Patents Assigned to The Chinese University of Hong Kong
  • Patent number: 11142799
    Abstract: Methods, systems, and apparatus determine whether a first chromosomal region exhibits a deletion or an amplification associated with cancer in a sample from a subject (e.g., where the sample includes a mixture of cell-free DNA from tumor cells and non-malignant cells. Nucleic acid molecules of the biological sample are sequenced. Respective amounts of a clinically-relevant chromosomal region and of background chromosomal region(s) are determined from results of the sequencing. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether first chromosomal region exhibits a deletion or an amplification associated with cancer.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: October 12, 2021
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan
  • Patent number: 11139548
    Abstract: A dual-mode dielectric resonator using two dissimilar modes is described, the dissimilar modes supported by a ridge waveguide resonator and a ¼-wavelength (¼?) metalized cylindrical resonator within a single, metal-coated dielectric block. Each ridge waveguide resonator and cylindrical resonator form a dual-mode resonator pair. Coupling control posts set between the ridge waveguide resonator and cylindrical resonator can adjust their coupling. Multiple pairs of ridge waveguide/cylindrical resonators are fabricated in the same dielectric block to form a coupled resonator bandpass filter, including an 8-pole or 10-pole dielectric resonator filter, for 5G or other applications. Transmission zeros can be introduced by a metalized blind hole extending vertically between two ridge waveguide resonators or a microstrip extending between two dual-mode resonator pairs between which there exists no partial-width or full-width dielectric window.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: October 5, 2021
    Assignee: The Chinese University of Hong Kong
    Inventors: Ke-Li Wu, Yuliang Chen, Yan Zhang
  • Patent number: 11137463
    Abstract: MRI techniques provide robust imaging in the presence of inhomogeneity in the B1 (RF) and/or B0 magnetic fields. The techniques include using a magnetization prep sequence that includes an adiabatic half passage (AHP) followed by a spin-lock pulse, followed by a reverse AHP, after which a data acquisition sequence can be applied. The AHP and reverse AHP can have amplitude and frequency modulated to sweep through a region of frequency space. The RF amplitude of the AHP and reverse AHP can be designed to be equal to the spin-lock amplitude. Quantification of a magnetization relaxation parameter (e.g., T1rho) can use a modified relaxation model that accounts for relaxation effects during the reverse AHP. A dual-acquisition technique in which the reverse AHP of the second magnetization prep sequence has opposite frequency modulation to the reverse AHP of the first magnetization prep sequence can also be used.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: October 5, 2021
    Assignee: The Chinese University of Hong Kong
    Inventors: Weitian Chen, Baiyan Jiang
  • Patent number: 11129766
    Abstract: Systems and methods for robotic and exoskeleton hands are provided. An exoskeleton hand can include a flexible actuator having a cavity and a reinforcement band. The cavity can be filled with a fluid from a pressure source, forcing the actuator to deform, bend or extend. The fluid that fills the cavity as a driving force can be a gas or liquid, which can be recyclable or disposable.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: September 28, 2021
    Assignee: THE CHINESE UNIVERSITY OF HONG KONG
    Inventors: Kai Yu Tong, Zheng Li, Ho Lam Heung, Trivoramai Jiralerspong, Choi Ling Wong
  • Patent number: 11124977
    Abstract: A robotic constructing system based on a cable-driven robot for constructing a structure formed by objects such as bricks is provided. The process of laying the bricks is performed by the cable-driven robot autonomously. The bricks are provided to the robotic constructing system by an external conveyor and a robot arm of the robotic constructing system is configured to pick up the bricks. The robot arm is then configured to place the bricks in a position to receive an adhesive from an adhesive dispenser of the robotic constructing system and further to load the bricks onto a linear rail. The linear rail can be configured to place the bricks within the proximity of the cable-driven robot. The cable-driven robot can be configured to pick up the bricks and lay the bricks in the designated position of a three-dimensional space.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: September 21, 2021
    Assignee: THE CHINESE UNIVERSITY OF HONG KONG
    Inventors: Darwin Tat Ming Lau, Adam Fingrut, Kristof Crolla, Yeung Yam, Yuen Shan Chan, Yulong Wu, Man Kit Cheung
  • Patent number: 11111547
    Abstract: The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the REC8 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing REC8 gene expression or activity. Lastly, a highly sensitive and accurate detection method is provided for rapid determination of REC8 gene methylation status.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: September 7, 2021
    Assignee: The Chinese University of Hong Kong
    Inventors: Jun Yu, Joseph Jao Yiu Sung, Qiaoyi Liang
  • Patent number: 11091794
    Abstract: Systems and methods for using determination of base modification in analyzing nucleic acid molecules and acquiring data for analysis of nucleic acid molecules are described herein. Base modifications may include methylations. Methods to determine base modifications may include using features derived from sequencing. These features may include the pulse width of an optical signal from sequencing bases, the interpulse duration of bases, and the identity of the bases. Machine learning models can be trained to detect the base modifications using these features. The relative modification or methylation levels between haplotypes may indicate a disorder. Modification or methylation statuses may also be used to detect chimeric molecules.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: August 17, 2021
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Suk Hang Cheng, Wenlei Peng, On Yee Tse
  • Patent number: 11089966
    Abstract: Devices and methods for non-invasive capillary blood pressure measurement are provided. An device can comprise a front end in contact with the body to compress and decompress the capillaries in the tissue, a pressure control module for regulating the contact pressure between the front end and the tissue, a pressure transducer coupled to the front end for measuring the contact pressure, a capillary sensing module for detecting the capillaries pulsations under the contact pressure modulation, and an algorithm for determining the capillaries pressures from the traces of capillary pulsation signals and the contact pressure signal. The methods include an oscillometric method for intermittent arterial and capillary blood pressure measurement and a volume-clamp method for continuous capillary blood pressure measurement.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: August 17, 2021
    Assignees: The Chinese University of Hong Kong, Massachusetts Institute of Technology
    Inventors: Ni Zhao, Jing Liu, Charles Sodini
  • Publication number: 20210215799
    Abstract: An optical phased array lidar includes: a laser, for emitting a laser signal; an optical beam splitter, for splitting a laser signal into multiple sub-signals, and distributing them to corresponding optical paths; a phase controller connected to the optical beam splitter, for regulating phases of the multiple sub-signals; an optical antenna array based on a one-dimensional grating structure, connected to the phase controller and for uniformly scattering the phase-regulated sub-signals into free space; and a silicon nitride waveguide array, for transmitting the sub-signals and phase-regulated sub-signals to realize the transmission of near-infrared light and visible light. The optical phased array lidar uses a silicon nitride waveguide array for transmission, thereby realizing the transmission of near-infrared light and visible light. In this way, the lidar can work in the visible light band, thereby broadening the working ranging thereof.
    Type: Application
    Filed: March 26, 2021
    Publication date: July 15, 2021
    Applicants: THE CHINESE UNIVERSITY OF HONG KONG, SHENZHEN, SHENZHEN INSTITUTE OF ARTIFICIAL INTELLIGENCE AND ROBOTICS FOR SOCIETY
    Inventors: Caiming SUN, Hongjie WANG, Aidong ZHANG
  • Patent number: 11062789
    Abstract: The contributions of different tissues to a DNA mixture are determined using methylation levels at particular genomic sites. Tissue-specific methylation levels of M tissue types can be used to deconvolve mixture methylation levels measured in the DNA mixture, to determine fraction contributions of each of the M tissue types. Various types of genomic sites can be chosen to have particular properties across tissue types and across individuals, so as to provide increased accuracy in determining contributions of the various tissue types. The fractional contributions can be used to detect abnormal contributions of a particular tissue, indicating a disease state for the tissue. A differential in fractional contributions for different sizes of DNA fragments can also be used to identify a diseased state of a particular tissue. A sequence imbalance for a particular chromosomal region can be detected in a particular tissue, e.g., identifying a location of a tumor.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: July 13, 2021
    Assignee: The Chinese University of Hong Kong
    Inventors: Rossa Wai Kwun Chiu, Kwan Chee Chan, Yuk-Ming Dennis Lo, Peiyong Jiang, Kun Sun
  • Patent number: 11048045
    Abstract: Low spherical aberration of a Mikaelian lens makes it suitable for focusing off-optical-axis light propagating in higher order modes. A Mikaelian lens can be used as a mode-size converter to expand light in a semiconductor waveguide before coupling light out of the waveguide. For example, a Mikaelian lens can be used in a waveguide to expand light from a 1 ?m wide multimode waveguide to a 20 ?m wide multimode grating coupler in a shorter distance than an adiabatic taper. 3D FDTD simulation results show that an embodiment of a 12 ?m long, subwavelength mode-size converter has comparable first-order mode transmission as a 600 ?m adiabatic taper.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: June 29, 2021
    Assignee: The Chinese University of Hong Kong
    Inventors: Hon Ki Tsang, Zunyue Zhang
  • Patent number: 11045445
    Abstract: Method of treating endometriosis and related indications, comprising the administration of Pro-EGCG, a synthetic and derivative product of epigallocatechin-3-gallate [(?)-EGCG]. Use of PRO-EGCG in the manufacture of a medicament for treating endometriosis and related indications. Pro-EGCG for use in the treatment of endometriosis and related indications.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: June 29, 2021
    Assignees: The Hong Kong Polytechnic University, The Chinese University of Hong Kong
    Inventors: Tak-Hang Chan, Chi-Chiu Wang
  • Patent number: 11041018
    Abstract: The present invention provides for novel compositions and methods for treating a neurodegenerative disease such as Alzheimer's Disease.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: June 22, 2021
    Assignee: The Chinese University of Hong Kong
    Inventors: Eugene Ponomarev, Marina Dukhinova, Tatyana Veremeyko, Andrew L. M. Chan
  • Patent number: 11033183
    Abstract: A new steerable endoscope for minimally invasive surgery is provided. The endoscope system includes: a wireless steerable endoscope (1), an external magnetic controller (2) and an image/video display (3). The wireless steerable endoscope (1) could be inserted through an incision (4-1) on the body skin (4) and be anchored/steered inside the body cavity by the external magnetic controller (2). It is shaftless, wireless, and can be steered inside the body, operating in a remote manner. Compared with existing endoscopes, it neither requires additional incision nor does it occupy trocar or port space. Without the endoscope shaft, the surgical access trauma and incision size can potentially be reduced, avoiding endoscope-instrument fencing. It can be placed remotely from the access incision, providing an improved and wider field of view. It is soft-bodied and compact in structure, therefore safety is high.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: June 15, 2021
    Assignee: The Chinese University of Hong Kong
    Inventors: Zheng Li, Calvin Sze Hang Ng, Philip Wai Yan Chiu, Joseph Jao Yiu Sung
  • Patent number: 11031100
    Abstract: A classification of a level of cancer in an organism is determined by analyzing a biological sample of the organism. The biological sample comprises clinically-relevant DNA and other DNA. At least some of the DNA is cell-free in the biological sample. An amount of a first set of DNA fragments from the biological sample corresponding to each of a plurality of sizes is measured. A first value of a first parameter is calculated based on the amounts of DNA fragments at the plurality of sizes. The first value is compared to a reference value. A classification of a level of cancer in the organism is determined based on the comparison.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: June 8, 2021
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Kwan Chee Chan, Wenli Zheng, Peiyong Jiang, Jiawei Liao
  • Publication number: 20210167483
    Abstract: A dual-mode dielectric resonator using two dissimilar modes is described, the dissimilar modes supported by a ridge waveguide resonator and a ¼-wavelength (¼?) metalized cylindrical resonator within a single, metal-coated dielectric block. Each ridge waveguide resonator and cylindrical resonator form a dual-mode resonator pair. Coupling control posts set between the ridge waveguide resonator and cylindrical resonator can adjust their coupling. Multiple pairs of ridge waveguide/cylindrical resonators are fabricated in the same dielectric block to form a coupled resonator bandpass filter, including an 8-pole or 10-pole dielectric resonator filter, for 5G or other applications. Transmission zeros can be introduced by a metalized blind hole extending vertically between two ridge waveguide resonators or a microstrip extending between two dual-mode resonator pairs between which there exists no partial-width or full-width dielectric window.
    Type: Application
    Filed: July 30, 2020
    Publication date: June 3, 2021
    Applicant: The Chinese University of Hong Kong
    Inventors: Ke-Li WU, Yuliang Chen, Yan Zhang
  • Patent number: 11020425
    Abstract: The present invention provides a hybrid hydrogel stabilized by multivalent cross-linking domains. The hydrogel combines inorganic nanoparticles along with an organic polymer network. The resulting material has reinforced mechanical properties and significant mineralization, and affords sustained long-term release of ions. Furthermore, ions released from the hydrogel can enhance cell spreading and promote the osteogenic differentiation of implanted cells. These promising results indicates that the provided compositions and methods are particularly appealing for bone regenerative applications.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: June 1, 2021
    Assignee: The Chinese University of Hong Kong
    Inventors: Liming Bian, Kunyu Zhang
  • Patent number: 10973927
    Abstract: Provided are DNA-coated nanoparticles (DNA-NPS), superparamagnetic nanoparticles (DNA-SPNs), and superparamagnetic iron oxide nanopa rticles (DNA-SPIONs) as efficient imaging agents for targeting and imaging atherosclerotic lesions and treating atherosclerotic disease. The DNA-NS, DNA-SPNs, and DNA-SPIONs can enter macrophage cells via the Class A scavenger receptor (SR-A)-mediated pathways and can be used to specifically target atheroscleortic plaques.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: April 13, 2021
    Assignee: THE CHINESE UNIVERSITY OF HONG KONG
    Inventors: Chung Hang Jonathan Choi, Lei Zhang
  • Patent number: 10973468
    Abstract: Methods and devices for long term, cuffless, and continuous arterial blood pressure estimation using an end-to-end deep learning approach are provided. A deep learning system comprises three modules: a deep convolutional neural network (CNN) module for learning powerful features; a one- or multi-layer recurrent neural network (RNN) module for modeling the temporal dependencies in blood pressure dynamics; and a mixture density network (MDN) module for predicting final blood pressure value. This system takes raw physiological signals, such as photoplethysmogram and/or electrocardiography signals, as inputs and yields arterial blood pressure readings in real time.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: April 13, 2021
    Assignee: The Chinese University of Hong Kong
    Inventors: Ni Zhao, Peng Su, Yuanting Zhang
  • Patent number: 10957045
    Abstract: Optimizations are provided for segmenting tissue objects included in an ultrasound image. Initially, raw pixel data is received. Here, each pixel corresponds to ultrasound information. This raw pixel data is processed through a first fully convolutional network to generate a first segmentation label map. This first map includes a first set of objects that have been segmented into a coarse segmentation class. Then, this first map is processed through a second fully convolutional network to generate a second segmentation label map. This second map is processed using the raw pixel data as a base reference. Further, this second map includes a second set of objects that have been segmented into a fine segmentation class. Then, a contour optimization algorithm is applied to at least one of the second set of objects in order to refine that object's contour boundary. Subsequently, that object is identified as corresponding to a lymph node.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: March 23, 2021
    Assignees: University of Notre Dame du Lac, Honk Kong Polytechnic University, Chinese University of Hong Kong
    Inventors: Danny Ziyi Chen, Yizhe Zhang, Lin Yang, Michael Tin-Cheung Ying, Anil Tejbhan Ahuja