Abstract: The subject invention pertains to a method of halogenating phenols, yielding a range of halogenated phenols with enantiomeric ratio of up to 99.5:0.5. In certain embodiments, the subject invention pertains to a method of asymmetric halogenation of bisphenol, yielding a range of chiral bisphenol ligands. The novel chiral bisphenols are potent privileged catalyst cores that can be applied to the preparation of ligands for various catalytic asymmetric reactions. The catalyst library can easily be accessed because late-stage modification of the scaffold can readily be executed through cross-coupling of the halogen handles on the bisphenols.

Abstract: The present invention provides novel methods and systems, including cell lines, recombinant polynucleotide constructs, compositions, and kits, for targeted yet universal genomic manipulation.

Abstract: The present invention concerns a method for the detection or monitoring of cancer using a biological sample selected from blood, plasma, serum, saliva, urine from an individual, said method comprising: (a) obtaining DNA from the said biological sample; (b) digesting the DNA sample with one or more methylation-sensitive restriction enzymes; (c) quantifying or detecting a DNA sequence of interest after step (b), wherein the target sequence of interest contains at least two methylation-sensitive restriction enzyme recognition sites; and (d) comparing the level of the DNA sequence from the individual to a normal standard, to detect, prognosticate or monitor cancer.

Abstract: A blocking signal cancellation low noise amplifier system includes a first low noise amplifier, a second low noise amplifier, a blocking signal extraction and bias generation circuit, a bias switching circuit, and a bias switching signal generating circuit. The first low noise amplifier is used for dynamic input matching, and the first low noise amplifier receives an input signal and outputs it after amplifying. The blocking signal extraction and bias generation circuit is used to extract a blocking signal from the output signal of the first low noise amplifier, and output a DC voltage signal. The bias switching circuit is used to switch the first low noise amplifier between a blocking mode and a small signal mode. The bias switching signal generating circuit is used to compare the DC bias voltage signal VB2 with a preset reference voltage signal Vref.

Abstract: The disclosure relates to a method or a platform for hydrogel-based 3D fabrication, wherein the hydrogel is patterned with a programmable femtosecond light sheet with a power density of 0.1 to 100 TW/cm2.

Abstract: Provided is an aqueous redox flow battery comprising a positive electrode, a negative electrode, a posolyte chamber containing a posolyte, a negolyte chamber containing a polyoxometalate as a negolyte, and a separator disposed between the posolyte chamber and the negolyte chamber, wherein the polyoxometalate has a conductivity of 65 mS cm?1 or more at ?20° C., and the aqueous redox flow battery has a power density of 250 mW cm?2 or more at ?20° C.

Abstract: Techniques are provided for detecting hematological disorders using cell-free DNA in a blood sample, e.g., using plasma or serum. For example, an assay can target one or more differentially-methylated regions specific to a particular hematological cell lineage (e.g., erythroblasts). A methylation level can be quantified from the assay to determine an amount of methylated or unmethylated DNA fragments in a cell-free mixture of the blood sample. The methylation level can be compared to one or more cutoff values, e.g., that correspond to a normal range for the particular hematological cell lineage as part of determining a level of a hematological disorder.

Abstract: The present disclosure provides a method of preparing unsaturated hydrocarbons by black body photocatalytic (thermal radiative catalytic) conversion of saturated hydrocarbons. In this method, a saturated hydrocarbon reaction gas is introduced into a reaction furnace, and the saturated hydrocarbon is catalyzed to convert under heating and illumination conditions to prepare the unsaturated hydrocarbons. The photocatalysis is combined to the conventional thermal catalysis to improve the catalytic performance, accelerate the reaction speed, increase the conversion rate, and/or improve the selectivity of the catalytic reaction.

Abstract: The subject invention pertains to methods and devices for generating mature oocytes from immature oocytes and improving oocyte quality for improved success of assistant reproductive technology (ART). The methods include the use of tunneling nanotube-forming cells and oocytes, wherein the tunneling nanotube-forming cells transfer autologous genomic materials, biomolecules and cellular components to the oocytes. The devices of the invention include microfluidic device to improve the efficiency of the transfer of biomolecules and cellular components between tunneling nanotube-forming cells and oocytes.

Abstract: A data sparse projection method, includes: randomly initializing a high-dimensional sparse two-dimensional matrix (S1); fixing the high-dimensional sparse two-dimensional matrix, and calculating an optimal output variable by using the high-dimensional sparse two-dimensional matrix (S2); fixing the optimal output variable, and calculating an optimal high-dimensional sparse two-dimensional matrix by using the optimal output variable (S3); and cyclically fixing the high-dimensional sparse two-dimensional matrix and the output variable until the optimal output variable is no longer increased when the high-dimensional sparse two-dimensional matrix is fixed (S4).

Abstract: The present disclosure provides a humidity-stiffening polymer material, and a preparation method therefor and a use thereof. The humidity-stiffening polymer material includes the following raw materials: a monomer, an ionic liquid, a salt, a cross-linking agent and an initiator, wherein the monomer includes benzyl methacrylate, the ionic liquid includes an imidazole-based ionic liquid, and the salt includes a hygroscopic salt. The method for preparing the humidity-stiffening polymer material includes: mixing the raw materials to obtain a precursor liquid, performing reaction on the mixture after degassing, and drying the mixture to obtain the humidity-stiffening polymer material. The humidity-stiffening polymer material is applied to actuators, soft robots and wearable biomedical devices based on bionic design.

Abstract: Disclosed is a method for analyzing a distribution of retinal lesions in a mouse model, including: scanning a mouse posterior polar fundus based on optical coherence tomography (OCT), and acquiring lesion images of the mouse posterior polar fundus; acquiring lesion distribution coordinates based on the lesion images of the mouse posterior polar fundus; constructing a coordinate map of a lesion distribution rule based on the lesion distribution coordinates; and acquiring lesion distribution in quadrants based on the coordinate map of the lesion distribution rule, and calculating and counting a number of lesions in each quadrant.

Abstract: Disclosed is a method for fabricating a wearable hydrogel glucose sensor, belonging to the technical field of biomedical sensing, including using polyacrylamide hydrogel as a basic material, preparing a hydrogel film by adding with phenylboronic acid group capable of recognizing glucose molecules, and carrying out grating writing on the hydrogel film in a femtosecond laser direct writing mode to obtain the wearable hydrogel glucose sensor. The hydrogel film combines with glucose and expands linearly, which makes the grating period and effective refractive index change. The quantitative measurement of glucose is realized by detecting the spatial position of diffraction band and the change of diffraction power intensity.

Abstract: Ultra-stable aqueous foam comprises hydrophobic silica particles residing within bubbles in an aqueous solution of a hydrophilic polymer, a protein, or aqueous dispersible colloidal particles. The combination of the hydrophobic and hydrophilic components stabilizes the foam interfaces to result in long term stability of the foam. The foams can be crosslinked to stable monolithic foams and used for structural foams, coatings, and thermal insulating for construction.

Abstract: It provides novel fusion proteins that are capable of self-crystallization and exhibit improved physical properties such as enhanced tolerance to organic solvents and increased thermostability. Polynucleotides encoding the fusion proteins as well as methods of making and using such fusion proteins are also described.

Abstract: The present invention provides an aptamer that specifically hinds CD44, composition comprising the aptamer, as well as methods for detecting CD44 and for targeted delivery to CD44-expressing cells.

Abstract: A blocking signal cancellation low noise amplifier system includes a first low noise amplifier, a second low noise amplifier, a blocking signal extraction and bias generation circuit, a bias switching circuit, and a bias switching signal generating circuit. The first low noise amplifier is used for dynamic input matching, and the first low noise amplifier receives an input signal and outputs it after amplifying. The blocking signal extraction and bias generation circuit is used to extract a blocking signal from the output signal of the first low noise amplifier, and output a DC voltage signal. The bias switching circuit is used to switch the first low noise amplifier between a blocking mode and a small signal mode. The bias switching signal generating circuit is used to compare the DC bias voltage signal VB2 with a preset reference voltage signal Vref.

Abstract: Denoising of magnetic resonance (MR) images can be achieved using a deep neural network and an image acquisition process that uses multi-NEX (Number of Excitations) or multi-NSA (Number of Signal Averages or Acquisitions) to produce two or more complex-valued images of a region of interest. The set of images resulting from the image acquisition process can be input to a deep neural network that has been trained to produce a denoised MR image from a set of multi-NEX or multi-NSA images. The deep neural network can be implemented using a two-dimensional or three-dimensional convolutional neural network to match the dimensionality of the input images. Training of the denoising neural network can use real MR images.

Abstract: The subject invention pertains to a pneumatic, hydraulic, or otherwise inflatable or pressurized artificial muscle. Also provided are methods for making, controlling, and using such a muscle useful for prostheses, movement aids, or wearable robots to assist the movement of impaired subjects or to improve the function of healthy subjects. Muscles can be made by densely winding tension wires around pressurized expandable tubes having one or more specific geometric shapes removed from the tube cross section. The curve of output characteristics such as output force vs. contraction ratio can be adjustable by changing parameters of the sectional view of the tube. The appropriate shape of tube and related output characteristics can be selected according to application area or body part to be assisted to achieve the most flexible and optimal design for one or more muscle groups.

Abstract: The present disclosure provides a humidity-stiffening polymer material, and a preparation method therefor and a use thereof. The humidity-stiffening polymer material includes the following raw materials: a monomer, an ionic liquid, a salt, a cross-linking agent and an initiator, wherein the monomer includes benzyl methacrylate, the ionic liquid includes an imidazole-based ionic liquid, and the salt includes a hygroscopic salt. The method for preparing the humidity-stiffening polymer material includes: mixing the raw materials to obtain a precursor liquid, performing reaction on the mixture after degassing, and drying the mixture to obtain the humidity-stiffening polymer material. The humidity-stiffening polymer material is applied to actuators, soft robots and wearable biomedical devices based on bionic design. The present disclosure provides a humidity-stiffening polymer material, and a preparation method therefor and a use thereof.