN'S HOSPITAL INC., THE BOARD OF REGENTS OF UNIVERSITY OF OKLAHOMA
    Inventors: Lauren O. Bakaletz, Robert S. Munson, JR., David W. Dyer
  • Publication number: 20100310601
    Abstract: The present invention provides adeno-associated virus (AAV) materials and methods which are useful for DNA delivery to cells. More particularly, the invention provides recombinant AAV (rAAV) genomes, methods for packaging rAAV genomes, stable host cell lines producing rAAV and methods for delivering genes of interest to cells utilizing the rAAV. Particularly disclosed are rAAV useful in generating immunity to human immunodeficiency virus-1 and in therapeutic gene delivery for treatment of neurological disorders.
    Type: Application
    Filed: January 19, 2010
    Publication date: December 9, 2010
    Applicant: NATIONWIDE CHILDREN'S HOSPITAL INC.
    Inventor: Philip R. Johnson
  • Patent number: 7816086
    Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: October 19, 2010
    Assignees: Nationwide Children's Hospital, Inc., The Board of Regents of University of Oklahoma
    Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr., David W. Dyer
  • Publication number: 20100261155
    Abstract: Provided herein are isolated paramyxovirus pre-triggered fusion proteins, or functional fragments thereof, which contain one or more CRAC domains in a location that is away from the transmembrane domain. Also provided herein is a computer model of the structure of the pre-triggered F protein. Compositions that directly or indirectly bind and interfere with the normal activity or binding of the pre-triggered F proteins, or the CRAC domains, are useful as antiviral agents in the treatment of paramyxovirus infections. Thus, disclosed herein are methods of screening for antiviral agents, using the isolated pre-triggered F protein, or functional fragments thereof.
    Type: Application
    Filed: June 6, 2008
    Publication date: October 14, 2010
    Applicant: NATIONWIDE CHILDREN'S HOSPITAL, INC.
    Inventors: Mark E. Peeples, Matthew Kennedy, William Ray
  • Publication number: 20100260800
    Abstract: The invention relates to Adeno-associated virus vectors. In particular, it relates to Adeno-associated virus vectors with modified capsid proteins and materials and methods for their preparation and use.
    Type: Application
    Filed: June 21, 2010
    Publication date: October 14, 2010
    Applicant: Nationwide Children's Hospital Inc.
    Inventors: Jeffrey S. Bartlett, Matthew Stachler
  • Patent number: 7811591
    Abstract: The invention described herein relates to a chimeric protein comprising the NTHi twitching pilus major subunit protein (PilA) presenting a portion of the NTHi OMP P5 protein. The invention provides for vaccine compositions comprising the recombinant chimeric protein and methods of eliciting an immune response using the recombinant chimeric proteins of the invention.
    Type: Grant
    Filed: July 5, 2006
    Date of Patent: October 12, 2010
    Assignee: Nationwide Children's Hospital, Inc.
    Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr.
  • Publication number: 20100196382
    Abstract: The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. The invention also relates to a novel 110 kDa NTHi outer membrane protein and the polynucleotide that encodes this outer membrane protein. Methods of screening for NTHi infection, and treating and preventing NTHi related disorders are also contemplated.
    Type: Application
    Filed: April 15, 2010
    Publication date: August 5, 2010
    Applicant: NATIONWIDE CHILDREN'S HOSPITAL, INC.
    Inventors: Lauren O. Bakaletz, Robert S. Munson, JR.
  • Patent number: 7749492
    Abstract: The invention relates to Adeno-associated virus vectors. In particular, it relates to Adeno-associated virus vectors with modified capsid proteins and materials and methods for their preparation and use.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: July 6, 2010
    Assignee: Nationwide Children's Hospital, Inc.
    Inventors: Jeffrey S. Bartlett, Matthew Stachler
  • Patent number: 7723504
    Abstract: The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. The invention also relates to a novel 110 kDa NTHi outer membrane protein and the polynucleotide that encodes this outer membrane protein. Methods of screening for NTHi infection, and treating and preventing NTHi related disorders are also contemplated.
    Type: Grant
    Filed: November 28, 2007
    Date of Patent: May 25, 2010
    Assignee: Nationwide Children's Hospital, Inc.
    Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr.
  • Patent number: 7662627
    Abstract: The present invention provides adeno-associated virus (AAV) materials and methods which are useful for DNA delivery to cells. More particularly, the invention provides recombinant AAV (rAAV) genomes, methods for packaging rAAV genomes, stable host cell lines producing rAAV and methods for delivering genes of interest to cells utilizing the rAAV. Particularly disclosed are rAAV useful in generating immunity to human immunodeficiency virus-1 and in therapeutic gene delivery for treatment of neurological disorders.
    Type: Grant
    Filed: May 9, 2006
    Date of Patent: February 16, 2010
    Assignee: Nationwide Children's Hospital, Inc.
    Inventor: Philip R. Johnson, Jr.
  • Publication number: 20100035973
    Abstract: The invention provides for methods of modulating an immune response against a therapeutic polypeptide or an antigenic polypeptide delivered via rAAV comprising administering a modulator of programmed death-1 (PD-1) signaling.
    Type: Application
    Filed: July 13, 2007
    Publication date: February 11, 2010
    Applicant: Nationwide Children's Hospital, Inc.
    Inventor: Christopher Walker
  • Patent number: 7638282
    Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: December 29, 2009
    Assignees: Nationwide Children's Hospital, Inc., The Board of Regents of University of Oklahoma
    Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr., David W. Dyer
  • Publication number: 20090105188
    Abstract: The present invention relates to a method for treating or preventing necrotizing enterocolitis (NEC) in a human neonate in need thereof, comprising administering to the neonate a pharmaceutically effective amount of a composition comprising a poly(ADP-ribose) synthetase/polymerase (PARP) inhibitor. Also contemplated herein is an infant food or treatment composition comprising a PARP inhibitor in an amount that is 5 to 500 times greater than a daily recommended intake dosage for the PARP inhibitor.
    Type: Application
    Filed: October 17, 2008
    Publication date: April 23, 2009
    Applicant: Nationwide Children's Hospital, Inc.
    Inventors: Peter J. Giannone, John a. Bauer
  • Patent number: 7501131
    Abstract: The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: March 10, 2009
    Assignee: Nationwide Children's Hospital, Inc.
    Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr.
  • Publication number: 20090041774
    Abstract: The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.
    Type: Application
    Filed: January 7, 2008
    Publication date: February 12, 2009
    Applicant: CHILDREN'S HOSPITAL INC.
    Inventors: Lauren O. Bakaletz, Robert S. Munson, JR.
  • Publication number: 20080311110
    Abstract: The invention described herein relates to a chimeric protein comprising the NTHi twitching pilus major subunit protein (PilA) presenting a portion of the NTHi OMP P5 protein. The invention provides for vaccine compositions comprising the recombinant chimeric protein and methods of eliciting an immune response using the recombinant chimeric proteins of the invention.
    Type: Application
    Filed: July 5, 2006
    Publication date: December 18, 2008
    Applicant: Nationwide Children's Hospital, Inc.
    Inventors: Lauren O. Bakaletz, Robert S. Munson, JR.
  • Patent number: 7306805
    Abstract: The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. The invention also relates to a novel 110 kDa NTHi outer membrane protein and the polynucleotide that encodes this outer membrane protein. Methods of screening for NTHi infection, and treating and preventing NTHi related disorders are also contemplated.
    Type: Grant
    Filed: March 24, 2004
    Date of Patent: December 11, 2007
    Assignee: Children's Hospital, Inc.
    Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr.
  • Publication number: 20070264256
    Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.
    Type: Application
    Filed: June 28, 2007
    Publication date: November 15, 2007
    Applicants: CHILDREN'S HOSPITAL INC., The Board of Regents of University of Oklahoma
    Inventors: Lauren Bakaletz, Robert Munson, David Dyer