Patents Assigned to The Chinese University of Hong Kong
  • Patent number: 10406000
    Abstract: A powered ankle-foot prosthesis and associated methods of use are described herein. Such prostheses can employ an actuator and elastic components, the actuator being controlled to deliver net positive work to propel the wearing amputee forward and the elastic components being used to store and release negative energy to improve efficiency. Elastic components can be linear springs coupled with a cam and configured in parallel to the actuator. The cam profile can be designed to generate a desired spring torque versus angle curve rather than a spring stroke versus angle curve, thereby reproducing human ankle controlled dorsiflexion stiffness. Such configurations improve system energy efficiency and reduce both actuator torque and power requirements. Such prostheses can also operate in a passive mode, in which a nearly normal gait can be achieved even without powered assist.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: September 10, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Fei Gao, Yan-Nan Liu, Wei-Hsin Liao
  • Patent number: 10401603
    Abstract: A device and method are for shaping and scanning an ultrafast laser beam. The device includes a laser source configured to output a pulsed laser beam containing different frequency spectrum, a digital micromirror device (DMD) consisting of micromirrors, which are configured to receive the laser beam and shape the received laser beam with computer generated holograms, and a dispersion compensation unit, arranged before or after the DMD, which is configured to transfer the laser beam from the laser source to the DMD with a designated angular dispersion for neutralizing the first angular dispersion introduced by the DMD.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: September 3, 2019
    Assignee: THE CHINESE UNIVERSITY OF HONG KONG
    Inventors: Shih-Chi Chen, Jiyi Cheng, Chenglin Gu, Dapeng Zhang
  • Patent number: 10392666
    Abstract: Systems, methods, and apparatuses can determine and use methylation profiles of various tissues and samples. Examples are provided. A methylation profile can be deduced for fetal/tumor tissue based on a comparison of plasma methylation (or other sample with cell-free DNA) to a methylation profile of the mother/patient. A methylation profile can be determined for fetal/tumor tissue using tissue-specific alleles to identify DNA from the fetus/tumor when the sample has a mixture of DNA. A methylation profile can be used to determine copy number variations in genome of a fetus/tumor. Methylation markers for a fetus have been identified via various techniques. The methylation profile can be determined by determining a size parameter of a size distribution of DNA fragments, where reference values for the size parameter can be used to determine methylation levels. Additionally, a methylation level can be used to determine a level of cancer.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: August 27, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Miu Fan Lun, Wai Man Chan, Peiyong Jiang
  • Patent number: 10384209
    Abstract: A microfluidic platform including a microfluidic layer and a contact layer. The microfluidic layer is embedded with a microfluidic structure including a micro-channel and a fluidic sample contained in the micro-channel. The contact layer is able to be attached to the microfluidic layer, and includes a first heater for heating a first area of the microfluidic structure to a first temperature and a second heater for heating a second area of the microfluidic structure to a second temperature. The microfluidic layer and the contact layer rotate together during operation. A method for controlling a sample in the micro-channel of the microfluidic structure.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: August 20, 2019
    Assignees: THE CHINESE UNIVERSITY OF HONG KONG, NANYANG TECHNOLOGICAL UNIVERSITY, HOSPITAL AUTHORITY
    Inventors: Qiu Lan Chen, Ho Pui Ho, Siu Kai Kong, Patrick Kwok Leung Kwan, Yiu Wa Kwan, Ho Chin Kwok, Ping Shum, Yick Keung Suen, Shu Yuen Wu, Alice Kar Lai Yang, Jun Qiang Zhou
  • Patent number: 10379124
    Abstract: The present invention provides a method for diagnosing and determining prognosis of colorectal cancer in a subject by detecting suppressed expression of the VSTM2A gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating colorectal cancer by increasing VSTM2A gene expression or activity.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: August 13, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Jun Yu, Joseph Jao Yiu Sung, Simon Siu Man Ng, Yujuan Dong
  • Patent number: 10364467
    Abstract: Analysis of tumor-derived circulating cell-free DNA opens up new possibilities for performing liquid biopsies for solid tumor assessment or cancer screening. However, many aspects of the biological characteristics of tumor-derived cell-free DNA remain unclear. Regarding the size profile of plasma DNA molecules, some studies reported increased integrity of tumor-derived plasma DNA while others reported shorter tumor-derived plasma DNA molecules. We performed an analysis of the size profiles of plasma DNA in patients with cancer using massively parallel sequencing at single base resolution and in a genomewide manner. Tumor-derived plasma DNA molecules were further identified using chromosome arm-level z-score analysis (CAZA). We showed that populations of aberrantly short and long DNA molecules co-existed in the plasma of patients with cancer. The short ones preferentially carried the tumor-associated copy number aberrations. These results show the ability to use plasma DNA as a molecular diagnostic tool.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: July 30, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang
  • Patent number: 10364471
    Abstract: The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the REC8 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing REC8 gene expression or activity. Lastly, a highly sensitive and accurate detection method is provided for rapid determination of REC8 gene methylation status.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: July 30, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Jun Yu, Joseph Jao Yiu Sung, Qiaoyi Liang
  • Patent number: 10357369
    Abstract: The present application discloses a method of producing a knee replacement implant, an implant for knee replacement formed by using the method, and a knee replacement implant. The method includes: defining a hip center, a knee center, an ankle center and a posterior femoral condylar axis of a lower limb; generating femoral geometric parameters and tibial geometric parameters, the femoral geometric parameters and the tibial geometric parameters being measured in relation to the hip center, the knee center, the ankle center and the posterior femoral condylar axis; collecting anthropometric data from a defined population using the femoral geometric parameters and the tibial geometric parameters; and creating a femoral component and/or a tibial component using the collected anthropometric data.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: July 23, 2019
    Assignees: Shandong Weigao Orthopaedic Device Co. Ltd., The Chinese University of Hong Kong, Shenzhen Institutes of Advanced Technology, Chinese Academy of Science
    Inventors: Kwok-Sui Leung, Wing-Hoi Cheung, Jianghui Qin, Chun-Sing Chui, Dufang Shi, Kwoon-Ho Chow, Ling Qin, Wanfu Kou, Chenglin Lu
  • Patent number: 10338526
    Abstract: A device, system and method for holographic 3D imaging. The device includes a laser light source that delivers a laser beam; an aperture disc including at least two pinholes, the laser beam being filtered by the pinholes so that a reference wave and an object wave are generated; a sample having a first area containing an object to be imaged and a second area without any object, in which the first area and the second area are illuminated by the object wave and the reference wave respectively; and an image sensor that captures an off-axis hologram for reconstructing an image of the object, in which the reference wave and the object wave are interfered on the image sensor and the hologram is captured based on an interference pattern of the reference wave and the object wave.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: July 2, 2019
    Assignee: THE CHINESE UNIVERSITY OF HONG KONG
    Inventors: Yujie Lu, Yunhui Liu
  • Patent number: 10329606
    Abstract: Disclosed herein are methods and kits for selectively amplifying, detecting or quantifying a DNA fragment with a specific end sequence, especially generated following restriction enzyme digestion. This method can be used, for example, to detect a hypomethylated DNA fragment. This methods and kits are especially useful in detecting or quantifying a hypomethylated fetal DNA fragment in a maternal plasma sample containing a corresponding hypermethylated maternal DNA fragment.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: June 25, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis Lo, Yu Kwan Tong, Wai Kwun Rossa Chiu, Chunming Ding
  • Patent number: 10319463
    Abstract: An aberration in a fetal genome can be identified by analyzing a sample of fetal and maternal DNA. Classifications of whether an aberration (amplification or deletion) exists in a subchromosomal region are determined using count-based and size-based methods. The count classification and the size classification can be used in combination to determine whether only the fetus or only the mother, or both, have the aberration in the subchromosomal region, thereby avoiding false positives when the mother has the aberration and the fetus does not.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: June 11, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Cheuk Yin Jandy Yu
  • Patent number: 10301365
    Abstract: The present invention provides isolated Met e 1 polypeptides and nucleic acids encoding the isolated polypeptides that can prevent and/or alleviate an allergic response to shellfish tropomyosin. The polypeptides are based on the shrimp tropomyosin Met e 1 protein and have been modified to act as hypoallergens. The Met e 1 hypoallergens have low to no IgE reactivity or allergenicity and are useful for prophylactic and/or therapeutic treatment of shellfish allergy in subject in need thereof.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: May 28, 2019
    Assignees: The Chinese University of Hong Kong, The Regents of the University of California
    Inventors: Ka Hou Chu, Patrick S. C. Leung, Yee Yan Christine Wai, Yat Hin Nicki Leung
  • Patent number: 10294530
    Abstract: The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the FOXF2 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing FOXF2 gene expression or activity.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: May 21, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Jun Yu, Joseph Jao Yiu Sung
  • Patent number: 10297342
    Abstract: A classification of a level of cancer in an organism is determined by analyzing a biological sample of the organism. The biological sample comprises clinically-relevant DNA and other DNA. At least some of the DNA is cell-free in the biological sample. An amount of a first set of DNA fragments from the biological sample corresponding to each of a plurality of sizes is measured. A first value of a first parameter is calculated based on the amounts of DNA fragments at the plurality of sizes. The first value is compared to a reference value. A classification of a level of cancer in the organism is determined based on the comparison.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: May 21, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Kwan Chee Chan, Wenli Zheng, Peiyong Jiang, Jiawei Liao
  • Patent number: 10273543
    Abstract: The present invention provides a new method for detecting or monitoring a liver disease in a subject that has no indication of any liver pathologies, by measuring the amount of concentration of albumin mRNA in an acellular blood sample from the subject, and then comparing the amount or concentration of albumin mRNA with a standard control.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: April 30, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis Lo, Rossa Wai Kwun Chiu, Rebecca Wing Yan Chan
  • Patent number: 10240190
    Abstract: The present invention provides novel nano-constructs useful for delivering polynucleotides into cells, methods of using the nano-constructs, and methods of making the nano-constructs.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: March 26, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Liming Bian, Chung Hang Jonathan Choi, Chun Kit Choi
  • Patent number: 10240209
    Abstract: Embodiments are related to the accurate detection of somatic mutations in the plasma (or other samples containing cell-free DNA) of cancer patients and for subjects being screened for cancer. The detection of these molecular markers would be useful for the screening, detection, monitoring, management, and prognostication of cancer patients. For example, a mutational load can be determined from the identified somatic mutations, and the mutational load can be used to screen for any or various types of cancers, where no prior knowledge about a tumor or possible cancer of the subject may be required. Embodiments can be useful for guiding the use of therapies (e.g. targeted therapy, immunotherapy, genome editing, surgery, chemotherapy, embolization therapy, anti-angiogenesis therapy) for cancers. Embodiments are also directed to identifying de novo mutations in a fetus by analyzing a maternal sample having cell-free DNA from the fetus.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: March 26, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang
  • Patent number: 10240199
    Abstract: Methods are provided for diagnosing pregnancy-associated disorders, determining allelic ratios, determining maternal or fetal contributions to circulating transcripts, and/or identifying maternal or fetal markers using a sample from a pregnant female subject. Also provided is use of a gene for diagnosing a pregnancy-associated disorder in a pregnant female subject.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: March 26, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Bo Yin Tsui
  • Patent number: 10237782
    Abstract: Hardware acceleration for batched sparse (BATS) codes is enabled. Hardware implementation of some timing-critical procedures can effectively offload computationally intensive overheads, for example, finite field arithmetic, Gaussian elimination, and belief propagation (BP) calculations, and this can be done without direct mapping of software codes to a hardware implementation. Suitable acceleration hardware may include pipelined multipliers configured to multiply input data with coefficients of a matrix associated with a random linear network code in a pipelined manner, addition components configured to add multiplier output to feedback data, and switches to direct data flows to and from memory components such that valid result data is not overwritten and such that feedback data corresponds to most recent valid result data. Acceleration hardware components (e.g., number and configuration) may be dynamically adjusted to modify BATS code parameters and adapt to changing network conditions.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: March 19, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Shenghao Yang, Wai-ho Yeung, Tak-Ion Chao, Kin-Hong Lee, Chi-Iam Ho
  • Patent number: 10220388
    Abstract: The disclosure provides a centrifugal microfluidics control system and a method configuring the same. The system may comprise a centrifugal tube; a centrifugal unit for accommodating the centrifugal tube and providing a centrifugal force to the centrifugal tube; a control unit fixed in bottom of the centrifugal tube; and a microfluidic supporting unit coupled to the control unit in the centrifugal tube. The control unit may change an orientation of the microfluidic supporting unit to change a direction of the centrifugal force applied to the microfluidic supporting unit.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: March 5, 2019
    Assignees: The Chinese University of Hong Kong, Nanjing University
    Inventors: Minghui Tang, Ho-Pui Ho, Guanghui Wang, Siu-Kai Kong, Fong-Chuen Loo, Ho Chin Kwok, Shu-Yuen Wu, Xuping Zhang